LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。
美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。

LKT Labs C0366 Carvedilol Phosphate

LKT Labs C0366 Carvedilol Phosphate

LKT O4531 Oligomycin A 5 mg 318.2 Macrolide; F1F0 ATP synthase inhibitor. 579-13-5 ≥97%, TLC, HPLC 791.06 C45H74O11 CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "He L, Jang JH, Choi HG, et al. Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression. Mol Carcinog. 2013 Feb;52(2):85-93. PMID: 23335397.

Ponnala S, Chetty C, Veeravalli KK, et al. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int J Oncol. 2012 Feb;40(2):509-18. PMID: 22076676.

Yang PW, Li MG, Zhao JY, et al. Oligomycins A and C, major secondary metabolites isolated from the newly isolated strain Streptomyces diastaticus. Folia Microbiol (Praha). 2010 Jan;55(1):10-6. PMID: 20336498.

" Not dangerous goods.

LKT O4532 Oligomycin B 1 mg 77.1 Macrolide; F1F0 ATP synthase inhibitor. 11050-94-5 ≥97%, TLC, HPLC 805.05 C45H72O12 CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "Grover GJ, Malm J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96. PMID: 19035880.

Grover GJ, Atwal KS, Sleph PG, et al. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484.  PMID: 15371268.

Koos BJ, Sameshima H, Power GG. Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol. 1986 Feb;8(1):67-75. PMID: 2937831.

" Xn Not dangerous goods.

LKT O4532 Oligomycin B 5 mg 318.2 Macrolide; F1F0 ATP synthase inhibitor. 11050-94-5 ≥97%, TLC, HPLC 805.05 C45H72O12 CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C Ambient 4°C Soluble in DMSO, ethanol, acetone. "Grover GJ, Malm J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc Ther. 2008 Winter;26(4):287-96. PMID: 19035880.

Grover GJ, Atwal KS, Sleph PG, et al. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484.  PMID: 15371268.

Koos BJ, Sameshima H, Power GG. Fetal breathing movement, sleep state and cardiovascular responses to an inhibitor of mitochondrial ATPase in sheep. J Dev Physiol. 1986 Feb;8(1):67-75. PMID: 2937831.

" Xn Not dangerous goods.

LKT T1855 Tentoxin 1 mg 693.2 Cyclic peptide mycotoxin produced by Alternaria; CF1 ATPase inhibitor. Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine 28540-82-1 ≥98%, HPLC 414.5 C22H30N4O4 CC1C(=O)NC(C(=O)N(C(=CC2=CC=CC=C2)C(=O)NCC(=O)N1C)C)CC(C)C Ambient 4°C Soluble in DMSO (10 mg/mL), methanol (10 mg/mL), ethanol (10 mg/mL. "Duke SO, Dayan FE. Modes of action of microbially-produced phytotoxins. Toxins (Basel). 2011 Aug;3(8):1038-64. Erratum in: Toxins (Basel). 2012;4(10):955.  PMID: 22069756.

Reimer S, Selman BR. Tentoxin-induced energy-independent adenine nucleotide exchange and ATPase activity with chloroplast coupling factor 1. J Biol Chem. 1978 Oct 25;253(20):7249-55. PMID: 151681.

Selman BR, Durbin RD. Evidence for a catalytic function of the coupling factor 1 protein reconstituted with chloroplast thylakoid membranes. Biochim Biophys Acta. 1978 Apr 11;502(1):29-37. PMID: 147703.

" T Not dangerous goods.

LKT T1855 Tentoxin 5 mg 2765.8 Cyclic peptide mycotoxin produced by Alternaria; CF1 ATPase inhibitor. Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine 28540-82-1 ≥98%, HPLC 414.5 C22H30N4O4 CC1C(=O)NC(C(=O)N(C(=CC2=CC=CC=C2)C(=O)NCC(=O)N1C)C)CC(C)C Ambient 4°C Soluble in DMSO (10 mg/mL), methanol (10 mg/mL), ethanol (10 mg/mL. "Duke SO, Dayan FE. Modes of action of microbially-produced phytotoxins. Toxins (Basel). 2011 Aug;3(8):1038-64. Erratum in: Toxins (Basel). 2012;4(10):955.  PMID: 22069756.

Reimer S, Selman BR. Tentoxin-induced energy-independent adenine nucleotide exchange and ATPase activity with chloroplast coupling factor 1. J Biol Chem. 1978 Oct 25;253(20):7249-55. PMID: 151681.

Selman BR, Durbin RD. Evidence for a catalytic function of the coupling factor 1 protein reconstituted with chloroplast thylakoid membranes. Biochim Biophys Acta. 1978 Apr 11;502(1):29-37. PMID: 147703.

" T Not dangerous goods.

LKT T1952 Tenuazonic Acid 1 mg 67.9 Mycotoxin produced by Alternaria; photosynthesis inhibitor. "3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

L-Tenuazonic acid" 610-88-8 ≥96% 197.23 C10H15NO3 CCC(C)C1C(=C(C(=O)N1)C(=O)C)O Ambient 4°C Soluble in DMSO and ethanol. "Schwarz C, Kreutzer M, Marko D. Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol Lett. 2012 Oct 2;214(1):46-52. PMID: 22906495.

Chen S, Yin C, Qiang S, et al. Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng. Biochim Biophys Acta. 2010 Mar;1797(3):391-405. PMID: 20026008.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Tenuazonic acid)"

LKT T1952 Tenuazonic Acid 5 mg 273 Mycotoxin produced by Alternaria; photosynthesis inhibitor. "3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

L-Tenuazonic acid" 610-88-8 ≥96% 197.23 C10H15NO3 CCC(C)C1C(=C(C(=O)N1)C(=O)C)O Ambient 4°C Soluble in DMSO and ethanol. "Schwarz C, Kreutzer M, Marko D. Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicol Lett. 2012 Oct 2;214(1):46-52. PMID: 22906495.

Chen S, Yin C, Qiang S, et al. Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng. Biochim Biophys Acta. 2010 Mar;1797(3):391-405. PMID: 20026008.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Tenuazonic acid)"

LKT T7676 HT-2 Toxin 1 mg 258 Trichothecene mycotoxin produced by Fusarium. 26934-87-2 ≥98%, TLC, HPLC 424.48 C22H32O8 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Soluble in Ethanol, DMSO.  Very slightly soluble in water. "Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.

Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.

" Xi, Xn, T+ "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (HT-2 Toxin)"

LKT T7676 HT-2 Toxin 5 mg 1021.2 Trichothecene mycotoxin produced by Fusarium. 26934-87-2 ≥98%, TLC, HPLC 424.48 C22H32O8 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Soluble in Ethanol, DMSO.  Very slightly soluble in water. "Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.

Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.

" Xi, Xn, T+ "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (HT-2 Toxin)"

LKT T3134 Thiostrepton 1 g 231.1 Thiazole; proteasome inhibitor, protein translocation inhibitor. 1393-48-2 ≥97%, HPLC 1664.89 C72H85N19O18S5 CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C Ambient 4°C Practically insoluble in water.  Soluble in chloroform, dichloromethane, DMF.  DMSO solution (1 %) is unstable - should be freshly prepared. "Newick K, Cunniff B, Preston K, et al. Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. PLoS One. 2012;7(6):e39404. PMID: 22761781

Rodnina MV, Savelsbergh A, Matassova NB, et al. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9586-90. PMID: 10449736.

Naaktgeboren N, Roobol K, Gubbens J, et al. The mode of action of thiostrepton in the initiation of protein synthesis. Eur J Biochem. 1976 Nov 1;70(1):39-47. PMID: 795651.

" Xn Not dangerous goods.

LKT T3134 Thiostrepton 5 g 927.7 Thiazole; proteasome inhibitor, protein translocation inhibitor. 1393-48-2 ≥97%, HPLC 1664.89 C72H85N19O18S5 CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C Ambient 4°C Practically insoluble in water.  Soluble in chloroform, dichloromethane, DMF.  DMSO solution (1 %) is unstable - should be freshly prepared. "Newick K, Cunniff B, Preston K, et al. Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. PLoS One. 2012;7(6):e39404. PMID: 22761781

Rodnina MV, Savelsbergh A, Matassova NB, et al. Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9586-90. PMID: 10449736.

Naaktgeboren N, Roobol K, Gubbens J, et al. The mode of action of thiostrepton in the initiation of protein synthesis. Eur J Biochem. 1976 Nov 1;70(1):39-47. PMID: 795651.

" Xn Not dangerous goods.

LKT D4802 17-Dimethylaminoethylamino Demethoxygeldanamycin 10 mg 169.9 Geldanamycin derivative; HSP90 inhibitor. 17-DMAG, Alvespimycin 467214-20-6 ≥98% 616.75 C32H48N4O8 CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C DMSO, Ethanol "Silva-Fernandes A, Duarte-Silva S, Neves-Carvalho A, et al. Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease. Neurotherapeutics. 2014 Jan 30. [Epub ahead of print]. PMID: 24477711.

Yi B, Yang J, Wang L. The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell line. Tumour Biol. 2013 Nov 30. [Epub ahead of print]. PMID: 24293393.

Sun X, Bristol JA, Iwahori S, et al. Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. J Virol. 2013 Sep;87(18):10126-38. PMID: 23843639.

Ikebe E, Kawaguchi A, Tezuka K, et al. Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. Blood Cancer J. 2013 Aug 16;3:e132. PMID: 23955587.

" Not dangerous goods.

LKT F8147 Fulvestrant 5 mg 47.6 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT F8147 Fulvestrant 25 mg 136 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT F8147 Fulvestrant 100 mg 407.7 Induces ER degradation. 129453-61-8 ≥98% 606.77 C32H47F5O3S CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient "Soluble in ethanol (>200 mg/mL), DMSO (>20 mg/mL).  Insoluble in water. DMF 20 mg/mL, chloroform.

" "Edavana VK, Penney RB, Yao-Borengasser A, et al. Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism. Springerplus. 2013 Nov 20;2:620. PMID: 24298433.

Krell J, Januszewski A, Yan K, et al. Role of fulvestrant in the management of postmenopausal breast cancer. Expert Rev Anticancer Ther. 2011 Nov;11(11):1641-52. PMID: 22050013.

Scott SM, Brown M, Come SE. Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer. Expert Opin Drug Saf. 2011 Sep;10(5):819-26. PMID: 21699443

Camerini A, Rondini M, Garrone O, et al. Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer Biol Ther. 2009 Aug;8(15):1450-5. PMID: 19556864.

" Not dangerous goods.

LKT K1978 Ketorolac Tromethamine 1 g 33.5 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT K1978 Ketorolac Tromethamine 5 g 125.6 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT K1978 Ketorolac Tromethamine 25 g 502.3 NSAID; COX-1/2 inhibitor. 74103-07-4 ≥98% 376.4 C19H24N2O6 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O Ambient Ambient "Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

" Xi "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Ketorolac tromethamine)"

LKT E5477 Entinostat 1 mg 54.4 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT E5477 Entinostat 5 mg 212.3 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT E5477 Entinostat 25 mg 758.4 Benzamide; HDAC1 inhibitor. N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester SNDX-275; MS-275; 209783-80-2    ≥98% 376.41 C21H20N4O3 C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 Ambient Ambient "Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.

" Xi Not dangerous goods.

LKT H9814 25-Hydroxyvitamin D2 1 mg 265 Vitamin D2, ergocalciferol metabolite; VDR agonist. (E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol 21343-40-8 ≥90% 412.65 C28H44O2 CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Shah I, Petroczi A, Tabet N, et al. Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Curr Alzheimer Res. 2012 Nov;9(9):1069-76. PMID: 22876849.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. PMID: 17023693.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (25-Hydroxyvitamin D2)"

LKT H9814 25-Hydroxyvitamin D2 5 mg 1141.6 Vitamin D2, ergocalciferol metabolite; VDR agonist. (E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol 21343-40-8 ≥90% 412.65 C28H44O2 CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Shah I, Petroczi A, Tabet N, et al. Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Curr Alzheimer Res. 2012 Nov;9(9):1069-76. PMID: 22876849.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. PMID: 17023693.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (25-Hydroxyvitamin D2)"

LKT H9815 25-Hydroxyvitamin D3 1 mg 88.3 Vitamin D, calcitriol prodrug; VDR agonist. Calcifediol, calcidiol, 25-hydroxycholecalciferol 19356-17-3 ≥98% 400.64 C27H44O2 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Wang Q, Li H, Xie H, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013 May;135:43-50. PMID: 23333931.

Li H, Xie H, Fu M, et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids. 2013 Feb;78(2):115-20. PMID: 23138030.

Ritter CS, Brown AJ. Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. J Mol Endocrinol. 2011 Feb 15;46(2):63-6. PMID: 21169421.

Tuohimaa P, Golovko O, Kalueff A, et al. Calcidiol and prostate cancer. J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):183-90. PMID: 15860261.

van Leeuwen JP, van Driel M, van den Bemd GJ, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226. PMID: 11693961.

" T+ "UN number: 2811     Class: 6.1     Packing group: II

Proper shipping name: Toxic solids, organic, n.o.s. (25-Hydroxyvitamin D3)  

Reportable Quantity (RQ):     Marine pollutant: No      Poison inhalation hazard: No"

LKT H9815 25-Hydroxyvitamin D3 5 mg 394.2 Vitamin D, calcitriol prodrug; VDR agonist. Calcifediol, calcidiol, 25-hydroxycholecalciferol 19356-17-3 ≥98% 400.64 C27H44O2 CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C Ambient -20°C "Wang Q, Li H, Xie H, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013 May;135:43-50. PMID: 23333931.

Li H, Xie H, Fu M, et al. 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids. 2013 Feb;78(2):115-20. PMID: 23138030.

Ritter CS, Brown AJ. Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. J Mol Endocrinol. 2011 Feb 15;46(2):63-6. PMID: 21169421.

Tuohimaa P, Golovko O, Kalueff A, et al. Calcidiol and prostate cancer. J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):183-90. PMID: 15860261.

van Leeuwen JP, van Driel M, van den Bemd GJ, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):199-226. PMID: 11693961.

" T+ "UN number: 2811     Class: 6.1     Packing group: II

Proper shipping name: Toxic solids, organic, n.o.s. (25-Hydroxyvitamin D3)  

Reportable Quantity (RQ):     Marine pollutant: No      Poison inhalation hazard: No"

LKT G0245 Gallocatechin Gallate 5 mg 160.2 Polyphenol found in Camilla sinensis; HIV integrase inhibitor. 4233-96-9 ≥98% 458.37 C22H18O11 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O Ambient 4°C -38° "Masler EP. Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. J Helminthol. 2013 May 2:1-8. [Epub ahead of print]. PMID: 23635519.

Timmel MA, Byl JA, Osheroff N. Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases. Chem Res Toxicol. 2013 Apr 4. [Epub ahead of print]. PMID: 23514406.

Boušová I, Hájek J, Dršata J, et al. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase. Xenobiotica. 2012 Sep;42(9):872-9. PMID: 22458346.

Cao P, Raleigh DP. Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry. 2012 Apr 3;51(13):2670-83. PMID: 22409724.

Jiang F, Chen W, Yi K, et al. The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. Clin Immunol. 2010 Dec;137(3):347-56. PMID: 20832370.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

" Xi Not dangerous goods.

LKT G0245 Gallocatechin Gallate 10 mg 254.8 Polyphenol found in Camilla sinensis; HIV integrase inhibitor. 4233-96-9 ≥98% 458.37 C22H18O11 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O Ambient 4°C -38° "Masler EP. Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. J Helminthol. 2013 May 2:1-8. [Epub ahead of print]. PMID: 23635519.

Timmel MA, Byl JA, Osheroff N. Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases. Chem Res Toxicol. 2013 Apr 4. [Epub ahead of print]. PMID: 23514406.

Boušová I, Hájek J, Dršata J, et al. Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase. Xenobiotica. 2012 Sep;42(9):872-9. PMID: 22458346.

Cao P, Raleigh DP. Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanols. Biochemistry. 2012 Apr 3;51(13):2670-83. PMID: 22409724.

Jiang F, Chen W, Yi K, et al. The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. Clin Immunol. 2010 Dec;137(3):347-56. PMID: 20832370.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

" Xi Not dangerous goods.

LKT I6804 Irbesartan 1 g 40.3 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT I6804 Irbesartan 5 g 70.2 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT I6804 Irbesartan 25 g 268 PPARγ agonist, AT1 inhibitor. 2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one Aprovel, Avapro 138402-11-6 ≥98% 428.53 C25H28N6O CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5 Ambient Ambient "Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

" Xn Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 1 mg 37.5 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 5 mg 65.6 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 25 mg 149.9 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT P0092 Paclitaxel, from Taxus yunnanensis 100 mg 337.6 Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor. Taxol; Taxol A; Paxene 33069-62-4 ≥98% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol (18mg/mL) or DMSO (50mg/ml) "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Repr. 2 , Carc. Cat 3 Not dangerous goods.

LKT H9614 Hydrochlorothiazide 5 g 58.7 Thiazide diuretic; NCCT inhibitor, carbonic anhydrase I inhibitor. 6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 58-93-5    ≥98% 297.74 C7H8ClN3O4S2 C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl Ambient Ambient "Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

" T Not dangerous goods.

LKT H9614 Hydrochlorothiazide 25 g 108.9 Thiazide diuretic; NCCT inhibitor, carbonic anhydrase I inhibitor. 6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 58-93-5    ≥98% 297.74 C7H8ClN3O4S2 C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl Ambient Ambient "Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

" T Not dangerous goods.

LKT N3301 Niacin 10 g 30.2 Vitamin B, required for formation of NAD and NADP; GPR109A agonist, hepatic diacylglycerol acyltransferase-2 inhibitor. Nicotinic acid 59-67-6    ≥98% 123.11 C6H5NO2 C1=CC(=CN=C1)C(=O)O Ambient Ambient Soluble in water (16 mg/mL). "Creider JC, Hegele RA, Joy TR. Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol. 2012 Sep;8(9):517-28. PMID: 22349076.

Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. PMID: 19691622.

Kamanna VS, Ganji SH, Kashyap ML. Niacin: an old drug rejuvenated. Curr Atheroscler Rep. 2009 Jan;11(1):45-51. PMID: 19080727.

Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17;101(8A):20B-26B. PMID: 18375237.

" T+, Xi, T Not dangerous goods.

LKT N3301 Niacin 50 g 36.9 Vitamin B, required for formation of NAD and NADP; GPR109A agonist, hepatic diacylglycerol acyltransferase-2 inhibitor. Nicotinic acid 59-67-6    ≥98% 123.11 C6H5NO2 C1=CC(=CN=C1)C(=O)O Ambient Ambient Soluble in water (16 mg/mL). "Creider JC, Hegele RA, Joy TR. Niacin: another look at an underutilized lipid-lowering medication. Nat Rev Endocrinol. 2012 Sep;8(9):517-28. PMID: 22349076.

Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. PMID: 19691622.

Kamanna VS, Ganji SH, Kashyap ML. Niacin: an old drug rejuvenated. Curr Atheroscler Rep. 2009 Jan;11(1):45-51. PMID: 19080727.

Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17;101(8A):20B-26B. PMID: 18375237.

" T+, Xi, T Not dangerous goods.

LKT V0146 Valsartan 1 g 41.9 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT V0146 Valsartan 5 g 75.3 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT V0146 Valsartan 25 g 276.3 AT1 inhibitor. N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine 137862-53-4 ≥98% 435.52 C24H29N5O3 CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O Ambient Ambient "Wu X, He L, Cai Y, et al. Induction of autophagy contributes to the myocardial protection of valsartan against ischemia reperfusion injury. Mol Med Rep. 2013 Dec;8(6):1824-30. PMID: 24084854.

Sohn YI, Lee NJ, Chung A, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013 Oct 4;439(4):464-70. PMID: 24012668.

Cheng CI, Hsiao CC, Wu SC, et al. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol. 2013 Sep 10;167(6):2765-74. PMID: 22805546.

Al-Mazroua HA, Al-Rasheed NM, Korashy HM. Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro: a novel mechanism of cardioprotection. J Cardiovasc Pharmacol. 2013 Apr;61(4):337-44. PMID: 23288202.

Iwashita M, Sakoda H, Kushiyama A, et al. Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. PMID: 22045314.

Müller DN, Mervaala EM, Dechend R, et al. Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol. 2000 Jul;157(1):111-22. PMID: 10880382.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

" Xi Not dangerous goods.

LKT C2961 Chondroitin Sulfate, chicken 5 g 51.1 Polyanionic sulfated glycosaminoglycan, endogenous component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83.  PMID: 18501644.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31.  PMID: 12723984.

Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

" Not dangerous goods.

LKT C2961 Chondroitin Sulfate, chicken 25 g 196.8 Polyanionic sulfated glycosaminoglycan, endogenous component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83.  PMID: 18501644.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31.  PMID: 12723984.

Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

" Not dangerous goods.

LKT C0016 Caerulomycin A 1 mg 388.3 Bipyridamine toxin. Cerulomycin 21802-37-9 ≥96% 229.23 C12H11N3O2 COC1=CC(=CN=O)NC(=C1)C2=CC=CC=N2 Ambient -20°C "Zhu Y, Zhang Q, Li S, et al. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. J Am Chem Soc. 2013 Dec 5. [Epub ahead of print]. PMID: 24295370.

Cristalli G, Franchetti P, Grifantini M, et al. 2,2'-Bipyridyl-6-carboxamidoximes with potential antitumor and antimicrobial properties. Farmaco Sci. 1986 Jul;41(7):499-507. PMID: 3743743

Chatterjee DK, Raether W, Iyer N, et al. Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica. Z Parasitenkd. 1984;70(5):569-73. PMID: 6095553.

" Not dangerous goods.

LKT P7057 Protodioscin 5 mg 120.4 Saponin found in Dioscorea; Na+/K+ ATPase and Ca2+/Mg2+ ATPase activator. 55056-80-9 ≥98% 1049.19 C50H82O22 CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)O Ambient Ambient "Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

" U/A Not dangerous goods.

LKT P7057 Protodioscin 25 mg 468.8 Saponin found in Dioscorea; Na+/K+ ATPase and Ca2+/Mg2+ ATPase activator. 55056-80-9 ≥98% 1049.19 C50H82O22 CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)O Ambient Ambient "Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

" U/A Not dangerous goods.

LKT G0243 (−)-Gallocatechin 5 mg 83.7 Polyphenol found in Camilla sinensis; HIV integrase and RT inhibitor, α-amylase inhibitor. 3371-27-5 ≥98% 306.27 C15H14O7 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O Ambient 4°C "Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013 May 15;61(19):4570-6. PMID: 23614772.

Colon M, Nerin C. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. J Agric Food Chem. 2012 Oct 3;60(39):9842-9. PMID: 22973940.

F Vale LH, Mendes MM, Fernandes RS, et al. Protective effect of schizolobium parahyba flavonoids against snake venoms and isolated toxins. Curr Top Med Chem. 2011;11(20):2566-77. PMID: 21682680

Jiang Y, Ng TB, Liu Z, et al. Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn) rhizome. Biosci Rep. 2010 Nov 30. PMID: 21114474.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

Ferrazzano GF, Amato I, Ingenito A, et al. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia. 2009 Jul;80(5):255-62. PMID: 19397954.

" Xi Not dangerous goods.

LKT G0243 (−)-Gallocatechin 10 mg 150.7 Polyphenol found in Camilla sinensis; HIV integrase and RT inhibitor, α-amylase inhibitor. 3371-27-5 ≥98% 306.27 C15H14O7 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O Ambient 4°C "Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013 May 15;61(19):4570-6. PMID: 23614772.

Colon M, Nerin C. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. J Agric Food Chem. 2012 Oct 3;60(39):9842-9. PMID: 22973940.

F Vale LH, Mendes MM, Fernandes RS, et al. Protective effect of schizolobium parahyba flavonoids against snake venoms and isolated toxins. Curr Top Med Chem. 2011;11(20):2566-77. PMID: 21682680

Jiang Y, Ng TB, Liu Z, et al. Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn) rhizome. Biosci Rep. 2010 Nov 30. PMID: 21114474.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

Ferrazzano GF, Amato I, Ingenito A, et al. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia. 2009 Jul;80(5):255-62. PMID: 19397954.

" Xi Not dangerous goods.

LKT G0243 (−)-Gallocatechin 25 mg 326.3 Polyphenol found in Camilla sinensis; HIV integrase and RT inhibitor, α-amylase inhibitor. 3371-27-5 ≥98% 306.27 C15H14O7 C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O Ambient 4°C "Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013 May 15;61(19):4570-6. PMID: 23614772.

Colon M, Nerin C. Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. J Agric Food Chem. 2012 Oct 3;60(39):9842-9. PMID: 22973940.

F Vale LH, Mendes MM, Fernandes RS, et al. Protective effect of schizolobium parahyba flavonoids against snake venoms and isolated toxins. Curr Top Med Chem. 2011;11(20):2566-77. PMID: 21682680

Jiang Y, Ng TB, Liu Z, et al. Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn) rhizome. Biosci Rep. 2010 Nov 30. PMID: 21114474.

Ko CH, Lau KM, Choy WY, et al. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26;57(16):7293-7. PMID: 19653629.

Ferrazzano GF, Amato I, Ingenito A, et al. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia. 2009 Jul;80(5):255-62. PMID: 19397954.

" Xi Not dangerous goods.

LKT N1755 Neomycin Sulfate 100 g 161.5 Polycationic aminoglycoside; protein translation inhibitor, cation channel/receptor (P2X, TRPV1) blocker. 1405-10-3 ≥98% 908.9 C23H46N6O13 3H2SO4 C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O Ambient Ambient Soluble in water (1 g/mL). "Wang L, Pulk A, Wasserman MR, et al. Allosteric control of the ribosome by small-molecule antibiotics. Nat Struct Mol Biol. 2012 Sep;19(9):957-63. PMID: 22902368.

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Anupam R, Denapoli L, Muchenditsi A, et al. Identification of neomycin B-binding site in T box antiterminator model RNA. Bioorg Med Chem. 2008 Apr 15;16(8):4466-70. PMID: 18329274.

Kawamoto SA, Sudhahar CG, Hatfield CL, et al. Studies on the mechanism of inhibition of bacterial ribonuclease P by aminoglycoside derivatives. Nucleic Acids Res. 2008 Feb;36(2):697-704. PMID: 18084035.

Raisinghani M, Premkumar LS. Block of native and cloned vanilloid receptor 1 (TRPV1) by aminoglycoside antibiotics. Pain. 2005 Jan;113(1-2):123-33. PMID: 15621372.

Wright JM, Collier B. The effects of neomycin upon transmitter release and action. J Pharmacol Exp Ther. 1977 Mar;200(3):576-87. PMID: 191590.

" Xn Not dangerous goods.

LKT M5876 Motesanib 5 mg 251.3 VEGFR1/2/3, PDGFR, c-Kit, RET inhibitor. N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide AMG-706 453562-69-1 ≥98% 373.45 C22H23N5O CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C Ambient Ambient "Ellis PM, Al-Saleh K. Multitargeted anti-angiogenic agents and NSCLC: clinical update and future directions. Crit Rev Oncol Hematol. 2012 Oct;84(1):47-58. PMID: 22405734.

Coxon A, Ziegler B, Kaufman S, et al. Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models. Mol Cancer. 2012 Sep 19;11:70. PMID: 22992329.

Coxon A, Bready J, Kaufman S, et al. Anti-tumor activity of motesanib in a medullary thyroid cancer model. J Endocrinol Invest. 2012 Feb;35(2):181-90. PMID: 21422803.

Raghav KP, Blumenschein GR. Motesanib and advanced NSCLC: experiences and expectations. Expert Opin Investig Drugs. 2011 Jun;20(6):859-69. PMID: 21534718.

Polverino A, Coxon A, Starnes C, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21. PMID: 16951187.

" Not dangerous goods.

LKT M5876 Motesanib 10 mg 335 VEGFR1/2/3, PDGFR, c-Kit, RET inhibitor. N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide AMG-706 453562-69-1 ≥98% 373.45 C22H23N5O CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C Ambient Ambient "Ellis PM, Al-Saleh K. Multitargeted anti-angiogenic agents and NSCLC: clinical update and future directions. Crit Rev Oncol Hematol. 2012 Oct;84(1):47-58. PMID: 22405734.

Coxon A, Ziegler B, Kaufman S, et al. Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models. Mol Cancer. 2012 Sep 19;11:70. PMID: 22992329.

Coxon A, Bready J, Kaufman S, et al. Anti-tumor activity of motesanib in a medullary thyroid cancer model. J Endocrinol Invest. 2012 Feb;35(2):181-90. PMID: 21422803.

Raghav KP, Blumenschein GR. Motesanib and advanced NSCLC: experiences and expectations. Expert Opin Investig Drugs. 2011 Jun;20(6):859-69. PMID: 21534718.

Polverino A, Coxon A, Starnes C, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21. PMID: 16951187.

" Not dangerous goods.

LKT M5876 Motesanib 25 mg 669.7 VEGFR1/2/3, PDGFR, c-Kit, RET inhibitor. N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide AMG-706 453562-69-1 ≥98% 373.45 C22H23N5O CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C Ambient Ambient "Ellis PM, Al-Saleh K. Multitargeted anti-angiogenic agents and NSCLC: clinical update and future directions. Crit Rev Oncol Hematol. 2012 Oct;84(1):47-58. PMID: 22405734.

Coxon A, Ziegler B, Kaufman S, et al. Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models. Mol Cancer. 2012 Sep 19;11:70. PMID: 22992329.

Coxon A, Bready J, Kaufman S, et al. Anti-tumor activity of motesanib in a medullary thyroid cancer model. J Endocrinol Invest. 2012 Feb;35(2):181-90. PMID: 21422803.

Raghav KP, Blumenschein GR. Motesanib and advanced NSCLC: experiences and expectations. Expert Opin Investig Drugs. 2011 Jun;20(6):859-69. PMID: 21534718.

Polverino A, Coxon A, Starnes C, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21. PMID: 16951187.

" Not dangerous goods.

LKT A0818 15-Acetoxyscirpenol 1 mg 150.7 Trichothecene mycotoxin produced by Fusarium. Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate "15-Acetoxyscirpen-3,4-diol, (3-alpha)-12,13-Epoxytrichothec-9-ene-3,4,15-triol 15-

acetate" 2623-22-5 ≥97% 324.37 C17H24O6 CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Chloroform, ethyl acetate, acetone, DMSO Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54. PMID: 16595895. T, Xi "UN number: 2811      Class: 6.1     Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (15-Acetoxyscirpenol)"

LKT A0818 15-Acetoxyscirpenol 5 mg 602.6 Trichothecene mycotoxin produced by Fusarium. Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate "15-Acetoxyscirpen-3,4-diol, (3-alpha)-12,13-Epoxytrichothec-9-ene-3,4,15-triol 15-

acetate" 2623-22-5 ≥97% 324.37 C17H24O6 CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C Ambient 4°C Chloroform, ethyl acetate, acetone, DMSO Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54. PMID: 16595895. T, Xi "UN number: 2811      Class: 6.1     Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (15-Acetoxyscirpenol)"

LKT N3584 Nivalenol 1 mg 401.8 Trichothecene mycotoxin produced by Fusarium; peptide chain initiation inhibitor. 23282-20-4 ≥99%, TLC 312.32 C15H20O7 CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)O)C)CO Ambient -20°C DMSO, Methanol, dichloromethane.  Slightly soluble in water. "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.

Nagashima H, Kushiro M, Nakagawa H. Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells. Environ Toxicol Pharmacol. 2011 Jan;31(1):258-61. PMID: 21787693.

Marzocco S, Russo R, Bianco G, et al. Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. Toxicol Lett. 2009 Aug 25;189(1):21-6. PMID: 19410639.

Nasri T, Bosch RR, Voorde St, et al. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol In Vitro. 2006 Sep;20(6):832-40. PMID: 16472964.

Cundliffe E, Cannon M, Davies J. Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4. PMID: 4521056.

" T+ "UN number: 2811     Class:  6.1      Packing Group:  II

Proper shipping name:  Toxic solids, organic, n.o.s. (Nivalenol)

Poison Inhalation Hazard:  No "

LKT N3584 Nivalenol 5 mg 1516.7 Trichothecene mycotoxin produced by Fusarium; peptide chain initiation inhibitor. 23282-20-4 ≥99%, TLC 312.32 C15H20O7 CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)O)C)CO Ambient -20°C DMSO, Methanol, dichloromethane.  Slightly soluble in water. "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.

Nagashima H, Kushiro M, Nakagawa H. Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells. Environ Toxicol Pharmacol. 2011 Jan;31(1):258-61. PMID: 21787693.

Marzocco S, Russo R, Bianco G, et al. Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. Toxicol Lett. 2009 Aug 25;189(1):21-6. PMID: 19410639.

Nasri T, Bosch RR, Voorde St, et al. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol In Vitro. 2006 Sep;20(6):832-40. PMID: 16472964.

Cundliffe E, Cannon M, Davies J. Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4. PMID: 4521056.

" T+ "UN number: 2811     Class:  6.1      Packing Group:  II

Proper shipping name:  Toxic solids, organic, n.o.s. (Nivalenol)

Poison Inhalation Hazard:  No "

LKT T0003 T2 Tetraol 1 mg 301.5 Trichothecene mycotoxin produced by Fusarium. "3-alpha,4-beta,8-alpha,15-Tetrahydroxy-12,13-epoxytrichothec-9-ene

Toxin T4, T4-ol" 34114-99-3 ≥97%, TLC 298.33 C15H22O6 CC1=CC2C(CC1O)(C3(C(C(C(C34CO4)O2)O)O)C)CO Ambient 4°C Madhyastha MS, Marquardt RR, Abramson D. Structure-activity relationships and interactions among trichothecene mycotoxins as assessed by yeast bioassay. Toxicon. 1994 Sep;32(9):1147-52. PMID: 7801350. T+, Xi "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (T2 Tetraol)"

LKT T0003 T2 Tetraol 5 mg 1205.4 Trichothecene mycotoxin produced by Fusarium. "3-alpha,4-beta,8-alpha,15-Tetrahydroxy-12,13-epoxytrichothec-9-ene

Toxin T4, T4-ol" 34114-99-3 ≥97%, TLC 298.33 C15H22O6 CC1=CC2C(CC1O)(C3(C(C(C(C34CO4)O2)O)O)C)CO Ambient 4°C Madhyastha MS, Marquardt RR, Abramson D. Structure-activity relationships and interactions among trichothecene mycotoxins as assessed by yeast bioassay. Toxicon. 1994 Sep;32(9):1147-52. PMID: 7801350. T+, Xi "UN number: 3462     Class: 6.1     Packing Group: I

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (T2 Tetraol)"

LKT T0004 T2 Triol 1 mg 301.5 Trichothecene mycotoxin produced by Fusarium; peptide chain initiation inhibitor. 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate 3-alpha,4-beta,15-Trihydroxy-8-alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene T2 toxin triol 34114-98-2 ≥97%, TLC 382.45 C20H30O7 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)CO "Ambient

" -20°C DMSO, Dichloromethane, methanol.  Slightly soluble in water. "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.

Edwards SG. Fusarium mycotoxin content of UK organic and conventional oats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jul;26(7):1063-9. PMID: 19680981.

" T "UN number: 2811     Class: 6.1     Packing Group: I

Proper shipping name: Toxic solid, organic, n.o.s. (T2 Triol)"

LKT T0004 T2 Triol 5 mg 1205.4 Trichothecene mycotoxin produced by Fusarium; peptide chain initiation inhibitor. 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate 3-alpha,4-beta,15-Trihydroxy-8-alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene T2 toxin triol 34114-98-2 ≥97%, TLC 382.45 C20H30O7 CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)O)C)CO "Ambient

" -20°C DMSO, Dichloromethane, methanol.  Slightly soluble in water. "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.

Edwards SG. Fusarium mycotoxin content of UK organic and conventional oats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jul;26(7):1063-9. PMID: 19680981.

" T "UN number: 2811     Class: 6.1     Packing Group: I

Proper shipping name: Toxic solid, organic, n.o.s. (T2 Triol)"

LKT F8272 Fusarenon X 1 mg 258 Trichothecene mycotoxin produced by Fusarium. "12,13-epoxy-3 alpha,4 beta,7 beta,15-tetrahydroxytrichothec-9-en-8-one 4-acetate

" "Nivalenol monoacetate

Nivalenol-4-o-acetate" 23255-69-8 ≥98% 354.35 C17H22O8 CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)CO "Ambient

" 4°C "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.

Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.

Bony S, Olivier-Loiseau L, Carcelen M, et al. Genotoxic potential associated with low levels of the Fusarium mycotoxins nivalenol and fusarenon X in a human intestinal cell line. Toxicol In Vitro. 2007 Apr;21(3):457-65. PMID: 17161579.

" T "UN number: 2811     Class: 6.1     Packing Group: I

Proper shipping name: Toxic solid, organic, n.o.s. (Fusarenon X)   "

LKT F8272 Fusarenon X 5 mg 1021.2 Trichothecene mycotoxin produced by Fusarium. "12,13-epoxy-3 alpha,4 beta,7 beta,15-tetrahydroxytrichothec-9-en-8-one 4-acetate

" "Nivalenol monoacetate

Nivalenol-4-o-acetate" 23255-69-8 ≥98% 354.35 C17H22O8 CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)CO "Ambient

" 4°C "Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.

Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.

Bony S, Olivier-Loiseau L, Carcelen M, et al. Genotoxic potential associated with low levels of the Fusarium mycotoxins nivalenol and fusarenon X in a human intestinal cell line. Toxicol In Vitro. 2007 Apr;21(3):457-65. PMID: 17161579.

" T "UN number: 2811     Class: 6.1     Packing Group: I

Proper shipping name: Toxic solid, organic, n.o.s. (Fusarenon X)   "

LKT H1862 Heptaplatin 5 mg 200.8 Pt-based DNA cross-linker. [SP-4-2-[4R-(2a,4a,5b)]]-[2-(1-Methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N'][propanedioato(2-)-O,O']-platinum Eptaplatin 146665-77-2 ≥98% 471.36 C11H20N2O6Pt CC(C)C1OC(C(O1)CN)CN.C(C(=O)O)C(=O)O.[Pt] Ambient -20°C "Lee JW, Park JK, Lee SH, et al. Anti-tumor activity of heptaplatin in combination with 5-fluorouracil or paclitaxel against human head and neck cancer cells in vitro. Anticancer Drugs. 2006 Apr;17(4):377-84. PMID: 16549994.

Kim NK, Im SA, Kim DW, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999 Oct 1;86(7):1109-15. PMID: 10506693.

Kim DK, Kim HT, Tai JH, et al. Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3- dioxolane]platinum(II), as determined by ex vivo pharmacodynamics. Cancer Chemother Pharmacol. 1995;37(1-2):1-6. PMID: 7497577.

" Not dangerous goods.

LKT H1862 Heptaplatin 10 mg 335 Pt-based DNA cross-linker. [SP-4-2-[4R-(2a,4a,5b)]]-[2-(1-Methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N'][propanedioato(2-)-O,O']-platinum Eptaplatin 146665-77-2 ≥98% 471.36 C11H20N2O6Pt CC(C)C1OC(C(O1)CN)CN.C(C(=O)O)C(=O)O.[Pt] Ambient -20°C "Lee JW, Park JK, Lee SH, et al. Anti-tumor activity of heptaplatin in combination with 5-fluorouracil or paclitaxel against human head and neck cancer cells in vitro. Anticancer Drugs. 2006 Apr;17(4):377-84. PMID: 16549994.

Kim NK, Im SA, Kim DW, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999 Oct 1;86(7):1109-15. PMID: 10506693.

Kim DK, Kim HT, Tai JH, et al. Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3- dioxolane]platinum(II), as determined by ex vivo pharmacodynamics. Cancer Chemother Pharmacol. 1995;37(1-2):1-6. PMID: 7497577.

" Not dangerous goods.

LKT H1862 Heptaplatin 25 mg 636.3 Pt-based DNA cross-linker. [SP-4-2-[4R-(2a,4a,5b)]]-[2-(1-Methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N'][propanedioato(2-)-O,O']-platinum Eptaplatin 146665-77-2 ≥98% 471.36 C11H20N2O6Pt CC(C)C1OC(C(O1)CN)CN.C(C(=O)O)C(=O)O.[Pt] Ambient -20°C "Lee JW, Park JK, Lee SH, et al. Anti-tumor activity of heptaplatin in combination with 5-fluorouracil or paclitaxel against human head and neck cancer cells in vitro. Anticancer Drugs. 2006 Apr;17(4):377-84. PMID: 16549994.

Kim NK, Im SA, Kim DW, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999 Oct 1;86(7):1109-15. PMID: 10506693.

Kim DK, Kim HT, Tai JH, et al. Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3- dioxolane]platinum(II), as determined by ex vivo pharmacodynamics. Cancer Chemother Pharmacol. 1995;37(1-2):1-6. PMID: 7497577.

" Not dangerous goods.

LKT P3210 Picoplatin 5 mg 353.3 Pt-based DNA cross-linker. azane; 2-methylpyridine; platinum(2+); dichloride 181630-15-9 ≥98% 376.15 C6H10N Pt Cl2 NH3 CC1=CC=CC=N1.N.[Cl-].[Cl-].[Pt+2] Ambient -20°C "Matos CS, de Carvalho AL, Lopes RP, et al. New strategies against prostate cancer--Pt(II)-based chemotherapy. Curr Med Chem. 2012;19(27):4678-87. PMID: 22856665.

Eckardt JR, Bentsion DL, Lipatov ON, et al. Phase II study of picoplatin as second-line therapy for patients with small-cell lung cancer. J Clin Oncol. 2009 Apr 20;27(12):2046-51. PMID: 19289620.

Kanzawa F, Akiyama Y, Saijo N, et al. In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line. Lung Cancer. 2003 Jun;40(3):325-32. PMID: 12781432.

Munk VP, Diakos CI, Ellis LT, et al. Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorg Chem. 2003 Jun 2;42(11):3582-90. PMID: 12767196.

" T Not dangerous goods.

LKT P3210 Picoplatin 10 mg 557.1 Pt-based DNA cross-linker. azane; 2-methylpyridine; platinum(2+); dichloride 181630-15-9 ≥98% 376.15 C6H10N Pt Cl2 NH3 CC1=CC=CC=N1.N.[Cl-].[Cl-].[Pt+2] Ambient -20°C "Matos CS, de Carvalho AL, Lopes RP, et al. New strategies against prostate cancer--Pt(II)-based chemotherapy. Curr Med Chem. 2012;19(27):4678-87. PMID: 22856665.

Eckardt JR, Bentsion DL, Lipatov ON, et al. Phase II study of picoplatin as second-line therapy for patients with small-cell lung cancer. J Clin Oncol. 2009 Apr 20;27(12):2046-51. PMID: 19289620.

Kanzawa F, Akiyama Y, Saijo N, et al. In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line. Lung Cancer. 2003 Jun;40(3):325-32. PMID: 12781432.

Munk VP, Diakos CI, Ellis LT, et al. Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorg Chem. 2003 Jun 2;42(11):3582-90. PMID: 12767196.

" T Not dangerous goods.

LKT P3210 Picoplatin 25 mg 1087.2 Pt-based DNA cross-linker. azane; 2-methylpyridine; platinum(2+); dichloride 181630-15-9 ≥98% 376.15 C6H10N Pt Cl2 NH3 CC1=CC=CC=N1.N.[Cl-].[Cl-].[Pt+2] Ambient -20°C "Matos CS, de Carvalho AL, Lopes RP, et al. New strategies against prostate cancer--Pt(II)-based chemotherapy. Curr Med Chem. 2012;19(27):4678-87. PMID: 22856665.

Eckardt JR, Bentsion DL, Lipatov ON, et al. Phase II study of picoplatin as second-line therapy for patients with small-cell lung cancer. J Clin Oncol. 2009 Apr 20;27(12):2046-51. PMID: 19289620.

Kanzawa F, Akiyama Y, Saijo N, et al. In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line. Lung Cancer. 2003 Jun;40(3):325-32. PMID: 12781432.

Munk VP, Diakos CI, Ellis LT, et al. Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorg Chem. 2003 Jun 2;42(11):3582-90. PMID: 12767196.

" T Not dangerous goods.

LKT G4781 Glucoraphanin Potassium 5 mg 361.5 Glucosinolate found in cruciferous vegetables. ≥98% 475.6 C12H22KNO10S3 xH2O Very hygroscopic Ambient 4°C "Galuppo M, Giacoppo S, De Nicola GR, et al. RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model. J Neurol Sci. 2013 Nov 15;334(1-2):88-96. PMID: 23992921.

Galuppo M, Iori R, De Nicola GR, et al. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorg Med Chem. 2013 Sep 1;21(17):5532-47. PMID: 23810671

Foti Cuzzola V, Galuppo M, Iori R, et al. Beneficial effects of (RS)-glucoraphanin on the tight junction dysfunction in a mouse model of restraint stress. Life Sci. 2013 Aug 28;93(7):288-305. PMID: 23871805.

Giacoppo S, Galuppo M, Iori R, et al. Protective role of (RS )-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis. CNS Neurosci Ther. 2013 Aug;19(8):577-84. PMID: 23638842.

" Not dangerous goods.

LKT G4781 Glucoraphanin Potassium 10 mg 564.3 Glucosinolate found in cruciferous vegetables. ≥98% 475.6 C12H22KNO10S3 xH2O Very hygroscopic Ambient 4°C "Galuppo M, Giacoppo S, De Nicola GR, et al. RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model. J Neurol Sci. 2013 Nov 15;334(1-2):88-96. PMID: 23992921.

Galuppo M, Iori R, De Nicola GR, et al. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorg Med Chem. 2013 Sep 1;21(17):5532-47. PMID: 23810671

Foti Cuzzola V, Galuppo M, Iori R, et al. Beneficial effects of (RS)-glucoraphanin on the tight junction dysfunction in a mouse model of restraint stress. Life Sci. 2013 Aug 28;93(7):288-305. PMID: 23871805.

Giacoppo S, Galuppo M, Iori R, et al. Protective role of (RS )-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis. CNS Neurosci Ther. 2013 Aug;19(8):577-84. PMID: 23638842.

" Not dangerous goods.

LKT G4781 Glucoraphanin Potassium 25 mg 1189.1 Glucosinolate found in cruciferous vegetables. ≥98% 475.6 C12H22KNO10S3 xH2O Very hygroscopic Ambient 4°C "Galuppo M, Giacoppo S, De Nicola GR, et al. RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model. J Neurol Sci. 2013 Nov 15;334(1-2):88-96. PMID: 23992921.

Galuppo M, Iori R, De Nicola GR, et al. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorg Med Chem. 2013 Sep 1;21(17):5532-47. PMID: 23810671

Foti Cuzzola V, Galuppo M, Iori R, et al. Beneficial effects of (RS)-glucoraphanin on the tight junction dysfunction in a mouse model of restraint stress. Life Sci. 2013 Aug 28;93(7):288-305. PMID: 23871805.

Giacoppo S, Galuppo M, Iori R, et al. Protective role of (RS )-glucoraphanin bioactivated with myrosinase in an experimental model of multiple sclerosis. CNS Neurosci Ther. 2013 Aug;19(8):577-84. PMID: 23638842.

" Not dangerous goods.

LKT G4782 Glucoraphenin Potassium 5 mg 388.3 Glucosinolate found in cruciferous vegetables. ≥98% 473.58 C12H20KNO10S3 xH2O Very hygroscopic Ambient -20°C "Abdull Razis AF, De Nicola GR, Pagnotta E, et al. A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase. Eur J Nutr. 2013 Apr;52(3):1279-85. PMID: 22710810.

Barillari J, Iori R, Broccoli M, et al. Glucoraphasatin and glucoraphenin, a redox pair of glucosinolates of brassicaceae, differently affect metabolizing enzymes in rats. J Agric Food Chem. 2007 Jul 11;55(14):5505-11. PMID: 17579433.

" Not dangerous goods.

LKT G4782 Glucoraphenin Potassium 10 mg 618.9 Glucosinolate found in cruciferous vegetables. ≥98% 473.58 C12H20KNO10S3 xH2O Very hygroscopic Ambient -20°C "Abdull Razis AF, De Nicola GR, Pagnotta E, et al. A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase. Eur J Nutr. 2013 Apr;52(3):1279-85. PMID: 22710810.

Barillari J, Iori R, Broccoli M, et al. Glucoraphasatin and glucoraphenin, a redox pair of glucosinolates of brassicaceae, differently affect metabolizing enzymes in rats. J Agric Food Chem. 2007 Jul 11;55(14):5505-11. PMID: 17579433.

" Not dangerous goods.

LKT G4782 Glucoraphenin Potassium 25 mg 1274.1 Glucosinolate found in cruciferous vegetables. ≥98% 473.58 C12H20KNO10S3 xH2O Very hygroscopic Ambient -20°C "Abdull Razis AF, De Nicola GR, Pagnotta E, et al. A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase. Eur J Nutr. 2013 Apr;52(3):1279-85. PMID: 22710810.

Barillari J, Iori R, Broccoli M, et al. Glucoraphasatin and glucoraphenin, a redox pair of glucosinolates of brassicaceae, differently affect metabolizing enzymes in rats. J Agric Food Chem. 2007 Jul 11;55(14):5505-11. PMID: 17579433.

" Not dangerous goods.

LKT H9816 2-Hydroxyestradiol 1 mg 83.7 Estradiol metabolite. 2-OH E2 362-05-0 ≥98% 288.38 C18H24O3 CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)O)O Ambient -20°C "Pavan B, Paganetto G, Dalpiaz A, et al. Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells. Life Sci. 2011 Mar 14;88(11-12):551-8. PMID: 21277863.

Becker CM, Rohwer N, Funakoshi T, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1 and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol. 2008 Feb;172(2):534-44. PMID: 18202195.

Dubey RK, Jackson EK, Gillespie DG, et al. Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004 Aug;89(8):3922-31. PMID: 15292328.

Zacharia LC, Piché CA, Fielding RM, et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther. 2004 Jun;309(3):1093-7. PMID: 14872091.

Teepker M, Anthes N, Krieg JC, et al. 2-OH-estradiol, an endogenous hormone with neuroprotective functions. J Psychiatr Res. 2003 Nov-Dec;37(6):517-23. PMID: 14563383.

" Repr. Cat 1 Not dangerous goods.

LKT H9816 2-Hydroxyestradiol 5 mg 293.1 Estradiol metabolite. 2-OH E2 362-05-0 ≥98% 288.38 C18H24O3 CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)O)O Ambient -20°C "Pavan B, Paganetto G, Dalpiaz A, et al. Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells. Life Sci. 2011 Mar 14;88(11-12):551-8. PMID: 21277863.

Becker CM, Rohwer N, Funakoshi T, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1 and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol. 2008 Feb;172(2):534-44. PMID: 18202195.

Dubey RK, Jackson EK, Gillespie DG, et al. Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004 Aug;89(8):3922-31. PMID: 15292328.

Zacharia LC, Piché CA, Fielding RM, et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther. 2004 Jun;309(3):1093-7. PMID: 14872091.

Teepker M, Anthes N, Krieg JC, et al. 2-OH-estradiol, an endogenous hormone with neuroprotective functions. J Psychiatr Res. 2003 Nov-Dec;37(6):517-23. PMID: 14563383.

" Repr. Cat 1 Not dangerous goods.

LKT H9816 2-Hydroxyestradiol 10 mg 544.1 Estradiol metabolite. 2-OH E2 362-05-0 ≥98% 288.38 C18H24O3 CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)O)O Ambient -20°C "Pavan B, Paganetto G, Dalpiaz A, et al. Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells. Life Sci. 2011 Mar 14;88(11-12):551-8. PMID: 21277863.

Becker CM, Rohwer N, Funakoshi T, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1 and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol. 2008 Feb;172(2):534-44. PMID: 18202195.

Dubey RK, Jackson EK, Gillespie DG, et al. Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004 Aug;89(8):3922-31. PMID: 15292328.

Zacharia LC, Piché CA, Fielding RM, et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther. 2004 Jun;309(3):1093-7. PMID: 14872091.

Teepker M, Anthes N, Krieg JC, et al. 2-OH-estradiol, an endogenous hormone with neuroprotective functions. J Psychiatr Res. 2003 Nov-Dec;37(6):517-23. PMID: 14563383.

" Repr. Cat 1 Not dangerous goods.

LKT F4518 Fleroxacin 5 g 173.3 Fluoroquinolone; bacterial DNA gyrase and helicase inhibitor. AM-833; Megalocin; Megalone; Quinodis AM-833; Megalocin; Megalone; Quinodis 79660-72-3 ≥98% 369.34 C17H18F3N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F Ambient Ambient Soluble in acid, alkali, not soluble in water "Luo H, Xu HQ, Chen X, et al. Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase. Biomed Environ Sci. 2013 Apr;26(4):231-42. PMID: 23534463.

Kawada A, Hatanaka K, Gomi H, et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatol Photoimmunol Photomed. 1999 Dec;15(6):226-30. PMID: 10599972

Gocke E. Mechanism of quinolone mutagenicity in bacteria. Mutat Res. 1991 May;248(1):135-43. PMID: 1851537.

" Not dangerous goods.

LKT F4518 Fleroxacin 10 g 277.4 Fluoroquinolone; bacterial DNA gyrase and helicase inhibitor. AM-833; Megalocin; Megalone; Quinodis AM-833; Megalocin; Megalone; Quinodis 79660-72-3 ≥98% 369.34 C17H18F3N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F Ambient Ambient Soluble in acid, alkali, not soluble in water "Luo H, Xu HQ, Chen X, et al. Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase. Biomed Environ Sci. 2013 Apr;26(4):231-42. PMID: 23534463.

Kawada A, Hatanaka K, Gomi H, et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatol Photoimmunol Photomed. 1999 Dec;15(6):226-30. PMID: 10599972

Gocke E. Mechanism of quinolone mutagenicity in bacteria. Mutat Res. 1991 May;248(1):135-43. PMID: 1851537.

" Not dangerous goods.

LKT F4518 Fleroxacin 25 g 577.6 Fluoroquinolone; bacterial DNA gyrase and helicase inhibitor. AM-833; Megalocin; Megalone; Quinodis AM-833; Megalocin; Megalone; Quinodis 79660-72-3 ≥98% 369.34 C17H18F3N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F Ambient Ambient Soluble in acid, alkali, not soluble in water "Luo H, Xu HQ, Chen X, et al. Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase. Biomed Environ Sci. 2013 Apr;26(4):231-42. PMID: 23534463.

Kawada A, Hatanaka K, Gomi H, et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatol Photoimmunol Photomed. 1999 Dec;15(6):226-30. PMID: 10599972

Gocke E. Mechanism of quinolone mutagenicity in bacteria. Mutat Res. 1991 May;248(1):135-43. PMID: 1851537.

" Not dangerous goods.

LKT P6903 Prasugrel 100 mg 83.7 Thienopyridine; P2Y12 antagonist. "5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-

tetrahydrothieno[3,2-c]pyridin-2-yl acetate" 150322-43-3 ≥98% 373.44 C20H20FNO3S CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4 Ambient Ambient "Secco GG, Parisi R, Mirabella F, et al. P2Y12 inhibitors: pharmacologic mechanism and clinical relevance. Cardiovasc Hematol Agents Med Chem. 2013 Jun;11(2):101-5. PMID: 22963529

Hagihara K, Kazui M, Kurihara A, et al. Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. Drug Metab Dispos. 2010 Jun;38(6):898-904. PMID: 20228231.

Scott DM, Norwood RM, Parra D. P2Y12 inhibitors in cardiovascular disease: focus on prasugrel. Ann Pharmacother. 2009 Jan;43(1):64-76. PMID: 19050170.

" None Not dangerous goods.

LKT P6903 Prasugrel 250 mg 159 Thienopyridine; P2Y12 antagonist. "5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-

tetrahydrothieno[3,2-c]pyridin-2-yl acetate" 150322-43-3 ≥98% 373.44 C20H20FNO3S CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4 Ambient Ambient "Secco GG, Parisi R, Mirabella F, et al. P2Y12 inhibitors: pharmacologic mechanism and clinical relevance. Cardiovasc Hematol Agents Med Chem. 2013 Jun;11(2):101-5. PMID: 22963529

Hagihara K, Kazui M, Kurihara A, et al. Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. Drug Metab Dispos. 2010 Jun;38(6):898-904. PMID: 20228231.

Scott DM, Norwood RM, Parra D. P2Y12 inhibitors in cardiovascular disease: focus on prasugrel. Ann Pharmacother. 2009 Jan;43(1):64-76. PMID: 19050170.

" None Not dangerous goods.

LKT P6903 Prasugrel 1 g 468.8 Thienopyridine; P2Y12 antagonist. "5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-

tetrahydrothieno[3,2-c]pyridin-2-yl acetate" 150322-43-3 ≥98% 373.44 C20H20FNO3S CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4 Ambient Ambient "Secco GG, Parisi R, Mirabella F, et al. P2Y12 inhibitors: pharmacologic mechanism and clinical relevance. Cardiovasc Hematol Agents Med Chem. 2013 Jun;11(2):101-5. PMID: 22963529

Hagihara K, Kazui M, Kurihara A, et al. Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. Drug Metab Dispos. 2010 Jun;38(6):898-904. PMID: 20228231.

Scott DM, Norwood RM, Parra D. P2Y12 inhibitors in cardiovascular disease: focus on prasugrel. Ann Pharmacother. 2009 Jan;43(1):64-76. PMID: 19050170.

" None Not dangerous goods.

LKT T3324 Tigecycline 100 mg 125.6 Glycylcycline; protein synthesis inhibitor. N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide 220620-09-7 ≥97% 585.65 C29H39N5O8 CC(C)(C)NCC(=O)NC1=C(C2=C(CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O Ambient 4°C DMSO (~3 mg/ml with warming) "Yagnik RM, Benzeroual KE. Tigecycline prevents LPS-induced release of pro-inflammatory and apoptotic mediators in neuronal cells. Toxicol In Vitro. 2013 Mar;27(2):686-93. PMID: 23200736.

da Silva LM, Nunes Salgado HR. Tigecycline: a review of properties, applications, and analytical methods. Ther Drug Monit. 2010 Jun;32(3):282-8. PMID: 20431506.

Olson MW, Ruzin A, Feyfant E, et al. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. PMID: 16723578.

" Xi Not dangerous goods.

LKT T3324 Tigecycline 250 mg 234.5 Glycylcycline; protein synthesis inhibitor. N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide 220620-09-7 ≥97% 585.65 C29H39N5O8 CC(C)(C)NCC(=O)NC1=C(C2=C(CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O Ambient 4°C DMSO (~3 mg/ml with warming) "Yagnik RM, Benzeroual KE. Tigecycline prevents LPS-induced release of pro-inflammatory and apoptotic mediators in neuronal cells. Toxicol In Vitro. 2013 Mar;27(2):686-93. PMID: 23200736.

da Silva LM, Nunes Salgado HR. Tigecycline: a review of properties, applications, and analytical methods. Ther Drug Monit. 2010 Jun;32(3):282-8. PMID: 20431506.

Olson MW, Ruzin A, Feyfant E, et al. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. PMID: 16723578.

" Xi Not dangerous goods.

LKT T3324 Tigecycline 1 g 669.7 Glycylcycline; protein synthesis inhibitor. N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide 220620-09-7 ≥97% 585.65 C29H39N5O8 CC(C)(C)NCC(=O)NC1=C(C2=C(CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O Ambient 4°C DMSO (~3 mg/ml with warming) "Yagnik RM, Benzeroual KE. Tigecycline prevents LPS-induced release of pro-inflammatory and apoptotic mediators in neuronal cells. Toxicol In Vitro. 2013 Mar;27(2):686-93. PMID: 23200736.

da Silva LM, Nunes Salgado HR. Tigecycline: a review of properties, applications, and analytical methods. Ther Drug Monit. 2010 Jun;32(3):282-8. PMID: 20431506.

Olson MW, Ruzin A, Feyfant E, et al. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. PMID: 16723578.

" Xi Not dangerous goods.

LKT T1733 Teicoplanin 100 mg 108.9 Glycopeptide, vancomycin analog; peptidoglycan formation inhibitor. ≥900 ug/mg, bio assay Ristomycin A 34-O-[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-.beta.-D-glucopyranosyl]-42-O-.alpha.-D-mannopyranosyl- 61036-62-2 ≥900 ug/mg, bio assay 1707.39 C78H77Cl2N9O31 Ambient Ambient "Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin. Infect Dis Clin North Am. 2009 Dec;23(4):965-82, ix. PMID: 19909893.

Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci. 2008 Aug;107(4):428-33. PMID: 18678985.

Kafková B, Bosáková Z, Tesarová E, et al. Chiral separation of beta-adrenergic antagonists, profen non-steroidal anti-inflammatory drugs and chlorophenoxypropionic acid herbicides using teicoplanin as the chiral selector in capillary liquid chromatography. J Chromatogr A. 2005 Sep 23;1088(1-2):82-93. PMID: 16130735.

Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother. 1984 Dec;26(6):917-23. PMID: 6240963.

" None Not dangerous goods.

LKT T1733 Teicoplanin 250 mg 194.1 Glycopeptide, vancomycin analog; peptidoglycan formation inhibitor. ≥900 ug/mg, bio assay Ristomycin A 34-O-[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-.beta.-D-glucopyranosyl]-42-O-.alpha.-D-mannopyranosyl- 61036-62-2 ≥900 ug/mg, bio assay 1707.39 C78H77Cl2N9O31 Ambient Ambient "Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin. Infect Dis Clin North Am. 2009 Dec;23(4):965-82, ix. PMID: 19909893.

Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci. 2008 Aug;107(4):428-33. PMID: 18678985.

Kafková B, Bosáková Z, Tesarová E, et al. Chiral separation of beta-adrenergic antagonists, profen non-steroidal anti-inflammatory drugs and chlorophenoxypropionic acid herbicides using teicoplanin as the chiral selector in capillary liquid chromatography. J Chromatogr A. 2005 Sep 23;1088(1-2):82-93. PMID: 16130735.

Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother. 1984 Dec;26(6):917-23. PMID: 6240963.

" None Not dangerous goods.

LKT T1733 Teicoplanin 1 g 582.4 Glycopeptide, vancomycin analog; peptidoglycan formation inhibitor. ≥900 ug/mg, bio assay Ristomycin A 34-O-[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-.beta.-D-glucopyranosyl]-42-O-.alpha.-D-mannopyranosyl- 61036-62-2 ≥900 ug/mg, bio assay 1707.39 C78H77Cl2N9O31 Ambient Ambient "Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infections: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, dalbavancin, and telavancin. Infect Dis Clin North Am. 2009 Dec;23(4):965-82, ix. PMID: 19909893.

Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci. 2008 Aug;107(4):428-33. PMID: 18678985.

Kafková B, Bosáková Z, Tesarová E, et al. Chiral separation of beta-adrenergic antagonists, profen non-steroidal anti-inflammatory drugs and chlorophenoxypropionic acid herbicides using teicoplanin as the chiral selector in capillary liquid chromatography. J Chromatogr A. 2005 Sep 23;1088(1-2):82-93. PMID: 16130735.

Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother. 1984 Dec;26(6):917-23. PMID: 6240963.

" None Not dangerous goods.

LKT N3323 Nifuratel 10 g 67 Nitrofuran derivative. 5-[(methylthio)methyl]-3--1,3-oxazolidin-2-one 4936-47-4 ≥98% 285.28 C10H11N3O5S CSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-] Ambient Ambient "Togni G, Battini V, Bulgheroni A, et al. In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis? Antimicrob Agents Chemother. 2011 May;55(5):2490-2. PMID: 21321147.

Hamilton-Miller JM, Brumfitt W. Comparative in vitro activity of five nitrofurans. Chemotherapy. 1978;24(3):161-5. PMID: 657876.

" Not dangerous goods.

LKT N3323 Nifuratel 25 g 108.9 Nitrofuran derivative. 5-[(methylthio)methyl]-3--1,3-oxazolidin-2-one 4936-47-4 ≥98% 285.28 C10H11N3O5S CSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-] Ambient Ambient "Togni G, Battini V, Bulgheroni A, et al. In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis? Antimicrob Agents Chemother. 2011 May;55(5):2490-2. PMID: 21321147.

Hamilton-Miller JM, Brumfitt W. Comparative in vitro activity of five nitrofurans. Chemotherapy. 1978;24(3):161-5. PMID: 657876.

" Not dangerous goods.

LKT N3323 Nifuratel 100 g 326.3 Nitrofuran derivative. 5-[(methylthio)methyl]-3--1,3-oxazolidin-2-one 4936-47-4 ≥98% 285.28 C10H11N3O5S CSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-] Ambient Ambient "Togni G, Battini V, Bulgheroni A, et al. In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis? Antimicrob Agents Chemother. 2011 May;55(5):2490-2. PMID: 21321147.

Hamilton-Miller JM, Brumfitt W. Comparative in vitro activity of five nitrofurans. Chemotherapy. 1978;24(3):161-5. PMID: 657876.

" Not dangerous goods.

LKT N1744 Nelarabine 10 mg 167.4 Nucleoside (guanosine) analog; DNA chain terminator. (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 506U78 121032-29-9 ≥98% 297.26 C11H15N5O5 COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N Ambient Ambient "Forcade E, Leguay T, Vey N, et al. Nelarabine for T cell acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation: an opportunity to improve survival. Biol Blood Marrow Transplant. 2013 Jul;19(7):1124-6. PMID: 23648236.

Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. PMID: 22591387.

Roecker AM, Stockert A, Kisor DF. Nelarabine in the treatment of refractory T-cell malignancies. Clin Med Insights Oncol. 2010 Dec 1;4:133-41. PMID: 21151585.

Reilly KM, Kisor DF. Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28. PMID: 20616909.

Buie LW, Epstein SS, Lindley CM. Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther. 2007 Sep;29(9):1887-99. PMID: 18035189.

" Not dangerous goods.

LKT N1744 Nelarabine 25 mg 309.6 Nucleoside (guanosine) analog; DNA chain terminator. (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 506U78 121032-29-9 ≥98% 297.26 C11H15N5O5 COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N Ambient Ambient "Forcade E, Leguay T, Vey N, et al. Nelarabine for T cell acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation: an opportunity to improve survival. Biol Blood Marrow Transplant. 2013 Jul;19(7):1124-6. PMID: 23648236.

Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. PMID: 22591387.

Roecker AM, Stockert A, Kisor DF. Nelarabine in the treatment of refractory T-cell malignancies. Clin Med Insights Oncol. 2010 Dec 1;4:133-41. PMID: 21151585.

Reilly KM, Kisor DF. Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28. PMID: 20616909.

Buie LW, Epstein SS, Lindley CM. Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther. 2007 Sep;29(9):1887-99. PMID: 18035189.

" Not dangerous goods.

LKT N1744 Nelarabine 100 mg 1004.5 Nucleoside (guanosine) analog; DNA chain terminator. (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 506U78 121032-29-9 ≥98% 297.26 C11H15N5O5 COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N Ambient Ambient "Forcade E, Leguay T, Vey N, et al. Nelarabine for T cell acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation: an opportunity to improve survival. Biol Blood Marrow Transplant. 2013 Jul;19(7):1124-6. PMID: 23648236.

Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. PMID: 22591387.

Roecker AM, Stockert A, Kisor DF. Nelarabine in the treatment of refractory T-cell malignancies. Clin Med Insights Oncol. 2010 Dec 1;4:133-41. PMID: 21151585.

Reilly KM, Kisor DF. Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28. PMID: 20616909.

Buie LW, Epstein SS, Lindley CM. Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther. 2007 Sep;29(9):1887-99. PMID: 18035189.

" Not dangerous goods.

LKT D3420 4-(3,4-Difluorobenzo)curcumin 100 mg 80.4 Curcumin derivative. (1E,6E)-1,7-bis-(4-hydroxy-3-methosyphenyl) hepta-1,6-diene [4(3,4-difluorobenzaldehyde)]-3,5-dione Difluorobenzocurcumin, CDF 1170354-22-9 ≥95% 492.47 C28H22F2O6 Ambient Ambient DMSO, 110mg/mL Not dangerous goods.

LKT D3420 4-(3,4-Difluorobenzo)curcumin 250 mg 142.4 Curcumin derivative. (1E,6E)-1,7-bis-(4-hydroxy-3-methosyphenyl) hepta-1,6-diene [4(3,4-difluorobenzaldehyde)]-3,5-dione Difluorobenzocurcumin, CDF 1170354-22-9 ≥95% 492.47 C28H22F2O6 Ambient Ambient DMSO, 110mg/mL Not dangerous goods.

LKT D3420 4-(3,4-Difluorobenzo)curcumin 1 g 335 Curcumin derivative. (1E,6E)-1,7-bis-(4-hydroxy-3-methosyphenyl) hepta-1,6-diene [4(3,4-difluorobenzaldehyde)]-3,5-dione Difluorobenzocurcumin, CDF 1170354-22-9 ≥95% 492.47 C28H22F2O6 Ambient Ambient DMSO, 110mg/mL Not dangerous goods.

LKT F1607 Febuxostat 250 mg 75.3 Xanthine oxidase inhibitor. 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid 144060-53-7 ≥98% 316.37 C16H16N2O3S CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O Ambient Ambient "Nomura J, Busso N, Ives A, et al. Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK. PLoS One. 2013 Sep 25;8(9):e75527. PMID: 24086554.

Karve AV, Jagtiani SS, Chitnis KA. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. PMID: 23833366.

Tsuda H, Kawada N, Kaimori JY, et al. Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress. Biochem Biophys Res Commun. 2012 Oct 19;427(2):266-72. PMID: 22995295.

Bisht M, Bist SS. Febuxostat: a novel agent for management of hyperuricemia in gout. Indian J Pharm Sci. 2011 Nov;73(6):597-600. PMID: 23112391.

" Xn Not dangerous goods.

LKT F1607 Febuxostat 1 g 200.8 Xanthine oxidase inhibitor. 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid 144060-53-7 ≥98% 316.37 C16H16N2O3S CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O Ambient Ambient "Nomura J, Busso N, Ives A, et al. Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK. PLoS One. 2013 Sep 25;8(9):e75527. PMID: 24086554.

Karve AV, Jagtiani SS, Chitnis KA. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. PMID: 23833366.

Tsuda H, Kawada N, Kaimori JY, et al. Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress. Biochem Biophys Res Commun. 2012 Oct 19;427(2):266-72. PMID: 22995295.

Bisht M, Bist SS. Febuxostat: a novel agent for management of hyperuricemia in gout. Indian J Pharm Sci. 2011 Nov;73(6):597-600. PMID: 23112391.

" Xn Not dangerous goods.

LKT L5862 Lopinavir 500 mg 125.6 HIV protease inhibitor, SERCA inhibitor. 192725-17-0 ≥98% 321.16 C37H48N4O5 CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate "Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

" Not dangerous goods.

LKT L5862 Lopinavir 1 g 167.4 HIV protease inhibitor, SERCA inhibitor. 192725-17-0 ≥98% 321.16 C37H48N4O5 CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate "Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

" Not dangerous goods.

LKT L5862 Lopinavir 5 g 636.3 HIV protease inhibitor, SERCA inhibitor. 192725-17-0 ≥98% 321.16 C37H48N4O5 CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O In DMSO at +4 for 2 weeks at -80 for 6 months. Ambient Ambient DMSO to 126 mg/mL, ethanol to 126 mg/mL, ethyl acetate "Kao E, Shinohara M, Feng M, et al. Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug;56(2):594-604. PMID: 22407670.

Batman G, Oliver AW, Zehbe I, et al. Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells. Antivir Ther. 2011;16(4):515-25. PMID: 21685539.

Johnson MD, O'Connell M, Pilcher W. Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism. J Neurooncol. 2011 Feb;101(3):441-8. PMID: 20596751.

" Not dangerous goods.

LKT T1844 Telbivudine 100 mg 251.3 Nucleoside (thymidine) analog; DNA chain terminator. "Epavudine, L-Thymidine, 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil

β-L-2-deoxythymidine

β-L-thymidine (LdT)

1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione" 3424-98-4 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Nan XP, Zhang Y, Yu HT, et al. Inhibition of viral replication downregulates CD4(+)CD25(high) regulatory T cells and programmed death-ligand 1 in chronic hepatitis B. Viral Immunol. 2012 Feb;25(1):21-8. PMID: 22233255.

Lv G, Ying L, Ma WJ, et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J. 2010 Aug 31;7:207. PMID: 20807412.

Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005 Aug;129(2):528-36. PMID: 16083710.

" Not dangerous goods.

LKT T1844 Telbivudine 250 mg 452 Nucleoside (thymidine) analog; DNA chain terminator. "Epavudine, L-Thymidine, 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil

β-L-2-deoxythymidine

β-L-thymidine (LdT)

1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione" 3424-98-4 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Nan XP, Zhang Y, Yu HT, et al. Inhibition of viral replication downregulates CD4(+)CD25(high) regulatory T cells and programmed death-ligand 1 in chronic hepatitis B. Viral Immunol. 2012 Feb;25(1):21-8. PMID: 22233255.

Lv G, Ying L, Ma WJ, et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J. 2010 Aug 31;7:207. PMID: 20807412.

Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005 Aug;129(2):528-36. PMID: 16083710.

" Not dangerous goods.

LKT T1844 Telbivudine 1 g 1195.2 Nucleoside (thymidine) analog; DNA chain terminator. "Epavudine, L-Thymidine, 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil

β-L-2-deoxythymidine

β-L-thymidine (LdT)

1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione" 3424-98-4 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Nan XP, Zhang Y, Yu HT, et al. Inhibition of viral replication downregulates CD4(+)CD25(high) regulatory T cells and programmed death-ligand 1 in chronic hepatitis B. Viral Immunol. 2012 Feb;25(1):21-8. PMID: 22233255.

Lv G, Ying L, Ma WJ, et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J. 2010 Aug 31;7:207. PMID: 20807412.

Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005 Aug;129(2):528-36. PMID: 16083710.

" Not dangerous goods.

LKT T3185 Thymidine 1 g 41.9 Pyrimidine nucleoside base, pairs with adenosine in DNA. Deoxythymidine, deoxyribosylthymine, thymine deoxyriboside 50-89-5 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Wang X, Pan L, Mao N, et al. Cell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines. Cancer Cell Int. 2013 Jul 30;13(1):77. PMID: 23899403.

Banfalvi G. Synchronization of mammalian cells and nuclei by centrifugal elutriation. Methods Mol Biol. 2011;761:25-45. PMID: 21755439.

Langridge R, Marvin DA, Seeds WE, et al. The molecular configuration of deoxyribonucleic acid *: II. Molecular models and their fourier transforms. J Mol Bio. Apr 1960;2(1):38-62.

Doty, P. The physical chemistry of deoxyribonucleic acids. J Cell and Comp Phys. May 1957;49(S1);27-57.

" None Not dangerous goods.

LKT T3185 Thymidine 5 g 83.7 Pyrimidine nucleoside base, pairs with adenosine in DNA. Deoxythymidine, deoxyribosylthymine, thymine deoxyriboside 50-89-5 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Wang X, Pan L, Mao N, et al. Cell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines. Cancer Cell Int. 2013 Jul 30;13(1):77. PMID: 23899403.

Banfalvi G. Synchronization of mammalian cells and nuclei by centrifugal elutriation. Methods Mol Biol. 2011;761:25-45. PMID: 21755439.

Langridge R, Marvin DA, Seeds WE, et al. The molecular configuration of deoxyribonucleic acid *: II. Molecular models and their fourier transforms. J Mol Bio. Apr 1960;2(1):38-62.

Doty, P. The physical chemistry of deoxyribonucleic acids. J Cell and Comp Phys. May 1957;49(S1);27-57.

" None Not dangerous goods.

LKT T3185 Thymidine 10 g 142.4 Pyrimidine nucleoside base, pairs with adenosine in DNA. Deoxythymidine, deoxyribosylthymine, thymine deoxyriboside 50-89-5 ≥98% 242.23 C10H14N2O5 CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Ambient Ambient "Wang X, Pan L, Mao N, et al. Cell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines. Cancer Cell Int. 2013 Jul 30;13(1):77. PMID: 23899403.

Banfalvi G. Synchronization of mammalian cells and nuclei by centrifugal elutriation. Methods Mol Biol. 2011;761:25-45. PMID: 21755439.

Langridge R, Marvin DA, Seeds WE, et al. The molecular configuration of deoxyribonucleic acid *: II. Molecular models and their fourier transforms. J Mol Bio. Apr 1960;2(1):38-62.

Doty, P. The physical chemistry of deoxyribonucleic acids. J Cell and Comp Phys. May 1957;49(S1);27-57.

" None Not dangerous goods.

LKT Z0252 Zanamivir 25 mg 167.4 Neuraminidase inhibitor. 5-acetamido- 4-guanidino- 6-(1,2,3-trihydroxypropyl)- 5,6-dihydro- 4H-pyran- 2-carboxylic acid 139110-80-8 ≥98% 332.31 C12H20N4O7 CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N Ambient Ambient "Kim JH, Resende R, Wennekes T, et al. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science. 2013 Apr 5;340(6128):71-5. PMID: 23429702.

Leyssen P, De Clercq E, Neyts J. Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res. 2008 Apr;78(1):9-25. PMID: 18313769.

" Not dangerous goods.

LKT Z0252 Zanamivir 100 mg 335 Neuraminidase inhibitor. 5-acetamido- 4-guanidino- 6-(1,2,3-trihydroxypropyl)- 5,6-dihydro- 4H-pyran- 2-carboxylic acid 139110-80-8 ≥98% 332.31 C12H20N4O7 CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N Ambient Ambient "Kim JH, Resende R, Wennekes T, et al. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science. 2013 Apr 5;340(6128):71-5. PMID: 23429702.

Leyssen P, De Clercq E, Neyts J. Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res. 2008 Apr;78(1):9-25. PMID: 18313769.

" Not dangerous goods.

LKT Z0252 Zanamivir 250 mg 636.3 Neuraminidase inhibitor. 5-acetamido- 4-guanidino- 6-(1,2,3-trihydroxypropyl)- 5,6-dihydro- 4H-pyran- 2-carboxylic acid 139110-80-8 ≥98% 332.31 C12H20N4O7 CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N Ambient Ambient "Kim JH, Resende R, Wennekes T, et al. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science. 2013 Apr 5;340(6128):71-5. PMID: 23429702.

Leyssen P, De Clercq E, Neyts J. Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res. 2008 Apr;78(1):9-25. PMID: 18313769.

" Not dangerous goods.

LKT S3476 Sitagliptin Phosphate Monohydrate 10 mg 47.3 DPP4 inhibitor. (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; phosphoric acid; hydrate MK-0431 654671-77-9 ≥98% 523.32 C16H15F6N5O H3PO4 H2O C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O Ambient Ambient "Chang G, Zhang P, Ye L, et al. Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol. 2013 Oct 15;718(1-3):105-13. PMID: 24041927.

Kubota Y, Miyamoto M, Takagi G, et al. The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. J Korean Med Sci. 2012 Nov;27(11):1364-70. PMID: 23166419.

Liu L, Liu J, Wong WT, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012 Sep;60(3):833-41. PMID: 22868389.

Waget A, Cabou C, Masseboeuf M, et al. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology. 2011 Aug;152(8):3018-29. PMID: 21673098.

" Not dangerous goods.

LKT S3476 Sitagliptin Phosphate Monohydrate 25 mg 95.1 DPP4 inhibitor. (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; phosphoric acid; hydrate MK-0431 654671-77-9 ≥98% 523.32 C16H15F6N5O H3PO4 H2O C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O Ambient Ambient "Chang G, Zhang P, Ye L, et al. Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol. 2013 Oct 15;718(1-3):105-13. PMID: 24041927.

Kubota Y, Miyamoto M, Takagi G, et al. The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. J Korean Med Sci. 2012 Nov;27(11):1364-70. PMID: 23166419.

Liu L, Liu J, Wong WT, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012 Sep;60(3):833-41. PMID: 22868389.

Waget A, Cabou C, Masseboeuf M, et al. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology. 2011 Aug;152(8):3018-29. PMID: 21673098.

" Not dangerous goods.

LKT S3476 Sitagliptin Phosphate Monohydrate 100 mg 224.3 DPP4 inhibitor. (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; phosphoric acid; hydrate MK-0431 654671-77-9 ≥98% 523.32 C16H15F6N5O H3PO4 H2O C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O Ambient Ambient "Chang G, Zhang P, Ye L, et al. Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol. 2013 Oct 15;718(1-3):105-13. PMID: 24041927.

Kubota Y, Miyamoto M, Takagi G, et al. The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. J Korean Med Sci. 2012 Nov;27(11):1364-70. PMID: 23166419.

Liu L, Liu J, Wong WT, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012 Sep;60(3):833-41. PMID: 22868389.

Waget A, Cabou C, Masseboeuf M, et al. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology. 2011 Aug;152(8):3018-29. PMID: 21673098.

" Not dangerous goods.

LKT N3208 Nicardipine 1 g 50.2 Dihydropyridine; L-type Ca2+ channel blocker. 55985-32-5 ≥98% 479.52 C26H29N3O6 CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC Ambient Ambient "Yue W, Wang L, Zhang F, et al. Inhibition of nicardipine on amygdala kindling in rats. Acta Pharmacol Sin. 2001 Apr;22(4):365-8. PMID: 11742591.

Eraković V, Zupan G, Mrsić J, et al. The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):633-47. PMID: 9194145.

Mashimo T, Pak M, Choe H, et al. Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1 on primary afferent nociceptors in humans. J Clin Pharmacol. 1997 Apr;37(4):330-5. PMID: 9115059.

Kanneganti M, Halpern NA. Acute hypertension and calcium-channel blockers. New Horiz. 1996 Feb;4(1):19-25. PMID: 8689271.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Nicardipine)"

LKT B1755 Benzimidazole 5 g 24.5 Microtubule polymerization inhibitor, potential topoisomerase I inhibitor. 51-17-2 ≥98% 118.14 C7H6N2 C1=CC=C2C(=C1)NC=N2 Ambient Ambient "Song WJ, Cheng JP, Jiang DH, et al. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct 14;121C:70-76. PMID: 24220672

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.

Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, Castillo R, Yépez-Mulia L, Medina-Franco JL, Hernández-Campos A.

J Mol Graph Model. 2013 Sep;45:26-37. PMID: 23995453.

Khabnadideh S, Rezaei Z, Pakshir K, et al. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci. 2012 Apr;7(2):65-72. PMID: 23181082.

Arjmand F, Parveen S, Afzal M, et al. Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes. J Photochem Photobiol B. 2012 Sep 3;114:15-26. PMID: 22695227.

" Xn, Xi Not dangerous goods.

LKT B1755 Benzimidazole 50 g 40.7 Microtubule polymerization inhibitor, potential topoisomerase I inhibitor. 51-17-2 ≥98% 118.14 C7H6N2 C1=CC=C2C(=C1)NC=N2 Ambient Ambient "Song WJ, Cheng JP, Jiang DH, et al. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct 14;121C:70-76. PMID: 24220672

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.

Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, Castillo R, Yépez-Mulia L, Medina-Franco JL, Hernández-Campos A.

J Mol Graph Model. 2013 Sep;45:26-37. PMID: 23995453.

Khabnadideh S, Rezaei Z, Pakshir K, et al. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci. 2012 Apr;7(2):65-72. PMID: 23181082.

Arjmand F, Parveen S, Afzal M, et al. Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes. J Photochem Photobiol B. 2012 Sep 3;114:15-26. PMID: 22695227.

" Xn, Xi Not dangerous goods.

LKT B1755 Benzimidazole 250 g 163.2 Microtubule polymerization inhibitor, potential topoisomerase I inhibitor. 51-17-2 ≥98% 118.14 C7H6N2 C1=CC=C2C(=C1)NC=N2 Ambient Ambient "Song WJ, Cheng JP, Jiang DH, et al. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct 14;121C:70-76. PMID: 24220672

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.

Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, Castillo R, Yépez-Mulia L, Medina-Franco JL, Hernández-Campos A.

J Mol Graph Model. 2013 Sep;45:26-37. PMID: 23995453.

Khabnadideh S, Rezaei Z, Pakshir K, et al. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci. 2012 Apr;7(2):65-72. PMID: 23181082.

Arjmand F, Parveen S, Afzal M, et al. Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes. J Photochem Photobiol B. 2012 Sep 3;114:15-26. PMID: 22695227.

" Xn, Xi Not dangerous goods.

LKT T1298 TDZD-8 25 mg 224.3 GSK-3β inhibitor. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 327036-89-5 ≥98% 222.26 C10H10N2O2S CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2 Protect from light. Packaged under inert gas. Ambient -20°C Soluble in DMSO (18mg/mL). "Jellestad L, Fink T, Pradarutti S, et al. Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock. Eur J Pharmacol. 2014 Feb 5;724:175-84. PMID: 24389157.

Kwon YJ, Yoon CH, Lee SW, et al. Inhibition of glycogen synthase kinase-3β suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis. Joint Bone Spine. 2013 Oct 28. [Epub ahead of print]. PMID: 24176738.

Willi R, Harmeier A, Giovanoli S, et al. Altered GSK3β signaling in an infection-based mouse model of developmental neuropsychiatric disease. Neuropharmacology. 2013 Oct;73:56-65. PMID: 23707483.

" Not dangerous goods.

LKT D0363 Daptomycin 25 mg 159 Anionic lipopeptide, alters cell membrane organization. N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo -3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone 103060-53-3 ≥90% 1620.67 C72H101N17O26 CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C Ambient -20°C Soluble in ethanol (50 mM), methano, DMF, DMSO (100 mM).  Slightly soluble in water (25 mg/mL, 5 mM). "Pogliano J, Pogliano N, Silverman JA. Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins. J Bacteriol. 2012 Sep;194(17):4494-504. PMID: 22661688.

Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev Med Chem. 2012 Mar;12(3):202-9. PMID: 22356191

Beiras-Fernandez A, Vogt F, Sodian R, et al. Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist. 2010;3:95-101. PMID: 21694898.

" None Not dangerous goods.

LKT D0363 Daptomycin 100 mg 502.3 Anionic lipopeptide, alters cell membrane organization. N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo -3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone 103060-53-3 ≥90% 1620.67 C72H101N17O26 CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C Ambient -20°C Soluble in ethanol (50 mM), methano, DMF, DMSO (100 mM).  Slightly soluble in water (25 mg/mL, 5 mM). "Pogliano J, Pogliano N, Silverman JA. Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins. J Bacteriol. 2012 Sep;194(17):4494-504. PMID: 22661688.

Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev Med Chem. 2012 Mar;12(3):202-9. PMID: 22356191

Beiras-Fernandez A, Vogt F, Sodian R, et al. Daptomycin: a novel lipopeptide antibiotic against Gram-positive pathogens. Infect Drug Resist. 2010;3:95-101. PMID: 21694898.

" None Not dangerous goods.

LKT P3209 Piceatannol 5 mg 82.2 Polyphenolic hydroxystilbene, resveratrol  derivative; HPH-2 inhibitor, potential PI3K and JAK1 inhibitor. 3,3’,4,5’-Tetrahydroxy-trans-stilbene 10083-24-6 ≥98% 244.24 C14H12O4 C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O Ambient 4°C DMSO (20mg/ml), Ethanol (10mg/ml) "Yum S, Doh HJ, Hong S, et al. Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1α protein by inhibiting HIF prolyl hydroxylase. Eur J Pharmacol. 2013 Jan 15;699(1-3):124-31. PMID: 23261967.

Jayasooriya RG, Lee YG, Kang CH, et al. Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-α-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-κB pathway. Oncol Lett. 2013 Jan;5(1):341-347. PMID: 23255946.

Li Z, Yang X, Dong S, et al. DNA breakage induced by piceatannol and copper(II): Mechanism and anticancer properties. Oncol Lett. 2012 May;3(5):1087-1094. PMID: 22783397.

Kwon JY, Seo SG, Heo YS, et al. Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation. J Biol Chem. 2012 Mar 30;287(14):11566-78. PMID: 22298784.

Kwon GT, Jung JI, Song HR, et al. Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 2012 Mar;23(3):228-38. PMID: 21497499.

Lee YM, Lim do Y, Cho HJ, et al. Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activity. Cancer Lett. 2009 Nov 28;285(2):166-73. PMID: 19487074.

Rossi M, Caruso F, Opazo C, et al. Crystal and molecular structure of piceatannol; scavenging features of resveratrol and piceatannol on hydroxyl and peroxyl radicals and docking with transthyretin. J Agric Food Chem. 2008 Nov 26;56(22):10557-66. PMID: 18959413.

Kim HJ, Lee KW, Kim MS, et al. Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. J Nutr Biochem. 2008 Jul;19(7):459-66. PMID: 17869087.

" Not dangerous goods.

LKT P3209 Piceatannol 25 mg 321.4 Polyphenolic hydroxystilbene, resveratrol  derivative; HPH-2 inhibitor, potential PI3K and JAK1 inhibitor. 3,3’,4,5’-Tetrahydroxy-trans-stilbene 10083-24-6 ≥98% 244.24 C14H12O4 C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O Ambient 4°C DMSO (20mg/ml), Ethanol (10mg/ml) "Yum S, Doh HJ, Hong S, et al. Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1α protein by inhibiting HIF prolyl hydroxylase. Eur J Pharmacol. 2013 Jan 15;699(1-3):124-31. PMID: 23261967.

Jayasooriya RG, Lee YG, Kang CH, et al. Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-α-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-κB pathway. Oncol Lett. 2013 Jan;5(1):341-347. PMID: 23255946.

Li Z, Yang X, Dong S, et al. DNA breakage induced by piceatannol and copper(II): Mechanism and anticancer properties. Oncol Lett. 2012 May;3(5):1087-1094. PMID: 22783397.

Kwon JY, Seo SG, Heo YS, et al. Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation. J Biol Chem. 2012 Mar 30;287(14):11566-78. PMID: 22298784.

Kwon GT, Jung JI, Song HR, et al. Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 2012 Mar;23(3):228-38. PMID: 21497499.

Lee YM, Lim do Y, Cho HJ, et al. Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activity. Cancer Lett. 2009 Nov 28;285(2):166-73. PMID: 19487074.

Rossi M, Caruso F, Opazo C, et al. Crystal and molecular structure of piceatannol; scavenging features of resveratrol and piceatannol on hydroxyl and peroxyl radicals and docking with transthyretin. J Agric Food Chem. 2008 Nov 26;56(22):10557-66. PMID: 18959413.

Kim HJ, Lee KW, Kim MS, et al. Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. J Nutr Biochem. 2008 Jul;19(7):459-66. PMID: 17869087.

" Not dangerous goods.

LKT D8014 DU-14 5 mg 71.7 Steroid sulfatase inhibitor. (ulfamoyl)-N-tetradecanoyl tyramine 186303-55-9 ≥98% 426.6 C22H38N2O4S CCCCCCCCCCCCCC(=O)NCCC1=CC=C(C=C1)OS(=O)(=O)N Ambient 4°C DMSO (25mg/ml) "Babalola PA, Fitz NF, Gibbs RB, et al. The effect of the steroid sulfatase inhibitor (-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem. 2012 Oct;98(3):303-10. PMID: 23022361.

Johnson DA, Wu T, Li P, et al. The effect of steroid sulfatase inhibition on learning and spatial memory. Brain Res. 2000 May 26;865(2):286-90. PMID: 10821934.

Johnson DA, Rhodes ME, Boni RL, et al. Chronic steroid sulfatase inhibition by (p-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain. Life Sci. 1997;61(24):PL 355-9. PMID: 9399636.

" Not dangerous goods.

LKT X0384 XAV-939 5 mg 47.1 Tankyrase inhibitor. 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol 284028-89-3 ≥95% 312.31 C14H11F3N2OS Ambient DMSO (25mg/ml) "Bilir B, Kucuk O, Moreno CS. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11(1):280. [Epub ahead of print]. PMID: 24188694

Distler A, Deloch L, Huang J, et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305.

Tenbaum SP, Ordóñez-Morán P, Puig I, et al. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 2012 Jun;18(6):892-901. PMID: 22610277.

" "UN number: 2811     Class: 6.1      Packing Group: III

Proper shipping name: Toxic solid, organic. n.o.s. (XAV939)"

LKT X0384 XAV-939 25 mg 193.2 Tankyrase inhibitor. 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol 284028-89-3 ≥95% 312.31 C14H11F3N2OS Ambient DMSO (25mg/ml) "Bilir B, Kucuk O, Moreno CS. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11(1):280. [Epub ahead of print]. PMID: 24188694

Distler A, Deloch L, Huang J, et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305.

Tenbaum SP, Ordóñez-Morán P, Puig I, et al. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 2012 Jun;18(6):892-901. PMID: 22610277.

" "UN number: 2811     Class: 6.1      Packing Group: III

Proper shipping name: Toxic solid, organic. n.o.s. (XAV939)"

LKT P6232 PP-1 5 mg 157.3 Src inhibitor. 4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine 172889-26-8 ≥98% 281.36 C16H19N5 CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C Ambient 4°C DMSO (25mg/ml), slightly soluble in ethanol "Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.

Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.

Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid organic, n.o.s. PP-1

Marine pollutant:  No     Poison inhalation hazard:  No"

LKT P6232 PP-1 25 mg 622.9 Src inhibitor. 4-Amino-1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidine 172889-26-8 ≥98% 281.36 C16H19N5 CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C Ambient 4°C DMSO (25mg/ml), slightly soluble in ethanol "Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.

Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.

Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid organic, n.o.s. PP-1

Marine pollutant:  No     Poison inhalation hazard:  No"

LKT S8098 SU-1498 5 mg 74.8 Tyrphostin; VEGFR inhibitor. (E)-N-(3-Phenylpropyl)-a-cyano-3’,5’-diisopropyl-4’-hydroxycinnamamide 168835-82-3 ≥98% 390.5 C25H30N2O2 CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2 Ambient 4°C DMSO (25mg/ml), Ethanol (20mg/ml) "Ligęza J, Ligęza J, Klein A. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. Acta Biochim Pol. 2011;58(3):391-6. PMID: 21887406.

Lu KT, Sun CL, Wo PY, et al. Hippocampal neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade. J Neurotrauma. 2011 Mar;28(3):441-50. PMID: 21091268

Lee SJ, Cho SJ, Ju SY, et al. Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor. Pediatr Int. 2010 Jun;52(3):386-92. PMID: 19761519

Boguslawski G, McGlynn PW, Harvey KA, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro. J Biol Chem. 2004 Feb 13;279(7):5716-24. PMID: 14625306.

" Not dangerous goods.

LKT S8098 SU-1498 25 mg 336.4 Tyrphostin; VEGFR inhibitor. (E)-N-(3-Phenylpropyl)-a-cyano-3’,5’-diisopropyl-4’-hydroxycinnamamide 168835-82-3 ≥98% 390.5 C25H30N2O2 CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2 Ambient 4°C DMSO (25mg/ml), Ethanol (20mg/ml) "Ligęza J, Ligęza J, Klein A. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. Acta Biochim Pol. 2011;58(3):391-6. PMID: 21887406.

Lu KT, Sun CL, Wo PY, et al. Hippocampal neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade. J Neurotrauma. 2011 Mar;28(3):441-50. PMID: 21091268

Lee SJ, Cho SJ, Ju SY, et al. Effect of retinoic acid on renal development in newborn mice treated with an angiogenesis inhibitor. Pediatr Int. 2010 Jun;52(3):386-92. PMID: 19761519

Boguslawski G, McGlynn PW, Harvey KA, et al. SU1498, an inhibitor of vascular endothelial growth factor receptor 2, causes accumulation of phosphorylated ERK kinases and inhibits their activity in vivo and in vitro. J Biol Chem. 2004 Feb 13;279(7):5716-24. PMID: 14625306.

" Not dangerous goods.

LKT W2933 WHI-P131 50 mg 97.2 JAK3 and EGFR inhibitor. 4-[(4’-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline JANEX-1 202475-60-3 ≥98% 333.77 C16H15N3O3 HCl COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC Ambient 4°C DMSO (25mg/ml) "Oh YB, Ahn M, Lee SM, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23. PMID: 23680658.

Lee JE, Lee AS, Kim DH, et al. Janex-1, a JAK3 inhibitor, ameliorates tumor necrosis factor-α-induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice. Int J Mol Med. 2012 May;29(5):864-70. PMID: 22344597

Uckun FM, Dibirdik I, Qazi S. Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase. Arzneimittelforschung. 2010;60(4):218-25. PMID: 20486473

Lv N, Kim EK, Song MY, et al. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res. 2009 Jul 15;315(12):2064-71. PMID: 19414010

Linwong W, Hirasawa N, Aoyama S, et al. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br J Pharmacol. 2005 Jul;145(6):818-28. PMID: 15852029.

" Not dangerous goods.

LKT W2933 WHI-P131 250 mg 426 JAK3 and EGFR inhibitor. 4-[(4’-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline JANEX-1 202475-60-3 ≥98% 333.77 C16H15N3O3 HCl COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC Ambient 4°C DMSO (25mg/ml) "Oh YB, Ahn M, Lee SM, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23. PMID: 23680658.

Lee JE, Lee AS, Kim DH, et al. Janex-1, a JAK3 inhibitor, ameliorates tumor necrosis factor-α-induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice. Int J Mol Med. 2012 May;29(5):864-70. PMID: 22344597

Uckun FM, Dibirdik I, Qazi S. Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase. Arzneimittelforschung. 2010;60(4):218-25. PMID: 20486473

Lv N, Kim EK, Song MY, et al. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res. 2009 Jul 15;315(12):2064-71. PMID: 19414010

Linwong W, Hirasawa N, Aoyama S, et al. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br J Pharmacol. 2005 Jul;145(6):818-28. PMID: 15852029.

" Not dangerous goods.

LKT P0013 P7C3 5 mg 104.6 Aminopropyl carbazole, neuroprotective. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol 301353-96-8 ≥98% 474.2 C21H18Br2N2O C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O Ambient 4°C DMSO (30mg/ml) "Asai-Coakwell M, March L, Dai XH, et al. Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Hum Mol Genet. 2013 Apr 1;22(7):1432-42. PMID: 23307924.

De Jesús-Cortés H, Xu P, Drawbridge J, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. PMID: 23027934.

Tesla R, Wolf HP, Xu P, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. PMID: 23027932.

MacMillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. PMID: 21210688

Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. PMID: 20603013.

" Not dangerous goods.

LKT P0013 P7C3 25 mg 411.1 Aminopropyl carbazole, neuroprotective. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol 301353-96-8 ≥98% 474.2 C21H18Br2N2O C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O Ambient 4°C DMSO (30mg/ml) "Asai-Coakwell M, March L, Dai XH, et al. Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Hum Mol Genet. 2013 Apr 1;22(7):1432-42. PMID: 23307924.

De Jesús-Cortés H, Xu P, Drawbridge J, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. PMID: 23027934.

Tesla R, Wolf HP, Xu P, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. PMID: 23027932.

MacMillan KS, Naidoo J, Liang J, et al. Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. PMID: 21210688

Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51. PMID: 20603013.

" Not dangerous goods.

LKT D5753 Donepezil Hydrochloride 25 mg 59.7 GSK3 and AChE inhibitor, potential σ1 agonist. Aricept 120011-70-3 ≥98% 415.95 C24H29NO3 HCl COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl Ambient Ambient "Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

" None Not dangerous goods.

LKT D5753 Donepezil Hydrochloride 100 mg 186.8 GSK3 and AChE inhibitor, potential σ1 agonist. Aricept 120011-70-3 ≥98% 415.95 C24H29NO3 HCl COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl Ambient Ambient "Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

" None Not dangerous goods.

LKT D5753 Donepezil Hydrochloride 500 mg 672.7 GSK3 and AChE inhibitor, potential σ1 agonist. Aricept 120011-70-3 ≥98% 415.95 C24H29NO3 HCl COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl Ambient Ambient "Jiang Y, Zou Y, Chen S, et al. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24. PMID: 23831366.

Xia Z, Zhang R, Wu P, et al. Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain Res. 2012 Mar 2;1441:27-37. PMID: 22305339.

Shen H, Kihara T, Hongo H, et al. Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol. 2010 Sep;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200. PMID: 20718745.

Handa T, Katare RG, Kakinuma Y, et al. Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. J Card Fail. 2009 Nov;15(9):805-11. PMID: 19879468.

Ishikawa M, Sakata M, Ishii K, et al. High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol. 2009 Sep;12(8):1127-31. PMID: 19573265.

Noh MY, Koh SH, Kim Y, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25. PMID: 19077054.

" None Not dangerous goods.

LKT B1979 Betulinic Acid 10 mg 52.3 Pentacyclic triterpene. 472-15-1 ≥98% 456.7 C30H48O3 CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O Ambient Ambient "Zhao GJ, Tang SL, Lv YC, et al. Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression. PLoS One. 2013 Sep 25;8(9):e74782. PMID: 24086374.

Hsu TI, Wang MC, Chen SY, et al. Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth. Mol Pharmacol. 2012 Dec;82(6):1115-28. PMID: 22956772.

Qian LB, Fu JY, Cai X, et al. Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas. Indian J Pharmacol. 2012 Sep-Oct;44(5):588-92. PMID: 23112419.

Tzakos AG, Kontogianni VG, Tsoumani M, et al. Exploration of the antiplatelet activity profile of betulinic acid on human platelets. J Agric Food Chem. 2012 Jul 18;60(28):6977-83. PMID: 22720759

Tsai JC, Peng WH, Chiu TH, et al. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am J Chin Med. 2011;39(5):943-56. PMID: 21905284.

Karna E, Szoka L, Palka JA. Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells. Mol Cell Biochem. 2010 Jul;340(1-2):15-20. PMID: 20174965.

Chen Z, Wu Q, Chen Y, et al. Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism. J Huazhong Univ Sci Technolog Med Sci. 2008 Dec;28(6):634-8. PMID: 19107355.

" None Not dangerous goods.

LKT B1979 Betulinic Acid 50 mg 164.3 Pentacyclic triterpene. 472-15-1 ≥98% 456.7 C30H48O3 CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O Ambient Ambient "Zhao GJ, Tang SL, Lv YC, et al. Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression. PLoS One. 2013 Sep 25;8(9):e74782. PMID: 24086374.

Hsu TI, Wang MC, Chen SY, et al. Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth. Mol Pharmacol. 2012 Dec;82(6):1115-28. PMID: 22956772.

Qian LB, Fu JY, Cai X, et al. Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas. Indian J Pharmacol. 2012 Sep-Oct;44(5):588-92. PMID: 23112419.

Tzakos AG, Kontogianni VG, Tsoumani M, et al. Exploration of the antiplatelet activity profile of betulinic acid on human platelets. J Agric Food Chem. 2012 Jul 18;60(28):6977-83. PMID: 22720759

Tsai JC, Peng WH, Chiu TH, et al. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am J Chin Med. 2011;39(5):943-56. PMID: 21905284.

Karna E, Szoka L, Palka JA. Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells. Mol Cell Biochem. 2010 Jul;340(1-2):15-20. PMID: 20174965.

Chen Z, Wu Q, Chen Y, et al. Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism. J Huazhong Univ Sci Technolog Med Sci. 2008 Dec;28(6):634-8. PMID: 19107355.

" None Not dangerous goods.

LKT B1979 Betulinic Acid 250 mg 598 Pentacyclic triterpene. 472-15-1 ≥98% 456.7 C30H48O3 CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O Ambient Ambient "Zhao GJ, Tang SL, Lv YC, et al. Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression. PLoS One. 2013 Sep 25;8(9):e74782. PMID: 24086374.

Hsu TI, Wang MC, Chen SY, et al. Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth. Mol Pharmacol. 2012 Dec;82(6):1115-28. PMID: 22956772.

Qian LB, Fu JY, Cai X, et al. Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas. Indian J Pharmacol. 2012 Sep-Oct;44(5):588-92. PMID: 23112419.

Tzakos AG, Kontogianni VG, Tsoumani M, et al. Exploration of the antiplatelet activity profile of betulinic acid on human platelets. J Agric Food Chem. 2012 Jul 18;60(28):6977-83. PMID: 22720759

Tsai JC, Peng WH, Chiu TH, et al. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am J Chin Med. 2011;39(5):943-56. PMID: 21905284.

Karna E, Szoka L, Palka JA. Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells. Mol Cell Biochem. 2010 Jul;340(1-2):15-20. PMID: 20174965.

Chen Z, Wu Q, Chen Y, et al. Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism. J Huazhong Univ Sci Technolog Med Sci. 2008 Dec;28(6):634-8. PMID: 19107355.

" None Not dangerous goods.

LKT I6932 Irinotecan 100 mg 271.7 Camptothecin analog; topoisomerase I inhibitor, potential AChE inhibitor. [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester 97682-44-5 ≥98% 586.68 C33H38N4O6 CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7 Ambient 4°C Insoluble in water.  Soluble in DMSO "Hu J, Kinn J, Zirakzadeh AA, et al. The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation. Clin Exp Immunol. 2013 Jun;172(3):490-9. PMID: 23600838.

Pan P, Li Y, Yu H, et al. Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches. J Chem Inf Model. 2013 Apr 22;53(4):997-1006. PMID: 23521602.

Chen AY, Chen PM, Chen YJ. DNA topoisomerase I drugs and radiotherapy for lung cancer. J Thorac Dis. 2012 Aug;4(4):390-7. PMID: 22934142.

Chintala S, Tóth K, Cao S, et al. Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha. Cancer Chemother Pharmacol. 2010 Oct;66(5):899-911. PMID: 20066420.

Dodds HM, Rivory LP. The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11). Mol Pharmacol. 1999 Dec;56(6):1346-53. PMID: 10570064." Xn Not dangerous goods.

LKT T7132 Triacetyl Resveratrol 10 mg 74.8 Resveratrol prodrug; potential SIRT1 activator. 42206-94-0 ≥98% 354.35 C20H18O6 CC(=O)OC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC(=O)C)OC(=O)C Ambient Ambient Soluble in DMSO (25mg/ml) or 100% ethanol (warm) (8mg/ml). "Hsieh TC, Wong C, John Bennett D, et al. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3. Int J Cancer. 2011 Dec 1;129(11):2732-43. PMID: 21225623.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT T7132 Triacetyl Resveratrol 25 mg 149.5 Resveratrol prodrug; potential SIRT1 activator. 42206-94-0 ≥98% 354.35 C20H18O6 CC(=O)OC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC(=O)C)OC(=O)C Ambient Ambient Soluble in DMSO (25mg/ml) or 100% ethanol (warm) (8mg/ml). "Hsieh TC, Wong C, John Bennett D, et al. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3. Int J Cancer. 2011 Dec 1;129(11):2732-43. PMID: 21225623.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT T7132 Triacetyl Resveratrol 100 mg 568.2 Resveratrol prodrug; potential SIRT1 activator. 42206-94-0 ≥98% 354.35 C20H18O6 CC(=O)OC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC(=O)C)OC(=O)C Ambient Ambient Soluble in DMSO (25mg/ml) or 100% ethanol (warm) (8mg/ml). "Hsieh TC, Wong C, John Bennett D, et al. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3. Int J Cancer. 2011 Dec 1;129(11):2732-43. PMID: 21225623.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT T7134 trans-3,4′,5-Trimethoxy Stilbene 100 mg 74.8 Resveratrol prodrug; potential SIRT1 activator. Trimethoxy resveratrol 22255-22-7 ≥98% 270.32 C17H18O3 COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC Ambient Ambient Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide. "Dias SJ, Li K, Rimando AM, et al. Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. Prostate. 2013 Aug;73(11):1135-46. PMID: 23657951.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT T7134 trans-3,4′,5-Trimethoxy Stilbene 250 mg 149.5 Resveratrol prodrug; potential SIRT1 activator. Trimethoxy resveratrol 22255-22-7 ≥98% 270.32 C17H18O3 COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC Ambient Ambient Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide. "Dias SJ, Li K, Rimando AM, et al. Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. Prostate. 2013 Aug;73(11):1135-46. PMID: 23657951.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT T7134 trans-3,4′,5-Trimethoxy Stilbene 1 g 448.5 Resveratrol prodrug; potential SIRT1 activator. Trimethoxy resveratrol 22255-22-7 ≥98% 270.32 C17H18O3 COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC Ambient Ambient Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide. "Dias SJ, Li K, Rimando AM, et al. Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. Prostate. 2013 Aug;73(11):1135-46. PMID: 23657951.

Hsieh TC, Huang YC, Wu JM. Control of prostate cell growth, DNA damage and repair and gene expression by resveratrol analogues, in vitro. Carcinogenesis. 2011 Jan;32(1):93-101. PMID: 21045015.

" Not dangerous goods.

LKT P7219 Pseudolaric Acid B 1 mg 118.9 Diterpene acid found in Pseudolarix kaempferi. PAB 82508-31-4 ≥98% 432.46 C23H28O8 CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)O Ambient Ambient "Pseudolaric acid B induces caspase-dependent cell death in human ovarian cancer cells. Yu B, Yue DM, Shu LH, Li NJ, Wang JH. Oncol Rep. 2013 Nov 25. [Epub ahead of print]. PMID: 24276652.

Role of pseudolaric acid B in A549 lung cancer cell proliferation and apoptosis. Guan T, Yang Y. Mol Med Rep. 2014 Jan;9(1):144-8. PMID: 24248012.

Yu Jh, Liu Cy, Zheng Gb, et al. Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell. Int J Med Sci. 2013 Apr 9;10(6):707-18. PMID: 23630435.

Sarkar T, Nguyen TL, Su ZW, et al. Interaction of pseudolaric acid B with the colchicine site of tubulin. Biochem Pharmacol. 2012 Aug 15;84(4):444-50. PMID: 22634405

Wei N, Li T, Chen H, Mei X, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. PMID: 22893196.

Liu J, Guo W, Xu B, et al. Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil. Acta Biochim Biophys Sin (Shanghai). 2012 Jun;44(6):490-502. PMID: 22551583

Hou L, Xu B, Guo W, et al. Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells. J Cancer Res Clin Oncol. 2012 Feb 8. [Epub ahead of print]. PMID: 22314698.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Pseudolaric acid B)"

LKT P7219 Pseudolaric Acid B 5 mg 533.9 Diterpene acid found in Pseudolarix kaempferi. PAB 82508-31-4 ≥98% 432.46 C23H28O8 CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)O Ambient Ambient "Pseudolaric acid B induces caspase-dependent cell death in human ovarian cancer cells. Yu B, Yue DM, Shu LH, Li NJ, Wang JH. Oncol Rep. 2013 Nov 25. [Epub ahead of print]. PMID: 24276652.

Role of pseudolaric acid B in A549 lung cancer cell proliferation and apoptosis. Guan T, Yang Y. Mol Med Rep. 2014 Jan;9(1):144-8. PMID: 24248012.

Yu Jh, Liu Cy, Zheng Gb, et al. Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell. Int J Med Sci. 2013 Apr 9;10(6):707-18. PMID: 23630435.

Sarkar T, Nguyen TL, Su ZW, et al. Interaction of pseudolaric acid B with the colchicine site of tubulin. Biochem Pharmacol. 2012 Aug 15;84(4):444-50. PMID: 22634405

Wei N, Li T, Chen H, Mei X, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. PMID: 22893196.

Liu J, Guo W, Xu B, et al. Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil. Acta Biochim Biophys Sin (Shanghai). 2012 Jun;44(6):490-502. PMID: 22551583

Hou L, Xu B, Guo W, et al. Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells. J Cancer Res Clin Oncol. 2012 Feb 8. [Epub ahead of print]. PMID: 22314698.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Pseudolaric acid B)"

LKT N5605 Nobiletin 25 mg 136 Polymethoxylated flavone found in citrus fruits; potential AMPA positive modulator. 478-01-3 ≥97% 402.39 C21H22O8 COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC Ambient Ambient "Yoshigai E, Machida T, Okuyama T, et al. Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes. Biochem Biophys Res Commun. 2013 Sep 13;439(1):54-9. PMID: 23958298.

Nakajima A, Aoyama Y, Nguyen TT, et al. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behav Brain Res. 2013 Aug 1;250:351-60. PMID: 23714077.

Ma X, Jin S, Zhang Y, et al. Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo. Phytother Res. 2013 Jul 1. [Epub ahead of print]. PMID: 23818450.

Aoki K, Yokosuka A, Mimaki Y, et al. Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells. Biol Pharm Bull. 2013;36(4):540-7. PMID: 23546290.

Lee YS, Cha BY, Choi SS, et al. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem. 2013 Jan;24(1):156-62. PMID: 22898571.

Baek SH, Kim SM, Nam D, et al. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9. Pharm Biol. 2012 Oct;50(10):1210-8. PMID: 22853317.

" Not dangerous goods.

LKT N5605 Nobiletin 100 mg 434.9 Polymethoxylated flavone found in citrus fruits; potential AMPA positive modulator. 478-01-3 ≥97% 402.39 C21H22O8 COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC Ambient Ambient "Yoshigai E, Machida T, Okuyama T, et al. Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes. Biochem Biophys Res Commun. 2013 Sep 13;439(1):54-9. PMID: 23958298.

Nakajima A, Aoyama Y, Nguyen TT, et al. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behav Brain Res. 2013 Aug 1;250:351-60. PMID: 23714077.

Ma X, Jin S, Zhang Y, et al. Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo. Phytother Res. 2013 Jul 1. [Epub ahead of print]. PMID: 23818450.

Aoki K, Yokosuka A, Mimaki Y, et al. Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells. Biol Pharm Bull. 2013;36(4):540-7. PMID: 23546290.

Lee YS, Cha BY, Choi SS, et al. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem. 2013 Jan;24(1):156-62. PMID: 22898571.

Baek SH, Kim SM, Nam D, et al. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9. Pharm Biol. 2012 Oct;50(10):1210-8. PMID: 22853317.

" Not dangerous goods.

LKT G1853 Genipin 25 mg 82.2 Iridoid glycoside found in Gardinia jasminoides; AChE inhibitor. 6902-77-8 ≥98% 226.23 C11H14O5 COC(=O)C1=COC(C2C1CC=C2CO)O Ambient Ambient "Liu TX, Wang Z. Collagen crosslinking of porcine sclera using genipin. Acta Ophthalmol. 2013 Jun;91(4):e253-7. PMID: 23710671.

Nam Y, Lee D. Ameliorating effect of zhizi (Fructus gardeniae) extract and its glycosides on scopolamine-induced memory impairment. J Tradit Chin Med. 2013 Apr;33(2):223-7. PMID: 23789221.

Yang X, Yao J, Luo Y, et al. P38 MAP kinase mediates apoptosis after genipin treatment in non-small-cell lung cancer H1299 cells via a mitochondrial apoptotic cascade. J Pharmacol Sci. 2013;121(4):272-81. PMID: 23603895.

Aramwit P, Siritienthong T, Srichana T, et al. Accelerated healing of full-thickness wounds by genipin-crosslinked silk sericin/PVA scaffolds. Cells Tissues Organs. 2013;197(3):224-38. PMID: 23307034.

Mu C, Zhang K, Lin W, et al. Ring-opening polymerization of genipin and its long-range crosslinking effect on collagen hydrogel. J Biomed Mater Res A. 2013 Feb;101(2):385-93. PMID: 22847997.

Qiu W, Zhou Y, Jiang L, et al. Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice. PLoS One. 2012;7(7):e41391. PMID: 22848482.

Li CC, Hsiang CY, Lo HY, et al. Genipin inhibits lipopolysaccharide-induced acute systemic inflammation in mice as evidenced by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis. Food Chem Toxicol. 2012 Sep;50(9):2978-86. PMID: 22687549.

Kim TH, Yoon SJ, Lee SM. Genipin attenuates sepsis by inhibiting Toll-like receptor signaling. Mol Med. 2012 May 9;18:455-65. PMID: 22252713.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Genipin)"

LKT G1853 Genipin 100 mg 276.5 Iridoid glycoside found in Gardinia jasminoides; AChE inhibitor. 6902-77-8 ≥98% 226.23 C11H14O5 COC(=O)C1=COC(C2C1CC=C2CO)O Ambient Ambient "Liu TX, Wang Z. Collagen crosslinking of porcine sclera using genipin. Acta Ophthalmol. 2013 Jun;91(4):e253-7. PMID: 23710671.

Nam Y, Lee D. Ameliorating effect of zhizi (Fructus gardeniae) extract and its glycosides on scopolamine-induced memory impairment. J Tradit Chin Med. 2013 Apr;33(2):223-7. PMID: 23789221.

Yang X, Yao J, Luo Y, et al. P38 MAP kinase mediates apoptosis after genipin treatment in non-small-cell lung cancer H1299 cells via a mitochondrial apoptotic cascade. J Pharmacol Sci. 2013;121(4):272-81. PMID: 23603895.

Aramwit P, Siritienthong T, Srichana T, et al. Accelerated healing of full-thickness wounds by genipin-crosslinked silk sericin/PVA scaffolds. Cells Tissues Organs. 2013;197(3):224-38. PMID: 23307034.

Mu C, Zhang K, Lin W, et al. Ring-opening polymerization of genipin and its long-range crosslinking effect on collagen hydrogel. J Biomed Mater Res A. 2013 Feb;101(2):385-93. PMID: 22847997.

Qiu W, Zhou Y, Jiang L, et al. Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice. PLoS One. 2012;7(7):e41391. PMID: 22848482.

Li CC, Hsiang CY, Lo HY, et al. Genipin inhibits lipopolysaccharide-induced acute systemic inflammation in mice as evidenced by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis. Food Chem Toxicol. 2012 Sep;50(9):2978-86. PMID: 22687549.

Kim TH, Yoon SJ, Lee SM. Genipin attenuates sepsis by inhibiting Toll-like receptor signaling. Mol Med. 2012 May 9;18:455-65. PMID: 22252713.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Genipin)"

LKT T0394 (+)-Taxifolin 10 mg 37.4 Catechol-type flavonoid; fatty acid synthesis inhibitor. 480-18-2 ≥92% 304.25 C15H12O7 "c1cc(c(cc1C2C(C(=O)c3c(cc(cc3O2)O)O)O)O)O

" Ambient Ambient "Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

" Not dangerous goods.

LKT T0394 (+)-Taxifolin 25 mg 59.7 Catechol-type flavonoid; fatty acid synthesis inhibitor. 480-18-2 ≥92% 304.25 C15H12O7 "c1cc(c(cc1C2C(C(=O)c3c(cc(cc3O2)O)O)O)O)O

" Ambient Ambient "Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

" Not dangerous goods.

LKT T0394 (+)-Taxifolin 100 mg 186.8 Catechol-type flavonoid; fatty acid synthesis inhibitor. 480-18-2 ≥92% 304.25 C15H12O7 "c1cc(c(cc1C2C(C(=O)c3c(cc(cc3O2)O)O)O)O)O

" Ambient Ambient "Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

" Not dangerous goods.

LKT Z1970 Zerumbone 10 mg 67.2 Cyclic sesquiterpene found in ginger root; potential TRPV1 antagonist. 471-05-6 ≥96% 218.33 C15H22O CC1=CCC(C=CC(=O)C(=CCC1)C)(C)C Ambient 4°C DMSO (≥10 mg/mL) "Tsuboi K, Matsuo Y, Shamoto T, et al. Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep. 2014 Jan;31(1):57-64. PMID: 24220661.

Tzeng TF, Liou SS, Chang CJ, et al. Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Evid Based Complement Alternat Med. 2013;2013:303061. PMID: 24223615.

Sun Y, Sheng Q, Cheng Y, et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie. 2013 Feb;68(2):141-5. PMID: 23469687.

Weng HY, Hsu MJ, Wang CC, et al. Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci. 2012 Oct 5;19:86. PMID: 23035900.

Shin JW, Ohnishi K, Murakami A, et al. Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Cancer Prev Res (Phila). 2011 Jun;4(6):860-70. PMID: 21367956.

Perimal EK, Akhtar MN, Mohamad AS, et al. Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):155-62. PMID: 20955360.

Sulaiman MR, Perimal EK, Akhtar MN, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010 Oct;81(7):855-8. PMID: 20546845.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Zerumbone)"

LKT Z1970 Zerumbone 50 mg 266.9 Cyclic sesquiterpene found in ginger root; potential TRPV1 antagonist. 471-05-6 ≥96% 218.33 C15H22O CC1=CCC(C=CC(=O)C(=CCC1)C)(C)C Ambient 4°C DMSO (≥10 mg/mL) "Tsuboi K, Matsuo Y, Shamoto T, et al. Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep. 2014 Jan;31(1):57-64. PMID: 24220661.

Tzeng TF, Liou SS, Chang CJ, et al. Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Evid Based Complement Alternat Med. 2013;2013:303061. PMID: 24223615.

Sun Y, Sheng Q, Cheng Y, et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie. 2013 Feb;68(2):141-5. PMID: 23469687.

Weng HY, Hsu MJ, Wang CC, et al. Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci. 2012 Oct 5;19:86. PMID: 23035900.

Shin JW, Ohnishi K, Murakami A, et al. Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Cancer Prev Res (Phila). 2011 Jun;4(6):860-70. PMID: 21367956.

Perimal EK, Akhtar MN, Mohamad AS, et al. Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):155-62. PMID: 20955360.

Sulaiman MR, Perimal EK, Akhtar MN, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010 Oct;81(7):855-8. PMID: 20546845.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Zerumbone)"

LKT P3461 Pipemidic Acid 10 g 59.7 Fluoroquinolone; bacterial DNA gyrase inhibitor and ATP-sensitive K+ channel blocker. 51940-44-4 ≥98% 303.32 C14H17N5O3 CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O Ambient Ambient "Aubry A, Pan XS, Fisher LM, et al. Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1281-8. PMID: 15047530.

Maeda N, Tamagawa T, Niki I, et al. Increase in insulin release from rat pancreatic islets by quinolone antibiotics. Br J Pharmacol. 1996 Jan;117(2):372-6. PMID: 8789393.

Linseman DA, Hampton LA, Branstetter DG. Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol. 1995 Nov;28(1):59-64. PMID: 8566484.

Aoyama H, Sato K, Fujii T, et al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. PMID: 2831810.

" Xi Not dangerous goods.

LKT P3461 Pipemidic Acid 100 g 373.7 Fluoroquinolone; bacterial DNA gyrase inhibitor and ATP-sensitive K+ channel blocker. 51940-44-4 ≥98% 303.32 C14H17N5O3 CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O Ambient Ambient "Aubry A, Pan XS, Fisher LM, et al. Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1281-8. PMID: 15047530.

Maeda N, Tamagawa T, Niki I, et al. Increase in insulin release from rat pancreatic islets by quinolone antibiotics. Br J Pharmacol. 1996 Jan;117(2):372-6. PMID: 8789393.

Linseman DA, Hampton LA, Branstetter DG. Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol. 1995 Nov;28(1):59-64. PMID: 8566484.

Aoyama H, Sato K, Fujii T, et al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. PMID: 2831810.

" Xi Not dangerous goods.

LKT O9458 Oxolinic Acid 5 g 67.2 Fluoroquinolone; bacterial DNA gyrase inhibitor. 14698-29-4 ≥98% 261.23 C13H11NO5 CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O Ambient Ambient "Kljun J, Bratsos I, Alessio E, et al. New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium. Inorg Chem. 2013 Aug 5;52(15):9039-52. PMID: 23886077.

Tarushi A, Lafazanis K, Kljun J, et al. First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives. J Inorg Biochem. 2013 Apr;121:53-65. PMID: 23353082.

Kwon HR, Choi GJ, Choi YH, et al. Suppression of pine wilt disease by an antibacterial agent, oxolinic acid. Pest Manag Sci. 2010 Jun;66(6):634-9. PMID: 20151406.

Williams PD, Helton DR. The proconvulsive activity of quinolone antibiotics in an animal model. Toxicol Lett. 1991 Sep;58(1):23-8. PMID: 1897004.

" Xn Not dangerous goods.

LKT O9458 Oxolinic Acid 25 g 298.9 Fluoroquinolone; bacterial DNA gyrase inhibitor. 14698-29-4 ≥98% 261.23 C13H11NO5 CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O Ambient Ambient "Kljun J, Bratsos I, Alessio E, et al. New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium. Inorg Chem. 2013 Aug 5;52(15):9039-52. PMID: 23886077.

Tarushi A, Lafazanis K, Kljun J, et al. First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives. J Inorg Biochem. 2013 Apr;121:53-65. PMID: 23353082.

Kwon HR, Choi GJ, Choi YH, et al. Suppression of pine wilt disease by an antibacterial agent, oxolinic acid. Pest Manag Sci. 2010 Jun;66(6):634-9. PMID: 20151406.

Williams PD, Helton DR. The proconvulsive activity of quinolone antibiotics in an animal model. Toxicol Lett. 1991 Sep;58(1):23-8. PMID: 1897004.

" Xn Not dangerous goods.

LKT C0167 Carbenoxolone 1 g 25.2 Synthetic glycyrrhetinic acid derivative; 11β-HSD inhibitor, gap junction connexin channel blocker. 5697-56-3 ≥97% 570.76 C34H50O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C Ambient Ambient "100 mg/ 550 µL DMSO; 

100 mg/ 3 mL Ethanol" "Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920.

Okuda H, Nishida K, Higashi Y, et al. NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci. 2013 Apr 19;92(13):808-14. PMID: 23454167.

Oishi S, Sasano T, Tateishi Y, et al. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J Pharmacol Sci. 2012;120(4):296-304. PMID: 23196902.

Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899.

Sano S, Nakagawa Y, Yamaguchi R, et al. Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice. Horm Metab Res. 2012 Jan;44(1):15-20. PMID: 22205568.

Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952.

" Not dangerous goods.

LKT C0167 Carbenoxolone 5 g 75.5 Synthetic glycyrrhetinic acid derivative; 11β-HSD inhibitor, gap junction connexin channel blocker. 5697-56-3 ≥97% 570.76 C34H50O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C Ambient Ambient "100 mg/ 550 µL DMSO; 

100 mg/ 3 mL Ethanol" "Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920.

Okuda H, Nishida K, Higashi Y, et al. NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci. 2013 Apr 19;92(13):808-14. PMID: 23454167.

Oishi S, Sasano T, Tateishi Y, et al. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J Pharmacol Sci. 2012;120(4):296-304. PMID: 23196902.

Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899.

Sano S, Nakagawa Y, Yamaguchi R, et al. Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice. Horm Metab Res. 2012 Jan;44(1):15-20. PMID: 22205568.

Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952.

" Not dangerous goods.

LKT C0167 Carbenoxolone 25 g 220.2 Synthetic glycyrrhetinic acid derivative; 11β-HSD inhibitor, gap junction connexin channel blocker. 5697-56-3 ≥97% 570.76 C34H50O7 CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C Ambient Ambient "100 mg/ 550 µL DMSO; 

100 mg/ 3 mL Ethanol" "Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920.

Okuda H, Nishida K, Higashi Y, et al. NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci. 2013 Apr 19;92(13):808-14. PMID: 23454167.

Oishi S, Sasano T, Tateishi Y, et al. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J Pharmacol Sci. 2012;120(4):296-304. PMID: 23196902.

Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899.

Sano S, Nakagawa Y, Yamaguchi R, et al. Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice. Horm Metab Res. 2012 Jan;44(1):15-20. PMID: 22205568.

Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952.

" Not dangerous goods.

LKT E7731 17-α-Ethynylestradiol 1 g 59.3 Synthetic steroid hormone; ER agonist. Ethinylestradiol 77538-56-8 ≥98% 296.4 C20H24O2 CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O Ambient Ambient "Kidd KA, Blanchfield PJ, Mills KH, et al. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901. PMID: 17517636.

Schultz IR, Skillman A, Nicolas JM, et al. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem. 2003 Jun;22(6):1272-80. PMID: 12785584.

Yasuda K, Furukawa M, Johnston JM. Effect of estrogens on plasma platelet-activating factor acetylhydrolase and the timing of parturition in the rat. Biol Reprod. 1996 Jan;54(1):224-9. PMID: 8838020.

Lacort M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 1995 Feb;30(2):141-6. PMID: 7769970.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (17α-Ethynylestradiol)"

LKT E7731 17-α-Ethynylestradiol 5 g 263.6 Synthetic steroid hormone; ER agonist. Ethinylestradiol 77538-56-8 ≥98% 296.4 C20H24O2 CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O Ambient Ambient "Kidd KA, Blanchfield PJ, Mills KH, et al. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901. PMID: 17517636.

Schultz IR, Skillman A, Nicolas JM, et al. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem. 2003 Jun;22(6):1272-80. PMID: 12785584.

Yasuda K, Furukawa M, Johnston JM. Effect of estrogens on plasma platelet-activating factor acetylhydrolase and the timing of parturition in the rat. Biol Reprod. 1996 Jan;54(1):224-9. PMID: 8838020.

Lacort M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 1995 Feb;30(2):141-6. PMID: 7769970.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (17α-Ethynylestradiol)"

LKT E7731 17-α-Ethynylestradiol 10 g 421.8 Synthetic steroid hormone; ER agonist. Ethinylestradiol 77538-56-8 ≥98% 296.4 C20H24O2 CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O Ambient Ambient "Kidd KA, Blanchfield PJ, Mills KH, et al. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901. PMID: 17517636.

Schultz IR, Skillman A, Nicolas JM, et al. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem. 2003 Jun;22(6):1272-80. PMID: 12785584.

Yasuda K, Furukawa M, Johnston JM. Effect of estrogens on plasma platelet-activating factor acetylhydrolase and the timing of parturition in the rat. Biol Reprod. 1996 Jan;54(1):224-9. PMID: 8838020.

Lacort M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 1995 Feb;30(2):141-6. PMID: 7769970.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (17α-Ethynylestradiol)"

LKT L0350 Lamivudine 1 g 52.3 Nucleoside (thymidine) analog; RT inhibitor. Epivir 134678-17-4 ≥98% 229.26 C8H11N3O3S C1C(OC(S1)CO)N2C=CC(=NC2=O)N Ambient Ambient "Blümer RM, van Vonderen MG, Sutinen J, et al. Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. AIDS. 2008 Jan 11;22(2):227-36. PMID: 18097225.

Saavedra-Lozano J, McCoig CC, Cao Y, et al. Zidovudine, lamivudine, and abacavir have different effects on resting cells infected with human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 2004 Aug;48(8):2825-30. PMID: 15273087

Balestrieri E, Forte G, Matteucci C, et al. Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. Antimicrob Agents Chemother. 2002 Sep;46(9):3080-3. PMID: 12183277.

" Not dangerous goods.

LKT L0350 Lamivudine 5 g 112.1 Nucleoside (thymidine) analog; RT inhibitor. Epivir 134678-17-4 ≥98% 229.26 C8H11N3O3S C1C(OC(S1)CO)N2C=CC(=NC2=O)N Ambient Ambient "Blümer RM, van Vonderen MG, Sutinen J, et al. Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. AIDS. 2008 Jan 11;22(2):227-36. PMID: 18097225.

Saavedra-Lozano J, McCoig CC, Cao Y, et al. Zidovudine, lamivudine, and abacavir have different effects on resting cells infected with human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 2004 Aug;48(8):2825-30. PMID: 15273087

Balestrieri E, Forte G, Matteucci C, et al. Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. Antimicrob Agents Chemother. 2002 Sep;46(9):3080-3. PMID: 12183277.

" Not dangerous goods.

LKT L0350 Lamivudine 25 g 478.3 Nucleoside (thymidine) analog; RT inhibitor. Epivir 134678-17-4 ≥98% 229.26 C8H11N3O3S C1C(OC(S1)CO)N2C=CC(=NC2=O)N Ambient Ambient "Blümer RM, van Vonderen MG, Sutinen J, et al. Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. AIDS. 2008 Jan 11;22(2):227-36. PMID: 18097225.

Saavedra-Lozano J, McCoig CC, Cao Y, et al. Zidovudine, lamivudine, and abacavir have different effects on resting cells infected with human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 2004 Aug;48(8):2825-30. PMID: 15273087

Balestrieri E, Forte G, Matteucci C, et al. Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. Antimicrob Agents Chemother. 2002 Sep;46(9):3080-3. PMID: 12183277.

" Not dangerous goods.

LKT I5313 Indinavir Sulfate 1 g 52.3 HIV protease, GLUT4, calpain inhibitor. Crixivan 157810-81-6 ≥98% 711.87 C36H49N5O8S CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5.OS(=O)(=O)O Ambient Ambient Soluble in Water "Ismail WI, King JA, Anwar K, et al. Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: potential role of the NFkappa B pathway. J Cell Biochem. 2013 Aug;114(8):1729-37. PMID: 23386514.

Toschi E, Sgadari C, Malavasi L, et al. Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome-independent block of angiogenesis and matrix metalloproteinases. Int J Cancer. 2011 Jan 1;128(1):82-93. PMID: 20617515.

Carper MJ, Cade WT, Cam M, et al. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. PMID: 18171911.

Ghibelli L, Mengoni F, Lichtner M, et al. Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain. Biochem Pharmacol. 2003 Oct 15;66(8):1505-12. PMID: 14555228.

Murata H, Hruz PW, Mueckler M. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS. 2002 Apr 12;16(6):859-63. PMID: 11919487.

Caron M, Auclair M, Vigouroux C, et al. The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes. 2001 Jun;50(6):1378-88. PMID: 11375339.

" Not dangerous goods.

LKT I5313 Indinavir Sulfate 5 g 112.1 HIV protease, GLUT4, calpain inhibitor. Crixivan 157810-81-6 ≥98% 711.87 C36H49N5O8S CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5.OS(=O)(=O)O Ambient Ambient Soluble in Water "Ismail WI, King JA, Anwar K, et al. Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: potential role of the NFkappa B pathway. J Cell Biochem. 2013 Aug;114(8):1729-37. PMID: 23386514.

Toschi E, Sgadari C, Malavasi L, et al. Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome-independent block of angiogenesis and matrix metalloproteinases. Int J Cancer. 2011 Jan 1;128(1):82-93. PMID: 20617515.

Carper MJ, Cade WT, Cam M, et al. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. PMID: 18171911.

Ghibelli L, Mengoni F, Lichtner M, et al. Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain. Biochem Pharmacol. 2003 Oct 15;66(8):1505-12. PMID: 14555228.

Murata H, Hruz PW, Mueckler M. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS. 2002 Apr 12;16(6):859-63. PMID: 11919487.

Caron M, Auclair M, Vigouroux C, et al. The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes. 2001 Jun;50(6):1378-88. PMID: 11375339.

" Not dangerous goods.

LKT I5313 Indinavir Sulfate 25 g 478.3 HIV protease, GLUT4, calpain inhibitor. Crixivan 157810-81-6 ≥98% 711.87 C36H49N5O8S CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC=C5.OS(=O)(=O)O Ambient Ambient Soluble in Water "Ismail WI, King JA, Anwar K, et al. Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: potential role of the NFkappa B pathway. J Cell Biochem. 2013 Aug;114(8):1729-37. PMID: 23386514.

Toschi E, Sgadari C, Malavasi L, et al. Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome-independent block of angiogenesis and matrix metalloproteinases. Int J Cancer. 2011 Jan 1;128(1):82-93. PMID: 20617515.

Carper MJ, Cade WT, Cam M, et al. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. PMID: 18171911.

Ghibelli L, Mengoni F, Lichtner M, et al. Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain. Biochem Pharmacol. 2003 Oct 15;66(8):1505-12. PMID: 14555228.

Murata H, Hruz PW, Mueckler M. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS. 2002 Apr 12;16(6):859-63. PMID: 11919487.

Caron M, Auclair M, Vigouroux C, et al. The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes. 2001 Jun;50(6):1378-88. PMID: 11375339.

" Not dangerous goods.

LKT K0023 K252c 1 mg 149.5 Staurosporine analog; PKC and PKA inhibitor. 85753-43-1 ≥98% 311.34 C20H13N3O CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N Ambient 4°C "Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;

soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;

Insoluble in water, 2-propanol" "Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.

Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.

Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.

" Not dangerous goods.

LKT K0023 K252c 5 mg 627.8 Staurosporine analog; PKC and PKA inhibitor. 85753-43-1 ≥98% 311.34 C20H13N3O CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N Ambient 4°C "Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;

soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;

Insoluble in water, 2-propanol" "Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.

Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.

Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.

" Not dangerous goods.

LKT R3584 Rivaroxaban 1 mg 97.2 Oxazolidone derivative; Factor Xa inhibitor. 366789-02-8 ≥98% 435.88 C19H18ClN3O5S C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl Ambient Ambient MeOH "Kreutz R. Pharmacokinetics and Pharmacodynamics of Rivaroxaban - An Oral, Direct Factor Xa Inhibitor. Curr Clin Pharmacol. 2013 Nov 11. [Epub ahead of print]. PMID: 24218999.

Somjen D, Katzburg S, Gigi R, et al. Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2. J Steroid Biochem Mol Biol. 2013 May;135:67-70. PMID: 23333933

Gigi R, Salai M, Dolkart O, et al. The effects of direct factor Xa inhibitor (Rivaroxaban) on the human osteoblastic cell line SaOS2. Connect Tissue Res. 2012;53(6):446-50. PMID: 22800431.

Samama MM. The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants. Thromb Res. 2011 Jun;127(6):497-504. PMID: 20888031.

" Not Dangerous Goods

LKT R3584 Rivaroxaban 5 mg 336.4 Oxazolidone derivative; Factor Xa inhibitor. 366789-02-8 ≥98% 435.88 C19H18ClN3O5S C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl Ambient Ambient MeOH "Kreutz R. Pharmacokinetics and Pharmacodynamics of Rivaroxaban - An Oral, Direct Factor Xa Inhibitor. Curr Clin Pharmacol. 2013 Nov 11. [Epub ahead of print]. PMID: 24218999.

Somjen D, Katzburg S, Gigi R, et al. Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2. J Steroid Biochem Mol Biol. 2013 May;135:67-70. PMID: 23333933

Gigi R, Salai M, Dolkart O, et al. The effects of direct factor Xa inhibitor (Rivaroxaban) on the human osteoblastic cell line SaOS2. Connect Tissue Res. 2012;53(6):446-50. PMID: 22800431.

Samama MM. The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants. Thromb Res. 2011 Jun;127(6):497-504. PMID: 20888031.

" Not Dangerous Goods

LKT R3584 Rivaroxaban 25 mg 1195.8 Oxazolidone derivative; Factor Xa inhibitor. 366789-02-8 ≥98% 435.88 C19H18ClN3O5S C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl Ambient Ambient MeOH "Kreutz R. Pharmacokinetics and Pharmacodynamics of Rivaroxaban - An Oral, Direct Factor Xa Inhibitor. Curr Clin Pharmacol. 2013 Nov 11. [Epub ahead of print]. PMID: 24218999.

Somjen D, Katzburg S, Gigi R, et al. Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2. J Steroid Biochem Mol Biol. 2013 May;135:67-70. PMID: 23333933

Gigi R, Salai M, Dolkart O, et al. The effects of direct factor Xa inhibitor (Rivaroxaban) on the human osteoblastic cell line SaOS2. Connect Tissue Res. 2012;53(6):446-50. PMID: 22800431.

Samama MM. The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants. Thromb Res. 2011 Jun;127(6):497-504. PMID: 20888031.

" Not Dangerous Goods

LKT I4962 Isoimperatorin 5 mg 67.2 Furocoumarin; COX-2 inhibitor. 482-45-1 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C Ambient Ambient "Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339

Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.

Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.

" Not dangerous goods.

LKT I4962 Isoimperatorin 25 mg 269.1 Furocoumarin; COX-2 inhibitor. 482-45-1 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C Ambient Ambient "Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339

Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.

Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.

" Not dangerous goods.

LKT I4962 Isoimperatorin 100 mg 747.5 Furocoumarin; COX-2 inhibitor. 482-45-1 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C Ambient Ambient "Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339

Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.

Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.

" Not dangerous goods.

LKT I4961 Imperatorin 5 mg 67.2 Furocoumarin; voltage-gated Na+ channel blocker, AChE and BChE inhibitor. 482-44-0 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C Ambient Ambient DMSO 10 mM. <0.3 mg/mL hot H2O. "Granica S, Kiss AK, Jarończyk M, et al. Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2013 Oct 14. [Epub ahead of print]. PMID: 24123207.

Wu KC, Chen YH, Cheng KS, et al. Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin. Eur J Pharmacol. 2013 Dec 5;721(1-3):49-55. PMID: 24113522.

Budzynska B, Boguszewska-Czubara A, Kruk-Slomka M, et al. Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice. Physiol Behav. 2013 Oct 2;122:46-55. PMID: 23999469.

Wang N, Wu L, Cao Y, et al. The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia. 2013 Oct;90:38-43. PMID: 23856091.

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Cao YJ, He X, Wang N, et al. Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Phytomedicine. 2013 Sep 15;20(12):1048-54. PMID: 23746952.

Wang Z, Kim JR, Wang M, et al. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. Pest Manag Sci. 2012 Jul;68(7):1041-7. PMID: 22389164.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

" None Not dangerous goods.

LKT I4961 Imperatorin 25 mg 269.1 Furocoumarin; voltage-gated Na+ channel blocker, AChE and BChE inhibitor. 482-44-0 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C Ambient Ambient DMSO 10 mM. <0.3 mg/mL hot H2O. "Granica S, Kiss AK, Jarończyk M, et al. Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2013 Oct 14. [Epub ahead of print]. PMID: 24123207.

Wu KC, Chen YH, Cheng KS, et al. Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin. Eur J Pharmacol. 2013 Dec 5;721(1-3):49-55. PMID: 24113522.

Budzynska B, Boguszewska-Czubara A, Kruk-Slomka M, et al. Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice. Physiol Behav. 2013 Oct 2;122:46-55. PMID: 23999469.

Wang N, Wu L, Cao Y, et al. The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia. 2013 Oct;90:38-43. PMID: 23856091.

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Cao YJ, He X, Wang N, et al. Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Phytomedicine. 2013 Sep 15;20(12):1048-54. PMID: 23746952.

Wang Z, Kim JR, Wang M, et al. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. Pest Manag Sci. 2012 Jul;68(7):1041-7. PMID: 22389164.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

" None Not dangerous goods.

LKT I4961 Imperatorin 100 mg 747.5 Furocoumarin; voltage-gated Na+ channel blocker, AChE and BChE inhibitor. 482-44-0 ≥98% 270.28 C16H14O4 CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C Ambient Ambient DMSO 10 mM. <0.3 mg/mL hot H2O. "Granica S, Kiss AK, Jarończyk M, et al. Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2013 Oct 14. [Epub ahead of print]. PMID: 24123207.

Wu KC, Chen YH, Cheng KS, et al. Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin. Eur J Pharmacol. 2013 Dec 5;721(1-3):49-55. PMID: 24113522.

Budzynska B, Boguszewska-Czubara A, Kruk-Slomka M, et al. Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice. Physiol Behav. 2013 Oct 2;122:46-55. PMID: 23999469.

Wang N, Wu L, Cao Y, et al. The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia. 2013 Oct;90:38-43. PMID: 23856091.

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Cao YJ, He X, Wang N, et al. Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Phytomedicine. 2013 Sep 15;20(12):1048-54. PMID: 23746952.

Wang Z, Kim JR, Wang M, et al. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. Pest Manag Sci. 2012 Jul;68(7):1041-7. PMID: 22389164.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

" None Not dangerous goods.

LKT C1650 β-Cembrenediol Methyl Ether 10 mg 269.1 Diterpene found in tobacco plants and cigarette smoke. ≥98% 320.51 C21H36O2 Ambient -80°C "Kulkarni RR, Shurpali K, Gawde RL, et al. Phyllocladane diterpenes from Anisomeles heyneana. J Asian Nat Prod Res. 2012;14(12):1162-8. PMID: 23157282.

Wright AD, Nielson JL, Tapiolas DM, et al. A great barrier reef Sinularia sp. yields two new cytotoxic diterpenes. Mar Drugs. 2012 Aug;10(8):1619-30. PMID: 23015765.

Kennedy BS, Nielsen MT, Severson RF. Biorationals fromNicotiana protect cucumbers againstColletotrichum lagenarium (Pass.) ell. & halst disease development. J Chem Ecol. 1995 Feb;21(2):221-31. PMID: 24234021.

" Not dangerous goods.

LKT G4799 Glycitin 5 mg 88.3 Glycosylated isoflavone found in soy; TAS2R agonist. 40246-10-4 ≥98% 446.4 C22H22O10 COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O Ambient Ambient Soluble in DMSO poorly; insoluble in other solvents "Roland WS, Vincken JP, Gouka RJ, et al. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem. 2011 Nov 9;59(21):11764-71. PMID: 21942422.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Li XH, Zhang JC, Sui SF, et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6. PMID: 16115375.

" Not dangerous goods.

LKT G4799 Glycitin 25 mg 394.2 Glycosylated isoflavone found in soy; TAS2R agonist. 40246-10-4 ≥98% 446.4 C22H22O10 COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O Ambient Ambient Soluble in DMSO poorly; insoluble in other solvents "Roland WS, Vincken JP, Gouka RJ, et al. Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem. 2011 Nov 9;59(21):11764-71. PMID: 21942422.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Li XH, Zhang JC, Sui SF, et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6. PMID: 16115375.

" Not dangerous goods.

LKT G4798 Glycitein 5 mg 140 Aglycone isoflavone found in soy and red clover. 40957-83-3 ≥98% 284.26 C16H12O5 COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)O Ambient Ambient "Hirohata M, Ono K, Takasaki J, et al. Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. Biochim Biophys Acta. 2012 Aug;1822(8):1316-24. PMID: 22587837.

Park JS, Jung JS, Jeong YH, et al. Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. J Neurochem. 2011 Dec;119(5):909-19. PMID: 21781119.

Winzer M, Rauner M, Pietschmann P. Glycitein decreases the generation of murine osteoclasts and increases apoptosis. Wien Med Wochenschr. 2010 Sep;160(17-18):446-51. PMID: 20714813.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem. 2007 Aug;18(8):525-32. PMID: 17156992.

Pan W, Ikeda K, Takebe M, et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001 Apr;131(4):1154-8. PMID: 11285318.

" Not dangerous goods.

LKT G4798 Glycitein 10 mg 224.3 Aglycone isoflavone found in soy and red clover. 40957-83-3 ≥98% 284.26 C16H12O5 COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)O Ambient Ambient "Hirohata M, Ono K, Takasaki J, et al. Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. Biochim Biophys Acta. 2012 Aug;1822(8):1316-24. PMID: 22587837.

Park JS, Jung JS, Jeong YH, et al. Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. J Neurochem. 2011 Dec;119(5):909-19. PMID: 21781119.

Winzer M, Rauner M, Pietschmann P. Glycitein decreases the generation of murine osteoclasts and increases apoptosis. Wien Med Wochenschr. 2010 Sep;160(17-18):446-51. PMID: 20714813.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem. 2007 Aug;18(8):525-32. PMID: 17156992.

Pan W, Ikeda K, Takebe M, et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001 Apr;131(4):1154-8. PMID: 11285318.

" Not dangerous goods.

LKT G4798 Glycitein 25 mg 462.1 Aglycone isoflavone found in soy and red clover. 40957-83-3 ≥98% 284.26 C16H12O5 COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)O Ambient Ambient "Hirohata M, Ono K, Takasaki J, et al. Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils. Biochim Biophys Acta. 2012 Aug;1822(8):1316-24. PMID: 22587837.

Park JS, Jung JS, Jeong YH, et al. Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. J Neurochem. 2011 Dec;119(5):909-19. PMID: 21781119.

Winzer M, Rauner M, Pietschmann P. Glycitein decreases the generation of murine osteoclasts and increases apoptosis. Wien Med Wochenschr. 2010 Sep;160(17-18):446-51. PMID: 20714813.

Lee EJ, Kim SY, Hyun JW, et al. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. Chem Biol Interact. 2010 Apr 15;185(1):18-24. PMID: 20188714.

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem. 2007 Aug;18(8):525-32. PMID: 17156992.

Pan W, Ikeda K, Takebe M, et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001 Apr;131(4):1154-8. PMID: 11285318.

" Not dangerous goods.

LKT L0077 Latrunculin B 1 mg 228.1 76343-94-7 395.51 C20H29NO5S "CC1CCC2CC(CC(O2)(C3CSC(=O)N3)O)OC(=O)C=C(CCC=C1)C

" Ambient 4°C Ethanol "Ahn YT, Shin IJ, Kim JM, et al. Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. Oncol Lett. 2013 Nov;6(5):1383-1389. PMID: 24179529.

Helal MA, Khalifa S, Ahmed S. Differential binding of latrunculins to G-actin: a molecular dynamics study. J Chem Inf Model. 2013 Sep 23;53(9):2369-75. PMID: 23988111.

Kudrimoti S, Ahmed SA, Daga PR, et al. Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. PMID: 19800245.

Yoshida K, Shimmen T. Involvement of actin filaments in rhizoid morphogenesis of Spirogyra. Physiol Plant. 2009 Jan;135(1):98-107. PMID: 19121103.

Kurilova LS, Krutetskaia ZI, Lebedev OE. Effect of latrunculin B, jasplakinolide and brefeldin A on the store-dependent Ca2+ entry in macrophages. Tsitologiia. 2006;48(10):867-74. PMID: 17162846.

" Not dangerous goods.

LKT V1868 Veratramine 1 mg 51.7 Steroidal alkaloid found in Veratrum and Fritillaria; hedgehog signaling pathway inhibitor. 60-70-8 ≥98% 409.6 C27H39NO2 CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O Ambient -20°C Soluble in Ethanol and Methanol "Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.

Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.

Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.

" "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Veratramine)"

LKT V1868 Veratramine 5 mg 67.9 Steroidal alkaloid found in Veratrum and Fritillaria; hedgehog signaling pathway inhibitor. 60-70-8 ≥98% 409.6 C27H39NO2 CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O Ambient -20°C Soluble in Ethanol and Methanol "Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.

Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.

Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.

" "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Veratramine)"

LKT M0255 Manzamine A 1 mg 224.5 Alkaloid found in marine sponges; vacuolar ATPase uncoupler, GSK3 inhibitor. 104196-68-1 ≥98% 548.76 C36H44N4O C1CCN2CCC3C(=CC(CCC=CC1)(C4C3(C2)CC5N4CCCCC=C5)O)C6=NC=CC7=C6NC8=CC=CC=C78 Ambient -20°C "Kallifatidis G, Hoepfner D, Jaeg T, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs. 2013 Sep 17;11(9):3500-16. PMID: 24048269.

Eguchi K, Fujiwara Y, Hayashida A, et al. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. Bioorg Med Chem. 2013 Jul 1;21(13):3831-8. PMID: 23665143.

Aqil F, Zahin M, El Sayed KA, et al. Antimicrobial, antioxidant, and antimutagenic activities of selected marine natural products and tobacco cembranoids. Drug Chem Toxicol. 2011 Apr;34(2):167-79. PMID: 21314466.

Palem JR, Bedadala GR, El Sayed KA, et al. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. Planta Med. 2011 Jan;77(1):46-51. PMID: 20645244.

Hamann M, Alonso D, Martín-Aparicio E, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 2007 Sep;70(9):1397-405. PMID: 17708655.

Winkler JD, Londregan AT, Hamann MT. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006 Jun 8;8(12):2591-4. PMID: 16737321.

" Not dangerous goods.

LKT M0255 Manzamine A 5 mg 819 Alkaloid found in marine sponges; vacuolar ATPase uncoupler, GSK3 inhibitor. 104196-68-1 ≥98% 548.76 C36H44N4O C1CCN2CCC3C(=CC(CCC=CC1)(C4C3(C2)CC5N4CCCCC=C5)O)C6=NC=CC7=C6NC8=CC=CC=C78 Ambient -20°C "Kallifatidis G, Hoepfner D, Jaeg T, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs. 2013 Sep 17;11(9):3500-16. PMID: 24048269.

Eguchi K, Fujiwara Y, Hayashida A, et al. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. Bioorg Med Chem. 2013 Jul 1;21(13):3831-8. PMID: 23665143.

Aqil F, Zahin M, El Sayed KA, et al. Antimicrobial, antioxidant, and antimutagenic activities of selected marine natural products and tobacco cembranoids. Drug Chem Toxicol. 2011 Apr;34(2):167-79. PMID: 21314466.

Palem JR, Bedadala GR, El Sayed KA, et al. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. Planta Med. 2011 Jan;77(1):46-51. PMID: 20645244.

Hamann M, Alonso D, Martín-Aparicio E, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 2007 Sep;70(9):1397-405. PMID: 17708655.

Winkler JD, Londregan AT, Hamann MT. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006 Jun 8;8(12):2591-4. PMID: 16737321.

" Not dangerous goods.

LKT P8382 Puupehenone 1 mg 84.9 Sesquiterpene found in marine sponges. 73573-17-8 ≥94% 328.45 C21H28O3 CC1(CCCC2(C1CCC3(C2C=C4C=C(C(=O)C=C4O3)O)C)C)C stock solutions stable up to 6 months stored at -20°C Ambient -20°C "0.1 mg/mL ethanol, 0.3 mg/mL methanol

*protect from light

*pack under inert gas" "Castro ME, González-Iriarte M, Barrero AF, et al. Study of puupehenone and related compounds as inhibitors of angiogenesis. Int J Cancer. 2004 May 20;110(1):31-8. PMID: 15054866.

Takamatsu S, Hodges TW, Rajbhandari I, et al. Marine natural products as novel antioxidant prototypes. J Nat Prod. 2003 May;66(5):605-8. PMID: 12762791.

"

LKT P8382 Puupehenone 5 mg 327.6 Sesquiterpene found in marine sponges. 73573-17-8 ≥94% 328.45 C21H28O3 CC1(CCCC2(C1CCC3(C2C=C4C=C(C(=O)C=C4O3)O)C)C)C stock solutions stable up to 6 months stored at -20°C Ambient -20°C "0.1 mg/mL ethanol, 0.3 mg/mL methanol

*protect from light

*pack under inert gas" "Castro ME, González-Iriarte M, Barrero AF, et al. Study of puupehenone and related compounds as inhibitors of angiogenesis. Int J Cancer. 2004 May 20;110(1):31-8. PMID: 15054866.

Takamatsu S, Hodges TW, Rajbhandari I, et al. Marine natural products as novel antioxidant prototypes. J Nat Prod. 2003 May;66(5):605-8. PMID: 12762791.

"

LKT P7060 Protocatechuic Acid Ethyl Ester 5 g 35.6 Dihydroxyphenolic acid found in cruciferous vegetables; topoisomerase II inhibitor. 3,4-Dihydroxybenzoic acid ethyl ester Ethyl 3,4-dihydroxybenzoate 3943-89-3 ≥98% 182.17 C9H10O4 CCOC(=O)C1=CC(=C(C=C1)O)O Ambient Ambient "Stumpf C, Fan Q, Hintermann C, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41(5):1065-77. PMID: 24117069.

Garcia-Alvarez MC, Moussa I, Njomnang Soh P, et al. Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle. J Ethnopharmacol. 2013 Oct 7;149(3):676-84. PMID: 23906782.

Kuriyama I, Nakajima Y, Nishida H, et al. Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Mol Med Rep. 2013 Aug;8(2):535-42. PMID: 23799608.

Muley MM, Thakare VN, Patil RR, et al. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci. 2013 Jul 19;93(1):51-7. PMID: 23743171.

Stojković DS, Zivković J, Soković M, et al. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. Food Chem Toxicol. 2013 May;55:209-13. PMID: 23333716.

Li J, Deng Y, Yuan C, et al. Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits. J Agric Food Chem. 2012 Nov 21;60(46):11551-9. PMID: 23131110.

Lin HH, Chen JH, Chou FP, et al. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol. 2011 Jan;162(1):237-54. PMID: 20840540.

" Xi Not dangerous goods.

LKT P7060 Protocatechuic Acid Ethyl Ester 25 g 106.8 Dihydroxyphenolic acid found in cruciferous vegetables; topoisomerase II inhibitor. 3,4-Dihydroxybenzoic acid ethyl ester Ethyl 3,4-dihydroxybenzoate 3943-89-3 ≥98% 182.17 C9H10O4 CCOC(=O)C1=CC(=C(C=C1)O)O Ambient Ambient "Stumpf C, Fan Q, Hintermann C, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41(5):1065-77. PMID: 24117069.

Garcia-Alvarez MC, Moussa I, Njomnang Soh P, et al. Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle. J Ethnopharmacol. 2013 Oct 7;149(3):676-84. PMID: 23906782.

Kuriyama I, Nakajima Y, Nishida H, et al. Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Mol Med Rep. 2013 Aug;8(2):535-42. PMID: 23799608.

Muley MM, Thakare VN, Patil RR, et al. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci. 2013 Jul 19;93(1):51-7. PMID: 23743171.

Stojković DS, Zivković J, Soković M, et al. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. Food Chem Toxicol. 2013 May;55:209-13. PMID: 23333716.

Li J, Deng Y, Yuan C, et al. Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits. J Agric Food Chem. 2012 Nov 21;60(46):11551-9. PMID: 23131110.

Lin HH, Chen JH, Chou FP, et al. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol. 2011 Jan;162(1):237-54. PMID: 20840540.

" Xi Not dangerous goods.

LKT P7060 Protocatechuic Acid Ethyl Ester 100 g 213.6 Dihydroxyphenolic acid found in cruciferous vegetables; topoisomerase II inhibitor. 3,4-Dihydroxybenzoic acid ethyl ester Ethyl 3,4-dihydroxybenzoate 3943-89-3 ≥98% 182.17 C9H10O4 CCOC(=O)C1=CC(=C(C=C1)O)O Ambient Ambient "Stumpf C, Fan Q, Hintermann C, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41(5):1065-77. PMID: 24117069.

Garcia-Alvarez MC, Moussa I, Njomnang Soh P, et al. Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle. J Ethnopharmacol. 2013 Oct 7;149(3):676-84. PMID: 23906782.

Kuriyama I, Nakajima Y, Nishida H, et al. Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Mol Med Rep. 2013 Aug;8(2):535-42. PMID: 23799608.

Muley MM, Thakare VN, Patil RR, et al. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci. 2013 Jul 19;93(1):51-7. PMID: 23743171.

Stojković DS, Zivković J, Soković M, et al. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. Food Chem Toxicol. 2013 May;55:209-13. PMID: 23333716.

Li J, Deng Y, Yuan C, et al. Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits. J Agric Food Chem. 2012 Nov 21;60(46):11551-9. PMID: 23131110.

Lin HH, Chen JH, Chou FP, et al. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol. 2011 Jan;162(1):237-54. PMID: 20840540.

" Xi Not dangerous goods.

LKT V3277 Vitamin E 250 g 337.1 Synthetic vitamin E, antioxidant. D,L-α-Tocopherol; (+-)-α-Tocopherol; Ephanyl 10191-41-0 ≥98% 430.7 C29H50O2 CC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O Stable to heat and alkalis. Protect from light. Ambient 4°C Soluble in ethanol, ether, chloroform, acetone or vegetable oils. "Reid VC, Mitchinson MJ. Toxicity of oxidised low density lipoprotein towards mouse peritoneal macrophages in vitro. Atherosclerosis. 1993 Jan 4;98(1):17-24. PMID: 8457247.

Williams RJ, Motteram JM, Sharp CH, et al. Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis. 1992 Jun;94(2-3):153-9. PMID: 1632869.

" Xi Not dangerous goods.

LKT V1745 Veliparib 5 mg 197.1 PARP inhibitor. ABT-888 912444-00-9 ≥98% 244.29 C13H16N4O CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N Ambient Ambient "Owonikoko TK, Zhang G, Deng X et al. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med. 2014 Dec;3(6):1579-94. PMID: 25124282.

Barazzuol L, Jena R, Burnet NG, et al. Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. Radiat Oncol. 2013 Mar 19;8:65. PMID: 23510353.

Ta LE, Schmelzer JD, Bieber AJ, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8(1):e54161. PMID: 23326593.

Anjos SM, Robert R, Waller D, et al. Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking. Front Pharmacol. 2012;3:165. PMID: 22988441." Not dangerous goods.

LKT O4402 Olaparib 5 mg 54.4 PARP1/2 inhibitor. AZD2281, KU-0059436 763113-22-0 ≥98% 434.47 C24H23FN4O3 C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F Ambient 4°C DMSO (10 mg/ml), DMF (3 mg/ml) "Lee JM, Ledermann JA, Kohn EC. PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2013 Nov 12. [Epub ahead of print]. PMID: 24225019.

Olaparib Enters Phase III Clinical Testing. Cancer Discov. 2013 Nov;3(11):1210. PMID: 24203936.

Postel-Vinay S, Bajrami I, Friboulet L, et al. A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer. Oncogene. 2013 Nov 21;32(47):5377-87. PMID: 23934192.

Kortmann U, McAlpine JN, Xue H, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res. 2011 Feb 15;17(4):783-91. PMID: 21097693.

" Not dangerous goods.

LKT O4402 Olaparib 10 mg 73.4 PARP1/2 inhibitor. AZD2281, KU-0059436 763113-22-0 ≥98% 434.47 C24H23FN4O3 C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F Ambient 4°C DMSO (10 mg/ml), DMF (3 mg/ml) "Lee JM, Ledermann JA, Kohn EC. PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2013 Nov 12. [Epub ahead of print]. PMID: 24225019.

Olaparib Enters Phase III Clinical Testing. Cancer Discov. 2013 Nov;3(11):1210. PMID: 24203936.

Postel-Vinay S, Bajrami I, Friboulet L, et al. A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer. Oncogene. 2013 Nov 21;32(47):5377-87. PMID: 23934192.

Kortmann U, McAlpine JN, Xue H, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res. 2011 Feb 15;17(4):783-91. PMID: 21097693.

" Not dangerous goods.

LKT I5354 Iniparib 5 mg 526.3 Cysteine adduct inducer, PARP-1 inhibitor. 160003-66-7 ≥98% 292.03 C7H5IN2O3 C1=CC(=C(C=C1C(=O)N)[N+](=O)[O-])I Ambient 4°C "Mateo J, Ong M, Tan DS, et al. Appraising iniparib, the PARP inhibitor that never was-what must we learn? Nat Rev Clin Oncol. 2013 Dec;10(12):688-96. PMID: 24129347.

Wilkinson-Ryan I, Mutch D. A review of iniparib in ovarian cancer. Expert Opin Investig Drugs. 2013 Mar;22(3):399-405. PMID: 23394483.

Ma W, Halweg CJ, Menendez D, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. PMID: 22493268

Liu X, Shi Y, Maag DX, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. PMID: 22128301.

" Not dangerous goods.

LKT T1776 D-Tetrahydropalmatine 25 mg 67.2 Alkaloid found in Corydalis; D1 antagonist, organic cation transporter 1 inhibitor. ≥98% 355.43 C21H25NO4 COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC Ambient Ambient "Tu M, Sun S, Wang K, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30. PMID: 23831208.

Xu SX, Yu LP, Han YR, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. PMID: 2530755.

" Not dangerous goods.

LKT T1776 D-Tetrahydropalmatine 100 mg 142 Alkaloid found in Corydalis; D1 antagonist, organic cation transporter 1 inhibitor. ≥98% 355.43 C21H25NO4 COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC Ambient Ambient "Tu M, Sun S, Wang K, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30. PMID: 23831208.

Xu SX, Yu LP, Han YR, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. PMID: 2530755.

" Not dangerous goods.

LKT T1776 D-Tetrahydropalmatine 500 mg 635.4 Alkaloid found in Corydalis; D1 antagonist, organic cation transporter 1 inhibitor. ≥98% 355.43 C21H25NO4 COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC Ambient Ambient "Tu M, Sun S, Wang K, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30. PMID: 23831208.

Xu SX, Yu LP, Han YR, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. PMID: 2530755.

" Not dangerous goods.

LKT "B3577

" Bitertanol 1 g 37.4 Pesticide; demethylation inhibitor. 55179-31-2 ≥95% 337.42 C20H23N3O2 CC(C)(C)C(C(N1C=NC=N1)OC2=CC=C(C=C2)C3=CC=CC=C3)O Ambient Ambient "Chan PK, Lu SY, Liao JW, et al. Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 2006 Dec;44(12):2047-57. PMID: 16971034.

Allen AR, MacPhail RC. Bitertanol, a triazole fungicide, increases operant responding but not motor activity. Neurotoxicol Teratol. 1993 Jul-Aug;15(4):237-42. PMID: 8413077.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Bitertanol)"

LKT B3577 Bitertanol 5 g 119.7 Pesticide; demethylation inhibitor. 55179-31-2 ≥95% 337.42 C20H23N3O2 CC(C)(C)C(C(N1C=NC=N1)OC2=CC=C(C=C2)C3=CC=CC=C3)O Ambient Ambient "Chan PK, Lu SY, Liao JW, et al. Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 2006 Dec;44(12):2047-57. PMID: 16971034.

Allen AR, MacPhail RC. Bitertanol, a triazole fungicide, increases operant responding but not motor activity. Neurotoxicol Teratol. 1993 Jul-Aug;15(4):237-42. PMID: 8413077.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Bitertanol)"

LKT B3577 Bitertanol 25 g 373.7 Pesticide; demethylation inhibitor. 55179-31-2 ≥95% 337.42 C20H23N3O2 CC(C)(C)C(C(N1C=NC=N1)OC2=CC=C(C=C2)C3=CC=CC=C3)O Ambient Ambient "Chan PK, Lu SY, Liao JW, et al. Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol. Food Chem Toxicol. 2006 Dec;44(12):2047-57. PMID: 16971034.

Allen AR, MacPhail RC. Bitertanol, a triazole fungicide, increases operant responding but not motor activity. Neurotoxicol Teratol. 1993 Jul-Aug;15(4):237-42. PMID: 8413077.

" "UN number: 2811     Class: 6.1     Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Bitertanol)"

LKT F4883 Flutriafol 500 mg 74.8 Triazole; demethylation inhibitor, NMDA agonist. 76674-21-0 ≥95% 301.29 C16H13F2N3O C1=CC=C(C(=C1)C(CN2C=NC=N2)(C3=CC=C(C=C3)F)O)F Ambient Ambient "Faro LR, Alfonso M, Maués LA, et al. Role of ionotropic glutamatergic receptors and nitric oxide in the effects of flutriafol, a triazole fungicide, on the in vivo striatal dopamine release. J Toxicol Sci. 2012;37(6):1135-42. PMID: 23208429.

Santana MB, Rodrigues KJ, Durán R, et al. Evaluation of the effects and mechanisms of action of flutriafol, a triazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats. Ecotoxicol Environ Saf. 2009 Jul;72(5):1565-71. PMID: 19232726.

Griffiths KM, Howlett BJ. Transcription of sterol Delta(5,6)-desaturase and sterol 14alpha-demethylase is induced in the plant pathogenic ascomycete, Leptosphaeria maculans, during treatment with a triazole fungicide. FEMS Microbiol Lett. 2002 Nov 19;217(1):81-7. PMID: 12445649.

" Not dangerous goods.

LKT F4883 Flutriafol 5 g 186.8 Triazole; demethylation inhibitor, NMDA agonist. 76674-21-0 ≥95% 301.29 C16H13F2N3O C1=CC=C(C(=C1)C(CN2C=NC=N2)(C3=CC=C(C=C3)F)O)F Ambient Ambient "Faro LR, Alfonso M, Maués LA, et al. Role of ionotropic glutamatergic receptors and nitric oxide in the effects of flutriafol, a triazole fungicide, on the in vivo striatal dopamine release. J Toxicol Sci. 2012;37(6):1135-42. PMID: 23208429.

Santana MB, Rodrigues KJ, Durán R, et al. Evaluation of the effects and mechanisms of action of flutriafol, a triazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats. Ecotoxicol Environ Saf. 2009 Jul;72(5):1565-71. PMID: 19232726.

Griffiths KM, Howlett BJ. Transcription of sterol Delta(5,6)-desaturase and sterol 14alpha-demethylase is induced in the plant pathogenic ascomycete, Leptosphaeria maculans, during treatment with a triazole fungicide. FEMS Microbiol Lett. 2002 Nov 19;217(1):81-7. PMID: 12445649.

" Not dangerous goods.

LKT F4883 Flutriafol 25 g 478.3 Triazole; demethylation inhibitor, NMDA agonist. 76674-21-0 ≥95% 301.29 C16H13F2N3O C1=CC=C(C(=C1)C(CN2C=NC=N2)(C3=CC=C(C=C3)F)O)F Ambient Ambient "Faro LR, Alfonso M, Maués LA, et al. Role of ionotropic glutamatergic receptors and nitric oxide in the effects of flutriafol, a triazole fungicide, on the in vivo striatal dopamine release. J Toxicol Sci. 2012;37(6):1135-42. PMID: 23208429.

Santana MB, Rodrigues KJ, Durán R, et al. Evaluation of the effects and mechanisms of action of flutriafol, a triazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats. Ecotoxicol Environ Saf. 2009 Jul;72(5):1565-71. PMID: 19232726.

Griffiths KM, Howlett BJ. Transcription of sterol Delta(5,6)-desaturase and sterol 14alpha-demethylase is induced in the plant pathogenic ascomycete, Leptosphaeria maculans, during treatment with a triazole fungicide. FEMS Microbiol Lett. 2002 Nov 19;217(1):81-7. PMID: 12445649.

" Not dangerous goods.

LKT H1992 Hexaconazole 500 mg 59.7 Triazole; demethylation inhibitor. 79983-71-4 ≥95% 314.21 C14H17Cl2N3O CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O Ambient Ambient "Hojati M, Modarres-Sanavy SA, Ghanati F, et al. Hexaconazole induces antioxidant protection and apigenin-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress. J Plant Physiol. 2011 May 15;168(8):782-91. PMID: 21208683.

Yilmaz S, Aksoy H, Unal F, et al. Genotoxic action of fungicide Conan 5FL (hexaconazole) on mammalian cells in vivo and in vitro. Genetika. 2008 Mar;44(3):323-8. PMID: 18664135.

Kalam A, Mukherjee AK. Influence of hexaconazole, carbofuran and ethion on soil microflora and dehydrogenase activities in soil and intact cell. Indian J Exp Biol. 2001 Jan;39(1):90-4. PMID: 11349536.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Hexaconazole)"

LKT H1992 Hexaconazole 5 g 179.3 Triazole; demethylation inhibitor. 79983-71-4 ≥95% 314.21 C14H17Cl2N3O CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O Ambient Ambient "Hojati M, Modarres-Sanavy SA, Ghanati F, et al. Hexaconazole induces antioxidant protection and apigenin-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress. J Plant Physiol. 2011 May 15;168(8):782-91. PMID: 21208683.

Yilmaz S, Aksoy H, Unal F, et al. Genotoxic action of fungicide Conan 5FL (hexaconazole) on mammalian cells in vivo and in vitro. Genetika. 2008 Mar;44(3):323-8. PMID: 18664135.

Kalam A, Mukherjee AK. Influence of hexaconazole, carbofuran and ethion on soil microflora and dehydrogenase activities in soil and intact cell. Indian J Exp Biol. 2001 Jan;39(1):90-4. PMID: 11349536.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Hexaconazole)"

LKT H1992 Hexaconazole 25 g 448.5 Triazole; demethylation inhibitor. 79983-71-4 ≥95% 314.21 C14H17Cl2N3O CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O Ambient Ambient "Hojati M, Modarres-Sanavy SA, Ghanati F, et al. Hexaconazole induces antioxidant protection and apigenin-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress. J Plant Physiol. 2011 May 15;168(8):782-91. PMID: 21208683.

Yilmaz S, Aksoy H, Unal F, et al. Genotoxic action of fungicide Conan 5FL (hexaconazole) on mammalian cells in vivo and in vitro. Genetika. 2008 Mar;44(3):323-8. PMID: 18664135.

Kalam A, Mukherjee AK. Influence of hexaconazole, carbofuran and ethion on soil microflora and dehydrogenase activities in soil and intact cell. Indian J Exp Biol. 2001 Jan;39(1):90-4. PMID: 11349536.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Hexaconazole)"

LKT F4881 Flumequine Sodium 1 g 37.4 Fluoroquinolone; bacterial DNA gyrase inhibitor, GABA-A antagonist. ≥98% 283.23 C14H11FNNaO3 CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O Ambient Ambient "Kuroiwa Y, Umemura T, Nishikawa A, et al. Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice. Arch Toxicol. 2007 Jan;81(1):63-9. PMID: 16802149.

Vik-Mo FT, Bergh O, Samuelsen OB. Efficacy of orally administered flumequine in the treatment of vibriosis caused by Listonella anguillarum in atlantic cod Gadus morhua. Dis Aquat Organ. 2005 Nov 9;67(1-2):87-92. PMID: 16385813.

Koutsoviti-Papadopoulou M, Kounenis G, Elezoglou V. Inhibitory effect of flumequine, enoxacin and norfloxacin on the GABA-induced contractile effect on the guinea pig ileum. Gen Pharmacol. 1995 Oct;26(6):1391-5. PMID: 7590136.

Schena FP, Gesualdo L, Caracciolo G. A multicentre study of flumequine in the treatment of urinary tract infections. J Antimicrob Chemother. 1988 Jan;21(1):101-6. PMID: 3356617.

Smith JT. The mode of action of 4-quinolones and possible mechanisms of resistance. J Antimicrob Chemother. 1986 Nov;18 Suppl D:21-9. PMID: 3542946.

" Not dangerous goods.

LKT F4881 Flumequine Sodium 5 g 119.7 Fluoroquinolone; bacterial DNA gyrase inhibitor, GABA-A antagonist. ≥98% 283.23 C14H11FNNaO3 CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O Ambient Ambient "Kuroiwa Y, Umemura T, Nishikawa A, et al. Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice. Arch Toxicol. 2007 Jan;81(1):63-9. PMID: 16802149.

Vik-Mo FT, Bergh O, Samuelsen OB. Efficacy of orally administered flumequine in the treatment of vibriosis caused by Listonella anguillarum in atlantic cod Gadus morhua. Dis Aquat Organ. 2005 Nov 9;67(1-2):87-92. PMID: 16385813.

Koutsoviti-Papadopoulou M, Kounenis G, Elezoglou V. Inhibitory effect of flumequine, enoxacin and norfloxacin on the GABA-induced contractile effect on the guinea pig ileum. Gen Pharmacol. 1995 Oct;26(6):1391-5. PMID: 7590136.

Schena FP, Gesualdo L, Caracciolo G. A multicentre study of flumequine in the treatment of urinary tract infections. J Antimicrob Chemother. 1988 Jan;21(1):101-6. PMID: 3356617.

Smith JT. The mode of action of 4-quinolones and possible mechanisms of resistance. J Antimicrob Chemother. 1986 Nov;18 Suppl D:21-9. PMID: 3542946.

" Not dangerous goods.

LKT F4881 Flumequine Sodium 25 g 373.7 Fluoroquinolone; bacterial DNA gyrase inhibitor, GABA-A antagonist. ≥98% 283.23 C14H11FNNaO3 CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O Ambient Ambient "Kuroiwa Y, Umemura T, Nishikawa A, et al. Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice. Arch Toxicol. 2007 Jan;81(1):63-9. PMID: 16802149.

Vik-Mo FT, Bergh O, Samuelsen OB. Efficacy of orally administered flumequine in the treatment of vibriosis caused by Listonella anguillarum in atlantic cod Gadus morhua. Dis Aquat Organ. 2005 Nov 9;67(1-2):87-92. PMID: 16385813.

Koutsoviti-Papadopoulou M, Kounenis G, Elezoglou V. Inhibitory effect of flumequine, enoxacin and norfloxacin on the GABA-induced contractile effect on the guinea pig ileum. Gen Pharmacol. 1995 Oct;26(6):1391-5. PMID: 7590136.

Schena FP, Gesualdo L, Caracciolo G. A multicentre study of flumequine in the treatment of urinary tract infections. J Antimicrob Chemother. 1988 Jan;21(1):101-6. PMID: 3356617.

Smith JT. The mode of action of 4-quinolones and possible mechanisms of resistance. J Antimicrob Chemother. 1986 Nov;18 Suppl D:21-9. PMID: 3542946.

" Not dangerous goods.

LKT O6805 Orbifloxacin 5 g 672.7 Fluoroquinolone; bacterial DNA gyrase inhibitor. 113617-63-3 ≥98% 395.38 C19H20F3N3O3 CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F Ambient Ambient "Scott DW, Peters J, Miller WH Jr. Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs. Can Vet J. 2006 Oct;47(10):999-1002. PMID: 17078249.

Ganière JP, Médaille C, Etoré F. In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. Res Vet Sci. 2004 Aug;77(1):67-71. PMID: 15120955.

" Not dangerous goods.

LKT O6805 Orbifloxacin 500 mg 224.3 Fluoroquinolone; bacterial DNA gyrase inhibitor. 113617-63-3 ≥98% 395.38 C19H20F3N3O3 CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F Ambient Ambient "Scott DW, Peters J, Miller WH Jr. Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs. Can Vet J. 2006 Oct;47(10):999-1002. PMID: 17078249.

Ganière JP, Médaille C, Etoré F. In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. Res Vet Sci. 2004 Aug;77(1):67-71. PMID: 15120955.

" Not dangerous goods.

LKT O6805 Orbifloxacin 100 mg 67.2 Fluoroquinolone; bacterial DNA gyrase inhibitor. 113617-63-3 ≥98% 395.38 C19H20F3N3O3 CC1CN(CC(N1)C)C2=C(C3=C(C(=C2F)F)C(=O)C(=CN3C4CC4)C(=O)O)F Ambient Ambient "Scott DW, Peters J, Miller WH Jr. Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs. Can Vet J. 2006 Oct;47(10):999-1002. PMID: 17078249.

Ganière JP, Médaille C, Etoré F. In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. Res Vet Sci. 2004 Aug;77(1):67-71. PMID: 15120955.

" Not dangerous goods.

LKT M8007 Mubritinib, Free Base 5 mg 89.7 EGFR2 inhibitor. 1-(4--1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole TAK-165 366017-09-6 ≥98% 468.47 C25H23F3N4O2 C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F Ambient Ambient Nagasawa J, Mizokami A, Koshida K, et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int J Urol. 2006 May;13(5):587-92. PMID: 16771730. Not dangerous goods.

LKT M8007 Mubritinib, Free Base 25 mg 358.9 EGFR2 inhibitor. 1-(4--1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole TAK-165 366017-09-6 ≥98% 468.47 C25H23F3N4O2 C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F Ambient Ambient Nagasawa J, Mizokami A, Koshida K, et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int J Urol. 2006 May;13(5):587-92. PMID: 16771730. Not dangerous goods.

LKT M8007 Mubritinib, Free Base 100 mg 717.6 EGFR2 inhibitor. 1-(4--1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole TAK-165 366017-09-6 ≥98% 468.47 C25H23F3N4O2 C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F Ambient Ambient Nagasawa J, Mizokami A, Koshida K, et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int J Urol. 2006 May;13(5):587-92. PMID: 16771730. Not dangerous goods.

LKT I4659 Iloperidone 100 mg 119.7 Benzisoxazole phenylethanone; D2 and 5-HT2A antagonist, potential hERG K+ channel blocker. 133454-47-4 ≥98% 426.48 C24H27FN2O4 CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC Ambient Ambient "Dargani NV, Malhotra AK. Safety profile of iloperidone in the treatment of schizophrenia. Expert Opin Drug Saf. 2013 Nov 11. [Epub ahead of print]. PMID: 24206391.

Achalia R, Andrade C. Ventricular premature contractions associated with iloperidone. Indian J Psychiatry. 2013 Apr;55(2):195-6. PMID: 23825860.

Marino J, Caballero J. Iloperidone for the treatment of schizophrenia. Ann Pharmacother. 2010 May;44(5):863-70. PMID: 20388862.

"

LKT I4659 Iloperidone 250 mg 261.6 Benzisoxazole phenylethanone; D2 and 5-HT2A antagonist, potential hERG K+ channel blocker. 133454-47-4 ≥98% 426.48 C24H27FN2O4 CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC Ambient Ambient "Dargani NV, Malhotra AK. Safety profile of iloperidone in the treatment of schizophrenia. Expert Opin Drug Saf. 2013 Nov 11. [Epub ahead of print]. PMID: 24206391.

Achalia R, Andrade C. Ventricular premature contractions associated with iloperidone. Indian J Psychiatry. 2013 Apr;55(2):195-6. PMID: 23825860.

Marino J, Caballero J. Iloperidone for the treatment of schizophrenia. Ann Pharmacother. 2010 May;44(5):863-70. PMID: 20388862.

"

LKT I4659 Iloperidone 1 g 598 Benzisoxazole phenylethanone; D2 and 5-HT2A antagonist, potential hERG K+ channel blocker. 133454-47-4 ≥98% 426.48 C24H27FN2O4 CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC Ambient Ambient "Dargani NV, Malhotra AK. Safety profile of iloperidone in the treatment of schizophrenia. Expert Opin Drug Saf. 2013 Nov 11. [Epub ahead of print]. PMID: 24206391.

Achalia R, Andrade C. Ventricular premature contractions associated with iloperidone. Indian J Psychiatry. 2013 Apr;55(2):195-6. PMID: 23825860.

Marino J, Caballero J. Iloperidone for the treatment of schizophrenia. Ann Pharmacother. 2010 May;44(5):863-70. PMID: 20388862.

"

LKT D5869 Doripenem Hydrate 10 mg 67.2 β-lactam carbapenem; penicillin binding protein inhibitor. 364622-82-2 ≥98% 438.52 C15H24N4O6S2 H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O.O Ambient Ambient "Schneider KD, Ortega CJ, Renck NA, et al. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. J Mol Biol. 2011 Mar 4;406(4):583-94. PMID: 21215758.

Davies TA, Shang W, Bush K, et al. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. PMID: 18250190.

Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. PMID: 15190031.

" Not dangerous goods.

LKT D5869 Doripenem Hydrate 25 mg 134.6 β-lactam carbapenem; penicillin binding protein inhibitor. 364622-82-2 ≥98% 438.52 C15H24N4O6S2 H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O.O Ambient Ambient "Schneider KD, Ortega CJ, Renck NA, et al. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. J Mol Biol. 2011 Mar 4;406(4):583-94. PMID: 21215758.

Davies TA, Shang W, Bush K, et al. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. PMID: 18250190.

Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. PMID: 15190031.

" Not dangerous goods.

LKT D5869 Doripenem Hydrate 100 mg 373.7 β-lactam carbapenem; penicillin binding protein inhibitor. 364622-82-2 ≥98% 438.52 C15H24N4O6S2 H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O.O Ambient Ambient "Schneider KD, Ortega CJ, Renck NA, et al. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. J Mol Biol. 2011 Mar 4;406(4):583-94. PMID: 21215758.

Davies TA, Shang W, Bush K, et al. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. PMID: 18250190.

Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. PMID: 15190031.

" Not dangerous goods.

LKT D5868 Doramapimod 10 mg 86.7 JNK, ALK, p38 MAPK inhibitor. 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea; BIRB796 2859873-48-4 ≥98% 527.66 C31H37N5O3 CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 Ambient Ambient "Hoogendijk AJ, Pinhanços SS, van der Poll T, et al. Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation. Immunobiology. 2013 Apr;218(4):435-42. PMID: 22727776.

af Gennäs GB, Mologni L, Ahmed S, et al. Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem. 2011 Sep 5;6(9):1680-92. PMID: 21721129.

Kuglstatter A, Ghate M, Tsing S, et al. X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5217-20. PMID: 20655210.

Joos H, Albrecht W, Laufer S, et al. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol. 2010 Jul;160(5):1252-62. PMID: 20590617.

Gruenbaum LM, Schwartz R, Woska JR Jr, et al. Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling. Biochem Pharmacol. 2009 Feb 1;77(3):422-32. PMID: 19027720.

Kuma Y, Sabio G, Bain J, et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem. 2005 May 20;280(20):19472-9. PMID: 15755732.

" Not dangerous goods.

LKT D5868 Doramapimod 25 mg 179.3 JNK, ALK, p38 MAPK inhibitor. 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea; BIRB796 2859873-48-4 ≥98% 527.66 C31H37N5O3 CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 Ambient Ambient "Hoogendijk AJ, Pinhanços SS, van der Poll T, et al. Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation. Immunobiology. 2013 Apr;218(4):435-42. PMID: 22727776.

af Gennäs GB, Mologni L, Ahmed S, et al. Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem. 2011 Sep 5;6(9):1680-92. PMID: 21721129.

Kuglstatter A, Ghate M, Tsing S, et al. X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5217-20. PMID: 20655210.

Joos H, Albrecht W, Laufer S, et al. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol. 2010 Jul;160(5):1252-62. PMID: 20590617.

Gruenbaum LM, Schwartz R, Woska JR Jr, et al. Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling. Biochem Pharmacol. 2009 Feb 1;77(3):422-32. PMID: 19027720.

Kuma Y, Sabio G, Bain J, et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem. 2005 May 20;280(20):19472-9. PMID: 15755732.

" Not dangerous goods.

LKT D5868 Doramapimod 100 mg 478.3 JNK, ALK, p38 MAPK inhibitor. 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea; BIRB796 2859873-48-4 ≥98% 527.66 C31H37N5O3 CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 Ambient Ambient "Hoogendijk AJ, Pinhanços SS, van der Poll T, et al. Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation. Immunobiology. 2013 Apr;218(4):435-42. PMID: 22727776.

af Gennäs GB, Mologni L, Ahmed S, et al. Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem. 2011 Sep 5;6(9):1680-92. PMID: 21721129.

Kuglstatter A, Ghate M, Tsing S, et al. X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5217-20. PMID: 20655210.

Joos H, Albrecht W, Laufer S, et al. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol. 2010 Jul;160(5):1252-62. PMID: 20590617.

Gruenbaum LM, Schwartz R, Woska JR Jr, et al. Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling. Biochem Pharmacol. 2009 Feb 1;77(3):422-32. PMID: 19027720.

Kuma Y, Sabio G, Bain J, et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem. 2005 May 20;280(20):19472-9. PMID: 15755732.

" Not dangerous goods.

LKT D1621 Deferasirox 25 mg 67.2 Iron chelator. 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic Acid ICL670A, CGP 72 670 201530-41-8 ≥98% 373.63 C21H15N3O4 C1=CC(=C2NC(=C3C=CC=CC3=O)N(N2)C4=CC=C(C=C4)C(=O)O)C(=O)C=C1 Ambient Ambient "Vazana-Barad L, Granot G, Mor-Tzuntz R, et al. Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma. Leuk Lymphoma. 2013 Apr;54(4):851-9. PMID: 23020673.

Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol. 2013 Jan;83(1):179-90. PMID: 23074173.

Zhao Y, Rempe DA. Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function. J Cereb Blood Flow Metab. 2011 Jun;31(6):1412-23. PMID: 21245873.

Messa E, Carturan S, Maffè C, et al. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging. Haematologica. 2010 Aug;95(8):1308-16. PMID: 20534700.

Lindsey WT, Olin BR. Deferasirox for transfusion-related iron overload: a clinical review. Clin Ther. 2007 Oct;29(10):2154-66. PMID: 18042472.

" T+, Xi, Repr Not dangerous goods.

LKT D1621 Deferasirox 100 mg 246.8 Iron chelator. 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic Acid ICL670A, CGP 72 670 201530-41-8 ≥98% 373.63 C21H15N3O4 C1=CC(=C2NC(=C3C=CC=CC3=O)N(N2)C4=CC=C(C=C4)C(=O)O)C(=O)C=C1 Ambient Ambient "Vazana-Barad L, Granot G, Mor-Tzuntz R, et al. Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma. Leuk Lymphoma. 2013 Apr;54(4):851-9. PMID: 23020673.

Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol. 2013 Jan;83(1):179-90. PMID: 23074173.

Zhao Y, Rempe DA. Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function. J Cereb Blood Flow Metab. 2011 Jun;31(6):1412-23. PMID: 21245873.

Messa E, Carturan S, Maffè C, et al. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging. Haematologica. 2010 Aug;95(8):1308-16. PMID: 20534700.

Lindsey WT, Olin BR. Deferasirox for transfusion-related iron overload: a clinical review. Clin Ther. 2007 Oct;29(10):2154-66. PMID: 18042472.

" T+, Xi, Repr Not dangerous goods.

LKT D1621 Deferasirox 250 mg 478.3 Iron chelator. 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic Acid ICL670A, CGP 72 670 201530-41-8 ≥98% 373.63 C21H15N3O4 C1=CC(=C2NC(=C3C=CC=CC3=O)N(N2)C4=CC=C(C=C4)C(=O)O)C(=O)C=C1 Ambient Ambient "Vazana-Barad L, Granot G, Mor-Tzuntz R, et al. Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma. Leuk Lymphoma. 2013 Apr;54(4):851-9. PMID: 23020673.

Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol. 2013 Jan;83(1):179-90. PMID: 23074173.

Zhao Y, Rempe DA. Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function. J Cereb Blood Flow Metab. 2011 Jun;31(6):1412-23. PMID: 21245873.

Messa E, Carturan S, Maffè C, et al. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging. Haematologica. 2010 Aug;95(8):1308-16. PMID: 20534700.

Lindsey WT, Olin BR. Deferasirox for transfusion-related iron overload: a clinical review. Clin Ther. 2007 Oct;29(10):2154-66. PMID: 18042472.

" T+, Xi, Repr Not dangerous goods.

LKT C5968 Cordycepin 10 mg 74.8 Nucleoside (deoxyadenosine) analog found in  Cordyceps; RNA and DNA synthesis inhibitor. 3'-deoxyadenosine 73-03-0 ≥98% 251.24 C10H13N5O3 C1C(OC(C1O)N2C=NC3=C2N=CN=C3N)CO Ambient Ambient Water "Yao LH, Huang JN, Li CH, et al. Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism. CNS Neurosci Ther. 2013 Apr;19(4):216-21. PMID: 23419191.

Lee HJ, Burger P, Vogel M, et al. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012 Oct;30(5):1917-25. PMID: 22821173.

Jeong JW, Jin CY, Park C, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro. 2011 Jun;25(4):817-24. PMID: 21310227.

Wang Z, Wang X, Qu K, et al. Binding of cordycepin monophosphate to AMP-activated protein kinase and its effect on AMP-activated protein kinase activation. Chem Biol Drug Des. 2010 Oct;76(4):340-4. PMID: 20738312.

Kim HG, Shrestha B, Lim SY, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006 Sep 18;545(2-3):192-9. PMID: 16899239.

Wataya Y, Hiraoka O. 3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes. Biochem Biophys Res Commun. 1984 Sep 17;123(2):677-83. PMID: 6487305.

Panicali DL, Nair CN. Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes. J Virol. 1978 Jan;25(1):124-8. PMID: 202731.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cordycepin)"

LKT C5968 Cordycepin 25 mg 149.5 Nucleoside (deoxyadenosine) analog found in  Cordyceps; RNA and DNA synthesis inhibitor. 3'-deoxyadenosine 73-03-0 ≥98% 251.24 C10H13N5O3 C1C(OC(C1O)N2C=NC3=C2N=CN=C3N)CO Ambient Ambient Water "Yao LH, Huang JN, Li CH, et al. Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism. CNS Neurosci Ther. 2013 Apr;19(4):216-21. PMID: 23419191.

Lee HJ, Burger P, Vogel M, et al. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012 Oct;30(5):1917-25. PMID: 22821173.

Jeong JW, Jin CY, Park C, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro. 2011 Jun;25(4):817-24. PMID: 21310227.

Wang Z, Wang X, Qu K, et al. Binding of cordycepin monophosphate to AMP-activated protein kinase and its effect on AMP-activated protein kinase activation. Chem Biol Drug Des. 2010 Oct;76(4):340-4. PMID: 20738312.

Kim HG, Shrestha B, Lim SY, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006 Sep 18;545(2-3):192-9. PMID: 16899239.

Wataya Y, Hiraoka O. 3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes. Biochem Biophys Res Commun. 1984 Sep 17;123(2):677-83. PMID: 6487305.

Panicali DL, Nair CN. Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes. J Virol. 1978 Jan;25(1):124-8. PMID: 202731.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cordycepin)"

LKT C5968 Cordycepin 100 mg 373.7 Nucleoside (deoxyadenosine) analog found in  Cordyceps; RNA and DNA synthesis inhibitor. 3'-deoxyadenosine 73-03-0 ≥98% 251.24 C10H13N5O3 C1C(OC(C1O)N2C=NC3=C2N=CN=C3N)CO Ambient Ambient Water "Yao LH, Huang JN, Li CH, et al. Cordycepin suppresses excitatory synaptic transmission in rat hippocampal slices via a presynaptic mechanism. CNS Neurosci Ther. 2013 Apr;19(4):216-21. PMID: 23419191.

Lee HJ, Burger P, Vogel M, et al. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012 Oct;30(5):1917-25. PMID: 22821173.

Jeong JW, Jin CY, Park C, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro. 2011 Jun;25(4):817-24. PMID: 21310227.

Wang Z, Wang X, Qu K, et al. Binding of cordycepin monophosphate to AMP-activated protein kinase and its effect on AMP-activated protein kinase activation. Chem Biol Drug Des. 2010 Oct;76(4):340-4. PMID: 20738312.

Kim HG, Shrestha B, Lim SY, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006 Sep 18;545(2-3):192-9. PMID: 16899239.

Wataya Y, Hiraoka O. 3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes. Biochem Biophys Res Commun. 1984 Sep 17;123(2):677-83. PMID: 6487305.

Panicali DL, Nair CN. Effect of cordycepin triphosphate on in vitro RNA synthesis by picornavirus polymerase complexes. J Virol. 1978 Jan;25(1):124-8. PMID: 202731.

" T "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cordycepin)"

LKT C1613 Cediranib 25 mg 97.2 VEGFR inhibitor. AZD2171 288383-20-0 ≥98% 450.51 C25H27FN4O3 CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 Ambient Ambient DMSO to 90 mg/ml "Kummar S, Allen D, Monks A, et al. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol. 2013 Jun 20;31(18):2296-302. PMID: 23630200.

JuanYin J, Tracy K, Zhang L, et al. Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clin Exp Metastasis. 2009;26(5):403-14. PMID: 19277878.

Goodlad RA, Ryan AJ, Wedge SR, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis. 2006 Oct;27(10):2133-9. PMID: 16782971.

" Not dangerous goods.

LKT C1613 Cediranib 100 mg 276.5 VEGFR inhibitor. AZD2171 288383-20-0 ≥98% 450.51 C25H27FN4O3 CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 Ambient Ambient DMSO to 90 mg/ml "Kummar S, Allen D, Monks A, et al. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol. 2013 Jun 20;31(18):2296-302. PMID: 23630200.

JuanYin J, Tracy K, Zhang L, et al. Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clin Exp Metastasis. 2009;26(5):403-14. PMID: 19277878.

Goodlad RA, Ryan AJ, Wedge SR, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis. 2006 Oct;27(10):2133-9. PMID: 16782971.

" Not dangerous goods.

LKT C1613 Cediranib 250 mg 553.1 VEGFR inhibitor. AZD2171 288383-20-0 ≥98% 450.51 C25H27FN4O3 CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 Ambient Ambient DMSO to 90 mg/ml "Kummar S, Allen D, Monks A, et al. Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol. 2013 Jun 20;31(18):2296-302. PMID: 23630200.

JuanYin J, Tracy K, Zhang L, et al. Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clin Exp Metastasis. 2009;26(5):403-14. PMID: 19277878.

Goodlad RA, Ryan AJ, Wedge SR, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis. 2006 Oct;27(10):2133-9. PMID: 16782971.

" Not dangerous goods.

LKT C0252 Canertinib Dihydrochloride 25 mg 89.7 EGFR inhibitor. CI1033 289499-45-2 ≥98% 558.86 C24H23ClFN5O3 2HCl C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl Ambient Ambient "Djerf Severinsson EA, Trinks C, Gréen H, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8. PMID: 21982771.

Trinks C, Severinsson EA, Holmlund B, et al. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):422-7. PMID: 21669187.

Zinner RG, Nemunaitis J, Eiseman I, et al. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2007 May 15;13(10):3006-14. PMID: 17505003.

" Xi Not dangerous goods.

LKT C0252 Canertinib Dihydrochloride 100 mg 269.1 EGFR inhibitor. CI1033 289499-45-2 ≥98% 558.86 C24H23ClFN5O3 2HCl C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl Ambient Ambient "Djerf Severinsson EA, Trinks C, Gréen H, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8. PMID: 21982771.

Trinks C, Severinsson EA, Holmlund B, et al. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):422-7. PMID: 21669187.

Zinner RG, Nemunaitis J, Eiseman I, et al. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2007 May 15;13(10):3006-14. PMID: 17505003.

" Xi Not dangerous goods.

LKT C0252 Canertinib Dihydrochloride 250 mg 538.1 EGFR inhibitor. CI1033 289499-45-2 ≥98% 558.86 C24H23ClFN5O3 2HCl C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl Ambient Ambient "Djerf Severinsson EA, Trinks C, Gréen H, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8. PMID: 21982771.

Trinks C, Severinsson EA, Holmlund B, et al. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):422-7. PMID: 21669187.

Zinner RG, Nemunaitis J, Eiseman I, et al. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2007 May 15;13(10):3006-14. PMID: 17505003.

" Xi Not dangerous goods.

LKT A2658 Agomelatine 500 mg 396.2 Melatonin analog; MT1/2 agonist, 5-HT2C antagonist. 138112-76-2 ≥98% 243.3 C15H17NO2 CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC Ambient Ambient "Smeraldi E, Delmonte D. Agomelatine in depression. Expert Opin Drug Saf. 2013 Nov;12(6):873-80. PMID: 24033095.

Pompili M, Serafini G, Innamorati M, et al. Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: a critical review. World J Biol Psychiatry. 2013 Aug;14(6):412-31. PMID: 23530731.

Srinivasan V, Zakaria R, Othaman Z, et al. Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. CNS Neurol Disord Drug Targets. 2012 Mar;11(2):180-9. PMID: 22483286.

Bertaina-Anglade V, la Rochelle CD, Boyer PA, et al. Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model. Behav Pharmacol. 2006 Dec;17(8):703-13. PMID: 17110796.

Papp M, Litwa E, Gruca P, et al. Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behav Pharmacol. 2006 Feb;17(1):9-18. PMID: 16377959.

" N Not dangerous goods.

LKT I7256 Isobavachalcone 1 mg 269.1 Prenylated chalcone flavonoid found in Psoraleae; cholesterol acyltransferase inhibitor. (E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 20784-50-3 ≥97% 324.37 C20H20O4 CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C Ambient -20°C "Chen X, Yang Y, Zhang Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587(18):2930-5. PMID: 23907009.

Jing H, Zhou X, Dong X, et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77. PMID: 20167420.

Choi JH, Rho MC, Lee SW, et al. Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia. Arch Pharm Res. 2008 Nov;31(11):1419-23. PMID: 19023538.

Nishimura R, Tabata K, Arakawa M, et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull. 2007 Oct;30(10):1878-83. PMID: 17917255.

Chen YG, Song XP, Hai LN, et al. Compounds with DNA cleaving activity from Kadsura ananosma. Pharmazie. 2006 Oct;61(10):891-2. PMID: 17069433.

Akihisa T, Tokuda H, Hasegawa D, et al. Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. J Nat Prod. 2006 Jan;69(1):38-42. PMID: 16441065.

ElSohly HN, Joshi AS, Nimrod AC, et al. Antifungal chalcones from Maclura tinctoria. Planta Med. 2001 Feb;67(1):87-9. PMID: 11270732.

Tsai WJ, Hsin WC, Chen CC. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J Nat Prod. 1996 Jul;59(7):671-2. PMID: 8759164.

" Not dangerous goods.

LKT I7256 Isobavachalcone 5 mg 1181 Prenylated chalcone flavonoid found in Psoraleae; cholesterol acyltransferase inhibitor. (E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 20784-50-3 ≥97% 324.37 C20H20O4 CC(=CCC1=C(C=CC(=C1O)C(=O)C=CC2=CC=C(C=C2)O)O)C Ambient -20°C "Chen X, Yang Y, Zhang Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587(18):2930-5. PMID: 23907009.

Jing H, Zhou X, Dong X, et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77. PMID: 20167420.

Choi JH, Rho MC, Lee SW, et al. Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia. Arch Pharm Res. 2008 Nov;31(11):1419-23. PMID: 19023538.

Nishimura R, Tabata K, Arakawa M, et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull. 2007 Oct;30(10):1878-83. PMID: 17917255.

Chen YG, Song XP, Hai LN, et al. Compounds with DNA cleaving activity from Kadsura ananosma. Pharmazie. 2006 Oct;61(10):891-2. PMID: 17069433.

Akihisa T, Tokuda H, Hasegawa D, et al. Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. J Nat Prod. 2006 Jan;69(1):38-42. PMID: 16441065.

ElSohly HN, Joshi AS, Nimrod AC, et al. Antifungal chalcones from Maclura tinctoria. Planta Med. 2001 Feb;67(1):87-9. PMID: 11270732.

Tsai WJ, Hsin WC, Chen CC. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J Nat Prod. 1996 Jul;59(7):671-2. PMID: 8759164.

" Not dangerous goods.

LKT P1200 PD-184352 5 mg 131 MEK1/2 and Raf inhibitor. 212631-79-3 ≥98% 478.66 C17H14ClF2IN2O2 C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl Ambient Ambient Soluble in DMSO "Wickenden JA, Jin H, Johnson M, et al. Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene. 2008 Dec 4;27(57):7150-61. PMID: 18806830.

Lunghi P, Giuliani N, Mazzera L, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008 Sep 15;112(6):2450-62. PMID: 18583568.

Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. PMID: 17850214.

Ji H, Wang Z, Perera SA, et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res. 2007 May 15;67(10):4933-9. PMID: 17510423.

Squires MS, Nixon PM, Cook SJ. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J. 2002 Sep 1;366(Pt 2):673-80. PMID: 12069688.

" N Not dangerous goods.

LKT P1200 PD-184352 25 mg 412.5 MEK1/2 and Raf inhibitor. 212631-79-3 ≥98% 478.66 C17H14ClF2IN2O2 C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl Ambient Ambient Soluble in DMSO "Wickenden JA, Jin H, Johnson M, et al. Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene. 2008 Dec 4;27(57):7150-61. PMID: 18806830.

Lunghi P, Giuliani N, Mazzera L, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008 Sep 15;112(6):2450-62. PMID: 18583568.

Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. PMID: 17850214.

Ji H, Wang Z, Perera SA, et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res. 2007 May 15;67(10):4933-9. PMID: 17510423.

Squires MS, Nixon PM, Cook SJ. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J. 2002 Sep 1;366(Pt 2):673-80. PMID: 12069688.

" N Not dangerous goods.

LKT P1200 PD-184352 100 mg 788.7 MEK1/2 and Raf inhibitor. 212631-79-3 ≥98% 478.66 C17H14ClF2IN2O2 C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl Ambient Ambient Soluble in DMSO "Wickenden JA, Jin H, Johnson M, et al. Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. Oncogene. 2008 Dec 4;27(57):7150-61. PMID: 18806830.

Lunghi P, Giuliani N, Mazzera L, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008 Sep 15;112(6):2450-62. PMID: 18583568.

Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. PMID: 17850214.

Ji H, Wang Z, Perera SA, et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res. 2007 May 15;67(10):4933-9. PMID: 17510423.

Squires MS, Nixon PM, Cook SJ. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1. Biochem J. 2002 Sep 1;366(Pt 2):673-80. PMID: 12069688.

" N Not dangerous goods.

LKT P1202 PD-325901 5 mg 101.6 MEK1/2 and Raf inhibitor. PD0325901 391210-10-9 ≥98% 482.19 C16H14F3IN2O4 C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O Ambient Ambient Soluble in DMSO at 12 mg/mL; soluble in ethanol at 6.3 mg/mL with slight warming; very poorly soluble in water "Haasbach E, Hartmayer C, Planz O. Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro. Antiviral Res. 2013 May;98(2):319-24. PMID: 23523553.

Leyton J, Smith G, Lees M, et al. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. Mol Cancer Ther. 2008 Sep;7(9):3112-21. PMID: 18790789.

Liu D, Xing M. Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways. Thyroid. 2008 Aug;18(8):853-64. PMID: 18651802.

Brown AP, Carlson TC, Loi CM, et al. Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration. Cancer Chemother Pharmacol. 2007 Apr;59(5):671-9. PMID: 16944149.

" T, N "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (PD325901)"

LKT P1202 PD-325901 25 mg 373.7 MEK1/2 and Raf inhibitor. PD0325901 391210-10-9 ≥98% 482.19 C16H14F3IN2O4 C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O Ambient Ambient Soluble in DMSO at 12 mg/mL; soluble in ethanol at 6.3 mg/mL with slight warming; very poorly soluble in water "Haasbach E, Hartmayer C, Planz O. Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro. Antiviral Res. 2013 May;98(2):319-24. PMID: 23523553.

Leyton J, Smith G, Lees M, et al. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. Mol Cancer Ther. 2008 Sep;7(9):3112-21. PMID: 18790789.

Liu D, Xing M. Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways. Thyroid. 2008 Aug;18(8):853-64. PMID: 18651802.

Brown AP, Carlson TC, Loi CM, et al. Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration. Cancer Chemother Pharmacol. 2007 Apr;59(5):671-9. PMID: 16944149.

" T, N "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (PD325901)"

LKT P1202 PD-325901 100 mg 777.2 MEK1/2 and Raf inhibitor. PD0325901 391210-10-9 ≥98% 482.19 C16H14F3IN2O4 C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O Ambient Ambient Soluble in DMSO at 12 mg/mL; soluble in ethanol at 6.3 mg/mL with slight warming; very poorly soluble in water "Haasbach E, Hartmayer C, Planz O. Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro. Antiviral Res. 2013 May;98(2):319-24. PMID: 23523553.

Leyton J, Smith G, Lees M, et al. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. Mol Cancer Ther. 2008 Sep;7(9):3112-21. PMID: 18790789.

Liu D, Xing M. Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways. Thyroid. 2008 Aug;18(8):853-64. PMID: 18651802.

Brown AP, Carlson TC, Loi CM, et al. Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration. Cancer Chemother Pharmacol. 2007 Apr;59(5):671-9. PMID: 16944149.

" T, N "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (PD325901)"

LKT P3592 Pixantrone Dimaleate 10 mg 119.7 Aza-anthracenedione, DNA intercalator; topoisomerase II inhibitor. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione,  BBR2778 144675-97-8 ≥98% 557.51 C25H27N5O10 C1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O Ambient Ambient "Péan E, Flores B, Hudson I, et al. The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. Oncologist. 2013;18(5):625-33. PMID: 23615696.

Marolda R, Ruocco C, Cordiglieri C, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013 May 15;258(1-2):41-50. PMID: 23523328.

Adnan N, Buck DP, Evison BJ, et al. DNA binding by pixantrone. Org Biomol Chem. 2010 Dec 7;8(23):5359-66. PMID: 20865205.

Colombo R, Carotti A, Catto M, et al. CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis. 2009 Apr;30(8):1418-29. PMID: 19306269.

Evison BJ, Chiu F, Pezzoni G, et al. Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets. Mol Pharmacol. 2008 Jul;74(1):184-94. PMID: 18413664.

Gonsette RE, Dubois B. Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. J Neurol Sci. 2004 Aug 15;223(1):81-6. Review. PMID: 15261566.

" Not Dangerous Goods

LKT P3592 Pixantrone Dimaleate 25 mg 224.3 Aza-anthracenedione, DNA intercalator; topoisomerase II inhibitor. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione,  BBR2778 144675-97-8 ≥98% 557.51 C25H27N5O10 C1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O Ambient Ambient "Péan E, Flores B, Hudson I, et al. The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. Oncologist. 2013;18(5):625-33. PMID: 23615696.

Marolda R, Ruocco C, Cordiglieri C, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013 May 15;258(1-2):41-50. PMID: 23523328.

Adnan N, Buck DP, Evison BJ, et al. DNA binding by pixantrone. Org Biomol Chem. 2010 Dec 7;8(23):5359-66. PMID: 20865205.

Colombo R, Carotti A, Catto M, et al. CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis. 2009 Apr;30(8):1418-29. PMID: 19306269.

Evison BJ, Chiu F, Pezzoni G, et al. Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets. Mol Pharmacol. 2008 Jul;74(1):184-94. PMID: 18413664.

Gonsette RE, Dubois B. Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. J Neurol Sci. 2004 Aug 15;223(1):81-6. Review. PMID: 15261566.

" Not Dangerous Goods

LKT P3592 Pixantrone Dimaleate 100 mg 598 Aza-anthracenedione, DNA intercalator; topoisomerase II inhibitor. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione,  BBR2778 144675-97-8 ≥98% 557.51 C25H27N5O10 C1=CC(=C2C(=C1NCCN)C(=O)C3=C(C2=O)C=NC=C3)NCCN.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O Ambient Ambient "Péan E, Flores B, Hudson I, et al. The European Medicines Agency review of pixantrone for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin's B-cell lymphomas: summary of the scientific assessment of the committee for medicinal products for human use. Oncologist. 2013;18(5):625-33. PMID: 23615696.

Marolda R, Ruocco C, Cordiglieri C, et al. Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravis. J Neuroimmunol. 2013 May 15;258(1-2):41-50. PMID: 23523328.

Adnan N, Buck DP, Evison BJ, et al. DNA binding by pixantrone. Org Biomol Chem. 2010 Dec 7;8(23):5359-66. PMID: 20865205.

Colombo R, Carotti A, Catto M, et al. CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis. 2009 Apr;30(8):1418-29. PMID: 19306269.

Evison BJ, Chiu F, Pezzoni G, et al. Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets. Mol Pharmacol. 2008 Jul;74(1):184-94. PMID: 18413664.

Gonsette RE, Dubois B. Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity. J Neurol Sci. 2004 Aug 15;223(1):81-6. Review. PMID: 15261566.

" Not Dangerous Goods

LKT S3346 Silodosin 25 mg 67.2 α1A-adrenergic antagonist. KAD 3213, KMD 3213 160970-54-7 ≥98% 495.53 C25H32F3N3O4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F Ambient Ambient "Yamaguchi K, Aoki Y, Yoshikawa T, et al. Silodosin versus naftopidil for the treatment of benign prostatic hyperplasia: A multicenter randomized trial. Int J Urol. 2013 Jun 3. [Epub ahead of print]. PMID: 23731168.

Goi Y, Tomiyama Y, Nomiya M, et al. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction. J Urol. 2013 Sep;190(3):1116-22. PMID: 23545103

Hennenberg M, Strittmatter F, Beckmann C, et al. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. PLoS One. 2012;7(11):e50904. PMID: 23226423.

" Not dangerous goods.

LKT S3346 Silodosin 100 mg 149.5 α1A-adrenergic antagonist. KAD 3213, KMD 3213 160970-54-7 ≥98% 495.53 C25H32F3N3O4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F Ambient Ambient "Yamaguchi K, Aoki Y, Yoshikawa T, et al. Silodosin versus naftopidil for the treatment of benign prostatic hyperplasia: A multicenter randomized trial. Int J Urol. 2013 Jun 3. [Epub ahead of print]. PMID: 23731168.

Goi Y, Tomiyama Y, Nomiya M, et al. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction. J Urol. 2013 Sep;190(3):1116-22. PMID: 23545103

Hennenberg M, Strittmatter F, Beckmann C, et al. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. PLoS One. 2012;7(11):e50904. PMID: 23226423.

" Not dangerous goods.

LKT S3346 Silodosin 500 mg 478.3 α1A-adrenergic antagonist. KAD 3213, KMD 3213 160970-54-7 ≥98% 495.53 C25H32F3N3O4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F Ambient Ambient "Yamaguchi K, Aoki Y, Yoshikawa T, et al. Silodosin versus naftopidil for the treatment of benign prostatic hyperplasia: A multicenter randomized trial. Int J Urol. 2013 Jun 3. [Epub ahead of print]. PMID: 23731168.

Goi Y, Tomiyama Y, Nomiya M, et al. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction. J Urol. 2013 Sep;190(3):1116-22. PMID: 23545103

Hennenberg M, Strittmatter F, Beckmann C, et al. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. PLoS One. 2012;7(11):e50904. PMID: 23226423.

" Not dangerous goods.

LKT T5847 Tolvaptan 25 mg 71.7 V2 antagonist. N-(4--3-methylphenyl)-2-methylbenzamide OPC-41061 150683-30-0 ≥98% 448.94 C26H25ClN2O3 CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C Ambient Ambient "Otsuka T, Sakai Y, Ohno D, et al. The effects of tolvaptan on patients with severe chronic kidney disease complicated by congestive heart failure. Clin Exp Nephrol. 2013 Mar 13. [Epub ahead of print]. PMID: 23483323.

Graziani G, Cucchiari D, Aroldi A, et al. Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. J Neurol Neurosurg Psychiatry. 2012 May;83(5):510-2. PMID: 22323742

Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G. PMID: 16181825.

" None Not dangerous goods.

LKT T5847 Tolvaptan 100 mg 157.1 V2 antagonist. N-(4--3-methylphenyl)-2-methylbenzamide OPC-41061 150683-30-0 ≥98% 448.94 C26H25ClN2O3 CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C Ambient Ambient "Otsuka T, Sakai Y, Ohno D, et al. The effects of tolvaptan on patients with severe chronic kidney disease complicated by congestive heart failure. Clin Exp Nephrol. 2013 Mar 13. [Epub ahead of print]. PMID: 23483323.

Graziani G, Cucchiari D, Aroldi A, et al. Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. J Neurol Neurosurg Psychiatry. 2012 May;83(5):510-2. PMID: 22323742

Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G. PMID: 16181825.

" None Not dangerous goods.

LKT T5847 Tolvaptan 500 mg 485.8 V2 antagonist. N-(4--3-methylphenyl)-2-methylbenzamide OPC-41061 150683-30-0 ≥98% 448.94 C26H25ClN2O3 CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C Ambient Ambient "Otsuka T, Sakai Y, Ohno D, et al. The effects of tolvaptan on patients with severe chronic kidney disease complicated by congestive heart failure. Clin Exp Nephrol. 2013 Mar 13. [Epub ahead of print]. PMID: 23483323.

Graziani G, Cucchiari D, Aroldi A, et al. Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. J Neurol Neurosurg Psychiatry. 2012 May;83(5):510-2. PMID: 22323742

Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G. PMID: 16181825.

" None Not dangerous goods.

LKT V0244 Valganciclovir Hydrochloride 25 mg 119.7 Nucleoside (deoxyguanosine) analog, ganciclovir prodrug; DNA chain elongation inhibitor. 175865-59-5 ≥98% 354.36 C14H22N6O5 CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1NC(=NC2=O)N)N.Cl Ambient Ambient "Stronati M, Lombardi G, Garofoli F, et al. Pharmacokinetics, pharmacodynamics and clinical use of valganciclovir in newborns with symptomatic congenital cytomegalovirus infection. Curr Drug Metab. 2013 Feb;14(2):208-15. PMID: 22935067.

Iwasenko JM, Scott GM, Rawlinson WD, et al. Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D. J Med Virol. 2009 Mar;81(3):507-10. PMID: 19152402.

Pantanowitz L, Früh K, Marconi S, et al. Pathology of rituximab-induced Kaposi sarcoma flare. BMC Clin Pathol. 2008 Jul 23;8:7. PMID: 18651955.

" None Not dangerous goods.

LKT V0244 Valganciclovir Hydrochloride 50 mg 186.8 Nucleoside (deoxyguanosine) analog, ganciclovir prodrug; DNA chain elongation inhibitor. 175865-59-5 ≥98% 354.36 C14H22N6O5 CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1NC(=NC2=O)N)N.Cl Ambient Ambient "Stronati M, Lombardi G, Garofoli F, et al. Pharmacokinetics, pharmacodynamics and clinical use of valganciclovir in newborns with symptomatic congenital cytomegalovirus infection. Curr Drug Metab. 2013 Feb;14(2):208-15. PMID: 22935067.

Iwasenko JM, Scott GM, Rawlinson WD, et al. Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D. J Med Virol. 2009 Mar;81(3):507-10. PMID: 19152402.

Pantanowitz L, Früh K, Marconi S, et al. Pathology of rituximab-induced Kaposi sarcoma flare. BMC Clin Pathol. 2008 Jul 23;8:7. PMID: 18651955.

" None Not dangerous goods.

LKT V0244 Valganciclovir Hydrochloride 100 mg 298.9 Nucleoside (deoxyguanosine) analog, ganciclovir prodrug; DNA chain elongation inhibitor. 175865-59-5 ≥98% 354.36 C14H22N6O5 CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1NC(=NC2=O)N)N.Cl Ambient Ambient "Stronati M, Lombardi G, Garofoli F, et al. Pharmacokinetics, pharmacodynamics and clinical use of valganciclovir in newborns with symptomatic congenital cytomegalovirus infection. Curr Drug Metab. 2013 Feb;14(2):208-15. PMID: 22935067.

Iwasenko JM, Scott GM, Rawlinson WD, et al. Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D. J Med Virol. 2009 Mar;81(3):507-10. PMID: 19152402.

Pantanowitz L, Früh K, Marconi S, et al. Pathology of rituximab-induced Kaposi sarcoma flare. BMC Clin Pathol. 2008 Jul 23;8:7. PMID: 18651955.

" None Not dangerous goods.

LKT V0269 Vardenafil Dihydrochloride 10 mg 61.1 PDE5 inhibitor. 224789-15-5 ≥98% 561.52 C23H32N6O4S 2HCl CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl.Cl Ambient Ambient "Vignozzi L, Gacci M, Cellai I, et al. PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS. Prostate. 2013 Sep;73(13):1391-402. PMID: 23765639.

Fan YF, Zhang R, Jiang X, et al. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res. 2013 Aug 1;99(3):395-403. PMID: 23650288.

Fang L, Radovits T, Szabó G, et al. Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes. Nephrol Dial Transplant. 2013 Jul;28(7):1751-61. PMID: 23203993

Zhu B, Strada SJ. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr Top Med Chem. 2007;7(4):437-54. PMID: 17305584.

Lau LC, Adaikan PG. Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum. Eur J Pharmacol. 2006 Jul 17;541(3):184-90. PMID: 16777087.

" Not dangerous goods.

LKT V0269 Vardenafil Dihydrochloride 25 mg 88.3 PDE5 inhibitor. 224789-15-5 ≥98% 561.52 C23H32N6O4S 2HCl CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl.Cl Ambient Ambient "Vignozzi L, Gacci M, Cellai I, et al. PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS. Prostate. 2013 Sep;73(13):1391-402. PMID: 23765639.

Fan YF, Zhang R, Jiang X, et al. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res. 2013 Aug 1;99(3):395-403. PMID: 23650288.

Fang L, Radovits T, Szabó G, et al. Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes. Nephrol Dial Transplant. 2013 Jul;28(7):1751-61. PMID: 23203993

Zhu B, Strada SJ. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr Top Med Chem. 2007;7(4):437-54. PMID: 17305584.

Lau LC, Adaikan PG. Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum. Eur J Pharmacol. 2006 Jul 17;541(3):184-90. PMID: 16777087.

" Not dangerous goods.

LKT V0269 Vardenafil Dihydrochloride 100 mg 237.8 PDE5 inhibitor. 224789-15-5 ≥98% 561.52 C23H32N6O4S 2HCl CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl.Cl Ambient Ambient "Vignozzi L, Gacci M, Cellai I, et al. PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS. Prostate. 2013 Sep;73(13):1391-402. PMID: 23765639.

Fan YF, Zhang R, Jiang X, et al. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res. 2013 Aug 1;99(3):395-403. PMID: 23650288.

Fang L, Radovits T, Szabó G, et al. Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes. Nephrol Dial Transplant. 2013 Jul;28(7):1751-61. PMID: 23203993

Zhu B, Strada SJ. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr Top Med Chem. 2007;7(4):437-54. PMID: 17305584.

Lau LC, Adaikan PG. Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum. Eur J Pharmacol. 2006 Jul 17;541(3):184-90. PMID: 16777087.

" Not dangerous goods.

LKT T5996 Tozasertib 25 mg 101.6 AurK, FLT3, Abl inhibitor. VX680, MK0457 639089-54-6 ≥98% 464.59 C23H28N8OS CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5 Ambient Ambient DMSO at 100 mg/mL "Okabe S, Tauchi T, Tanaka Y, et al. Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells. Cancer Cell Int. 2013 Apr 4;13(1):32. PMID: 23556431.

Li Y, Zhou W, Wei L, et al. The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma. Int J Oncol. 2012 Dec;41(6):2139-49. PMID: 23007526.

Giles FJ, Swords RT, Nagler A, et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia. 2013 Jan;27(1):113-7. PMID: 22772060.

Jeet V, Russell PJ, Verma ND, et al. Targeting aurora kinases: a novel approach to curb the growth & chemoresistance of androgen refractory prostate cancer. Curr Cancer Drug Targets. 2012 Feb;12(2):144-63. PMID: 22229247.

Salah E, Ugochukwu E, Barr AJ, et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class. J Med Chem. 2011 Apr 14;54(7):2359-67. PMID: 21417343.

Oliveira TM, Ahmad R, Engh RA. VX680 binding in Aurora A: π-π interactions involving the conserved aromatic amino acid of the flexible glycine-rich loop. J Phys Chem A. 2011 Apr 28;115(16):3895-904. PMID: 21306143.

" Not dangerous goods.

LKT T5996 Tozasertib 100 mg 298.9 AurK, FLT3, Abl inhibitor. VX680, MK0457 639089-54-6 ≥98% 464.59 C23H28N8OS CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5 Ambient Ambient DMSO at 100 mg/mL "Okabe S, Tauchi T, Tanaka Y, et al. Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells. Cancer Cell Int. 2013 Apr 4;13(1):32. PMID: 23556431.

Li Y, Zhou W, Wei L, et al. The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma. Int J Oncol. 2012 Dec;41(6):2139-49. PMID: 23007526.

Giles FJ, Swords RT, Nagler A, et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia. 2013 Jan;27(1):113-7. PMID: 22772060.

Jeet V, Russell PJ, Verma ND, et al. Targeting aurora kinases: a novel approach to curb the growth & chemoresistance of androgen refractory prostate cancer. Curr Cancer Drug Targets. 2012 Feb;12(2):144-63. PMID: 22229247.

Salah E, Ugochukwu E, Barr AJ, et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class. J Med Chem. 2011 Apr 14;54(7):2359-67. PMID: 21417343.

Oliveira TM, Ahmad R, Engh RA. VX680 binding in Aurora A: π-π interactions involving the conserved aromatic amino acid of the flexible glycine-rich loop. J Phys Chem A. 2011 Apr 28;115(16):3895-904. PMID: 21306143.

" Not dangerous goods.

LKT T5996 Tozasertib 250 mg 568.2 AurK, FLT3, Abl inhibitor. VX680, MK0457 639089-54-6 ≥98% 464.59 C23H28N8OS CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5 Ambient Ambient DMSO at 100 mg/mL "Okabe S, Tauchi T, Tanaka Y, et al. Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells. Cancer Cell Int. 2013 Apr 4;13(1):32. PMID: 23556431.

Li Y, Zhou W, Wei L, et al. The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma. Int J Oncol. 2012 Dec;41(6):2139-49. PMID: 23007526.

Giles FJ, Swords RT, Nagler A, et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia. 2013 Jan;27(1):113-7. PMID: 22772060.

Jeet V, Russell PJ, Verma ND, et al. Targeting aurora kinases: a novel approach to curb the growth & chemoresistance of androgen refractory prostate cancer. Curr Cancer Drug Targets. 2012 Feb;12(2):144-63. PMID: 22229247.

Salah E, Ugochukwu E, Barr AJ, et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class. J Med Chem. 2011 Apr 14;54(7):2359-67. PMID: 21417343.

Oliveira TM, Ahmad R, Engh RA. VX680 binding in Aurora A: π-π interactions involving the conserved aromatic amino acid of the flexible glycine-rich loop. J Phys Chem A. 2011 Apr 28;115(16):3895-904. PMID: 21306143.

" Not dangerous goods.

LKT G1849 Gemifloxacin Mesylate 1 g 102.9 Fluoroquinolone; bacterial DNA gyrase inhibitor. 210353-53-0 ≥98% 485.49 C18H21FN5O4 CH3SO3 CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O Ambient Ambient "Anzueto A, Miravitlles M. Short-course fluoroquinolone therapy in exacerbations of chronic bronchitis and COPD. Respir Med. 2010 Oct;104(10):1396-403. PMID: 20580215.

Lode HM, Schmidt-Ionas M, Stahlmann R. Gemifloxacin for community-acquired pneumonia. Expert Opin Investig Drugs. 2008 May;17(5):779-86. PMID: 18447602.

Bhavnani SM, Andes DR. Gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy. 2005 May;25(5):717-40. PMID: 15899734.

" Not dangerous goods.

LKT G1849 Gemifloxacin Mesylate 5 g 367.5 Fluoroquinolone; bacterial DNA gyrase inhibitor. 210353-53-0 ≥98% 485.49 C18H21FN5O4 CH3SO3 CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O Ambient Ambient "Anzueto A, Miravitlles M. Short-course fluoroquinolone therapy in exacerbations of chronic bronchitis and COPD. Respir Med. 2010 Oct;104(10):1396-403. PMID: 20580215.

Lode HM, Schmidt-Ionas M, Stahlmann R. Gemifloxacin for community-acquired pneumonia. Expert Opin Investig Drugs. 2008 May;17(5):779-86. PMID: 18447602.

Bhavnani SM, Andes DR. Gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy. 2005 May;25(5):717-40. PMID: 15899734.

" Not dangerous goods.

LKT G1849 Gemifloxacin Mesylate 25 g 1260 Fluoroquinolone; bacterial DNA gyrase inhibitor. 210353-53-0 ≥98% 485.49 C18H21FN5O4 CH3SO3 CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O Ambient Ambient "Anzueto A, Miravitlles M. Short-course fluoroquinolone therapy in exacerbations of chronic bronchitis and COPD. Respir Med. 2010 Oct;104(10):1396-403. PMID: 20580215.

Lode HM, Schmidt-Ionas M, Stahlmann R. Gemifloxacin for community-acquired pneumonia. Expert Opin Investig Drugs. 2008 May;17(5):779-86. PMID: 18447602.

Bhavnani SM, Andes DR. Gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy. 2005 May;25(5):717-40. PMID: 15899734.

" Not dangerous goods.

LKT R5722 Rofecoxib 100 mg 67.9 NSAID; COX-2 inhibitor. 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)- furanone "Vioxx

" 162011-90-7 ≥98% 314.36 C17H14O4S CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3 Ambient Ambient Slightly soluble in methanol and acetone. Insoluble in water. "D'Arca D, LeNoir J, Wildemore B, et al. Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. Urol Oncol. 2010 Mar-Apr;28(2):189-94. PMID: 19372053.

Akula KK, Dhir A, Kulkarni SK. Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. Epilepsy Res. 2008 Jan;78(1):60-70. PMID: 18054463." Not dangerous goods.

LKT R5722 Rofecoxib 250 mg 136 NSAID; COX-2 inhibitor. 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)- furanone "Vioxx

" 162011-90-7 ≥98% 314.36 C17H14O4S CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3 Ambient Ambient Slightly soluble in methanol and acetone. Insoluble in water. "D'Arca D, LeNoir J, Wildemore B, et al. Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. Urol Oncol. 2010 Mar-Apr;28(2):189-94. PMID: 19372053.

Akula KK, Dhir A, Kulkarni SK. Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. Epilepsy Res. 2008 Jan;78(1):60-70. PMID: 18054463." Not dangerous goods.

LKT Z5645 Zoledronate Disodium Tetrahydrate 10 mg 92.5 Bisphosphonate; FPPS inhibitor. [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]- bisphosphonic acid disodium salt tetrahydrate Zoledronic acid disodium salt tetrahydrate 165800-07-7 ≥98% 390.13 C5H10N2O7P2 2Na+ 4H2O C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O.O.O.O.[Na+].[Na+] Ambient Ambient "Yang T, Zheng XF, Li M, et al. Stimulation of osteogenic differentiation in stromal cells of giant cell tumour of bone by zoledronic acid. Asian Pac J Cancer Prev. 2013;14(9):5379-83. PMID: 24175830.

Schech AJ, Kazi AA, Gilani RA, et al. Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol Cancer Ther. 2013 Jul;12(7):1356-66. PMID: 23619300.

Idrees AS, Sugie T, Inoue C, et al. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci. 2013 May;104(5):536-42. PMID: 23387443.

Ibrahim T, Mercatali L, Sacanna E, et al. Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid. Cancer Cell Int. 2012 Nov 22;12(1):48. PMID: 23173568.

Soltau J, Zirrgiebel U, Esser N, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008 Mar-Apr;28(2A):933-41. PMID: 18507039.

Kavanagh KL, Guo K, Dunford JE, et al The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. PMID: 16684881.

Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.

" Not dangerous goods.

LKT Z5645 Zoledronate Disodium Tetrahydrate 25 mg 169.9 Bisphosphonate; FPPS inhibitor. [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]- bisphosphonic acid disodium salt tetrahydrate Zoledronic acid disodium salt tetrahydrate 165800-07-7 ≥98% 390.13 C5H10N2O7P2 2Na+ 4H2O C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O.O.O.O.[Na+].[Na+] Ambient Ambient "Yang T, Zheng XF, Li M, et al. Stimulation of osteogenic differentiation in stromal cells of giant cell tumour of bone by zoledronic acid. Asian Pac J Cancer Prev. 2013;14(9):5379-83. PMID: 24175830.

Schech AJ, Kazi AA, Gilani RA, et al. Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol Cancer Ther. 2013 Jul;12(7):1356-66. PMID: 23619300.

Idrees AS, Sugie T, Inoue C, et al. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci. 2013 May;104(5):536-42. PMID: 23387443.

Ibrahim T, Mercatali L, Sacanna E, et al. Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid. Cancer Cell Int. 2012 Nov 22;12(1):48. PMID: 23173568.

Soltau J, Zirrgiebel U, Esser N, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008 Mar-Apr;28(2A):933-41. PMID: 18507039.

Kavanagh KL, Guo K, Dunford JE, et al The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. PMID: 16684881.

Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.

" Not dangerous goods.

LKT Z5645 Zoledronate Disodium Tetrahydrate 100 mg 475.7 Bisphosphonate; FPPS inhibitor. [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]- bisphosphonic acid disodium salt tetrahydrate Zoledronic acid disodium salt tetrahydrate 165800-07-7 ≥98% 390.13 C5H10N2O7P2 2Na+ 4H2O C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O.O.O.O.[Na+].[Na+] Ambient Ambient "Yang T, Zheng XF, Li M, et al. Stimulation of osteogenic differentiation in stromal cells of giant cell tumour of bone by zoledronic acid. Asian Pac J Cancer Prev. 2013;14(9):5379-83. PMID: 24175830.

Schech AJ, Kazi AA, Gilani RA, et al. Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol Cancer Ther. 2013 Jul;12(7):1356-66. PMID: 23619300.

Idrees AS, Sugie T, Inoue C, et al. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci. 2013 May;104(5):536-42. PMID: 23387443.

Ibrahim T, Mercatali L, Sacanna E, et al. Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid. Cancer Cell Int. 2012 Nov 22;12(1):48. PMID: 23173568.

Soltau J, Zirrgiebel U, Esser N, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008 Mar-Apr;28(2A):933-41. PMID: 18507039.

Kavanagh KL, Guo K, Dunford JE, et al The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. PMID: 16684881.

Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.

" Not dangerous goods.

LKT A0025 17-Allylaminogeldanamycin 5 mg 78.9 Geldanamycin derivative; HSP90 inhibitor. 17-(Allylamino)-17-desmethoxy-geldanamycin; allylaminogeldanamycin; 17-AAG; telatinib. 75747-14-7 ≥97% 585.69 C31H43N3O8 CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC Protect from light. Ambient 4°C Soluble in DMSO or methanol. "Thangjam GS, Dimitropoulou C, Joshi AD, et al. Novel mechanism of attenuation of LPS-induced NF-κB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol. 2014 May;50(5):942-52. PMID: 24303801.

Powers MV, Valenti M, Miranda S, et al. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. 2013 Nov;4(11):1963-75. PMID: 24185264.

Evers DL, Chao CF, Zhang Z, et al. 17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells. Arch Virol. 2012 Oct;157(10):1971-4. PMID: 22711259.

Gloesenkamp C, Nitzsche B, Lim AR, et al. Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors. Int J Oncol. 2012 May;40(5):1659-67. PMID: 22246317." Not dangerous goods.

LKT C9710 Cyclopamine 25 mg 122.3 Steroidal jerveratrum alkaloid found in Veratrum; Smo inhibitor. "Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-

ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-

octadecahydro-3',6',10,11b-tetramethyl-, 

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-" 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505. 4449-51-8 ≥98% 411.62 C27H41NO2 CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 Ambient -20°C Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL).  Soluble in DMSO & insoluble in water. "Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066." Not dangerous goods.

LKT C9710 Cyclopamine 100 mg 339.8 Steroidal jerveratrum alkaloid found in Veratrum; Smo inhibitor. "Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-

ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-

octadecahydro-3',6',10,11b-tetramethyl-, 

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-" 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505. 4449-51-8 ≥98% 411.62 C27H41NO2 CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 Ambient -20°C Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL).  Soluble in DMSO & insoluble in water. "Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066." Not dangerous goods.

LKT C9710 Cyclopamine 500 mg 1223 Steroidal jerveratrum alkaloid found in Veratrum; Smo inhibitor. "Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-

ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-

octadecahydro-3',6',10,11b-tetramethyl-, 

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-" 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505. 4449-51-8 ≥98% 411.62 C27H41NO2 CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 Ambient -20°C Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL).  Soluble in DMSO & insoluble in water. "Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066." Not dangerous goods.

LKT C9710 Cyclopamine 1 g 2038.5 Steroidal jerveratrum alkaloid found in Veratrum; Smo inhibitor. "Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-

ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-

octadecahydro-3',6',10,11b-tetramethyl-, 

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-" 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505. 4449-51-8 ≥98% 411.62 C27H41NO2 CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 Ambient -20°C Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL).  Soluble in DMSO & insoluble in water. "Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066." Not dangerous goods.

LKT O4578 Oltipraz 250 mg 169.9 Antioxidant; Nrf2 activator. 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione BRN 0978110 64224-21-1 ≥98% 226.34 C8H6N2S3 CC1=C(SSC1=S)C2=NC=CN=C2 Keep away from light. Ambient 4°C Soluble in methanol. "Shimozono R, Asaoka Y, Yoshizawa Y, et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul;84(1):62-70. PMID: 23592516.

Yu Z, Shao W, Chiang Y, et al. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia. 2011 Apr;54(4):922-34. Erratum in: Diabetologia. 2011 Apr;54(4):989.  PMID: 21161163.

Lee WH, Kim YW, Choi JH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. PMID: 19789218.

Morsy GH. Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz. J Egypt Soc Parasitol. 2009 Aug;39(2):687-701. PMID: 19795775.

Merrell MD, Jackson JP, Augustine LM, et al. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos. 2008 Aug;36(8):1716-21. PMID: 18474683.

" Xi Not dangerous goods.

LKT V3253 Vinblastine Sulfate 25 mg 295.9 Vinca alkaloid found in Catharanthus; microtubule polymerization inhibitor. Vincaleukblastine sulfate Exal; Velban; Velbe 143-67-9 ≥96% 909.07 C46H58N4O9S H2SO4 CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O Ambient -20°C Slightly soluble in ethanol or water (10 parts). Practically insoluble in ether. "Pliarchopoulou K, Laschos K, Pectasides D. Current chemotherapeutic options for the treatment of advanced bladder cancer: a review. Urol Oncol. 2013 Apr;31(3):294-302. PMID: 20843708.

Rendine S, Pieraccini S, Sironi M. Vinblastine perturbation of tubulin protofilament structure: a computational insight. Phys Chem Chem Phys. 2010 Dec 21;12(47):15530-6. PMID: 20978652.

Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.

" Xn Not dangerous goods.

LKT O4402 Olaparib 25 mg 101.9 PARP1/2 inhibitor. AZD2281, KU-0059436 763113-22-0 ≥98% 434.47 C24H23FN4O3 C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F Ambient 4°C DMSO (10 mg/ml), DMF (3 mg/ml) "Lee JM, Ledermann JA, Kohn EC. PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2013 Nov 12. [Epub ahead of print]. PMID: 24225019.

Olaparib Enters Phase III Clinical Testing. Cancer Discov. 2013 Nov;3(11):1210. PMID: 24203936.

Postel-Vinay S, Bajrami I, Friboulet L, et al. A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer. Oncogene. 2013 Nov 21;32(47):5377-87. PMID: 23934192.

Kortmann U, McAlpine JN, Xue H, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res. 2011 Feb 15;17(4):783-91. PMID: 21097693.

" Not dangerous goods.

LKT B6918 Brevetoxin 3 1 mg 1834.7 Polyether neurotoxin found in Karenia brevis; Nav1.4/1.5 Na+ channel activator. PbTx-3 85079-48-7 ≥95% 897.2 C50H72O14 CC1CC2C(CC3(C(O2)CC4C(O3)C(=CC(=O)O4)C)C)OC5C1OC6CC7C(CC8C(O7)(CC=CC9C(O8)CC1C(O9)CC2C(O1)(C(CC(O2)CC(=C)CO)O)C)C)(OC6(CC5)C)C Ambient -20°C Soluble in acetone, ethyl acetate, ethanol, and methanol. "Zaias J, Fleming LE, Baden DG, et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep. Inhal Toxicol. 2011 Mar;23(4):205-11. PMID: 21456953.

Liberona JL, Cárdenas JC, Reyes R, et al. Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes. Cell Calcium. 2008 Sep;44(3):289-97. PMID: 18276006.

Cao Z, George J, Baden DG, et al. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways. Brain Res. 2007 Dec 12;1184:17-27. PMID: 17963734.

Radwan FF, Ramsdell JS. Characterization of in vitro oxidative and conjugative metabolic pathways for brevetoxin (PbTx-2). Toxicol Sci. 2006 Jan;89(1):57-65. PMID: 16221966.

Colman JR, Ramsdell JS. The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryos. Environ Health Perspect. 2003 Dec;111(16):1920-5. PMID: 14644667.

Bottein Dechraoui MY, Ramsdell JS. Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels. Toxicon. 2003 Jun;41(7):919-27. PMID: 12782093.

Berman FW, Murray TF. Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons. J Pharmacol Exp Ther. 1999 Jul;290(1):439-44. PMID: 10381810.

Jeglitsch G, Rein K, Baden DG, et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. J Pharmacol Exp Ther. 1998 Feb;284(2):516-25. PMID: 9454792.

" "UN number: 3462     Class: 6.1     Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Brevetoxin 3)"

LKT B6917 Brevetoxin 2 1 mg 1359 Polyether neurotoxin found in Karenia brevis; Nav1.4/1.5 Na+ channel activator. PbTx-2 79580-28-2 ≥95% 895.2 C50H70O14 CC1CC2C(CC3(C(O2)CC4C(O3)C(=CC(=O)O4)C)C)OC5C1OC6CC7C(CC8C(O7)(CC=CC9C(O8)CC1C(O9)CC2C(O1)(C(CC(O2)CC(=C)C=O)O)C)C)(OC6(CC5)C)C Ambient -20°C "Zaias J, Fleming LE, Baden DG, et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep. Inhal Toxicol. 2011 Mar;23(4):205-11. PMID: 21456953.

Liberona JL, Cárdenas JC, Reyes R, et al. Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes. Cell Calcium. 2008 Sep;44(3):289-97. PMID: 18276006.

Radwan FF, Ramsdell JS. Brevetoxin forms covalent DNA adducts in rat lung following intratracheal exposure. Environ Health Perspect. 2008 Jul;116(7):930-6. PMID: 18629316.

Cao Z, George J, Baden DG, et al. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways. Brain Res. 2007 Dec 12;1184:17-27. PMID: 17963734.

Bottein Dechraoui MY, Ramsdell JS. Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels. Toxicon. 2003 Jun;41(7):919-27. PMID: 12782093.

Berman FW, Murray TF. Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons. J Pharmacol Exp Ther. 1999 Jul;290(1):439-44. PMID: 10381810.

" "UN Number: 3462     Class: 6.1     Packing Group: II

Proper Shipping Name:  Toxins, extracted from living sources, solid, n.o.s. (Brevetoxin 2) "

LKT I6933 Irinotecan Hydrochloride Trihydrate 100 mg 228.4 Camptothecin analog; topoisomerase I inhibitor, potential AChE inhibitor. [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate Irinotecan hydrochloride trihydrate; Camptosar; Campto; CPT-11 136572-09-3 ≥98% 677.19 C33H38N4O6 HCl 3H2O CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl Ambient 4°C Slightly soluble in water (25 mg/mL),  ethanol (7 mg/mL), chloroform. DMSO (100  mg/mL) "Hu J, Kinn J, Zirakzadeh AA, et al. The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation. Clin Exp Immunol. 2013 Jun;172(3):490-9. PMID: 23600838.

Pan P, Li Y, Yu H, et al. Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches. J Chem Inf Model. 2013 Apr 22;53(4):997-1006. PMID: 23521602.

Chen AY, Chen PM, Chen YJ. DNA topoisomerase I drugs and radiotherapy for lung cancer. J Thorac Dis. 2012 Aug;4(4):390-7. PMID: 22934142.

Chintala S, Tóth K, Cao S, et al. Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha. Cancer Chemother Pharmacol. 2010 Oct;66(5):899-911. PMID: 20066420.

Dodds HM, Rivory LP. The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11). Mol Pharmacol. 1999 Dec;56(6):1346-53. PMID: 10570064.

" Not dangerous goods.

LKT C3374 Cisplatin 1 g 336.4 Pt-based DNA cross-linker. cis-Dichlorodiammine platinum(II) Abiplatin; DDP; Platiblastin; cis- Dichlorodi- ammineplatinum 15663-27-1 ≥98% 300.04 Cl2H6N2Pt [Cl-][Pt+2]([NH3])([NH3])[Cl-] Ambient 4°C Slightly soluble in water. DMSO to 60mg/mL "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.

Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.

Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

" Mut., Carc., T, Repr., Xi "UN number: 3288     Class:  6.1     Packing group:  II

Proper shipping name:  Toxic solid, inorganic, n.o.s. (Cisplatin)

Reportable Quantity (RQ):       Marine pollutant:  No     Poison Inhalation Hazard:  No"

LKT C5654 Concanavalin A 1 g 570.8 Lectin found in Canavelia, plant mitogen that binds α-D-mannosyl and α-D-glucosyl residues, used to study cell adhesion. ConA 11028-71-0 ≥98% Ambient -20°C Soluble in water. (Hazy) "Wan Y, Tang MH, Chen XC, et al. Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res. 2014 Aug;47(8):655-61. PMID: 25098714.

Lei HY, Chang CP. Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. J Biomed Sci. 2009 Jan 19;16:10. PMID: 19272170.

Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. Clin Exp Immunol. 1981 Nov;46(2):237-49. PMID: 6461456.

Noonan KD, Burger MM. The relationship of concanavalin A binding to lectin-initiated cell agglutination. J Cell Biol. 1973 Oct;59(1):134-42. PMID: 4201706.

" Xn Not dangerous goods.

LKT P3563 Piperlonguminine 10 mg 61.1 Found in Piper longum. (2E, 4E)-5-Benzo[d][1,3]-dioxol-5-yl)-N-isobutylpenta-2,4-dienamide 5950-12-9 ≥99% 273.33 C16H19NO3 CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2 Ambient -20°C DMSO "Lee W, Yoo H, Ku SK, et al. Anticoagulant activities of piperlonguminine in vitro and in vivo. BMB Rep. 2013 Oct;46(10):484-9. PMID: 24148768.

Ku SK, Kim JA, Bae JS. Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo. Inflammation. 2013 Oct 15. [Epub ahead of print]. PMID: 24127121.

Lee W, Yoo H, Kim JA, et al. Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo. Food Chem Toxicol. 2013 Aug;58:149-57. PMID: 23619565.

Yamaguchi I, Matsuda H, Zhang H, et al. Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice. J Nat Med. 2013 Apr 13. [Epub ahead of print]. PMID: 23584920.

Bao L, Borjihan G. Hypolipidemic effects of piperlonguminine in HepG2 cells and in Wistar rats. Pharmazie. 2012 Oct;67(10):858-61. PMID: 23136721.

Qi HS, Liu P, Gao SQ, et al. Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells. Chin J Physiol. 2009 Jun 30;52(3):160-8. PMID: 19777802.

Silva DR, Endo EH, Filho BP, et al. Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl. Molecules. 2009 Mar 16;14(3):1171-82. PMID: 19325517

Bezerra DP, Pessoa C, Moraes MO, et al. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol. 2008 Jul;28(5):599-607. PMID: 17975786.

" Not dangerous goods

LKT P3563 Piperlonguminine 25 mg 115.5 Found in Piper longum. (2E, 4E)-5-Benzo[d][1,3]-dioxol-5-yl)-N-isobutylpenta-2,4-dienamide 5950-12-9 ≥99% 273.33 C16H19NO3 CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2 Ambient -20°C DMSO "Lee W, Yoo H, Ku SK, et al. Anticoagulant activities of piperlonguminine in vitro and in vivo. BMB Rep. 2013 Oct;46(10):484-9. PMID: 24148768.

Ku SK, Kim JA, Bae JS. Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo. Inflammation. 2013 Oct 15. [Epub ahead of print]. PMID: 24127121.

Lee W, Yoo H, Kim JA, et al. Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo. Food Chem Toxicol. 2013 Aug;58:149-57. PMID: 23619565.

Yamaguchi I, Matsuda H, Zhang H, et al. Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice. J Nat Med. 2013 Apr 13. [Epub ahead of print]. PMID: 23584920.

Bao L, Borjihan G. Hypolipidemic effects of piperlonguminine in HepG2 cells and in Wistar rats. Pharmazie. 2012 Oct;67(10):858-61. PMID: 23136721.

Qi HS, Liu P, Gao SQ, et al. Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells. Chin J Physiol. 2009 Jun 30;52(3):160-8. PMID: 19777802.

Silva DR, Endo EH, Filho BP, et al. Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl. Molecules. 2009 Mar 16;14(3):1171-82. PMID: 19325517

Bezerra DP, Pessoa C, Moraes MO, et al. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol. 2008 Jul;28(5):599-607. PMID: 17975786.

" Not dangerous goods

LKT P3563 Piperlonguminine 100 mg 339.8 Found in Piper longum. (2E, 4E)-5-Benzo[d][1,3]-dioxol-5-yl)-N-isobutylpenta-2,4-dienamide 5950-12-9 ≥99% 273.33 C16H19NO3 CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2 Ambient -20°C DMSO "Lee W, Yoo H, Ku SK, et al. Anticoagulant activities of piperlonguminine in vitro and in vivo. BMB Rep. 2013 Oct;46(10):484-9. PMID: 24148768.

Ku SK, Kim JA, Bae JS. Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo. Inflammation. 2013 Oct 15. [Epub ahead of print]. PMID: 24127121.

Lee W, Yoo H, Kim JA, et al. Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo. Food Chem Toxicol. 2013 Aug;58:149-57. PMID: 23619565.

Yamaguchi I, Matsuda H, Zhang H, et al. Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice. J Nat Med. 2013 Apr 13. [Epub ahead of print]. PMID: 23584920.

Bao L, Borjihan G. Hypolipidemic effects of piperlonguminine in HepG2 cells and in Wistar rats. Pharmazie. 2012 Oct;67(10):858-61. PMID: 23136721.

Qi HS, Liu P, Gao SQ, et al. Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells. Chin J Physiol. 2009 Jun 30;52(3):160-8. PMID: 19777802.

Silva DR, Endo EH, Filho BP, et al. Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl. Molecules. 2009 Mar 16;14(3):1171-82. PMID: 19325517

Bezerra DP, Pessoa C, Moraes MO, et al. In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species. J Appl Toxicol. 2008 Jul;28(5):599-607. PMID: 17975786.

" Not dangerous goods

LKT C8070 Curcumin, high purity 10 mg 88.3 Active compound found in turmeric; MST1 activator, CRMP2 inhibitor. (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Turmeric yellow 458-37-7 ≥98% 368.38 C21H20O6 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O Ambient Ambient Insoluble in water.  Soluble in ethanol, DMSO. "Kawanishi N, Kato K, Takahashi M, et al. Curcumin attenuates oxidative stress following downhill running-induced muscle damage. Biochem Biophys Res Commun. 2013 Oct 30. [Epub ahead of print]. PMID: 24184481.

Du WZ, Feng Y, Wang XF, et al. Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo. CNS Neurosci Ther. 2013 Oct 25. [Epub ahead of print]. PMID: 24165291.

Tian N, Li X, Luo Y, et al. Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes. Mol Med Rep. 2013 Oct 24. [Epub ahead of print]. PMID: 24173373.

Wang Y, Yin H, Li J, et al. Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation. Neurosci Lett. 2013 Oct 21. [Epub ahead of print]. PMID: 24157857.

Antoine F, Simard JC, Girard D. Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo. Int Immunopharmacol. 2013 Oct 21. [Epub ahead of print]. PMID: 24157330.

Gunes H, Gulen D, Mutlu R, et al. Antibacterial effects of curcumin: an in vitro minimum inhibitory concentration study. Toxicol Ind Health. 2013 Oct 21. [Epub ahead of print]. PMID: 24097361.

Kumar A, Dhamgaye S, Maurya IK, et al. Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans. Antimicrob Agents Chemother. 2013 Oct 21. [Epub ahead of print]. PMID: 24145527.

Yu T, Ji J, Guo YL. MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Biochem Biophys Res Commun. 2013 Oct 14. [Epub ahead of print]. PMID: 24134840.

Narayanan N, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009Feb 6;125(1):1-8. PMID: 19326431." Xi Not dangerous goods.

LKT C8070 Curcumin, high purity 25 mg 183.4 Active compound found in turmeric; MST1 activator, CRMP2 inhibitor. (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Turmeric yellow 458-37-7 ≥98% 368.38 C21H20O6 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O Ambient Ambient Insoluble in water.  Soluble in ethanol, DMSO. "Kawanishi N, Kato K, Takahashi M, et al. Curcumin attenuates oxidative stress following downhill running-induced muscle damage. Biochem Biophys Res Commun. 2013 Oct 30. [Epub ahead of print]. PMID: 24184481.

Du WZ, Feng Y, Wang XF, et al. Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo. CNS Neurosci Ther. 2013 Oct 25. [Epub ahead of print]. PMID: 24165291.

Tian N, Li X, Luo Y, et al. Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes. Mol Med Rep. 2013 Oct 24. [Epub ahead of print]. PMID: 24173373.

Wang Y, Yin H, Li J, et al. Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation. Neurosci Lett. 2013 Oct 21. [Epub ahead of print]. PMID: 24157857.

Antoine F, Simard JC, Girard D. Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo. Int Immunopharmacol. 2013 Oct 21. [Epub ahead of print]. PMID: 24157330.

Gunes H, Gulen D, Mutlu R, et al. Antibacterial effects of curcumin: an in vitro minimum inhibitory concentration study. Toxicol Ind Health. 2013 Oct 21. [Epub ahead of print]. PMID: 24097361.

Kumar A, Dhamgaye S, Maurya IK, et al. Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans. Antimicrob Agents Chemother. 2013 Oct 21. [Epub ahead of print]. PMID: 24145527.

Yu T, Ji J, Guo YL. MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Biochem Biophys Res Commun. 2013 Oct 14. [Epub ahead of print]. PMID: 24134840.

Narayanan N, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009Feb 6;125(1):1-8. PMID: 19326431." Xi Not dangerous goods.

LKT C8070 Curcumin, high purity 100 mg 475.7 Active compound found in turmeric; MST1 activator, CRMP2 inhibitor. (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Turmeric yellow 458-37-7 ≥98% 368.38 C21H20O6 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O Ambient Ambient Insoluble in water.  Soluble in ethanol, DMSO. "Kawanishi N, Kato K, Takahashi M, et al. Curcumin attenuates oxidative stress following downhill running-induced muscle damage. Biochem Biophys Res Commun. 2013 Oct 30. [Epub ahead of print]. PMID: 24184481.

Du WZ, Feng Y, Wang XF, et al. Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo. CNS Neurosci Ther. 2013 Oct 25. [Epub ahead of print]. PMID: 24165291.

Tian N, Li X, Luo Y, et al. Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes. Mol Med Rep. 2013 Oct 24. [Epub ahead of print]. PMID: 24173373.

Wang Y, Yin H, Li J, et al. Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation. Neurosci Lett. 2013 Oct 21. [Epub ahead of print]. PMID: 24157857.

Antoine F, Simard JC, Girard D. Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo. Int Immunopharmacol. 2013 Oct 21. [Epub ahead of print]. PMID: 24157330.

Gunes H, Gulen D, Mutlu R, et al. Antibacterial effects of curcumin: an in vitro minimum inhibitory concentration study. Toxicol Ind Health. 2013 Oct 21. [Epub ahead of print]. PMID: 24097361.

Kumar A, Dhamgaye S, Maurya IK, et al. Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans. Antimicrob Agents Chemother. 2013 Oct 21. [Epub ahead of print]. PMID: 24145527.

Yu T, Ji J, Guo YL. MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Biochem Biophys Res Commun. 2013 Oct 14. [Epub ahead of print]. PMID: 24134840.

Narayanan N, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009Feb 6;125(1):1-8. PMID: 19326431." Xi Not dangerous goods.

LKT D1850 Demethoxycurcumin 5 mg 122.3 Curcumin derivative; AMPK activator, STAT3 and eIF4E-bp3 inhibitor, potential AChE and EGFR inhibitor. "1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-

(4-hydroxyphenyl)- (VAN)" 24939-17-1 ≥98% 338.35 C20H18O5 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient "Sheu MJ, Lin HY, Yang YH, et al. Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study. Mol Nutr Food Res. 2013 Sep;57(9):1586-97. PMID: 23520190.

Shieh JM, Chen YC, Lin YC, et al. Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells. J Agric Food Chem. 2013 Jul 3;61(26):6366-75. PMID: 23777448.

Villaflores OB, Chen YJ, Chen CP, et al. Curcuminoids and resveratrol as anti-Alzheimer agents. Taiwan J Obstet Gynecol. 2012 Dec;51(4):515-25. PMID: 23276553.

Hung CM, Su YH, Lin HY, et al. Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR. J Agric Food Chem. 2012 Aug 16. PMID: 22849866.

Ni X, Zhang A, Zhao Z, et al. Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells. Oncol Rep. 2012 Jul;28(1):85-90. PMID: 22552297.

Zhang L, Wu C, Zhao S, et al. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. Int Immunopharmacol. 2010 Mar;10(3):331-8. PMID: 20018257.

Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. 2009 Feb;91(4):554-9. PMID: 18930076.

Agrawal DK, Saikia D, Tiwari R, et al. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008 Dec;74(15):1828-31. PMID: 18991209.

" Not dangerous goods.

LKT D1850 Demethoxycurcumin 10 mg 217.4 Curcumin derivative; AMPK activator, STAT3 and eIF4E-bp3 inhibitor, potential AChE and EGFR inhibitor. "1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-

(4-hydroxyphenyl)- (VAN)" 24939-17-1 ≥98% 338.35 C20H18O5 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient "Sheu MJ, Lin HY, Yang YH, et al. Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study. Mol Nutr Food Res. 2013 Sep;57(9):1586-97. PMID: 23520190.

Shieh JM, Chen YC, Lin YC, et al. Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells. J Agric Food Chem. 2013 Jul 3;61(26):6366-75. PMID: 23777448.

Villaflores OB, Chen YJ, Chen CP, et al. Curcuminoids and resveratrol as anti-Alzheimer agents. Taiwan J Obstet Gynecol. 2012 Dec;51(4):515-25. PMID: 23276553.

Hung CM, Su YH, Lin HY, et al. Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR. J Agric Food Chem. 2012 Aug 16. PMID: 22849866.

Ni X, Zhang A, Zhao Z, et al. Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells. Oncol Rep. 2012 Jul;28(1):85-90. PMID: 22552297.

Zhang L, Wu C, Zhao S, et al. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. Int Immunopharmacol. 2010 Mar;10(3):331-8. PMID: 20018257.

Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. 2009 Feb;91(4):554-9. PMID: 18930076.

Agrawal DK, Saikia D, Tiwari R, et al. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008 Dec;74(15):1828-31. PMID: 18991209.

" Not dangerous goods.

LKT D1850 Demethoxycurcumin 25 mg 434.9 Curcumin derivative; AMPK activator, STAT3 and eIF4E-bp3 inhibitor, potential AChE and EGFR inhibitor. "1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-

(4-hydroxyphenyl)- (VAN)" 24939-17-1 ≥98% 338.35 C20H18O5 COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient "Sheu MJ, Lin HY, Yang YH, et al. Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study. Mol Nutr Food Res. 2013 Sep;57(9):1586-97. PMID: 23520190.

Shieh JM, Chen YC, Lin YC, et al. Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells. J Agric Food Chem. 2013 Jul 3;61(26):6366-75. PMID: 23777448.

Villaflores OB, Chen YJ, Chen CP, et al. Curcuminoids and resveratrol as anti-Alzheimer agents. Taiwan J Obstet Gynecol. 2012 Dec;51(4):515-25. PMID: 23276553.

Hung CM, Su YH, Lin HY, et al. Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR. J Agric Food Chem. 2012 Aug 16. PMID: 22849866.

Ni X, Zhang A, Zhao Z, et al. Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells. Oncol Rep. 2012 Jul;28(1):85-90. PMID: 22552297.

Zhang L, Wu C, Zhao S, et al. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. Int Immunopharmacol. 2010 Mar;10(3):331-8. PMID: 20018257.

Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. 2009 Feb;91(4):554-9. PMID: 18930076.

Agrawal DK, Saikia D, Tiwari R, et al. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008 Dec;74(15):1828-31. PMID: 18991209.

" Not dangerous goods.

LKT B3573 Bisdemethoxycurcumin 5 mg 101.9 Curcumin derivative; DNMT1 and α-amylase inhibitor, WIF-1 promoter demethylation inhibitor, potential SIRT1 and AMPK activator. 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)- 24939-16-0 ≥98% 308.33 C19H16O4 C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient DMSO "Li YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830.

Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593.

Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078.

Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852.

Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103.

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

" Not dangerous goods.

LKT B3573 Bisdemethoxycurcumin 10 mg 190.3 Curcumin derivative; DNMT1 and α-amylase inhibitor, WIF-1 promoter demethylation inhibitor, potential SIRT1 and AMPK activator. 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)- 24939-16-0 ≥98% 308.33 C19H16O4 C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient DMSO "Li YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830.

Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593.

Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078.

Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852.

Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103.

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

" Not dangerous goods.

LKT B3573 Bisdemethoxycurcumin 25 mg 380.5 Curcumin derivative; DNMT1 and α-amylase inhibitor, WIF-1 promoter demethylation inhibitor, potential SIRT1 and AMPK activator. 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)- 24939-16-0 ≥98% 308.33 C19H16O4 C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O Ambient Ambient DMSO "Li YB, Zhong ZF, Chen MW, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. Epub 2013 Sep 2. PMID: 24078830.

Li YB, Gao JL, Zhong ZF, et al. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 2013;65(3):700-9. PMID: 23950593.

Hua Y, Dolence J, Ramanan S, et al. Bisdemethoxycurcumin inhibits PDGF-induced vascular smooth muscle cell motility and proliferation. Mol Nutr Food Res. 2013 Sep;57(9):1611-8. PMID: 23554078.

Ponnusamy S, Zinjarde S, Bhargava S, et al. Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Food Chem. 2012 Dec 15;135(4):2638-42. PMID: 22980852.

Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets. 2011 Nov;11(9):1098-110. PMID: 21933103.

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

" Not dangerous goods.

LKT D3449 Dimethoxycurcumin 5 mg 133.2 Curcumin derivative. 160096-59-3 ≥98% 396.43 C23H24O6 Ambient Ambient "Kunwar A, Jayakumar S, Srivastava AK, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14. PMID: 22119759.

Patwardhan RS, Checker R, Sharma D, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol. 2011 Sep 15;82(6):642-57. PMID: 21726543.

Kunwar A, Barik A, Sandur SK, et al. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65. PMID: 21615275.

Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7. PMID: 21244640

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Pae HO, Jeong SO, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. PMID: 18481332.

Tamvakopoulos C, Dimas K, Sofianos ZD, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007 Feb 15;13(4):1269-77. PMID: 17317839.

" Not dangerous goods.

LKT D3449 Dimethoxycurcumin 10 mg 203.8 Curcumin derivative. 160096-59-3 ≥98% 396.43 C23H24O6 Ambient Ambient "Kunwar A, Jayakumar S, Srivastava AK, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14. PMID: 22119759.

Patwardhan RS, Checker R, Sharma D, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol. 2011 Sep 15;82(6):642-57. PMID: 21726543.

Kunwar A, Barik A, Sandur SK, et al. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65. PMID: 21615275.

Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7. PMID: 21244640

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Pae HO, Jeong SO, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. PMID: 18481332.

Tamvakopoulos C, Dimas K, Sofianos ZD, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007 Feb 15;13(4):1269-77. PMID: 17317839.

" Not dangerous goods.

LKT D3449 Dimethoxycurcumin 25 mg 407.7 Curcumin derivative. 160096-59-3 ≥98% 396.43 C23H24O6 Ambient Ambient "Kunwar A, Jayakumar S, Srivastava AK, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14. PMID: 22119759.

Patwardhan RS, Checker R, Sharma D, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol. 2011 Sep 15;82(6):642-57. PMID: 21726543.

Kunwar A, Barik A, Sandur SK, et al. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65. PMID: 21615275.

Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7. PMID: 21244640

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Pae HO, Jeong SO, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. PMID: 18481332.

Tamvakopoulos C, Dimas K, Sofianos ZD, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007 Feb 15;13(4):1269-77. PMID: 17317839.

" Not dangerous goods.

LKT P3561 Piperlongumine 25 mg 51.7 Found in Piper longum; TxA2 antagonist, ubiquitin-proteasome inhibitor. (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 1-[(2E)-3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2-(1H)-one; Piplartine 20069-09-4 ≥98% 317.34 C17H19NO5 COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O Ambient -20°C DMSO (~25 mg/ml) "Ginzburg S, Golovine KV, Makhov PB, et al. Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells. Prostate. 2013 Oct 22. [Epub ahead of print]. PMID: 24151226.

Wang Y, Wang JW, Xiao X, et al. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 3;4:e824. PMID: 24091667.

Liu JM, Pan F, Li L, et al. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun. 2013 Jul 19;437(1):87-93. PMID: 23796709.

Jarvius M, Fryknäs M, D'Arcy P, et al. Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. PMID: 23318177.

Son DJ, Kim SY, Han SS, et al. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun. 2012 Oct 19;427(2):349-54. PMID: 22995306.

Golovine KV, Makhov PB, Teper E, et al. Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 2013 Jan;73(1):23-30. PMID: 22592999.

Iwashita M, Oka N, Ohkubo S, et al. Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. Eur J Pharmacol. 2007 Sep 10;570(1-3):38-42. PMID: 17618620.

" None Not dangerous goods.

LKT P3561 Piperlongumine 100 mg 163.2 Found in Piper longum; TxA2 antagonist, ubiquitin-proteasome inhibitor. (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 1-[(2E)-3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2-(1H)-one; Piplartine 20069-09-4 ≥98% 317.34 C17H19NO5 COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O Ambient -20°C DMSO (~25 mg/ml) "Ginzburg S, Golovine KV, Makhov PB, et al. Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells. Prostate. 2013 Oct 22. [Epub ahead of print]. PMID: 24151226.

Wang Y, Wang JW, Xiao X, et al. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 3;4:e824. PMID: 24091667.

Liu JM, Pan F, Li L, et al. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun. 2013 Jul 19;437(1):87-93. PMID: 23796709.

Jarvius M, Fryknäs M, D'Arcy P, et al. Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. PMID: 23318177.

Son DJ, Kim SY, Han SS, et al. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun. 2012 Oct 19;427(2):349-54. PMID: 22995306.

Golovine KV, Makhov PB, Teper E, et al. Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 2013 Jan;73(1):23-30. PMID: 22592999.

Iwashita M, Oka N, Ohkubo S, et al. Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. Eur J Pharmacol. 2007 Sep 10;570(1-3):38-42. PMID: 17618620.

" None Not dangerous goods.

LKT P3561 Piperlongumine 250 mg 339.8 Found in Piper longum; TxA2 antagonist, ubiquitin-proteasome inhibitor. (E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 1-[(2E)-3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2-(1H)-one; Piplartine 20069-09-4 ≥98% 317.34 C17H19NO5 COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O Ambient -20°C DMSO (~25 mg/ml) "Ginzburg S, Golovine KV, Makhov PB, et al. Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells. Prostate. 2013 Oct 22. [Epub ahead of print]. PMID: 24151226.

Wang Y, Wang JW, Xiao X, et al. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 3;4:e824. PMID: 24091667.

Liu JM, Pan F, Li L, et al. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun. 2013 Jul 19;437(1):87-93. PMID: 23796709.

Jarvius M, Fryknäs M, D'Arcy P, et al. Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. PMID: 23318177.

Son DJ, Kim SY, Han SS, et al. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun. 2012 Oct 19;427(2):349-54. PMID: 22995306.

Golovine KV, Makhov PB, Teper E, et al. Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate. 2013 Jan;73(1):23-30. PMID: 22592999.

Iwashita M, Oka N, Ohkubo S, et al. Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. Eur J Pharmacol. 2007 Sep 10;570(1-3):38-42. PMID: 17618620.

" None Not dangerous goods.

LKT F1670 Ferulic Acid Methyl Ester 1 g 61.1 Hydroxycinnamic aicd, verbascoside metabolite, ion chelator. 2309-07-1 ≥98% 208.21 C11H12O4 COC1=C(C=CC(=C1)C=CC(=O)OC)O Ambient Ambient "Quirantes-Piné R, Herranz-López M, Funes L, et al. Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine. 2013 Sep 15;20(12):1112-8. PMID: 23827667.

Xu Y, Zhang L, Shao T, et al. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis. 2013 Dec;28(4):571-83. PMID: 23584961.

Picone P, Nuzzo D, Di Carlo M. Ferulic acid: a natural antioxidant against oxidative stress induced by oligomeric A-beta on sea urchin embryo. Biol Bull. 2013 Feb;224(1):18-28. PMID: 23493505.

Lin TY, Lu CW, Huang SK, et al. Ferulic acid suppresses glutamate release through inhibition of voltage-dependent calcium entry in rat cerebrocortical nerve terminals. J Med Food. 2013 Feb;16(2):112-9. PMID: 23342970.

Choi R, Kim BH, Naowaboot J, et al. Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Exp Mol Med. 2011 Dec 31;43(12):676-83. PMID: 21975281.

" Not dangerous goods.

LKT F1670 Ferulic Acid Methyl Ester 5 g 160.2 Hydroxycinnamic aicd, verbascoside metabolite, ion chelator. 2309-07-1 ≥98% 208.21 C11H12O4 COC1=C(C=CC(=C1)C=CC(=O)OC)O Ambient Ambient "Quirantes-Piné R, Herranz-López M, Funes L, et al. Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine. 2013 Sep 15;20(12):1112-8. PMID: 23827667.

Xu Y, Zhang L, Shao T, et al. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis. 2013 Dec;28(4):571-83. PMID: 23584961.

Picone P, Nuzzo D, Di Carlo M. Ferulic acid: a natural antioxidant against oxidative stress induced by oligomeric A-beta on sea urchin embryo. Biol Bull. 2013 Feb;224(1):18-28. PMID: 23493505.

Lin TY, Lu CW, Huang SK, et al. Ferulic acid suppresses glutamate release through inhibition of voltage-dependent calcium entry in rat cerebrocortical nerve terminals. J Med Food. 2013 Feb;16(2):112-9. PMID: 23342970.

Choi R, Kim BH, Naowaboot J, et al. Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Exp Mol Med. 2011 Dec 31;43(12):676-83. PMID: 21975281.

" Not dangerous goods.

LKT F1670 Ferulic Acid Methyl Ester 25 g 618.9 Hydroxycinnamic aicd, verbascoside metabolite, ion chelator. 2309-07-1 ≥98% 208.21 C11H12O4 COC1=C(C=CC(=C1)C=CC(=O)OC)O Ambient Ambient "Quirantes-Piné R, Herranz-López M, Funes L, et al. Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine. 2013 Sep 15;20(12):1112-8. PMID: 23827667.

Xu Y, Zhang L, Shao T, et al. Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis. 2013 Dec;28(4):571-83. PMID: 23584961.

Picone P, Nuzzo D, Di Carlo M. Ferulic acid: a natural antioxidant against oxidative stress induced by oligomeric A-beta on sea urchin embryo. Biol Bull. 2013 Feb;224(1):18-28. PMID: 23493505.

Lin TY, Lu CW, Huang SK, et al. Ferulic acid suppresses glutamate release through inhibition of voltage-dependent calcium entry in rat cerebrocortical nerve terminals. J Med Food. 2013 Feb;16(2):112-9. PMID: 23342970.

Choi R, Kim BH, Naowaboot J, et al. Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Exp Mol Med. 2011 Dec 31;43(12):676-83. PMID: 21975281.

" Not dangerous goods.

LKT D8014 DU-14 25 mg 314 Steroid sulfatase inhibitor. (p-Oulfamoyl)-N-tetradecanoyl tyramine 186303-55-9 ≥98% 426.6 C22H38N2O4S CCCCCCCCCCCCCC(=O)NCCC1=CC=C(C=C1)OS(=O)(=O)N Ambient 4°C DMSO (25mg/ml) "Babalola PA, Fitz NF, Gibbs RB, et al. The effect of the steroid sulfatase inhibitor (p-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract. Neurobiol Learn Mem. 2012 Oct;98(3):303-10. PMID: 23022361.

Johnson DA, Wu T, Li P, et al. The effect of steroid sulfatase inhibition on learning and spatial memory. Brain Res. 2000 May 26;865(2):286-90. PMID: 10821934.

Johnson DA, Rhodes ME, Boni RL, et al. Chronic steroid sulfatase inhibition by (O-sulfamoyl)-N-tetradecanoyl tyramine increases dehydroepiandrosterone sulfate in whole brain. Life Sci. 1997;61(24):PL 355-9. PMID: 9399636.

" Not dangerous goods.

LKT B1992 Bexarotene 25 mg 47.6 RXR agonist. Targretin, Targretyn, LGD-1069 153559-49-0 ≥98% 348.48 C24H28O2 CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C Ambient -20°C Practically insoluble in water.  Soluble in DMSO (≥60 mg/ml). "McFarland K, Spalding TA, Hubbard D, et al. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease. ACS Chem Neurosci. 2013 Oct 11. [Epub ahead of print]. PMID: 24117438.

Schadt CR. Topical and oral bexarotene. Dermatol Ther. 2013 Sep;26(5):400-3. PMID: 24099070.

Aicardi G. New Hope from an Old Drug: Fighting Alzheimer's Disease with the Cancer Drug Bexarotene (Targretin)? Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]. PMID: 24047423.

Quéreux G, Saint-Jean M, Peuvrel L, et al. Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature. Expert Opin Pharmacother. 2013 Sep;14(13):1711-21. 10. PMID: 23837676.

Mukherjee R, Strasser J, Jow L, et al. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):272-6. PMID: 9484993.

" Not dangerous goods.

LKT B1992 Bexarotene 100 mg 101.9 RXR agonist. Targretin, Targretyn, LGD-1069 153559-49-0 ≥98% 348.48 C24H28O2 CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C Ambient -20°C Practically insoluble in water.  Soluble in DMSO (≥60 mg/ml). "McFarland K, Spalding TA, Hubbard D, et al. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease. ACS Chem Neurosci. 2013 Oct 11. [Epub ahead of print]. PMID: 24117438.

Schadt CR. Topical and oral bexarotene. Dermatol Ther. 2013 Sep;26(5):400-3. PMID: 24099070.

Aicardi G. New Hope from an Old Drug: Fighting Alzheimer's Disease with the Cancer Drug Bexarotene (Targretin)? Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]. PMID: 24047423.

Quéreux G, Saint-Jean M, Peuvrel L, et al. Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature. Expert Opin Pharmacother. 2013 Sep;14(13):1711-21. 10. PMID: 23837676.

Mukherjee R, Strasser J, Jow L, et al. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):272-6. PMID: 9484993.

" Not dangerous goods.

LKT B1992 Bexarotene 250 mg 217.4 RXR agonist. Targretin, Targretyn, LGD-1069 153559-49-0 ≥98% 348.48 C24H28O2 CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C Ambient -20°C Practically insoluble in water.  Soluble in DMSO (≥60 mg/ml). "McFarland K, Spalding TA, Hubbard D, et al. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease. ACS Chem Neurosci. 2013 Oct 11. [Epub ahead of print]. PMID: 24117438.

Schadt CR. Topical and oral bexarotene. Dermatol Ther. 2013 Sep;26(5):400-3. PMID: 24099070.

Aicardi G. New Hope from an Old Drug: Fighting Alzheimer's Disease with the Cancer Drug Bexarotene (Targretin)? Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]. PMID: 24047423.

Quéreux G, Saint-Jean M, Peuvrel L, et al. Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature. Expert Opin Pharmacother. 2013 Sep;14(13):1711-21. 10. PMID: 23837676.

Mukherjee R, Strasser J, Jow L, et al. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):272-6. PMID: 9484993.

" Not dangerous goods.

LKT D3215 Didymin 1 mg 129 Flavonoid glycoside found in citrus fruit. (S)-5,7-Dihydroxy-4′-methoxyflavanone-7-β-rutinoside Isosakuranetin 14259-47-3 ≥98% 594.56 C28H34O14 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O Ambient Ambient MeOH "Singhal J, Nagaprashantha LD, Vatsyayan R, et al. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. PMID: 22174364.

Hung JY, Hsu YL, Ko YC, et al. Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer. 2010 Jun;68(3):366-74. PMID: 19733932.

" Not dangerous goods.

LKT D3215 Didymin 5 mg 509.7 Flavonoid glycoside found in citrus fruit. (S)-5,7-Dihydroxy-4′-methoxyflavanone-7-β-rutinoside Isosakuranetin 14259-47-3 ≥98% 594.56 C28H34O14 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O Ambient Ambient MeOH "Singhal J, Nagaprashantha LD, Vatsyayan R, et al. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. PMID: 22174364.

Hung JY, Hsu YL, Ko YC, et al. Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer. 2010 Jun;68(3):366-74. PMID: 19733932.

" Not dangerous goods.

LKT D3215 Didymin 10 mg 758.4 Flavonoid glycoside found in citrus fruit. (S)-5,7-Dihydroxy-4′-methoxyflavanone-7-β-rutinoside Isosakuranetin 14259-47-3 ≥98% 594.56 C28H34O14 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O Ambient Ambient MeOH "Singhal J, Nagaprashantha LD, Vatsyayan R, et al. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. PMID: 22174364.

Hung JY, Hsu YL, Ko YC, et al. Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer. 2010 Jun;68(3):366-74. PMID: 19733932.

" Not dangerous goods.

LKT B3211 (+)-Bicuculline 25 mg 54.4 NMDA potentiator, GABA-A antagonist. 485-49-4 ≥98% 367.35 C20H17NO6 CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 Ambient Ambient "Dela Peña IJ, Lee HL, Yoon SY, et al. The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABA(A) receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice. Drug Discov Ther. 2013 Feb;7(1):18-23. PMID: 23524939.

Torkaman-Boutorabi A, Soltani S, Oryan S, et al. Involvement of the dorsal hippocampal GABA-A receptors in histamine-induced facilitation of memory in the Morris water maze. Pharmacol Biochem Behav. 2013 Apr;105:142-50. PMID: 23438692.

Ionov ID, Roslavtseva LA. Coadministration of bicuculline and NMDA induces paraplegia in the rat. Brain Res. 2012 Apr 27;1451:27-33. PMID: 22445063

Ji G, Neugebauer V. Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol. 2011 Nov;106(5):2642-52. PMID: 21880942.

Costa LG, Doctor SV, Murphy SD. Antinociceptive and hypothermic effects of trimethyltin. Life Sci. 1982 Sep 13;31(11):1093-102. PMID: 6890611.

Heyer EJ, Nowak LM, Macdonald RL. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. PMID: 7055710.

" T, N "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. ((+)-Bicuculline)"

LKT B3211 (+)-Bicuculline 100 mg 101.9 NMDA potentiator, GABA-A antagonist. 485-49-4 ≥98% 367.35 C20H17NO6 CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 Ambient Ambient "Dela Peña IJ, Lee HL, Yoon SY, et al. The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABA(A) receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice. Drug Discov Ther. 2013 Feb;7(1):18-23. PMID: 23524939.

Torkaman-Boutorabi A, Soltani S, Oryan S, et al. Involvement of the dorsal hippocampal GABA-A receptors in histamine-induced facilitation of memory in the Morris water maze. Pharmacol Biochem Behav. 2013 Apr;105:142-50. PMID: 23438692.

Ionov ID, Roslavtseva LA. Coadministration of bicuculline and NMDA induces paraplegia in the rat. Brain Res. 2012 Apr 27;1451:27-33. PMID: 22445063

Ji G, Neugebauer V. Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol. 2011 Nov;106(5):2642-52. PMID: 21880942.

Costa LG, Doctor SV, Murphy SD. Antinociceptive and hypothermic effects of trimethyltin. Life Sci. 1982 Sep 13;31(11):1093-102. PMID: 6890611.

Heyer EJ, Nowak LM, Macdonald RL. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. PMID: 7055710.

" T, N "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. ((+)-Bicuculline)"

LKT B3211 (+)-Bicuculline 500 mg 373.7 NMDA potentiator, GABA-A antagonist. 485-49-4 ≥98% 367.35 C20H17NO6 CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 Ambient Ambient "Dela Peña IJ, Lee HL, Yoon SY, et al. The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABA(A) receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice. Drug Discov Ther. 2013 Feb;7(1):18-23. PMID: 23524939.

Torkaman-Boutorabi A, Soltani S, Oryan S, et al. Involvement of the dorsal hippocampal GABA-A receptors in histamine-induced facilitation of memory in the Morris water maze. Pharmacol Biochem Behav. 2013 Apr;105:142-50. PMID: 23438692.

Ionov ID, Roslavtseva LA. Coadministration of bicuculline and NMDA induces paraplegia in the rat. Brain Res. 2012 Apr 27;1451:27-33. PMID: 22445063

Ji G, Neugebauer V. Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol. 2011 Nov;106(5):2642-52. PMID: 21880942.

Costa LG, Doctor SV, Murphy SD. Antinociceptive and hypothermic effects of trimethyltin. Life Sci. 1982 Sep 13;31(11):1093-102. PMID: 6890611.

Heyer EJ, Nowak LM, Macdonald RL. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. PMID: 7055710.

" T, N "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. ((+)-Bicuculline)"

LKT M1769 Meropenem Trihydrate 10 mg 54.4 β-lactam carbapenem; penicillin binding protein inhibitor. 119478-56-7 ≥98% 437.51 C17H25N3O5S 3H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O Ambient Ambient "Mallick M, Odedra D, Vidyarthi AS, et al. Meropenem: a potent drug against superbug as unveiled through bioinformatics approaches. Int J Bioinform Res Appl. 2013;9(2):109-20. PMID: 23467058.

Pernot L, Frénois F, Rybkine T, et al. Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem. J Mol Biol. 2001 Jul 20;310(4):859-74. PMID: 11453693.

Sumita Y, Fukasawa M. Potent activity of meropenem against Escherichia coli arising from its simultaneous binding to penicillin-binding proteins 2 and 3. J Antimicrob Chemother. 1995 Jul;36(1):53-64. PMID: 8537284.

" Xi Not dangerous goods.

LKT M1769 Meropenem Trihydrate 50 mg 224.3 β-lactam carbapenem; penicillin binding protein inhibitor. 119478-56-7 ≥98% 437.51 C17H25N3O5S 3H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O Ambient Ambient "Mallick M, Odedra D, Vidyarthi AS, et al. Meropenem: a potent drug against superbug as unveiled through bioinformatics approaches. Int J Bioinform Res Appl. 2013;9(2):109-20. PMID: 23467058.

Pernot L, Frénois F, Rybkine T, et al. Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem. J Mol Biol. 2001 Jul 20;310(4):859-74. PMID: 11453693.

Sumita Y, Fukasawa M. Potent activity of meropenem against Escherichia coli arising from its simultaneous binding to penicillin-binding proteins 2 and 3. J Antimicrob Chemother. 1995 Jul;36(1):53-64. PMID: 8537284.

" Xi Not dangerous goods.

LKT M1769 Meropenem Trihydrate 100 mg 271.7 β-lactam carbapenem; penicillin binding protein inhibitor. 119478-56-7 ≥98% 437.51 C17H25N3O5S 3H2O CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O Ambient Ambient "Mallick M, Odedra D, Vidyarthi AS, et al. Meropenem: a potent drug against superbug as unveiled through bioinformatics approaches. Int J Bioinform Res Appl. 2013;9(2):109-20. PMID: 23467058.

Pernot L, Frénois F, Rybkine T, et al. Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem. J Mol Biol. 2001 Jul 20;310(4):859-74. PMID: 11453693.

Sumita Y, Fukasawa M. Potent activity of meropenem against Escherichia coli arising from its simultaneous binding to penicillin-binding proteins 2 and 3. J Antimicrob Chemother. 1995 Jul;36(1):53-64. PMID: 8537284.

" Xi Not dangerous goods.

LKT V3213 Vidarabine Monophosphate 100 mg 81.6 Nucleoside (adenosine) analog found in Tethyra crypta; viral DNA polymerase inhibitor, potential ribonucleotide reductase inhibitor. 29984-33-6 ≥98.0% 347.22 C10H14N5O7P C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O Ambient Ambient "Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

" Not dangerous goods.

LKT V3213 Vidarabine Monophosphate 500 mg 203.8 Nucleoside (adenosine) analog found in Tethyra crypta; viral DNA polymerase inhibitor, potential ribonucleotide reductase inhibitor. 29984-33-6 ≥98.0% 347.22 C10H14N5O7P C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O Ambient Ambient "Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

" Not dangerous goods.

LKT V3213 Vidarabine Monophosphate 1 g 305.9 Nucleoside (adenosine) analog found in Tethyra crypta; viral DNA polymerase inhibitor, potential ribonucleotide reductase inhibitor. 29984-33-6 ≥98.0% 347.22 C10H14N5O7P C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O Ambient Ambient "Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

" Not dangerous goods.

LKT P5747 Polymyxin B sulfate 250 mg 47.6 Cationic lipid polypeptide, mixture of polymyxin B1, B2, B3 and B1-1 sulfates; oxidative phosphorylation inhibitor. ≥6500 iu/mg "

" 1405-20-5 ≥6500 iu/mg C56H100N16O17S CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O Ambient Ambient "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2013 Oct 30. [Epub ahead of print]. PMID: 24169795.

Zhai B, Lin X. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. PMID: 23313397

Domingues MM, Inácio RG, Raimundo JM, et al. Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. Biopolymers. 2012;98(4):338-44. PMID: 23193598.

Martin EL, Ranieri VM. Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors. Contrib Nephrol. 2010;167:65-76. PMID: 20519900.

" Xn Not dangerous goods.

LKT P5747 Polymyxin B sulfate 1 g 111.7 Cationic lipid polypeptide, mixture of polymyxin B1, B2, B3 and B1-1 sulfates; oxidative phosphorylation inhibitor. ≥6500 iu/mg "

" 1405-20-5 ≥6500 iu/mg C56H100N16O17S CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O Ambient Ambient "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2013 Oct 30. [Epub ahead of print]. PMID: 24169795.

Zhai B, Lin X. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. PMID: 23313397

Domingues MM, Inácio RG, Raimundo JM, et al. Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. Biopolymers. 2012;98(4):338-44. PMID: 23193598.

Martin EL, Ranieri VM. Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors. Contrib Nephrol. 2010;167:65-76. PMID: 20519900.

" Xn Not dangerous goods.

LKT P5747 Polymyxin B sulfate 5 g 485.3 Cationic lipid polypeptide, mixture of polymyxin B1, B2, B3 and B1-1 sulfates; oxidative phosphorylation inhibitor. ≥6500 iu/mg "

" 1405-20-5 ≥6500 iu/mg C56H100N16O17S CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O Ambient Ambient "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2013 Oct 30. [Epub ahead of print]. PMID: 24169795.

Zhai B, Lin X. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. PMID: 23313397

Domingues MM, Inácio RG, Raimundo JM, et al. Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. Biopolymers. 2012;98(4):338-44. PMID: 23193598.

Martin EL, Ranieri VM. Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors. Contrib Nephrol. 2010;167:65-76. PMID: 20519900.

" Xn Not dangerous goods.

LKT A1217 Adefovir 10 mg 47.6 Acyclic nucleotide (adenosine) analog; viral DNA polymerase inhibitor, DNA chain terminator. 106941-25-7 ≥98% 273.19 C8H12N5O4P C1=NC2=C(C(=N1)N)N=CN2CCOCP(=O)(O)O Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" T Not dangerous goods.

LKT A1217 Adefovir 50 mg 169.9 Acyclic nucleotide (adenosine) analog; viral DNA polymerase inhibitor, DNA chain terminator. 106941-25-7 ≥98% 273.19 C8H12N5O4P C1=NC2=C(C(=N1)N)N=CN2CCOCP(=O)(O)O Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" T Not dangerous goods.

LKT A1217 Adefovir 250 mg 475.7 Acyclic nucleotide (adenosine) analog; viral DNA polymerase inhibitor, DNA chain terminator. 106941-25-7 ≥98% 273.19 C8H12N5O4P C1=NC2=C(C(=N1)N)N=CN2CCOCP(=O)(O)O Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" T Not dangerous goods.

LKT A1218 Adefovir Dipivoxil 10 mg 47.6 Acyclic nucleotide (adenosine) analog, adefovir prodrug; viral DNA polymerase inhibitor, DNA chain terminator. 142340-99-6 ≥98% 501.47 C20H32N5O8P CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" Xn Not dangerous goods.

LKT A1218 Adefovir Dipivoxil 50 mg 136 Acyclic nucleotide (adenosine) analog, adefovir prodrug; viral DNA polymerase inhibitor, DNA chain terminator. 142340-99-6 ≥98% 501.47 C20H32N5O8P CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" Xn Not dangerous goods.

LKT A1218 Adefovir Dipivoxil 250 mg 407.7 Acyclic nucleotide (adenosine) analog, adefovir prodrug; viral DNA polymerase inhibitor, DNA chain terminator. 142340-99-6 ≥98% 501.47 C20H32N5O8P CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C Ambient Ambient "Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

" Xn Not dangerous goods.

LKT B0246 Balofloxacin Dihydrate 10 mg 61.1 Fluoroquinolone; bacterial DNA gyrase inhibitor. 151060-21-8 ≥98% 425.45 C20H24FN3O4 2H2O CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.O.O Ambient Ambient "Iwasaki H, Miyazaki S, Tsuji A, et al. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy. 1995 Mar-Apr;41(2):100-12. PMID: 7758353.

Ito T, Kojima K, Koizumi K, et al. Inhibitory activity on DNA gyrase and intracellular accumulation of quinolones: structure-activity relationship of Q-35 analogs. Biol Pharm Bull. 1994 Jul;17(7):927-30. PMID: 8000379.

Gohara Y, Arai S, Akashi A, et al. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae. Antimicrob Agents Chemother. 1993 Sep;37(9):1826-30. PMID: 8239590.

Ito T, Otsuki M, Nishino T. In vitro antibacterial activity of Q-35, a new fluoroquinolone. Antimicrob Agents Chemother. 1992 Aug;36(8):1708-14. PMID: 1329626.

" Not dangerous goods.

LKT B0246 Balofloxacin Dihydrate 50 mg 169.9 Fluoroquinolone; bacterial DNA gyrase inhibitor. 151060-21-8 ≥98% 425.45 C20H24FN3O4 2H2O CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.O.O Ambient Ambient "Iwasaki H, Miyazaki S, Tsuji A, et al. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy. 1995 Mar-Apr;41(2):100-12. PMID: 7758353.

Ito T, Kojima K, Koizumi K, et al. Inhibitory activity on DNA gyrase and intracellular accumulation of quinolones: structure-activity relationship of Q-35 analogs. Biol Pharm Bull. 1994 Jul;17(7):927-30. PMID: 8000379.

Gohara Y, Arai S, Akashi A, et al. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae. Antimicrob Agents Chemother. 1993 Sep;37(9):1826-30. PMID: 8239590.

Ito T, Otsuki M, Nishino T. In vitro antibacterial activity of Q-35, a new fluoroquinolone. Antimicrob Agents Chemother. 1992 Aug;36(8):1708-14. PMID: 1329626.

" Not dangerous goods.

LKT B0246 Balofloxacin Dihydrate 250 mg 475.7 Fluoroquinolone; bacterial DNA gyrase inhibitor. 151060-21-8 ≥98% 425.45 C20H24FN3O4 2H2O CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.O.O Ambient Ambient "Iwasaki H, Miyazaki S, Tsuji A, et al. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy. 1995 Mar-Apr;41(2):100-12. PMID: 7758353.

Ito T, Kojima K, Koizumi K, et al. Inhibitory activity on DNA gyrase and intracellular accumulation of quinolones: structure-activity relationship of Q-35 analogs. Biol Pharm Bull. 1994 Jul;17(7):927-30. PMID: 8000379.

Gohara Y, Arai S, Akashi A, et al. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae. Antimicrob Agents Chemother. 1993 Sep;37(9):1826-30. PMID: 8239590.

Ito T, Otsuki M, Nishino T. In vitro antibacterial activity of Q-35, a new fluoroquinolone. Antimicrob Agents Chemother. 1992 Aug;36(8):1708-14. PMID: 1329626.

" Not dangerous goods.

LKT M1669 6-Mercaptopurine Monohydrate 1 g 52.8 Thiopurine antimetabolite; PRPP amidotransferase inhibitor. 1,7-Dihydro-6H-pyrine-6-thione Purine-6-thiol; 6MP; Leukerin Mercaleukin; Purinethol: 6-Purinethiol 6112-76-1 ≥98% 170.2 C5H4N4S H2O C1=NC2=C(N1)C(=S)N=CN2.O Ambient Ambient Insoluble in water.  Soluble in Methanol and hot ethanol. "Bradford K, Shih DQ. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World J Gastroenterol. 2011 Oct 7;17(37):4166-73. PMID: 22072847.

Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther. 2001 Nov;15(11):1699-708. PMID: 11683683.

Lennard L, Welch JC, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol. 1997 Nov;44(5):455-61. PMID: 9384462.

" Xn Not dangerous goods.

LKT V1868 Veratramine 25 mg 136 Steroidal alkaloid found in Veratrum and Fritillaria; hedgehog signaling pathway inhibitor. 60-70-8 ≥98% 409.6 C27H39NO2 CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O Ambient -20°C Soluble in Ethanol and Methanol "Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.

Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.

Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.

" "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Veratramine)"

LKT V1868 Veratramine 100 mg 360 Steroidal alkaloid found in Veratrum and Fritillaria; hedgehog signaling pathway inhibitor. 60-70-8 ≥98% 409.6 C27H39NO2 CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O Ambient -20°C Soluble in Ethanol and Methanol "Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.

Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.

Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.

" "UN number: 1544     Class: 6.1     Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Veratramine)"

LKT B0025 Bafilomycin A1 1 mg 266.9 Macrolide antibiotic; vacuolar H+ ATPase inhibitor. 88899-55-2 ≥90% 622.83 C35H58O9 CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C Light sensitive Ambient -20°C Soluble in DMSO, ethanol and methanol. "Graham RM, Thompson JW, Webster KA. Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. Oncotarget. 2014 Mar 15;5(5):1162-73. PMID: 24811485.

Xu MY, Lee SY, Kang SS, et al. Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy. J Nat Prod. 2014 Feb 28;77(2):370-6. PMID: 24547878.

van Schalkwyk DA, Chan XW, Misiano P, et al. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol. 2010 May 1;79(9):1291-9. PMID: 20067768.

" Xi Not dangerous goods.

LKT E6256 Epothilone A 1 mg 61.1 Microtubule depolymerization inhibitor. 152044-53-6 ≥95% 493.66 C26H39NO6S CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C Ambient -20°C Soluble in DMSO (≥99mg/mL) and Ethanol (≥99mg/mL).  Practically insoluble in Water (<1mg/mL).    "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Rusinska-Roszak D, Tatka H, Pawlak R, et al. Extended and clustered conformers of epothilone A. J Phys Chem B. 2011 Apr 7;115(13):3698-707. PMID: 21405036.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6256 Epothilone A 5 mg 108.8 Microtubule depolymerization inhibitor. 152044-53-6 ≥95% 493.66 C26H39NO6S CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C Ambient -20°C Soluble in DMSO (≥99mg/mL) and Ethanol (≥99mg/mL).  Practically insoluble in Water (<1mg/mL).    "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Rusinska-Roszak D, Tatka H, Pawlak R, et al. Extended and clustered conformers of epothilone A. J Phys Chem B. 2011 Apr 7;115(13):3698-707. PMID: 21405036.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6256 Epothilone A 10 mg 190.3 Microtubule depolymerization inhibitor. 152044-53-6 ≥95% 493.66 C26H39NO6S CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C Ambient -20°C Soluble in DMSO (≥99mg/mL) and Ethanol (≥99mg/mL).  Practically insoluble in Water (<1mg/mL).    "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Rusinska-Roszak D, Tatka H, Pawlak R, et al. Extended and clustered conformers of epothilone A. J Phys Chem B. 2011 Apr 7;115(13):3698-707. PMID: 21405036.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6256 Epothilone A 25 mg 400.9 Microtubule depolymerization inhibitor. 152044-53-6 ≥95% 493.66 C26H39NO6S CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C Ambient -20°C Soluble in DMSO (≥99mg/mL) and Ethanol (≥99mg/mL).  Practically insoluble in Water (<1mg/mL).    "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Rusinska-Roszak D, Tatka H, Pawlak R, et al. Extended and clustered conformers of epothilone A. J Phys Chem B. 2011 Apr 7;115(13):3698-707. PMID: 21405036.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6257 Epothilone B 1 mg 74.8 Microtubule depolymerization inhibitor. 152044-54-7 ≥98% 507.68 C27H41NO6S CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C Ambient -20°C Soluble in DMSO (≥102mg/mL) and     Ethanol (≥102mg/mL). Practically insoluble in Water (<1mg/mL).  "Ruschel J, Hellal F, Flynn KC, et al. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Mar 12. [Epub ahead of print]. PMID: 25765066.

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Pagano A, Honoré S, Mohan R, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. PMID: 22634050.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Khrapunovich-Baine M, Menon V, Yang CP, et al. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem. 2011 Apr 1;286(13):11765-78. PMID: 21245138.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6257 Epothilone B 5 mg 163.2 Microtubule depolymerization inhibitor. 152044-54-7 ≥98% 507.68 C27H41NO6S CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C Ambient -20°C Soluble in DMSO (≥102mg/mL) and     Ethanol (≥102mg/mL). Practically insoluble in Water (<1mg/mL).  "Ruschel J, Hellal F, Flynn KC, et al. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Mar 12. [Epub ahead of print]. PMID: 25765066.

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Pagano A, Honoré S, Mohan R, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. PMID: 22634050.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Khrapunovich-Baine M, Menon V, Yang CP, et al. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem. 2011 Apr 1;286(13):11765-78. PMID: 21245138.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6257 Epothilone B 10 mg 285.4 Microtubule depolymerization inhibitor. 152044-54-7 ≥98% 507.68 C27H41NO6S CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C Ambient -20°C Soluble in DMSO (≥102mg/mL) and     Ethanol (≥102mg/mL). Practically insoluble in Water (<1mg/mL).  "Ruschel J, Hellal F, Flynn KC, et al. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Mar 12. [Epub ahead of print]. PMID: 25765066.

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Pagano A, Honoré S, Mohan R, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. PMID: 22634050.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Khrapunovich-Baine M, Menon V, Yang CP, et al. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem. 2011 Apr 1;286(13):11765-78. PMID: 21245138.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6257 Epothilone B 25 mg 611.5 Microtubule depolymerization inhibitor. 152044-54-7 ≥98% 507.68 C27H41NO6S CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C Ambient -20°C Soluble in DMSO (≥102mg/mL) and     Ethanol (≥102mg/mL). Practically insoluble in Water (<1mg/mL).  "Ruschel J, Hellal F, Flynn KC, et al. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Mar 12. [Epub ahead of print]. PMID: 25765066.

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Pagano A, Honoré S, Mohan R, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43. PMID: 22634050.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Khrapunovich-Baine M, Menon V, Yang CP, et al. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem. 2011 Apr 1;286(13):11765-78. PMID: 21245138.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6356 Epothilone D 1 mg 74.8 Microtubule depolymerization inhibitor. 189453-10-9 ≥98% 491.68 C27H41NO5S CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C Ambient -20°C "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6356 Epothilone D 5 mg 163.2 Microtubule depolymerization inhibitor. 189453-10-9 ≥98% 491.68 C27H41NO5S CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C Ambient -20°C "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6356 Epothilone D 10 mg 285.4 Microtubule depolymerization inhibitor. 189453-10-9 ≥98% 491.68 C27H41NO5S CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C Ambient -20°C "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT E6356 Epothilone D 25 mg 611.5 Microtubule depolymerization inhibitor. 189453-10-9 ≥98% 491.68 C27H41NO5S CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C Ambient -20°C "Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

" Not dangerous goods.

LKT AM104 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM105 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM106 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM107 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM108 Antimicrobial 1 kit 302 Dry Ice -80°C

LKT AM109 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM110 Antimicrobial 1 kit 312.4 Dry Ice -80°C

LKT AM111 Antimicrobial 1 kit 255 Dry Ice -80°C

LKT AM112 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT TT100 Taxanes 1 kit 239.3 Dry Ice -80°C

LKT TT101 Taxanes 1 kit 239.3 Dry Ice -80°C

LKT CF100 Coffee Compounds 1 kit 148.4 Dry Ice -80°C

LKT CF101 Coffee Compounds 1 kit 148.4 Dry Ice -80°C

LKT CL100 Cyclovirs 1 kit 145.1 Dry Ice -80°C

LKT AM100 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM101 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM102 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM103 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM113 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM114 Antimicrobial 1 kit 1422.4 Dry Ice -80°C

LKT AM115 Antimicrobial 1 kit 266.3 Dry Ice -80°C

LKT AM116 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM117 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM118 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AM119 Antimicrobial 1 kit 208.1 Dry Ice -80°C

LKT AN100 Antineoplastics 1 kit 208.1 Dry Ice -80°C

LKT AN101 Antineoplastics 1 kit 1457.2 Dry Ice -80°C

LKT AN102 Antineoplastics 1 kit 208.1 Dry Ice -80°C

LKT AN103 Antineoplastics 1 kit 324.3 Dry Ice -80°C

LKT AN104 Antineoplastics 1 kit 346.9 Dry Ice -80°C

LKT AN105 Antineoplastics 1 kit 266.3 Dry Ice -80°C

LKT AN106 Antineoplastics 1 kit 208.1 Dry Ice -80°C

LKT AN107 Antineoplastics 1 kit 266.3 Dry Ice -80°C

LKT AN108 Antineoplastics 1 kit 232.5 Dry Ice -80°C

LKT AN109 Antineoplastics 1 kit 197 Dry Ice -80°C

LKT AN110 Antineoplastics 1 kit 255 Dry Ice -80°C

LKT AN111 Antineoplastics 1 kit 266.3 Dry Ice -80°C

LKT AN112 Antineoplastics 1 kit 221.2 Dry Ice -80°C

LKT AN113 Antineoplastics 1 kit 485.7 Dry Ice -80°C

LKT AN114 Antineoplastics 1 kit 371.3 Dry Ice -80°C

LKT AN115 Antineoplastics 1 kit 277.6 Dry Ice -80°C

LKT AN116 Antineoplastics 1 kit 555 Dry Ice -80°C

LKT AN117 Antineoplastics 1 kit 208.1 Dry Ice -80°C

LKT TT102 Taxanes 1 kit 422.8 Dry Ice -80°C

LKT XX100 Non-Categorized 1 kit 247.6 Dry Ice -80°C

LKT XX101 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX102 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX103 Non-Categorized 1 kit 216.6 Dry Ice -80°C

LKT XX104 Non-Categorized 1 kit 175.4 Dry Ice -80°C

LKT XX105 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX106 Non-Categorized 1 kit 175.4 Dry Ice -80°C

LKT XX107 Non-Categorized 1 kit 195.9 Dry Ice -80°C

LKT XX108 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX109 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX110 Non-Categorized 1 kit 216.6 Dry Ice -80°C

LKT XX111 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX112 Non-Categorized 1 kit 175.4 Dry Ice -80°C

LKT XX113 Non-Categorized 1 kit 175.4 Dry Ice -80°C

LKT XX114 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT XX115 Non-Categorized 1 kit 165.1 Dry Ice -80°C

LKT A0534 Abiraterone 5 mg 136 Progesterone derivative; Cyp17A1 inhibitor. 154229-19-3 ≥98% 349.51 C24H31NO CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O Ambient Ambient MeOH "Ryan CJ, Cheng ML. Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. PMID: 23199349.

Rehman Y, Rosenberg JE. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. Drug Des Devel Ther. 2012;6:13-8. PMID: 22291466.

Soifer HS, Souleimanian N, Wu S, et al. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem. 2012 Feb 3;287(6):3777-87. PMID: 22174412.

" Not dangerous goods.

LKT A0534 Abiraterone 25 mg 543.6 Progesterone derivative; Cyp17A1 inhibitor. 154229-19-3 ≥98% 349.51 C24H31NO CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O Ambient Ambient MeOH "Ryan CJ, Cheng ML. Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. PMID: 23199349.

Rehman Y, Rosenberg JE. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. Drug Des Devel Ther. 2012;6:13-8. PMID: 22291466.

Soifer HS, Souleimanian N, Wu S, et al. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem. 2012 Feb 3;287(6):3777-87. PMID: 22174412.

" Not dangerous goods.

LKT A0534 Abiraterone 100 mg 1630.8 Progesterone derivative; Cyp17A1 inhibitor. 154229-19-3 ≥98% 349.51 C24H31NO CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O Ambient Ambient MeOH "Ryan CJ, Cheng ML. Abiraterone acetate for the treatment of prostate cancer. Expert Opin Pharmacother. 2013 Jan;14(1):91-6. PMID: 23199349.

Rehman Y, Rosenberg JE. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. Drug Des Devel Ther. 2012;6:13-8. PMID: 22291466.

Soifer HS, Souleimanian N, Wu S, et al. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem. 2012 Feb 3;287(6):3777-87. PMID: 22174412.

" Not dangerous goods.

LKT I0902 Icaritin 1 mg 46.1 Flavonoid found in Epimedium. 118525-40-9 ≥98% 368.38 C21H20O6 CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)OC)O)O)C Ambient 4°C MeOH "Wu X, Wu J, Xia S, et al. Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. Behav Brain Res. 2013 Sep 21;256C:602-608. PMID: 24064280.

Sheng H, Rui XF, Sheng CJ, et al. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013 Apr 23;10(6):782-9. PMID: 23630444.

Lai X, Ye Y, Sun C, et al. Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model. Int Immunopharmacol. 2013 May;16(1):41-9. PMID: 23566810.

Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013 May;97(5):617-23. PMID: 23550021.

" Not dangerous goods.

LKT I0902 Icaritin 5 mg 103.1 Flavonoid found in Epimedium. 118525-40-9 ≥98% 368.38 C21H20O6 CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)OC)O)O)C Ambient 4°C MeOH "Wu X, Wu J, Xia S, et al. Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. Behav Brain Res. 2013 Sep 21;256C:602-608. PMID: 24064280.

Sheng H, Rui XF, Sheng CJ, et al. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013 Apr 23;10(6):782-9. PMID: 23630444.

Lai X, Ye Y, Sun C, et al. Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model. Int Immunopharmacol. 2013 May;16(1):41-9. PMID: 23566810.

Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013 May;97(5):617-23. PMID: 23550021.

" Not dangerous goods.

LKT I0902 Icaritin 25 mg 398 Flavonoid found in Epimedium. 118525-40-9 ≥98% 368.38 C21H20O6 CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)OC)O)O)C Ambient 4°C MeOH "Wu X, Wu J, Xia S, et al. Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. Behav Brain Res. 2013 Sep 21;256C:602-608. PMID: 24064280.

Sheng H, Rui XF, Sheng CJ, et al. A novel semisynthetic molecule icaritin stimulates osteogenic differentiation and inhibits adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013 Apr 23;10(6):782-9. PMID: 23630444.

Lai X, Ye Y, Sun C, et al. Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model. Int Immunopharmacol. 2013 May;16(1):41-9. PMID: 23566810.

Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol. 2013 May;97(5):617-23. PMID: 23550021.

" Not dangerous goods.

LKT H9726 Hygromycin B 50 mg 47.6 Protein translocation inhibitor. 31282-04-9 ≥98.0% 527.52 C20H37N3O13 CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N Ambient Ambient "Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

" T+ "UN number: 3462     Class:  6.1     Packing group:  I

Proper shipping name:  Toxins, extracted from living sources, solid, n.o.s. (Hygromycin B).  Marine pollutant:  No.

Reportable Quantity (RQ).  Poison inhalation hazard:  No.

"

LKT H9726 Hygromycin B 100 mg 74.8 Protein translocation inhibitor. 31282-04-9 ≥98.0% 527.52 C20H37N3O13 CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N Ambient Ambient "Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

" T+ "UN number: 3462     Class:  6.1     Packing group:  I

Proper shipping name:  Toxins, extracted from living sources, solid, n.o.s. (Hygromycin B).  Marine pollutant:  No.

Reportable Quantity (RQ).  Poison inhalation hazard:  No.

"

LKT H9726 Hygromycin B 250 mg 136 Protein translocation inhibitor. 31282-04-9 ≥98.0% 527.52 C20H37N3O13 CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N Ambient Ambient "Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

" T+ "UN number: 3462     Class:  6.1     Packing group:  I

Proper shipping name:  Toxins, extracted from living sources, solid, n.o.s. (Hygromycin B).  Marine pollutant:  No.

Reportable Quantity (RQ).  Poison inhalation hazard:  No.

"

LKT H9726 Hygromycin B 1 g 380.5 Protein translocation inhibitor. 31282-04-9 ≥98.0% 527.52 C20H37N3O13 CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N Ambient Ambient "Brodersen DE, Clemons WM Jr, Carter AP, et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22;103(7):1143-54. PMID: 11163189.

Ro YT, Scheffter SM, Patterson JL. Hygromycin B resistance mediates elimination of Leishmania virus from persistently infected parasites. J Virol. 1997 Dec;71(12):8991-8. PMID: 9371555.

Macintyre G, Woods DE, Anderson R. Hygromycin B inhibits synthesis of murine coronavirus RNA. Antimicrob Agents Chemother. 1991 Dec;35(12):2630-3. PMID: 1667257.

" T+ "UN number: 3462     Class:  6.1     Packing group:  I

Proper shipping name:  Toxins, extracted from living sources, solid, n.o.s. (Hygromycin B).  Marine pollutant:  No.

Reportable Quantity (RQ).  Poison inhalation hazard:  No.

"

LKT E5569 Enramycin B 1 mg 85.5 Polypeptide; peptidoglycan inhibitor. Enduracidin 34304-21-7 ≥83% CCC(C)CCCCC=CC=CC(=O)NC(CC(=O)O)C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C2=CC=C(C=C2)O)CCCN)C(C)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)C(C)O)CCCNC(=O)N)CC5CNC(=N5)N)C6=CC=C(C=C6)O)CO)C7=CC(=C(C(=C7)Cl)O)Cl)CC8CNC(=N8)N)C)C9=CC=C(C=C9)O)C Ambient 4°C 0.1% Formic acid in H2O "Pedroso AA, Menten JF, Lambais MR, et al. Intestinal bacterial community and growth performance of chickens fed diets containing antibiotics. Poult Sci. 2006 Apr;85(4):747-52. PMID: 16615359.

Ohya T, Sato S. Effects of dietary antibiotics on intestinal microflora in broiler chickens. Natl Inst Anim Health Q (Tokyo). 1983 Summer;23(2):49-60. PMID: 6680771.

Kariyama R. Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall. J Antibiot (Tokyo). 1982 Dec;35(12):1700-4. PMID: 7166534.

Kawakami M, Nagai Y, Fujii T, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6. PMID: 5132246.

" Not dangerous goods.

LKT E5569 Enramycin B 5 mg 370.2 Polypeptide; peptidoglycan inhibitor. Enduracidin 34304-21-7 ≥83% CCC(C)CCCCC=CC=CC(=O)NC(CC(=O)O)C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C2=CC=C(C=C2)O)CCCN)C(C)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)C(C)O)CCCNC(=O)N)CC5CNC(=N5)N)C6=CC=C(C=C6)O)CO)C7=CC(=C(C(=C7)Cl)O)Cl)CC8CNC(=N8)N)C)C9=CC=C(C=C9)O)C Ambient 4°C 0.1% Formic acid in H2O "Pedroso AA, Menten JF, Lambais MR, et al. Intestinal bacterial community and growth performance of chickens fed diets containing antibiotics. Poult Sci. 2006 Apr;85(4):747-52. PMID: 16615359.

Ohya T, Sato S. Effects of dietary antibiotics on intestinal microflora in broiler chickens. Natl Inst Anim Health Q (Tokyo). 1983 Summer;23(2):49-60. PMID: 6680771.

Kariyama R. Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall. J Antibiot (Tokyo). 1982 Dec;35(12):1700-4. PMID: 7166534.

Kawakami M, Nagai Y, Fujii T, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6. PMID: 5132246.

" Not dangerous goods.

LKT E5569 Enramycin B 25 mg 1300 Polypeptide; peptidoglycan inhibitor. Enduracidin 34304-21-7 ≥83% CCC(C)CCCCC=CC=CC(=O)NC(CC(=O)O)C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C2=CC=C(C=C2)O)CCCN)C(C)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)C(C)O)CCCNC(=O)N)CC5CNC(=N5)N)C6=CC=C(C=C6)O)CO)C7=CC(=C(C(=C7)Cl)O)Cl)CC8CNC(=N8)N)C)C9=CC=C(C=C9)O)C Ambient 4°C 0.1% Formic acid in H2O "Pedroso AA, Menten JF, Lambais MR, et al. Intestinal bacterial community and growth performance of chickens fed diets containing antibiotics. Poult Sci. 2006 Apr;85(4):747-52. PMID: 16615359.

Ohya T, Sato S. Effects of dietary antibiotics on intestinal microflora in broiler chickens. Natl Inst Anim Health Q (Tokyo). 1983 Summer;23(2):49-60. PMID: 6680771.

Kariyama R. Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall. J Antibiot (Tokyo). 1982 Dec;35(12):1700-4. PMID: 7166534.

Kawakami M, Nagai Y, Fujii T, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6. PMID: 5132246.

" Not dangerous goods.

LKT E5568 Enramycin A 5 mg 339.8 Polypeptide; peptidoglycan inhibitor. 34438-27-2 ≥95% C107H138Cl2N26O31 CC1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O) Ambient 4°C 0.1% Formic acid in H2O "Pedroso AA, Menten JF, Lambais MR, et al. Intestinal bacterial community and growth performance of chickens fed diets containing antibiotics. Poult Sci. 2006 Apr;85(4):747-52. PMID: 16615359.

Ohya T, Sato S. Effects of dietary antibiotics on intestinal microflora in broiler chickens. Natl Inst Anim Health Q (Tokyo). 1983 Summer;23(2):49-60. PMID: 6680771.

Kariyama R. Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall. J Antibiot (Tokyo). 1982 Dec;35(12):1700-4. PMID: 7166534.

Kawakami M, Nagai Y, Fujii T, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6. PMID: 5132246.

" Not dangerous goods.

LKT E5568 Enramycin A 25 mg 1209.5 Polypeptide; peptidoglycan inhibitor. 34438-27-2 ≥95% C107H138Cl2N26O31 CC1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O) Ambient 4°C 0.1% Formic acid in H2O "Pedroso AA, Menten JF, Lambais MR, et al. Intestinal bacterial community and growth performance of chickens fed diets containing antibiotics. Poult Sci. 2006 Apr;85(4):747-52. PMID: 16615359.

Ohya T, Sato S. Effects of dietary antibiotics on intestinal microflora in broiler chickens. Natl Inst Anim Health Q (Tokyo). 1983 Summer;23(2):49-60. PMID: 6680771.

Kariyama R. Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall. J Antibiot (Tokyo). 1982 Dec;35(12):1700-4. PMID: 7166534.

Kawakami M, Nagai Y, Fujii T, et al. Anti-microbial activities of enduracidin (enramycin) in vitro and in vivo. J Antibiot (Tokyo). 1971 Sep;24(9):583-6. PMID: 5132246.

" Not dangerous goods.

LKT E6245 Eplerenone 10 mg 95.1 Mineralocorticoid antagonist. 107724-20-9 ≥98% 414.29 C24H30O6 CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC Ambient Ambient CH3CN "Yasuoka S, Kai H, Kajimoto H, et al. Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats. Circ J. 2013;77(6):1474-81. PMID: 23470864.

Bayorh M, Rollins-Hairston A, Adiyiah J, et al. Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase. J Renin Angiotensin Aldosterone Syst. 2012 Sep;13(3):353-9. PMID: 22554826.

Bayorh MA, Rollins-Hairston A, Adiyiah J, et al. Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):195-201. PMID: 21292834.

Eatman D, Layas MF, Bayorh MA. Eplerenone Suppresses Salt-Induced Vascular Endothelial Growth Factor Expression in the Kidney. Kidney Blood Press Res. 2010 Jun 23;33(3):167-173. PMID: 20571278.

" None Not dangerous goods.

LKT E6245 Eplerenone 25 mg 203.8 Mineralocorticoid antagonist. 107724-20-9 ≥98% 414.29 C24H30O6 CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC Ambient Ambient CH3CN "Yasuoka S, Kai H, Kajimoto H, et al. Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats. Circ J. 2013;77(6):1474-81. PMID: 23470864.

Bayorh M, Rollins-Hairston A, Adiyiah J, et al. Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase. J Renin Angiotensin Aldosterone Syst. 2012 Sep;13(3):353-9. PMID: 22554826.

Bayorh MA, Rollins-Hairston A, Adiyiah J, et al. Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):195-201. PMID: 21292834.

Eatman D, Layas MF, Bayorh MA. Eplerenone Suppresses Salt-Induced Vascular Endothelial Growth Factor Expression in the Kidney. Kidney Blood Press Res. 2010 Jun 23;33(3):167-173. PMID: 20571278.

" None Not dangerous goods.

LKT E6245 Eplerenone 100 mg 611.5 Mineralocorticoid antagonist. 107724-20-9 ≥98% 414.29 C24H30O6 CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC Ambient Ambient CH3CN "Yasuoka S, Kai H, Kajimoto H, et al. Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats. Circ J. 2013;77(6):1474-81. PMID: 23470864.

Bayorh M, Rollins-Hairston A, Adiyiah J, et al. Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase. J Renin Angiotensin Aldosterone Syst. 2012 Sep;13(3):353-9. PMID: 22554826.

Bayorh MA, Rollins-Hairston A, Adiyiah J, et al. Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4. J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):195-201. PMID: 21292834.

Eatman D, Layas MF, Bayorh MA. Eplerenone Suppresses Salt-Induced Vascular Endothelial Growth Factor Expression in the Kidney. Kidney Blood Press Res. 2010 Jun 23;33(3):167-173. PMID: 20571278.

" None Not dangerous goods.

LKT B5875 Bosutinib, structural isomer 10 mg 197.1 Bosutinib isomer; Src and Abl inhibitor. 4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile 1391063-17-4 ≥98% 530.45 C26H29Cl2N5O3 CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC Ambient Ambient "Rassi FE, Khoury HJ. Bosutinib: a SRC-ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia. Pharmgenomics Pers Med. 2013 Aug 5;6:57-62. PMID: 24019749.

Lonskaya I, Hebron ML, Desforges NM, et al. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med. 2013 Aug;5(8):1247-62. PMID: 23737459.

Ulmer A, Tabea Tauer J, Glauche I, et al. TK inhibitor treatment disrupts growth hormone axis: clinical observations in children with CML and experimental data from a juvenile animal model. Klin Padiatr. 2013 May;225(3):120-6. PMID: 23716272.

Amsberg GK, Schafhausen P. Bosutinib in the management of chronic myelogenous leukemia. Biologics. 2013;7:115-22. PMID: 23674887.

Kim WG, Guigon CJ, Fozzatti L, et al. SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer. Clin Cancer Res. 2012 Mar 1;18(5):1281-90. PMID: 22271876.

" Not dangerous goods.

LKT B5875 Bosutinib, structural isomer 25 mg 367 Bosutinib isomer; Src and Abl inhibitor. 4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile 1391063-17-4 ≥98% 530.45 C26H29Cl2N5O3 CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC Ambient Ambient "Rassi FE, Khoury HJ. Bosutinib: a SRC-ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia. Pharmgenomics Pers Med. 2013 Aug 5;6:57-62. PMID: 24019749.

Lonskaya I, Hebron ML, Desforges NM, et al. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med. 2013 Aug;5(8):1247-62. PMID: 23737459.

Ulmer A, Tabea Tauer J, Glauche I, et al. TK inhibitor treatment disrupts growth hormone axis: clinical observations in children with CML and experimental data from a juvenile animal model. Klin Padiatr. 2013 May;225(3):120-6. PMID: 23716272.

Amsberg GK, Schafhausen P. Bosutinib in the management of chronic myelogenous leukemia. Biologics. 2013;7:115-22. PMID: 23674887.

Kim WG, Guigon CJ, Fozzatti L, et al. SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer. Clin Cancer Res. 2012 Mar 1;18(5):1281-90. PMID: 22271876.

" Not dangerous goods.

LKT B5875 Bosutinib, structural isomer 100 mg 1087.2 Bosutinib isomer; Src and Abl inhibitor. 4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile 1391063-17-4 ≥98% 530.45 C26H29Cl2N5O3 CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC Ambient Ambient "Rassi FE, Khoury HJ. Bosutinib: a SRC-ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia. Pharmgenomics Pers Med. 2013 Aug 5;6:57-62. PMID: 24019749.

Lonskaya I, Hebron ML, Desforges NM, et al. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med. 2013 Aug;5(8):1247-62. PMID: 23737459.

Ulmer A, Tabea Tauer J, Glauche I, et al. TK inhibitor treatment disrupts growth hormone axis: clinical observations in children with CML and experimental data from a juvenile animal model. Klin Padiatr. 2013 May;225(3):120-6. PMID: 23716272.

Amsberg GK, Schafhausen P. Bosutinib in the management of chronic myelogenous leukemia. Biologics. 2013;7:115-22. PMID: 23674887.

Kim WG, Guigon CJ, Fozzatti L, et al. SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer. Clin Cancer Res. 2012 Mar 1;18(5):1281-90. PMID: 22271876.

" Not dangerous goods.

LKT L1852 Lenalidomide 50 mg 101.9 Thalidomide derivative; cereblon and TNF-α inhibitor. CC-5013, Revlimid 191732-72-6 ≥98% 259.26 C13H13N3O3 C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N Ambient Ambient DMSO (≥50 mg/mL).  Very slightly soluble in water (≤1 mg/mL). "Kim K, An S, Cha HJ, et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett. 2013 Feb;5(2):588-592. PMID: 23420263.

Chen Y, Borthakur G. Lenalidomide as a novel treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Mar;22(3):389-97. PMID: 23316859.

Lu L, Payvandi F, Wu L, et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. PMID: 18805433.

Vallet S, Palumbo A, Raje N, et al. Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leuk Lymphoma. 2008 Jul;49(7):1238-45. PMID: 18452080.

" Not dangerous goods

LKT L1852 Lenalidomide 100 mg 136 Thalidomide derivative; cereblon and TNF-α inhibitor. CC-5013, Revlimid 191732-72-6 ≥98% 259.26 C13H13N3O3 C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N Ambient Ambient DMSO (≥50 mg/mL).  Very slightly soluble in water (≤1 mg/mL). "Kim K, An S, Cha HJ, et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett. 2013 Feb;5(2):588-592. PMID: 23420263.

Chen Y, Borthakur G. Lenalidomide as a novel treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Mar;22(3):389-97. PMID: 23316859.

Lu L, Payvandi F, Wu L, et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. PMID: 18805433.

Vallet S, Palumbo A, Raje N, et al. Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leuk Lymphoma. 2008 Jul;49(7):1238-45. PMID: 18452080.

" Not dangerous goods

LKT L1852 Lenalidomide 250 mg 237.8 Thalidomide derivative; cereblon and TNF-α inhibitor. CC-5013, Revlimid 191732-72-6 ≥98% 259.26 C13H13N3O3 C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N Ambient Ambient DMSO (≥50 mg/mL).  Very slightly soluble in water (≤1 mg/mL). "Kim K, An S, Cha HJ, et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett. 2013 Feb;5(2):588-592. PMID: 23420263.

Chen Y, Borthakur G. Lenalidomide as a novel treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Mar;22(3):389-97. PMID: 23316859.

Lu L, Payvandi F, Wu L, et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. PMID: 18805433.

Vallet S, Palumbo A, Raje N, et al. Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leuk Lymphoma. 2008 Jul;49(7):1238-45. PMID: 18452080.

" Not dangerous goods

LKT C6935 Crizotinib 5 mg 67.9 ALK, ROS1, c-MET inhibitor. 877399-52-5 ≥98% 450.34 C21H22Cl2FN5O CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N Ambient Ambient "Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

" "UN number: 3077     Class: 9      Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Crizotinib) 

Marine Pollutant: Yes     Poison Inhalation Hazard: No"

LKT C6935 Crizotinib 10 mg 101.9 ALK, ROS1, c-MET inhibitor. 877399-52-5 ≥98% 450.34 C21H22Cl2FN5O CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N Ambient Ambient "Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

" "UN number: 3077     Class: 9      Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Crizotinib) 

Marine Pollutant: Yes     Poison Inhalation Hazard: No"

LKT C6935 Crizotinib 25 mg 224.3 ALK, ROS1, c-MET inhibitor. 877399-52-5 ≥98% 450.34 C21H22Cl2FN5O CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N Ambient Ambient "Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

" "UN number: 3077     Class: 9      Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Crizotinib) 

Marine Pollutant: Yes     Poison Inhalation Hazard: No"

LKT C6935 Crizotinib 100 mg 543.6 ALK, ROS1, c-MET inhibitor. 877399-52-5 ≥98% 450.34 C21H22Cl2FN5O CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N Ambient Ambient "Timm A, Kolesar JM. Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. PMID: 23686600.

Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. PMID: 22729845.

Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011 Oct;6(10):1624-31. PMID: 21716144.

" "UN number: 3077     Class: 9      Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Crizotinib) 

Marine Pollutant: Yes     Poison Inhalation Hazard: No"

LKT T3585 Tivozanib 5 mg 101.9 VEGFR1/2/3, c-Kit, PDGFR inhibitor. AV-951 475108-18-0 ≥98% 454.86 C22H19ClN4O5 CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl Ambient Ambient "Cowey CL. Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma. Drug Des Devel Ther. 2013 Jun 21;7:519-27. PMID: 23818763.

Hepgur M, Sadeghi S, Dorff TB, et al. Tivozanib in the treatment of renal cell carcinoma. Biologics. 2013;7:139-48. PMID: 23788831.

Kang S, Roh YJ, Kim IB. Antiangiogenic effects of tivozanib, an oral VEGF receptor tyrosine kinase inhibitor, on experimental choroidal neovascularization in mice. Exp Eye Res. 2013 Jul;112:125-33. PMID: 23701975.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Tivozanib)"

LKT T3585 Tivozanib 10 mg 157.7 VEGFR1/2/3, c-Kit, PDGFR inhibitor. AV-951 475108-18-0 ≥98% 454.86 C22H19ClN4O5 CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl Ambient Ambient "Cowey CL. Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma. Drug Des Devel Ther. 2013 Jun 21;7:519-27. PMID: 23818763.

Hepgur M, Sadeghi S, Dorff TB, et al. Tivozanib in the treatment of renal cell carcinoma. Biologics. 2013;7:139-48. PMID: 23788831.

Kang S, Roh YJ, Kim IB. Antiangiogenic effects of tivozanib, an oral VEGF receptor tyrosine kinase inhibitor, on experimental choroidal neovascularization in mice. Exp Eye Res. 2013 Jul;112:125-33. PMID: 23701975.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Tivozanib)"

LKT T3585 Tivozanib 25 mg 333.7 VEGFR1/2/3, c-Kit, PDGFR inhibitor. AV-951 475108-18-0 ≥98% 454.86 C22H19ClN4O5 CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl Ambient Ambient "Cowey CL. Profile of tivozanib and its potential for the treatment of advanced renal cell carcinoma. Drug Des Devel Ther. 2013 Jun 21;7:519-27. PMID: 23818763.

Hepgur M, Sadeghi S, Dorff TB, et al. Tivozanib in the treatment of renal cell carcinoma. Biologics. 2013;7:139-48. PMID: 23788831.

Kang S, Roh YJ, Kim IB. Antiangiogenic effects of tivozanib, an oral VEGF receptor tyrosine kinase inhibitor, on experimental choroidal neovascularization in mice. Exp Eye Res. 2013 Jul;112:125-33. PMID: 23701975.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Tivozanib)"

LKT M1978 S-(+)-Methoprene 25 mg 61.1 Juvenille insect growth hormone analog. Altosid, Apex, Diacan, Dianex, Kabat, Minex, Pharorid, Precor, ZR-515 65733-16-6 ≥95% 310.47 C19H34O3 CC(C)OC(=O)C=C(C)C=CCC(C)CCCC(C)(C)OC Ambient Ambient "Monteiro JP, Jurado AS, Moreno AJ, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005 Oct;19(7):951-6. PMID: 16081242.

Olmstead AW, LeBlanc GA. Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna. Environ Health Perspect. 2003 Jun;111(7):919-24. PMID: 12782492.

Wright JE. Environmental and toxicological aspects of insect growth regulators. Environ Health Perspect. 1976 Apr;14:127-32. PMID: 789059.

" Not dangerous goods.

LKT M1978 S-(+)-Methoprene 100 mg 136 Juvenille insect growth hormone analog. Altosid, Apex, Diacan, Dianex, Kabat, Minex, Pharorid, Precor, ZR-515 65733-16-6 ≥95% 310.47 C19H34O3 CC(C)OC(=O)C=C(C)C=CCC(C)CCCC(C)(C)OC Ambient Ambient "Monteiro JP, Jurado AS, Moreno AJ, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005 Oct;19(7):951-6. PMID: 16081242.

Olmstead AW, LeBlanc GA. Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna. Environ Health Perspect. 2003 Jun;111(7):919-24. PMID: 12782492.

Wright JE. Environmental and toxicological aspects of insect growth regulators. Environ Health Perspect. 1976 Apr;14:127-32. PMID: 789059.

" Not dangerous goods.

LKT I0417 R-(−)-Iberin 10 mg 203.8 Sulforaphane homolog, ITC found in cruciferous vegetables. R(-) 1-Isothiocyanato-3-(methylsufinyl) propane 3-Methylsulfinylpropyl isothiocyanate ≥98% 163.26 C5H9NOS2 CS(=O)CCCN=C=S Ambient -20°C [α]22D = -82.5° "Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987." Not dangerous goods.

LKT I0417 R-(−)-Iberin 25 mg 407.7 Sulforaphane homolog, ITC found in cruciferous vegetables. R(-) 1-Isothiocyanato-3-(methylsufinyl) propane 3-Methylsulfinylpropyl isothiocyanate ≥98% 163.26 C5H9NOS2 CS(=O)CCCN=C=S Ambient -20°C [α]22D = -82.5° "Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987." Not dangerous goods.

LKT I0417 R-(−)-Iberin 50 mg 679.5 Sulforaphane homolog, ITC found in cruciferous vegetables. R(-) 1-Isothiocyanato-3-(methylsufinyl) propane 3-Methylsulfinylpropyl isothiocyanate ≥98% 163.26 C5H9NOS2 CS(=O)CCCN=C=S Ambient -20°C [α]22D = -82.5° "Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987." Not dangerous goods.

LKT I0417 R-(−)-Iberin 100 mg 1019.2 Sulforaphane homolog, ITC found in cruciferous vegetables. R(-) 1-Isothiocyanato-3-(methylsufinyl) propane 3-Methylsulfinylpropyl isothiocyanate ≥98% 163.26 C5H9NOS2 CS(=O)CCCN=C=S Ambient -20°C [α]22D = -82.5° "Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987." Not dangerous goods.

LKT C0006 Cabozantinib 10 mg 61.1 VEGFR2, c-Met, RET inhibitor. N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide XL-184, BMS-907351 849217-68-1 ≥98% 501.51 C28H24FN3O5 COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Ambient Ambient Soluble in DMSO (≥117mg/mL), insoluble in water (≤1 mg/mL). "Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2013 Oct 4. [Epub ahead of print]. PMID: 24097861.

Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. PMID: 24002501.

Bentzien F, Zuzow M, Heald N, et al. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer. Thyroid. 2013 Sep 17. [Epub ahead of print]. PMID: 23705946.

Navis AC, Bourgonje A, Wesseling P, et al. Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS One. 2013;8(3):e58262. PMID: 23484006.

" Not dangerous goods.

LKT C0006 Cabozantinib 25 mg 101.9 VEGFR2, c-Met, RET inhibitor. N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide XL-184, BMS-907351 849217-68-1 ≥98% 501.51 C28H24FN3O5 COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Ambient Ambient Soluble in DMSO (≥117mg/mL), insoluble in water (≤1 mg/mL). "Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2013 Oct 4. [Epub ahead of print]. PMID: 24097861.

Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. PMID: 24002501.

Bentzien F, Zuzow M, Heald N, et al. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer. Thyroid. 2013 Sep 17. [Epub ahead of print]. PMID: 23705946.

Navis AC, Bourgonje A, Wesseling P, et al. Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS One. 2013;8(3):e58262. PMID: 23484006.

" Not dangerous goods.

LKT C0006 Cabozantinib 100 mg 271.7 VEGFR2, c-Met, RET inhibitor. N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide XL-184, BMS-907351 849217-68-1 ≥98% 501.51 C28H24FN3O5 COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Ambient Ambient Soluble in DMSO (≥117mg/mL), insoluble in water (≤1 mg/mL). "Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2013 Oct 4. [Epub ahead of print]. PMID: 24097861.

Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. PMID: 24002501.

Bentzien F, Zuzow M, Heald N, et al. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer. Thyroid. 2013 Sep 17. [Epub ahead of print]. PMID: 23705946.

Navis AC, Bourgonje A, Wesseling P, et al. Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS One. 2013;8(3):e58262. PMID: 23484006.

" Not dangerous goods.

LKT C0006 Cabozantinib 250 mg 475.7 VEGFR2, c-Met, RET inhibitor. N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide XL-184, BMS-907351 849217-68-1 ≥98% 501.51 C28H24FN3O5 COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F Ambient Ambient Soluble in DMSO (≥117mg/mL), insoluble in water (≤1 mg/mL). "Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2013 Oct 4. [Epub ahead of print]. PMID: 24097861.

Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. PMID: 24002501.

Bentzien F, Zuzow M, Heald N, et al. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer. Thyroid. 2013 Sep 17. [Epub ahead of print]. PMID: 23705946.

Navis AC, Bourgonje A, Wesseling P, et al. Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2. PLoS One. 2013;8(3):e58262. PMID: 23484006.

" Not dangerous goods.

LKT A2077 Afatinib 5 mg 88.3 EGFR inhibitor. N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide BIBW 2992 850140-72-6 ≥98% 485.94 C24H25ClFN5O3 "CN(C)CC=CC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F

" Ambient 4°C "Yap TA, Popat S. The role of afatinib in the management of non-small cell lung carcinoma. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1529-39. PMID: 23985030.

Janjigian YY, Viola-Villegas N, Holland JP, et al. Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997.

Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. PMID: 22888144.

Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011 Jul;7(7):817-25. PMID: 21732753.

" Not dangerous goods.

LKT A2077 Afatinib 10 mg 136 EGFR inhibitor. N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide BIBW 2992 850140-72-6 ≥98% 485.94 C24H25ClFN5O3 "CN(C)CC=CC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F

" Ambient 4°C "Yap TA, Popat S. The role of afatinib in the management of non-small cell lung carcinoma. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1529-39. PMID: 23985030.

Janjigian YY, Viola-Villegas N, Holland JP, et al. Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997.

Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. PMID: 22888144.

Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011 Jul;7(7):817-25. PMID: 21732753.

" Not dangerous goods.

LKT A2077 Afatinib 25 mg 237.8 EGFR inhibitor. N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide BIBW 2992 850140-72-6 ≥98% 485.94 C24H25ClFN5O3 "CN(C)CC=CC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F

" Ambient 4°C "Yap TA, Popat S. The role of afatinib in the management of non-small cell lung carcinoma. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1529-39. PMID: 23985030.

Janjigian YY, Viola-Villegas N, Holland JP, et al. Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997.

Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. PMID: 22888144.

Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011 Jul;7(7):817-25. PMID: 21732753.

" Not dangerous goods.

LKT A2077 Afatinib 100 mg 679.5 EGFR inhibitor. N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide BIBW 2992 850140-72-6 ≥98% 485.94 C24H25ClFN5O3 "CN(C)CC=CC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F

" Ambient 4°C "Yap TA, Popat S. The role of afatinib in the management of non-small cell lung carcinoma. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1529-39. PMID: 23985030.

Janjigian YY, Viola-Villegas N, Holland JP, et al. Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997.

Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. PMID: 22888144.

Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011 Jul;7(7):817-25. PMID: 21732753.

" Not dangerous goods.

LKT P1845 Pelitinib 5 mg 136 EGFR inhibitor. (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide EKB-569 257933-82-7 ≥98% 467.92 C24H23ClFN5O2 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient Insoluble in water.  Soulble in DMSO (≥13 mg/mL). "Aravindan N, Aravindan S, Herman TS, et al. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar;179(3):304-12. PMID: 23379415.

Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011 Dec;26(12):1563-8. PMID: 22147992.

Yoshimura N, Kudoh S, Kimura T, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. PMID: 16364494.

" Not dangerous goods.

LKT P1845 Pelitinib 10 mg 237.8 EGFR inhibitor. (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide EKB-569 257933-82-7 ≥98% 467.92 C24H23ClFN5O2 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient Insoluble in water.  Soulble in DMSO (≥13 mg/mL). "Aravindan N, Aravindan S, Herman TS, et al. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar;179(3):304-12. PMID: 23379415.

Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011 Dec;26(12):1563-8. PMID: 22147992.

Yoshimura N, Kudoh S, Kimura T, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. PMID: 16364494.

" Not dangerous goods.

LKT P1845 Pelitinib 25 mg 407.7 EGFR inhibitor. (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide EKB-569 257933-82-7 ≥98% 467.92 C24H23ClFN5O2 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient Insoluble in water.  Soulble in DMSO (≥13 mg/mL). "Aravindan N, Aravindan S, Herman TS, et al. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar;179(3):304-12. PMID: 23379415.

Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011 Dec;26(12):1563-8. PMID: 22147992.

Yoshimura N, Kudoh S, Kimura T, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. PMID: 16364494.

" Not dangerous goods.

LKT P1845 Pelitinib 100 mg 1331.8 EGFR inhibitor. (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide EKB-569 257933-82-7 ≥98% 467.92 C24H23ClFN5O2 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient Insoluble in water.  Soulble in DMSO (≥13 mg/mL). "Aravindan N, Aravindan S, Herman TS, et al. EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma. Radiat Res. 2013 Mar;179(3):304-12. PMID: 23379415.

Kim H, Lim HY. Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. J Korean Med Sci. 2011 Dec;26(12):1563-8. PMID: 22147992.

Yoshimura N, Kudoh S, Kimura T, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. PMID: 16364494.

" Not dangerous goods.

LKT N1868 Neratinib 5 mg 136 EGFR inhibitor. (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide HKI-272, WAY-179272 698387-09-6 ≥98% 557.04 C30H29ClN6O3 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient "López-Tarruella S, Jerez Y, Márquez-Rodas I, et al. Neratinib (HKI-272) in the treatment of breast cancer. Future Oncol. 2012 Jun;8(6):671-81. PMID: 22764764.

Sánchez-Martín M, Pandiella A. Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: therapeutic implications. Int J Cancer. 2012 Jul 1;131(1):244-52. PMID: 21826647.

Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res. 2009 Apr 1;15(7):2552-8. PMID: 19318484.

Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 1517300.

" Not dangerous goods

LKT N1868 Neratinib 10 mg 237.8 EGFR inhibitor. (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide HKI-272, WAY-179272 698387-09-6 ≥98% 557.04 C30H29ClN6O3 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient "López-Tarruella S, Jerez Y, Márquez-Rodas I, et al. Neratinib (HKI-272) in the treatment of breast cancer. Future Oncol. 2012 Jun;8(6):671-81. PMID: 22764764.

Sánchez-Martín M, Pandiella A. Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: therapeutic implications. Int J Cancer. 2012 Jul 1;131(1):244-52. PMID: 21826647.

Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res. 2009 Apr 1;15(7):2552-8. PMID: 19318484.

Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 1517300.

" Not dangerous goods

LKT N1868 Neratinib 25 mg 407.7 EGFR inhibitor. (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide HKI-272, WAY-179272 698387-09-6 ≥98% 557.04 C30H29ClN6O3 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient "López-Tarruella S, Jerez Y, Márquez-Rodas I, et al. Neratinib (HKI-272) in the treatment of breast cancer. Future Oncol. 2012 Jun;8(6):671-81. PMID: 22764764.

Sánchez-Martín M, Pandiella A. Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: therapeutic implications. Int J Cancer. 2012 Jul 1;131(1):244-52. PMID: 21826647.

Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res. 2009 Apr 1;15(7):2552-8. PMID: 19318484.

Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 1517300.

" Not dangerous goods

LKT N1868 Neratinib 100 mg 1331.8 EGFR inhibitor. (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide HKI-272, WAY-179272 698387-09-6 ≥98% 557.04 C30H29ClN6O3 CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C Ambient Ambient "López-Tarruella S, Jerez Y, Márquez-Rodas I, et al. Neratinib (HKI-272) in the treatment of breast cancer. Future Oncol. 2012 Jun;8(6):671-81. PMID: 22764764.

Sánchez-Martín M, Pandiella A. Differential action of small molecule HER kinase inhibitors on receptor heterodimerization: therapeutic implications. Int J Cancer. 2012 Jul 1;131(1):244-52. PMID: 21826647.

Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res. 2009 Apr 1;15(7):2552-8. PMID: 19318484.

Rabindran SK, Discafani CM, Rosfjord EC, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 1517300.

" Not dangerous goods

LKT R0351 Ramoplanin 100 mg 169.9 Peptide; peptidoglycan inhibitor. 76168-82-6 ≥96% 2254.06 C106H170ClN21O30 CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O Ambient Ambient "Mathur H, O'Connor PM, Hill C, et al. Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. Antimicrob Agents Chemother. 2013 Jun;57(6):2882-6. PMID: 23571539.

Fulco P, Wenzel RP. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti Infect Ther. 2006 Dec;4(6):939-45. PMID: 17181409.

Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipeptide antibiotic. Ann Pharmacother. 2005 May;39(5):863-8. PMID: 15784805.

Hu Y, Helm JS, Chen L, et al. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. J Am Chem Soc. 2003 Jul 23;125(29):8736-7. PMID: 12862463.

" Not dangerous goods.

LKT R0351 Ramoplanin 250 mg 326.1 Peptide; peptidoglycan inhibitor. 76168-82-6 ≥96% 2254.06 C106H170ClN21O30 CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O Ambient Ambient "Mathur H, O'Connor PM, Hill C, et al. Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. Antimicrob Agents Chemother. 2013 Jun;57(6):2882-6. PMID: 23571539.

Fulco P, Wenzel RP. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti Infect Ther. 2006 Dec;4(6):939-45. PMID: 17181409.

Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipeptide antibiotic. Ann Pharmacother. 2005 May;39(5):863-8. PMID: 15784805.

Hu Y, Helm JS, Chen L, et al. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. J Am Chem Soc. 2003 Jul 23;125(29):8736-7. PMID: 12862463.

" Not dangerous goods.

LKT A4679 Altrenogest 100 mg 67.9 Synthetic progestogen; PR agonist. 17-α-Allyl-17-β-hydroxyoestra-4,9,11-trien-3-one (17beta)-17-Allyl-17-hydroxyestra-4,9,11-trien-3-one, Altrenogestrel, Allyltrenbolone, Regumate 850-52-2 ≥98% 310.44 C21H26O2 CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(CC=C)O Ambient Ambient "Horsley BR, Estienne MJ, Harper AF, et al. Effect of P.G. 600 on the timing of ovulation in gilts treated with altrenogest. J Anim Sci. 2005 Jul;83(7):1690-5. PMID: 15956478.

dos Santos JM, Wentz I, Bortolozzo FP, et al. Early-weaned sows: altrenogest therapy, estrus, ovulation, and reproductive performance. Anim Reprod Sci. 2004 Sep;84(3-4):407-13. PMID: 15302382.

Webel SK, Squires EL. Control of the oestrous cycle in mares with altrenogest. J Reprod Fertil Suppl. 1982;32:193-8. PMID: 6962854.

" Not dangerous goods.

LKT A4679 Altrenogest 250 mg 136 Synthetic progestogen; PR agonist. 17-α-Allyl-17-β-hydroxyoestra-4,9,11-trien-3-one (17beta)-17-Allyl-17-hydroxyestra-4,9,11-trien-3-one, Altrenogestrel, Allyltrenbolone, Regumate 850-52-2 ≥98% 310.44 C21H26O2 CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(CC=C)O Ambient Ambient "Horsley BR, Estienne MJ, Harper AF, et al. Effect of P.G. 600 on the timing of ovulation in gilts treated with altrenogest. J Anim Sci. 2005 Jul;83(7):1690-5. PMID: 15956478.

dos Santos JM, Wentz I, Bortolozzo FP, et al. Early-weaned sows: altrenogest therapy, estrus, ovulation, and reproductive performance. Anim Reprod Sci. 2004 Sep;84(3-4):407-13. PMID: 15302382.

Webel SK, Squires EL. Control of the oestrous cycle in mares with altrenogest. J Reprod Fertil Suppl. 1982;32:193-8. PMID: 6962854.

" Not dangerous goods.

LKT A4679 Altrenogest 1 g 339.8 Synthetic progestogen; PR agonist. 17-α-Allyl-17-β-hydroxyoestra-4,9,11-trien-3-one (17beta)-17-Allyl-17-hydroxyestra-4,9,11-trien-3-one, Altrenogestrel, Allyltrenbolone, Regumate 850-52-2 ≥98% 310.44 C21H26O2 CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(CC=C)O Ambient Ambient "Horsley BR, Estienne MJ, Harper AF, et al. Effect of P.G. 600 on the timing of ovulation in gilts treated with altrenogest. J Anim Sci. 2005 Jul;83(7):1690-5. PMID: 15956478.

dos Santos JM, Wentz I, Bortolozzo FP, et al. Early-weaned sows: altrenogest therapy, estrus, ovulation, and reproductive performance. Anim Reprod Sci. 2004 Sep;84(3-4):407-13. PMID: 15302382.

Webel SK, Squires EL. Control of the oestrous cycle in mares with altrenogest. J Reprod Fertil Suppl. 1982;32:193-8. PMID: 6962854.

" Not dangerous goods.

LKT A4534 Aliskiren Hemifumarate 25 mg 61.1 Renin inhibitor. (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7--8-methyl-2-(propan-2-yl)nonanamide hemifumarate 173334-58-2 ≥98% 609.83 C30H53N3O6 1/2 C4H4O4 CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O Ambient -20°C Soluble in water (≥122 mg/mL), ethanol ≥122 mg/mL), and DMSO (≥122 mg/mL). "Yen TH, Yang HY, Yeh YH, et al. Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism. Lupus. 2013 Feb;22(2):180-9. PMID: 23257405.

Hermanowicz JM, Hermanowicz A, Buczko P, et al. Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats. Thromb Res. 2013 Jan;131(1):e39-44. PMID: 23174623.

Gandhi S, Srinivasan B, Akarte AS. Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-induced diabetic rats. J Renin Angiotensin Aldosterone Syst. 2013 Mar;14(1):3-13. PMID: 22791702.

Kühnast S, van der Hoorn JW, van den Hoek AM, et al. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. J Hypertens. 2012 Jan;30(1):107-16. PMID: 22134386.

Buczko W, Hermanowicz JM. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. PMID: 19066408.

" Not dangerous goods.

LKT A4534 Aliskiren Hemifumarate 100 mg 163.2 Renin inhibitor. (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7--8-methyl-2-(propan-2-yl)nonanamide hemifumarate 173334-58-2 ≥98% 609.83 C30H53N3O6 1/2 C4H4O4 CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O Ambient -20°C Soluble in water (≥122 mg/mL), ethanol ≥122 mg/mL), and DMSO (≥122 mg/mL). "Yen TH, Yang HY, Yeh YH, et al. Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism. Lupus. 2013 Feb;22(2):180-9. PMID: 23257405.

Hermanowicz JM, Hermanowicz A, Buczko P, et al. Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats. Thromb Res. 2013 Jan;131(1):e39-44. PMID: 23174623.

Gandhi S, Srinivasan B, Akarte AS. Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-induced diabetic rats. J Renin Angiotensin Aldosterone Syst. 2013 Mar;14(1):3-13. PMID: 22791702.

Kühnast S, van der Hoorn JW, van den Hoek AM, et al. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. J Hypertens. 2012 Jan;30(1):107-16. PMID: 22134386.

Buczko W, Hermanowicz JM. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. PMID: 19066408.

" Not dangerous goods.

LKT A4534 Aliskiren Hemifumarate 250 mg 271.7 Renin inhibitor. (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7--8-methyl-2-(propan-2-yl)nonanamide hemifumarate 173334-58-2 ≥98% 609.83 C30H53N3O6 1/2 C4H4O4 CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O Ambient -20°C Soluble in water (≥122 mg/mL), ethanol ≥122 mg/mL), and DMSO (≥122 mg/mL). "Yen TH, Yang HY, Yeh YH, et al. Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism. Lupus. 2013 Feb;22(2):180-9. PMID: 23257405.

Hermanowicz JM, Hermanowicz A, Buczko P, et al. Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats. Thromb Res. 2013 Jan;131(1):e39-44. PMID: 23174623.

Gandhi S, Srinivasan B, Akarte AS. Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-induced diabetic rats. J Renin Angiotensin Aldosterone Syst. 2013 Mar;14(1):3-13. PMID: 22791702.

Kühnast S, van der Hoorn JW, van den Hoek AM, et al. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. J Hypertens. 2012 Jan;30(1):107-16. PMID: 22134386.

Buczko W, Hermanowicz JM. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. PMID: 19066408.

" Not dangerous goods.

LKT A0933 Acitretin 25 mg 47.6 Retinoid; RARα/β/γ agonist. 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid Neotigason; Soriatane 55079-83-9 ≥98%, multiple isomers 326.43 C21H26O3 CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC Ambient -20°C "Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391.

Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.

Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Acitretin)"

LKT A0933 Acitretin 100 mg 101.9 Retinoid; RARα/β/γ agonist. 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid Neotigason; Soriatane 55079-83-9 ≥98%, multiple isomers 326.43 C21H26O3 CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC Ambient -20°C "Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391.

Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.

Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Acitretin)"

LKT A0933 Acitretin 250 mg 169.9 Retinoid; RARα/β/γ agonist. 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid Neotigason; Soriatane 55079-83-9 ≥98%, multiple isomers 326.43 C21H26O3 CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC Ambient -20°C "Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391.

Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.

Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830.

" "UN number: 3077     Class: 9     Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Acitretin)"

LKT D3203 Diallyl Tetrasulfide 5 mg 61.1 Organosulfur found in garlic; Microtubule polymerization inhibitor. Allyl tetrasulfide 2444-49-7 ≥90% 210.4 C6H10S4 C=CCSSSSCC=C Blue Ice -80°C "Saidu NE, Abu Asali I, Czepukojc B, et al. Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells. Biochim Biophys Acta. 2013 Nov;1830(11):5267-76. PMID: 23948592.

Kelkel M, Cerella C, Mack F, et al. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis. 2012 Nov;33(11):2162-71. PMID: 22822094.

Ponnusamy M, Pari L. Protective role of diallyl tetrasulfide on cadmium-induced testicular damage in adult rats: a biochemical and histological study. Toxicol Ind Health. 2011 Jun;27(5):407-16. PMID: 21245201.

Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol. 2001 Jul;50(7):646-9. PMID: 11444776.

" Not dangerous goods.

LKT D3203 Diallyl Tetrasulfide 25 mg 169.9 Organosulfur found in garlic; Microtubule polymerization inhibitor. Allyl tetrasulfide 2444-49-7 ≥90% 210.4 C6H10S4 C=CCSSSSCC=C Blue Ice -80°C "Saidu NE, Abu Asali I, Czepukojc B, et al. Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells. Biochim Biophys Acta. 2013 Nov;1830(11):5267-76. PMID: 23948592.

Kelkel M, Cerella C, Mack F, et al. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis. 2012 Nov;33(11):2162-71. PMID: 22822094.

Ponnusamy M, Pari L. Protective role of diallyl tetrasulfide on cadmium-induced testicular damage in adult rats: a biochemical and histological study. Toxicol Ind Health. 2011 Jun;27(5):407-16. PMID: 21245201.

Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol. 2001 Jul;50(7):646-9. PMID: 11444776.

" Not dangerous goods.

LKT D3203 Diallyl Tetrasulfide 100 mg 387.2 Organosulfur found in garlic; Microtubule polymerization inhibitor. Allyl tetrasulfide 2444-49-7 ≥90% 210.4 C6H10S4 C=CCSSSSCC=C Blue Ice -80°C "Saidu NE, Abu Asali I, Czepukojc B, et al. Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells. Biochim Biophys Acta. 2013 Nov;1830(11):5267-76. PMID: 23948592.

Kelkel M, Cerella C, Mack F, et al. ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis. 2012 Nov;33(11):2162-71. PMID: 22822094.

Ponnusamy M, Pari L. Protective role of diallyl tetrasulfide on cadmium-induced testicular damage in adult rats: a biochemical and histological study. Toxicol Ind Health. 2011 Jun;27(5):407-16. PMID: 21245201.

Tsao SM, Yin MC. In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. J Med Microbiol. 2001 Jul;50(7):646-9. PMID: 11444776.

" Not dangerous goods.

LKT Q8139 Quizartinib  5 mg 136 FLT3, c-Kit, PDGFR inhibitor. AC220, AC-220 950769-58-1 ≥98% 560.67 C29H32N6O4S CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3 Ambient -20°C "Ostronoff F, Estey E. The role of quizartinib in the treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Sep 26. [Epub ahead of print]. PMID: 24070241.

Bhullar J, Natarajan K, Shukla S, et al. The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions. PLoS One. 2013;8(8):e71266. PMID: 23967177.

Kampa-Schittenhelm KM, Heinrich MC, Akmut F, et al. Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Mol Cancer. 2013 Mar 7;12:19. PMID: 23497317.

Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009 Oct 1;114(14):2984-92. PMID: 19654408.

" Not dangerous goods.

LKT Q8139 Quizartinib  10 mg 237.8 FLT3, c-Kit, PDGFR inhibitor. AC220, AC-220 950769-58-1 ≥98% 560.67 C29H32N6O4S CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3 Ambient -20°C "Ostronoff F, Estey E. The role of quizartinib in the treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Sep 26. [Epub ahead of print]. PMID: 24070241.

Bhullar J, Natarajan K, Shukla S, et al. The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions. PLoS One. 2013;8(8):e71266. PMID: 23967177.

Kampa-Schittenhelm KM, Heinrich MC, Akmut F, et al. Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Mol Cancer. 2013 Mar 7;12:19. PMID: 23497317.

Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009 Oct 1;114(14):2984-92. PMID: 19654408.

" Not dangerous goods.

LKT Q8139 Quizartinib  25 mg 475.7 FLT3, c-Kit, PDGFR inhibitor. AC220, AC-220 950769-58-1 ≥98% 560.67 C29H32N6O4S CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3 Ambient -20°C "Ostronoff F, Estey E. The role of quizartinib in the treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Sep 26. [Epub ahead of print]. PMID: 24070241.

Bhullar J, Natarajan K, Shukla S, et al. The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions. PLoS One. 2013;8(8):e71266. PMID: 23967177.

Kampa-Schittenhelm KM, Heinrich MC, Akmut F, et al. Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Mol Cancer. 2013 Mar 7;12:19. PMID: 23497317.

Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009 Oct 1;114(14):2984-92. PMID: 19654408.

" Not dangerous goods.

LKT V1869 Verbascoside 5 mg 163.2 Phenylpropanoid found in Castilleja, Verbena, Verbascum; potential PKC, DPP4, prolyl oligopeptidase inhibitor. Acteoside 61276-17-3 ≥98% 624.59 C29H36O15 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O Ambient Ambient "Campo G, Marchesini J, Bristot L, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012 Oct;34(3):318-25. PMID: 22723176.

Filho AG, Morel AF, Adolpho L, et al. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytother Res. 2012 Oct;26(10):1472-5. PMID: 22275311.

Paola RD, Oteri G, Mazzon E, et al. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. J Pharm Pharmacol. 2011 May;63(5):707-17. PMID: 21492173.

Isacchi B, Iacopi R, Bergonzi MC, et al. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. PMID: 21401613.

Kahraman C, Tatli II, Orhan IE, et al. Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Z Naturforsch C. 2010 Nov-Dec;65(11-12):667-74. PMID: 21319708.

" None Not dangerous goods.

LKT V1869 Verbascoside 10 mg 244.5 Phenylpropanoid found in Castilleja, Verbena, Verbascum; potential PKC, DPP4, prolyl oligopeptidase inhibitor. Acteoside 61276-17-3 ≥98% 624.59 C29H36O15 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O Ambient Ambient "Campo G, Marchesini J, Bristot L, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012 Oct;34(3):318-25. PMID: 22723176.

Filho AG, Morel AF, Adolpho L, et al. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytother Res. 2012 Oct;26(10):1472-5. PMID: 22275311.

Paola RD, Oteri G, Mazzon E, et al. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. J Pharm Pharmacol. 2011 May;63(5):707-17. PMID: 21492173.

Isacchi B, Iacopi R, Bergonzi MC, et al. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. PMID: 21401613.

Kahraman C, Tatli II, Orhan IE, et al. Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Z Naturforsch C. 2010 Nov-Dec;65(11-12):667-74. PMID: 21319708.

" None Not dangerous goods.

LKT V1869 Verbascoside 25 mg 475.7 Phenylpropanoid found in Castilleja, Verbena, Verbascum; potential PKC, DPP4, prolyl oligopeptidase inhibitor. Acteoside 61276-17-3 ≥98% 624.59 C29H36O15 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O Ambient Ambient "Campo G, Marchesini J, Bristot L, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012 Oct;34(3):318-25. PMID: 22723176.

Filho AG, Morel AF, Adolpho L, et al. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytother Res. 2012 Oct;26(10):1472-5. PMID: 22275311.

Paola RD, Oteri G, Mazzon E, et al. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. J Pharm Pharmacol. 2011 May;63(5):707-17. PMID: 21492173.

Isacchi B, Iacopi R, Bergonzi MC, et al. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. PMID: 21401613.

Kahraman C, Tatli II, Orhan IE, et al. Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Z Naturforsch C. 2010 Nov-Dec;65(11-12):667-74. PMID: 21319708.

" None Not dangerous goods.

LKT W5727 Wogonoside 5 mg 67.9 Flavonoid glycoside found in Scutellaria. 51059-44-0 ≥98% 460.39 C22H20O11 COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)OC4C(C(C(C(O4)C(=O)O)O)O)O Ambient Ambient "Yang YZ, Tang YZ, Liu YH. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6. PMID: 23612420.

Chen Y, Hui H, Yang H, et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91. PMID: 23487022.

Sun Y, Zou M, Hu C, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60. PMID: 23000445.

Chen Y, Lu N, Ling Y, et al. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology. 2009 May 2;259(1-2):10-7. PMID: 19428938.

" Not dangerous goods.

LKT W5727 Wogonoside 10 mg 101.9 Flavonoid glycoside found in Scutellaria. 51059-44-0 ≥98% 460.39 C22H20O11 COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)OC4C(C(C(C(O4)C(=O)O)O)O)O Ambient Ambient "Yang YZ, Tang YZ, Liu YH. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6. PMID: 23612420.

Chen Y, Hui H, Yang H, et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91. PMID: 23487022.

Sun Y, Zou M, Hu C, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60. PMID: 23000445.

Chen Y, Lu N, Ling Y, et al. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology. 2009 May 2;259(1-2):10-7. PMID: 19428938.

" Not dangerous goods.

LKT W5727 Wogonoside 25 mg 183.4 Flavonoid glycoside found in Scutellaria. 51059-44-0 ≥98% 460.39 C22H20O11 COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)OC4C(C(C(C(O4)C(=O)O)O)O)O Ambient Ambient "Yang YZ, Tang YZ, Liu YH. Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells. J Ethnopharmacol. 2013 Jun 21;148(1):271-6. PMID: 23612420.

Chen Y, Hui H, Yang H, et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells. Blood. 2013 May 2;121(18):3682-91. PMID: 23487022.

Sun Y, Zou M, Hu C, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013 Jan;51:53-60. PMID: 23000445.

Chen Y, Lu N, Ling Y, et al. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology. 2009 May 2;259(1-2):10-7. PMID: 19428938.

" Not dangerous goods.

LKT P5745 Polygalic Acid 5 mg 163.2 Saponin found in Polygala. ≥97% 488.66 C29H44O6 Ambient Ambient Ling Y, Wu B, Wang K, et al. In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn. Biomed Chromatogr. 2012 Feb;26(2):220-4. PMID: 21618563. Not dangerous goods.

LKT P5745 Polygalic Acid 10 mg 244.5 Saponin found in Polygala. ≥97% 488.66 C29H44O6 Ambient Ambient Ling Y, Wu B, Wang K, et al. In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn. Biomed Chromatogr. 2012 Feb;26(2):220-4. PMID: 21618563. Not dangerous goods.

LKT P5745 Polygalic Acid 25 mg 475.7 Saponin found in Polygala. ≥97% 488.66 C29H44O6 Ambient Ambient Ling Y, Wu B, Wang K, et al. In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn. Biomed Chromatogr. 2012 Feb;26(2):220-4. PMID: 21618563. Not dangerous goods.

LKT A7461 Asperosaponin VI 10 mg 61.1 Triterpene saponin found in Dipsacus asper. Akebia Saponin D 39524-08-8 ≥98% 929.1 C47H76O18 CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C Ambient Ambient "Li C, Gao Y, Tian J, et al. Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012 May;50(5):1432-8. PMID: 22343037.

Li C, Tian J, Li G, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7. PMID: 20863824.

Li C, Liu Z, Tian J, et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):235-41. PMID: 19909736.

" Not dangerous goods.

LKT A7461 Asperosaponin VI 25 mg 122.3 Triterpene saponin found in Dipsacus asper. Akebia Saponin D 39524-08-8 ≥98% 929.1 C47H76O18 CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C Ambient Ambient "Li C, Gao Y, Tian J, et al. Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012 May;50(5):1432-8. PMID: 22343037.

Li C, Tian J, Li G, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7. PMID: 20863824.

Li C, Liu Z, Tian J, et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):235-41. PMID: 19909736.

" Not dangerous goods.

LKT A7461 Asperosaponin VI 100 mg 407.7 Triterpene saponin found in Dipsacus asper. Akebia Saponin D 39524-08-8 ≥98% 929.1 C47H76O18 CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)COC8C(C(C(C(O8)CO)O)O)O)O)O)O)C Ambient Ambient "Li C, Gao Y, Tian J, et al. Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012 May;50(5):1432-8. PMID: 22343037.

Li C, Tian J, Li G, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7. PMID: 20863824.

Li C, Liu Z, Tian J, et al. Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):235-41. PMID: 19909736.

" Not dangerous goods.

LKT R3197 Rhyncholphylline 5 mg 129 Oxyindole alkaloid found in Uncaria sinensis; hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist. Rhynchophylline 76-66-4 ≥98% 384.47 C22H28N2O4 CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O Ambient Ambient "Zhou JY, Mo ZX, Zhou SW. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Arch Pharm Res. 2010 Apr;33(4):557-65. PMID: 20422365.

Hsieh CL, Ho TY, Su SY, et al. Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am J Chin Med. 2009;37(2):351-60. PMID: 19507277.

Gui L, Li ZW, Du R, et al. Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel. Sheng Li Xue Bao. 2005 Oct 25;57(5):648-52. PMID: 162Viv体育5.

Zhang WB, Chen CX, Sim SM, et al. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):232-8. PMID: 14668978.

Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin. 2002 May;23(5):445-9. PMID: 11978195.

Shimada Y, Goto H, Itoh T, et al. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol. 1999 Jun;51(6):715-22. PMID: 10454049.

" Not dangerous goods.

LKT R3197 Rhyncholphylline 10 mg 224.3 Oxyindole alkaloid found in Uncaria sinensis; hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist. Rhynchophylline 76-66-4 ≥98% 384.47 C22H28N2O4 CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O Ambient Ambient "Zhou JY, Mo ZX, Zhou SW. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Arch Pharm Res. 2010 Apr;33(4):557-65. PMID: 20422365.

Hsieh CL, Ho TY, Su SY, et al. Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am J Chin Med. 2009;37(2):351-60. PMID: 19507277.

Gui L, Li ZW, Du R, et al. Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel. Sheng Li Xue Bao. 2005 Oct 25;57(5):648-52. PMID: 162Viv体育5.

Zhang WB, Chen CX, Sim SM, et al. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):232-8. PMID: 14668978.

Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin. 2002 May;23(5):445-9. PMID: 11978195.

Shimada Y, Goto H, Itoh T, et al. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol. 1999 Jun;51(6):715-22. PMID: 10454049.

" Not dangerous goods.

LKT R3197 Rhyncholphylline 25 mg 407.7 Oxyindole alkaloid found in Uncaria sinensis; hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist. Rhynchophylline 76-66-4 ≥98% 384.47 C22H28N2O4 CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O Ambient Ambient "Zhou JY, Mo ZX, Zhou SW. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Arch Pharm Res. 2010 Apr;33(4):557-65. PMID: 20422365.

Hsieh CL, Ho TY, Su SY, et al. Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am J Chin Med. 2009;37(2):351-60. PMID: 19507277.

Gui L, Li ZW, Du R, et al. Inhibitory effect of rhynchophylline on human ether-a-go-go related gene channel. Sheng Li Xue Bao. 2005 Oct 25;57(5):648-52. PMID: 162Viv体育5.

Zhang WB, Chen CX, Sim SM, et al. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):232-8. PMID: 14668978.

Shi JS, Kenneth HG. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin. 2002 May;23(5):445-9. PMID: 11978195.

Shimada Y, Goto H, Itoh T, et al. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol. 1999 Jun;51(6):715-22. PMID: 10454049.

" Not dangerous goods.

LKT I7559 Isoliquiritigenin, natural 5 mg 115.5 Chalcone; SIRT activator, GABA-A positive modulator, NMDA antagonist, VEGFR2 and HDAC inhibitor. (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 4,2’,4’-Trihydroxychalcone 961-29-5 ≥98% 256.25 C15H12O4 C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O Ambient 4°C "Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.

" None Not dangerous goods.

LKT I7559 Isoliquiritigenin, natural 10 mg 203.8 Chalcone; SIRT activator, GABA-A positive modulator, NMDA antagonist, VEGFR2 and HDAC inhibitor. (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 4,2’,4’-Trihydroxychalcone 961-29-5 ≥98% 256.25 C15H12O4 C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O Ambient 4°C "Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.

" None Not dangerous goods.

LKT I7559 Isoliquiritigenin, natural 25 mg 373.7 Chalcone; SIRT activator, GABA-A positive modulator, NMDA antagonist, VEGFR2 and HDAC inhibitor. (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 4,2’,4’-Trihydroxychalcone 961-29-5 ≥98% 256.25 C15H12O4 C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O Ambient 4°C "Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.

" None Not dangerous goods.

LKT S1872 Sesamin 5 mg 88.3 Lignin found in Sesamin indicum; 5,5'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H- furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) 607-80-7 ≥98% 354.35 C20H18O6 C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 Blue Ice -20°C "Deng P, Wang C, Chen L, et al. Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2. Biol Pharm Bull. 2013;36(10):1540-1548. PMID: 24088253.

Liu CM, Zheng GH, Ming QL, et al. Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway. J Agric Food Chem. 2013 Feb 6;61(5):1146-54. PMID: 23317420.

Li WX, Kong X, Zhang JX, et al. Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats. Food Funct. 2013 Feb 26;4(3):453-60. PMID: 23238059.

Phitak T, Pothacharoen P, Settakorn J, et al. Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry. 2012 Aug;80:77-88. PMID: 22704650.

Wanachewin O, Boonmaleerat K, Pothacharoen P, et al. Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways. BMC Complement Altern Med. 2012 May 30;12:71. PMID: 22646286.

" None Not dangerous goods.

LKT S1872 Sesamin 10 mg 136 Lignin found in Sesamin indicum; 5,5'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H- furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) 607-80-7 ≥98% 354.35 C20H18O6 C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 Blue Ice -20°C "Deng P, Wang C, Chen L, et al. Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2. Biol Pharm Bull. 2013;36(10):1540-1548. PMID: 24088253.

Liu CM, Zheng GH, Ming QL, et al. Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway. J Agric Food Chem. 2013 Feb 6;61(5):1146-54. PMID: 23317420.

Li WX, Kong X, Zhang JX, et al. Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats. Food Funct. 2013 Feb 26;4(3):453-60. PMID: 23238059.

Phitak T, Pothacharoen P, Settakorn J, et al. Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry. 2012 Aug;80:77-88. PMID: 22704650.

Wanachewin O, Boonmaleerat K, Pothacharoen P, et al. Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways. BMC Complement Altern Med. 2012 May 30;12:71. PMID: 22646286.

" None Not dangerous goods.

LKT S1872 Sesamin 25 mg 244.5 Lignin found in Sesamin indicum; 5,5'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H- furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole) 607-80-7 ≥98% 354.35 C20H18O6 C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6 Blue Ice -20°C "Deng P, Wang C, Chen L, et al. Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2. Biol Pharm Bull. 2013;36(10):1540-1548. PMID: 24088253.

Liu CM, Zheng GH, Ming QL, et al. Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway. J Agric Food Chem. 2013 Feb 6;61(5):1146-54. PMID: 23317420.

Li WX, Kong X, Zhang JX, et al. Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats. Food Funct. 2013 Feb 26;4(3):453-60. PMID: 23238059.

Phitak T, Pothacharoen P, Settakorn J, et al. Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry. 2012 Aug;80:77-88. PMID: 22704650.

Wanachewin O, Boonmaleerat K, Pothacharoen P, et al. Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways. BMC Complement Altern Med. 2012 May 30;12:71. PMID: 22646286.

" None Not dangerous goods.

LKT L5624 Loganin 10 mg 61.1 Iridoid glucoside found in Cornus officialis; β-secretase inhibitor. Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate 7-Hydroxy-6-desoxyverbenalin; (1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester 18524-94-2 ≥98% 390.38 C17H26O10 CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O Ambient Ambient "Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211.

Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885.

Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639.

Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.

" None Not dangerous goods.

LKT L5624 Loganin 25 mg 122.3 Iridoid glucoside found in Cornus officialis; β-secretase inhibitor. Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate 7-Hydroxy-6-desoxyverbenalin; (1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester 18524-94-2 ≥98% 390.38 C17H26O10 CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O Ambient Ambient "Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211.

Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885.

Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639.

Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.

" None Not dangerous goods.

LKT L5624 Loganin 100 mg 407.7 Iridoid glucoside found in Cornus officialis; β-secretase inhibitor. Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate 7-Hydroxy-6-desoxyverbenalin; (1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester 18524-94-2 ≥98% 390.38 C17H26O10 CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O Ambient Ambient "Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211.

Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885.

Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639.

Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.

" None Not dangerous goods.

LKT G4400 Glabridin 5 mg 88.3 Isoflavonoid found in Glycyrrhiza; GABA-A positive modulator. 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol 59870-68-7 ≥98% 324.37 C20H20O4 CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C Ambient Ambient DMSO ≥14 mg/mL "Jin Z, Kim S, Cho S, et al. Potentiating Effect of Glabridin on GABAA Receptor-Mediated Responses in Dorsal Raphe Neurons. Planta Med. 2013 Aug 23. [Epub ahead of print]. PMID: 23975867.

Kim HS, Suh KS, Ko A, et al. The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. Int J Mol Med. 2013 Jan;31(1):243-51. PMID: 23128413.

Ahn J, Lee H, Jang J, et al. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. Food Chem Toxicol. 2013 Jan;51:439-45. PMID: 22967722.

Lee JW, Choe SS, Jang H, et al. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res. 2012 Jul;53(7):1277-86. PMID: 22493094.

Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. 2011 Jun;98(2):221-30. PMID: 21616781.

Tsai YM, Yang CJ, Hsu YL, et al. Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther. 2011 Dec;10(4):341-9. PMID: 21059620.

" None Not dangerous goods.

LKT G4400 Glabridin 10 mg 163.2 Isoflavonoid found in Glycyrrhiza; GABA-A positive modulator. 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol 59870-68-7 ≥98% 324.37 C20H20O4 CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C Ambient Ambient DMSO ≥14 mg/mL "Jin Z, Kim S, Cho S, et al. Potentiating Effect of Glabridin on GABAA Receptor-Mediated Responses in Dorsal Raphe Neurons. Planta Med. 2013 Aug 23. [Epub ahead of print]. PMID: 23975867.

Kim HS, Suh KS, Ko A, et al. The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. Int J Mol Med. 2013 Jan;31(1):243-51. PMID: 23128413.

Ahn J, Lee H, Jang J, et al. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. Food Chem Toxicol. 2013 Jan;51:439-45. PMID: 22967722.

Lee JW, Choe SS, Jang H, et al. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res. 2012 Jul;53(7):1277-86. PMID: 22493094.

Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. 2011 Jun;98(2):221-30. PMID: 21616781.

Tsai YM, Yang CJ, Hsu YL, et al. Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther. 2011 Dec;10(4):341-9. PMID: 21059620.

" None Not dangerous goods.

LKT G4400 Glabridin 25 mg 326.1 Isoflavonoid found in Glycyrrhiza; GABA-A positive modulator. 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol 59870-68-7 ≥98% 324.37 C20H20O4 CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C Ambient Ambient DMSO ≥14 mg/mL "Jin Z, Kim S, Cho S, et al. Potentiating Effect of Glabridin on GABAA Receptor-Mediated Responses in Dorsal Raphe Neurons. Planta Med. 2013 Aug 23. [Epub ahead of print]. PMID: 23975867.

Kim HS, Suh KS, Ko A, et al. The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. Int J Mol Med. 2013 Jan;31(1):243-51. PMID: 23128413.

Ahn J, Lee H, Jang J, et al. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. Food Chem Toxicol. 2013 Jan;51:439-45. PMID: 22967722.

Lee JW, Choe SS, Jang H, et al. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res. 2012 Jul;53(7):1277-86. PMID: 22493094.

Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. 2011 Jun;98(2):221-30. PMID: 21616781.

Tsai YM, Yang CJ, Hsu YL, et al. Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther. 2011 Dec;10(4):341-9. PMID: 21059620.

" None Not dangerous goods.

LKT E6134 Epimedin C 5 mg 108.8 Flavonoid found in Epimedium sagittatum. 3-[(6-Deoxy-2-O-(6-deoxy-a-L-mannoppyranosyl)-a-L-mannopyranosyl)oxy]-7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one 110642-44-9 ≥98% 822.8 C39H50O19 CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C(OC4=C(C3=O)C(=CC(=C4CC=C(C)C)OC5C(C(C(C(O5)CO)O)O)O)O)C6=CC=C(C=C6)OC)C)O)O)O)O)O Ambient Ambient "Liu TZ, Chen CY, Yiin SJ, et al. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006 Feb;44(2):227-35. PMID: 16112786.

Liang HR, Vuorela P, Vuorela H, et al. Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Planta Med. 1997 Aug;63(4):316-9. PMID: 9270375.

" Not dangerous goods.

LKT E6134 Epimedin C 10 mg 197.1 Flavonoid found in Epimedium sagittatum. 3-[(6-Deoxy-2-O-(6-deoxy-a-L-mannoppyranosyl)-a-L-mannopyranosyl)oxy]-7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one 110642-44-9 ≥98% 822.8 C39H50O19 CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C(OC4=C(C3=O)C(=CC(=C4CC=C(C)C)OC5C(C(C(C(O5)CO)O)O)O)O)C6=CC=C(C=C6)OC)C)O)O)O)O)O Ambient Ambient "Liu TZ, Chen CY, Yiin SJ, et al. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006 Feb;44(2):227-35. PMID: 16112786.

Liang HR, Vuorela P, Vuorela H, et al. Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Planta Med. 1997 Aug;63(4):316-9. PMID: 9270375.

" Not dangerous goods.

LKT E6134 Epimedin C 25 mg 407.7 Flavonoid found in Epimedium sagittatum. 3-[(6-Deoxy-2-O-(6-deoxy-a-L-mannoppyranosyl)-a-L-mannopyranosyl)oxy]-7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one 110642-44-9 ≥98% 822.8 C39H50O19 CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C(OC4=C(C3=O)C(=CC(=C4CC=C(C)C)OC5C(C(C(C(O5)CO)O)O)O)O)C6=CC=C(C=C6)OC)C)O)O)O)O)O Ambient Ambient "Liu TZ, Chen CY, Yiin SJ, et al. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006 Feb;44(2):227-35. PMID: 16112786.

Liang HR, Vuorela P, Vuorela H, et al. Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Planta Med. 1997 Aug;63(4):316-9. PMID: 9270375.

" Not dangerous goods.

LKT A7577 Astilbin 5 mg 74.8 Flavonoid found in various plant sources. 5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside Astibin 29838-67-3 ≥98% 450.39 C21H22O11 CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O Ambient Ambient "Li P, Gao S, Jie W, et al. Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene. J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. PMID: 22528217.

Huang H, Cheng Z, Shi H, et al. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. J Agric Food Chem. 2011 May 11;59(9):4562-9. PMID: 21476602.

Petacci F, Freitas SS, Brunetti IL, et al. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biol Res. 2010;43(1):63-74. PMID: 21157633.

Zou S, Shen X, Tang Y, et al. Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice. Transplant Proc. 2010 Nov;42(9):3798-802. PMID: 21094859.

Lucas-Filho MD, Silva GC, Cortes SF, et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine. 2010 Apr;17(5):383-7. PMID: 19879122.

Sa F, Gao JL, Fung KP, et al. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chem Biol Interact. 2008 Jan 10;171(1):1-14. PMID: 17996228.

" U/A Not dangerous goods.

LKT A7577 Astilbin 10 mg 115.5 Flavonoid found in various plant sources. 5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside Astibin 29838-67-3 ≥98% 450.39 C21H22O11 CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O Ambient Ambient "Li P, Gao S, Jie W, et al. Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene. J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. PMID: 22528217.

Huang H, Cheng Z, Shi H, et al. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. J Agric Food Chem. 2011 May 11;59(9):4562-9. PMID: 21476602.

Petacci F, Freitas SS, Brunetti IL, et al. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biol Res. 2010;43(1):63-74. PMID: 21157633.

Zou S, Shen X, Tang Y, et al. Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice. Transplant Proc. 2010 Nov;42(9):3798-802. PMID: 21094859.

Lucas-Filho MD, Silva GC, Cortes SF, et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine. 2010 Apr;17(5):383-7. PMID: 19879122.

Sa F, Gao JL, Fung KP, et al. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chem Biol Interact. 2008 Jan 10;171(1):1-14. PMID: 17996228.

" U/A Not dangerous goods.

LKT A7577 Astilbin 25 mg 203.8 Flavonoid found in various plant sources. 5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside Astibin 29838-67-3 ≥98% 450.39 C21H22O11 CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O Ambient Ambient "Li P, Gao S, Jie W, et al. Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene. J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. PMID: 22528217.

Huang H, Cheng Z, Shi H, et al. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. J Agric Food Chem. 2011 May 11;59(9):4562-9. PMID: 21476602.

Petacci F, Freitas SS, Brunetti IL, et al. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biol Res. 2010;43(1):63-74. PMID: 21157633.

Zou S, Shen X, Tang Y, et al. Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice. Transplant Proc. 2010 Nov;42(9):3798-802. PMID: 21094859.

Lucas-Filho MD, Silva GC, Cortes SF, et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine. 2010 Apr;17(5):383-7. PMID: 19879122.

Sa F, Gao JL, Fung KP, et al. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chem Biol Interact. 2008 Jan 10;171(1):1-14. PMID: 17996228.

" U/A Not dangerous goods.

LKT G1855 Gentiopicroside 10 mg 88.3 Secoiridoid glycoside found in Gentiana and Cephalaria. 20831-76-9 ≥97% 356.32 C16H20O9 C=CC1C(OC=C2C1=CCOC2=O)OC3C(C(C(C(O3)CO)O)O)O Ambient Ambient "Liu SB, Ma L, Guo HJ, et al. Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. CNS Neurosci Ther. 2012 Aug;18(8):652-8. PMID: 22621711.

Wei S, Chen G, He W, et al. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytother Res. 2012 Feb;26(2):168-73. PMID: 21584870.

Lian LH, Wu YL, Wan Y, et al. Anti-apoptotic activity of gentiopicroside in D-galactosamine/ lipopolysaccharide-induced murine fulminant hepatic failure. Chem Biol Interact. 2010 Oct 6;188(1):127-33. PMID: 20558151.

Chen L, Liu JC, Zhang XN, et al. Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain. Neuropharmacology. 2008 Jun;54(8):1175-81. PMID: 18410946.

" Not dangerous goods.

LKT G1855 Gentiopicroside 25 mg 169.9 Secoiridoid glycoside found in Gentiana and Cephalaria. 20831-76-9 ≥97% 356.32 C16H20O9 C=CC1C(OC=C2C1=CCOC2=O)OC3C(C(C(C(O3)CO)O)O)O Ambient Ambient "Liu SB, Ma L, Guo HJ, et al. Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. CNS Neurosci Ther. 2012 Aug;18(8):652-8. PMID: 22621711.

Wei S, Chen G, He W, et al. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytother Res. 2012 Feb;26(2):168-73. PMID: 21584870.

Lian LH, Wu YL, Wan Y, et al. Anti-apoptotic activity of gentiopicroside in D-galactosamine/ lipopolysaccharide-induced murine fulminant hepatic failure. Chem Biol Interact. 2010 Oct 6;188(1):127-33. PMID: 20558151.

Chen L, Liu JC, Zhang XN, et al. Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain. Neuropharmacology. 2008 Jun;54(8):1175-81. PMID: 18410946.

" Not dangerous goods.

LKT G1855 Gentiopicroside 100 mg 543.6 Secoiridoid glycoside found in Gentiana and Cephalaria. 20831-76-9 ≥97% 356.32 C16H20O9 C=CC1C(OC=C2C1=CCOC2=O)OC3C(C(C(C(O3)CO)O)O)O Ambient Ambient "Liu SB, Ma L, Guo HJ, et al. Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. CNS Neurosci Ther. 2012 Aug;18(8):652-8. PMID: 22621711.

Wei S, Chen G, He W, et al. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytother Res. 2012 Feb;26(2):168-73. PMID: 21584870.

Lian LH, Wu YL, Wan Y, et al. Anti-apoptotic activity of gentiopicroside in D-galactosamine/ lipopolysaccharide-induced murine fulminant hepatic failure. Chem Biol Interact. 2010 Oct 6;188(1):127-33. PMID: 20558151.

Chen L, Liu JC, Zhang XN, et al. Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain. Neuropharmacology. 2008 Jun;54(8):1175-81. PMID: 18410946.

" Not dangerous goods.

LKT P1635 Peiminine 5 mg 74.8 Steroidal alkaloid found in Fritillaria; M2 mAChR antagonist, potential TRPV1 and TRPA1 antagonist. Imperialine 18059-10-4 ≥98% 429.64 C27H43NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O Ambient Ambient "Guo H, Ji F, Liu B, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10. PMID: 23404624.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

Zhou Y, Ji H, Lin BQ, et al. The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid. Am J Chin Med. 2006;34(5):901-10. PMID: 17080553.

" Not dangerous goods.

LKT P1635 Peiminine 10 mg 115.5 Steroidal alkaloid found in Fritillaria; M2 mAChR antagonist, potential TRPV1 and TRPA1 antagonist. Imperialine 18059-10-4 ≥98% 429.64 C27H43NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O Ambient Ambient "Guo H, Ji F, Liu B, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10. PMID: 23404624.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

Zhou Y, Ji H, Lin BQ, et al. The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid. Am J Chin Med. 2006;34(5):901-10. PMID: 17080553.

" Not dangerous goods.

LKT P1635 Peiminine 25 mg 203.8 Steroidal alkaloid found in Fritillaria; M2 mAChR antagonist, potential TRPV1 and TRPA1 antagonist. Imperialine 18059-10-4 ≥98% 429.64 C27H43NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O Ambient Ambient "Guo H, Ji F, Liu B, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10. PMID: 23404624.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

Zhou Y, Ji H, Lin BQ, et al. The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid. Am J Chin Med. 2006;34(5):901-10. PMID: 17080553.

" Not dangerous goods.

LKT P1634 Peimine 5 mg 67.9 Steroidal alkaloid found in Fritillaria; TRPV1 and TRPA1 antagonist. Verticine 23496-41-5 ≥98% 431.65 C27H45NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O Ambient Ambient "Yi PF, Wu YC, Dong HB, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. PMID: 23944357.

Ma L, Song F, Liu Z, et al. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. PMID: 23239316.

Wang D, Zhu J, Wang S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011 Dec;82(8):1290-4. PMID: 21958967.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

" Not dangerous goods.

LKT P1634 Peimine 10 mg 108.8 Steroidal alkaloid found in Fritillaria; TRPV1 and TRPA1 antagonist. Verticine 23496-41-5 ≥98% 431.65 C27H45NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O Ambient Ambient "Yi PF, Wu YC, Dong HB, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. PMID: 23944357.

Ma L, Song F, Liu Z, et al. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. PMID: 23239316.

Wang D, Zhu J, Wang S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011 Dec;82(8):1290-4. PMID: 21958967.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

" Not dangerous goods.

LKT P1634 Peimine 25 mg 201.2 Steroidal alkaloid found in Fritillaria; TRPV1 and TRPA1 antagonist. Verticine 23496-41-5 ≥98% 431.65 C27H45NO3 CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O Ambient Ambient "Yi PF, Wu YC, Dong HB, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. PMID: 23944357.

Ma L, Song F, Liu Z, et al. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. PMID: 23239316.

Wang D, Zhu J, Wang S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011 Dec;82(8):1290-4. PMID: 21958967.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

" Not dangerous goods.

LKT G0247 2″O-Galloylhyperin 5 mg 108.8 Flavonoid glycoside found in Pyrola. 2’-O-Galloylhyperin 53209-27-1 ≥98% 616.48 C28H24O16 COC1=C(C=C(C=C1O)C(=O)OC2C(CC(C(C2O)O)CO)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O Ambient Ambient Grabber JH, Ress D, Ralph J. Identifying new lignin bioengineering targets: impact of epicatechin, quercetin glycoside, and gallate derivatives on the lignification and fermentation of maize cell walls. J Agric Food Chem. 2012 May 23;60(20):5152-60. PMID: 22475000. Not dangerous goods.

LKT G0247 2″O-Galloylhyperin 10 mg 197.1 Flavonoid glycoside found in Pyrola. 2’-O-Galloylhyperin 53209-27-1 ≥98% 616.48 C28H24O16 COC1=C(C=C(C=C1O)C(=O)OC2C(CC(C(C2O)O)CO)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O Ambient Ambient Grabber JH, Ress D, Ralph J. Identifying new lignin bioengineering targets: impact of epicatechin, quercetin glycoside, and gallate derivatives on the lignification and fermentation of maize cell walls. J Agric Food Chem. 2012 May 23;60(20):5152-60. PMID: 22475000. Not dangerous goods.

LKT G0247 2″O-Galloylhyperin 25 mg 407.7 Flavonoid glycoside found in Pyrola. 2’-O-Galloylhyperin 53209-27-1 ≥98% 616.48 C28H24O16 COC1=C(C=C(C=C1O)C(=O)OC2C(CC(C(C2O)O)CO)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O Ambient Ambient Grabber JH, Ress D, Ralph J. Identifying new lignin bioengineering targets: impact of epicatechin, quercetin glycoside, and gallate derivatives on the lignification and fermentation of maize cell walls. J Agric Food Chem. 2012 May 23;60(20):5152-60. PMID: 22475000. Not dangerous goods.

LKT P7718 Pterostilbene 50 mg 81.6 Stilbene, resveratrol analog. 537-42-8 ≥98% 256.3 C16H16O3 COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC Ambient Ambient "Acharya JD, Ghaskadbi SS. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13(1):238. [Epub ahead of print]. PMID: 24070177.

Lee CM, Su YH, Huynh TT, et al. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evid Based Complement Alternat Med. 2013;2013:258425. PMID: 23878592.

Al Rahim M, Rimando AM, Silistreli K, et al. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013 Jun;79(9):723-30. PMID: 23677525.

Mak KK, Wu AT, Lee WH, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. PMID: 23504987.

Li K, Dias SJ, Rimando AM, et al. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PLoS One. 2013;8(3):e57542. PMID: 23469203.

" Xi, N "UN numner: 3077     Class: 9     Packing Group: III

Proper shipping naen: Environmentally hazardous substance, solid, n.o.s. (Pterostilbene)"

LKT P7718 Pterostilbene 100 mg 136 Stilbene, resveratrol analog. 537-42-8 ≥98% 256.3 C16H16O3 COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC Ambient Ambient "Acharya JD, Ghaskadbi SS. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13(1):238. [Epub ahead of print]. PMID: 24070177.

Lee CM, Su YH, Huynh TT, et al. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evid Based Complement Alternat Med. 2013;2013:258425. PMID: 23878592.

Al Rahim M, Rimando AM, Silistreli K, et al. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013 Jun;79(9):723-30. PMID: 23677525.

Mak KK, Wu AT, Lee WH, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. PMID: 23504987.

Li K, Dias SJ, Rimando AM, et al. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PLoS One. 2013;8(3):e57542. PMID: 23469203.

" Xi, N "UN numner: 3077     Class: 9     Packing Group: III

Proper shipping naen: Environmentally hazardous substance, solid, n.o.s. (Pterostilbene)"

LKT P7718 Pterostilbene 250 mg 271.7 Stilbene, resveratrol analog. 537-42-8 ≥98% 256.3 C16H16O3 COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC Ambient Ambient "Acharya JD, Ghaskadbi SS. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13(1):238. [Epub ahead of print]. PMID: 24070177.

Lee CM, Su YH, Huynh TT, et al. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evid Based Complement Alternat Med. 2013;2013:258425. PMID: 23878592.

Al Rahim M, Rimando AM, Silistreli K, et al. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013 Jun;79(9):723-30. PMID: 23677525.

Mak KK, Wu AT, Lee WH, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. PMID: 23504987.

Li K, Dias SJ, Rimando AM, et al. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PLoS One. 2013;8(3):e57542. PMID: 23469203.

" Xi, N "UN numner: 3077     Class: 9     Packing Group: III

Proper shipping naen: Environmentally hazardous substance, solid, n.o.s. (Pterostilbene)"

LKT P7718 Pterostilbene 1 g 883.3 Stilbene, resveratrol analog. 537-42-8 ≥98% 256.3 C16H16O3 COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC Ambient Ambient "Acharya JD, Ghaskadbi SS. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26;13(1):238. [Epub ahead of print]. PMID: 24070177.

Lee CM, Su YH, Huynh TT, et al. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evid Based Complement Alternat Med. 2013;2013:258425. PMID: 23878592.

Al Rahim M, Rimando AM, Silistreli K, et al. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013 Jun;79(9):723-30. PMID: 23677525.

Mak KK, Wu AT, Lee WH, et al. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Mol Nutr Food Res. 2013 Jul;57(7):1123-34. PMID: 23504987.

Li K, Dias SJ, Rimando AM, et al. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PLoS One. 2013;8(3):e57542. PMID: 23469203.

" Xi, N "UN numner: 3077     Class: 9     Packing Group: III

Proper shipping naen: Environmentally hazardous substance, solid, n.o.s. (Pterostilbene)"

LKT E0929 Echinacoside 5 mg 67.9 Phenylethanoid glycoside found in Echinacea. 82854-37-3 ≥98% 786.73 C35H46O20 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O Ambient Ambient Soluble in water and ethanol. "Yang X, Li F, Yang Y, et al. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013;2013:926928. PMID: 23573159.

Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80. PMID: 23189969.

Wei LL, Chen H, Jiang Y, et al. Effects of echinacoside on histio-central levels of active mass in middle cerebral artery occlusion rats. Biomed Environ Sci. 2012 Apr;25(2):238-44.PMID: 22998833.

Zhao Q, Gao J, Li W, et al. Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 2010 Jul 30;1346:224-36. PMID: 20478277.

He WJ, Fang TH, Ma X, et al. Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. Planta Med. 2009 Oct;75(13):1400-4. PMID: 19468974.

" None Not dangerous goods.

LKT E0929 Echinacoside 10 mg 106.1 Phenylethanoid glycoside found in Echinacea. 82854-37-3 ≥98% 786.73 C35H46O20 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O Ambient Ambient Soluble in water and ethanol. "Yang X, Li F, Yang Y, et al. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013;2013:926928. PMID: 23573159.

Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80. PMID: 23189969.

Wei LL, Chen H, Jiang Y, et al. Effects of echinacoside on histio-central levels of active mass in middle cerebral artery occlusion rats. Biomed Environ Sci. 2012 Apr;25(2):238-44.PMID: 22998833.

Zhao Q, Gao J, Li W, et al. Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 2010 Jul 30;1346:224-36. PMID: 20478277.

He WJ, Fang TH, Ma X, et al. Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. Planta Med. 2009 Oct;75(13):1400-4. PMID: 19468974.

" None Not dangerous goods.

LKT E0929 Echinacoside 25 mg 197.1 Phenylethanoid glycoside found in Echinacea. 82854-37-3 ≥98% 786.73 C35H46O20 CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O Ambient Ambient Soluble in water and ethanol. "Yang X, Li F, Yang Y, et al. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013;2013:926928. PMID: 23573159.

Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80. PMID: 23189969.

Wei LL, Chen H, Jiang Y, et al. Effects of echinacoside on histio-central levels of active mass in middle cerebral artery occlusion rats. Biomed Environ Sci. 2012 Apr;25(2):238-44.PMID: 22998833.

Zhao Q, Gao J, Li W, et al. Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 2010 Jul 30;1346:224-36. PMID: 20478277.

He WJ, Fang TH, Ma X, et al. Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. Planta Med. 2009 Oct;75(13):1400-4. PMID: 19468974.

" None Not dangerous goods.

LKT M1873 S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine 5 mg 335 Sulforaphane-cysteine conjugate. L-cysteine sulforaphane 364083-21-6 ≥98% 298.45 C9H18N2O3S3 Ambient -20°C Methanol, Water Not dangerous goods.

LKT M1873 S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine 10 mg 598 Sulforaphane-cysteine conjugate. L-cysteine sulforaphane 364083-21-6 ≥98% 298.45 C9H18N2O3S3 Ambient -20°C Methanol, Water Not dangerous goods.

LKT M1873 S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine 25 mg 1331.8 Sulforaphane-cysteine conjugate. L-cysteine sulforaphane 364083-21-6 ≥98% 298.45 C9H18N2O3S3 Ambient -20°C Methanol, Water Not dangerous goods.

LKT A0822 N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine 5 mg 335 Sulforaphane-cysteine conjugate. N-Acetyl cysteine sulforaphane 334829-66-2 ≥98% 340.48 C11H20N2O4S3 Ambient -20°C Ethanol (5 mg/ml), DMSO (10 mg/ml ), DMF (10 mg/ml) Not dangerous goods.

LKT A0822 N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine 10 mg 598 Sulforaphane-cysteine conjugate. N-Acetyl cysteine sulforaphane 334829-66-2 ≥98% 340.48 C11H20N2O4S3 Ambient -20°C Ethanol (5 mg/ml), DMSO (10 mg/ml ), DMF (10 mg/ml) Not dangerous goods.

LKT A0822 N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine 25 mg 1331.8 Sulforaphane-cysteine conjugate. N-Acetyl cysteine sulforaphane 334829-66-2 ≥98% 340.48 C11H20N2O4S3 Ambient -20°C Ethanol (5 mg/ml), DMSO (10 mg/ml ), DMF (10 mg/ml) Not dangerous goods.

LKT A2658 Agomelatine 100 mg 97.2 Melatonin analog; MT1/2 agonist, 5-HT2C antagonist. 138112-76-2 ≥98% 243.3 C15H17NO2 CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC Ambient Ambient "Smeraldi E, Delmonte D. Agomelatine in depression. Expert Opin Drug Saf. 2013 Nov;12(6):873-80. PMID: 24033095.

Pompili M, Serafini G, Innamorati M, et al. Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: a critical review. World J Biol Psychiatry. 2013 Aug;14(6):412-31. PMID: 23530731.

Srinivasan V, Zakaria R, Othaman Z, et al. Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. CNS Neurol Disord Drug Targets. 2012 Mar;11(2):180-9. PMID: 22483286.

Bertaina-Anglade V, la Rochelle CD, Boyer PA, et al. Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model. Behav Pharmacol. 2006 Dec;17(8):703-13. PMID: 17110796.

Papp M, Litwa E, Gruca P, et al. Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behav Pharmacol. 2006 Feb;17(1):9-18. PMID: 16377959.

" N Not dangerous goods.

LKT A2658 Agomelatine 50 mg 67.2 Melatonin analog; MT1/2 agonist, 5-HT2C antagonist. 138112-76-2 ≥98% 243.3 C15H17NO2 CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC Ambient Ambient "Smeraldi E, Delmonte D. Agomelatine in depression. Expert Opin Drug Saf. 2013 Nov;12(6):873-80. PMID: 24033095.

Pompili M, Serafini G, Innamorati M, et al. Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: a critical review. World J Biol Psychiatry. 2013 Aug;14(6):412-31. PMID: 23530731.

Srinivasan V, Zakaria R, Othaman Z, et al. Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. CNS Neurol Disord Drug Targets. 2012 Mar;11(2):180-9. PMID: 22483286.

Bertaina-Anglade V, la Rochelle CD, Boyer PA, et al. Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model. Behav Pharmacol. 2006 Dec;17(8):703-13. PMID: 17110796.

Papp M, Litwa E, Gruca P, et al. Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behav Pharmacol. 2006 Feb;17(1):9-18. PMID: 16377959.

" N Not dangerous goods.

LKT S1853 Senegenin 5 mg 108.8 Found in Polygata tennifolia. 2469-34-3 ≥98% 537.13 C30H45ClO6 CC1(CCC2(CCC3=C(C2C1)C(CC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)CCl)C(=O)O)C Ambient Ambient "Xie W, Yang Y, Gu X, et al. Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. PLoS One. 2012;7(9):e45575. PMID: 23029109.

" Not dangerous goods.

LKT S1853 Senegenin 10 mg 197.1 Found in Polygata tennifolia. 2469-34-3 ≥98% 537.13 C30H45ClO6 CC1(CCC2(CCC3=C(C2C1)C(CC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)CCl)C(=O)O)C Ambient Ambient "Xie W, Yang Y, Gu X, et al. Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. PLoS One. 2012;7(9):e45575. PMID: 23029109.

" Not dangerous goods.

LKT S1853 Senegenin 25 mg 407.7 Found in Polygata tennifolia. 2469-34-3 ≥98% 537.13 C30H45ClO6 CC1(CCC2(CCC3=C(C2C1)C(CC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)CCl)C(=O)O)C Ambient Ambient "Xie W, Yang Y, Gu X, et al. Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. PLoS One. 2012;7(9):e45575. PMID: 23029109.

" Not dangerous goods.

LKT I7455 R-1-Isothiocyanato-7-(methylsulfinyl)-heptane 5 mg 271.7 ITC, antioxidant. ≥98% 219.37 C9H17NOS2 Ambient -20°C "Rose P, Huang Q, Ong CN, et al. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 2005 Dec 1;209(2):105-13. PMID: 15953625.

Kinae N, Masuda H, Shin IS, et al. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9. PMID: 11237192.

Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158.

" Not dangerous goods.

LKT I7455 R-1-Isothiocyanato-7-(methylsulfinyl)-heptane 10 mg 475.7 ITC, antioxidant. ≥98% 219.37 C9H17NOS2 Ambient -20°C "Rose P, Huang Q, Ong CN, et al. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 2005 Dec 1;209(2):105-13. PMID: 15953625.

Kinae N, Masuda H, Shin IS, et al. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9. PMID: 11237192.

Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158.

" Not dangerous goods.

LKT I7455 R-1-Isothiocyanato-7-(methylsulfinyl)-heptane 25 mg 951.3 ITC, antioxidant. ≥98% 219.37 C9H17NOS2 Ambient -20°C "Rose P, Huang Q, Ong CN, et al. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol. 2005 Dec 1;209(2):105-13. PMID: 15953625.

Kinae N, Masuda H, Shin IS, et al. Functional properties of wasabi and horseradish. Biofactors. 2000;13(1-4):265-9. PMID: 11237192.

Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158.

" Not dangerous goods.

LKT P3456 Pimobendan 10 mg 88.3 PDE3 inhibitor. Acardi; pimobendane 74150-27-9 ≥98% 334.37 C19H18N4O2 CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC Ambient Ambient DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 5 mg/mL "Shipley EA, Hogan DF, Fiakpui NN, et al. In vitro effect of pimobendan on platelet aggregation in dogs. Am J Vet Res. 2013 Mar;74(3):403-7. PMID: 23438115.

Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408. PMID: 22928748.

Verdouw PD, Hartog JM, Duncker DJ, et al. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986 Jul 15;126(1-2):21-30. PMID: 2875884.

Scholz H, Meyer W. Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation. 1986 Mar;73(3 Pt 2):III99-108. PMID: 2417748.

" Not dangerous goods.

LKT P3456 Pimobendan 25 mg 136 PDE3 inhibitor. Acardi; pimobendane 74150-27-9 ≥98% 334.37 C19H18N4O2 CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC Ambient Ambient DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 5 mg/mL "Shipley EA, Hogan DF, Fiakpui NN, et al. In vitro effect of pimobendan on platelet aggregation in dogs. Am J Vet Res. 2013 Mar;74(3):403-7. PMID: 23438115.

Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408. PMID: 22928748.

Verdouw PD, Hartog JM, Duncker DJ, et al. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986 Jul 15;126(1-2):21-30. PMID: 2875884.

Scholz H, Meyer W. Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation. 1986 Mar;73(3 Pt 2):III99-108. PMID: 2417748.

" Not dangerous goods.

LKT P3456 Pimobendan 100 mg 339.8 PDE3 inhibitor. Acardi; pimobendane 74150-27-9 ≥98% 334.37 C19H18N4O2 CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC Ambient Ambient DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 5 mg/mL "Shipley EA, Hogan DF, Fiakpui NN, et al. In vitro effect of pimobendan on platelet aggregation in dogs. Am J Vet Res. 2013 Mar;74(3):403-7. PMID: 23438115.

Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408. PMID: 22928748.

Verdouw PD, Hartog JM, Duncker DJ, et al. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986 Jul 15;126(1-2):21-30. PMID: 2875884.

Scholz H, Meyer W. Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation. 1986 Mar;73(3 Pt 2):III99-108. PMID: 2417748.

" Not dangerous goods.

LKT P3456 Pimobendan 500 mg 1087.2 PDE3 inhibitor. Acardi; pimobendane 74150-27-9 ≥98% 334.37 C19H18N4O2 CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC Ambient Ambient DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 5 mg/mL "Shipley EA, Hogan DF, Fiakpui NN, et al. In vitro effect of pimobendan on platelet aggregation in dogs. Am J Vet Res. 2013 Mar;74(3):403-7. PMID: 23438115.

Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012 Aug;22(4):398-408. PMID: 22928748.

Verdouw PD, Hartog JM, Duncker DJ, et al. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986 Jul 15;126(1-2):21-30. PMID: 2875884.

Scholz H, Meyer W. Phosphodiesterase-inhibiting properties of newer inotropic agents. Circulation. 1986 Mar;73(3 Pt 2):III99-108. PMID: 2417748.

" Not dangerous goods.

LKT I7460 R-1-Isothiocyanato-8-(methylsulfinyl)-octane 5 mg 237.8 ITC found in Nasturtium officinale. ≥98% 233.39 C10H19NOS2 Ambient -20°C -55° Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158. Not dangerous goods.

LKT I7460 R-1-Isothiocyanato-8-(methylsulfinyl)-octane 10 mg 407.7 ITC found in Nasturtium officinale. ≥98% 233.39 C10H19NOS2 Ambient -20°C -55° Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158. Not dangerous goods.

LKT I7460 R-1-Isothiocyanato-8-(methylsulfinyl)-octane 25 mg 815.4 ITC found in Nasturtium officinale. ≥98% 233.39 C10H19NOS2 Ambient -20°C -55° Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8. PMID: 11062158. Not dangerous goods.

LKT A4441 Allicin, aqueous solution 1 mg 273.3 Organosulfur found in garlic; Kir K+ channel activator, L-type Ca2+ channel blocker. Thio-2-propene-1-sulfinic acid S-allyl ester Allylthiosulphinic acid allyl ester; Diallyl thiosulfinate 539-86-6 ≥98% 162.27 C6H10OS2 C=CCSS(=O)CC=C Extremely heat sensitive Dry Ice -80°C Soluble in water. Miscible with alcohol "Chu YL, Ho CT, Chung JG, et al. Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy. J Agric Food Chem. 2013 Oct 16;61(41):9839-9848. PMID: 24059278.

Tyagi G, Pradhan S, Srivastava T, et al. Nucleic acid binding properties of allicin: Spectroscopic analysis and estimation of anti-tumor potential. Biochim Biophys Acta. 2013 Sep 13;1840(1):350-356. PMID: 24041991.

Liu DS, Gao W, Liang ES, et al. Effects of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction. Eur J Pharmacol. 2013 Aug 15;714(1-3):163-9. PMID: 23792140.

Ashry NA, Gameil NM, Suddek GM. Modulation of cyclophosphamide-induced early lung injury by allicin. Pharm Biol. 2013 Jun;51(6):806-11. PMID: 23675840.

Elkayam A, Peleg E, Grossman E, et al. Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J. 2013 Mar;15(3):170-3. PMID: 23662381.

Huang W, Wang Y, Cao YG, et al. Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin. Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):697-704. PMID: 23604291.

Osman M, Adnan A, Salmah Bakar N, et al. Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats. Pol J Pathol. 2012 Dec;63(4):248-54. PMID: 23359194.

Jesús Corral-Caridad M, Moreno I, Toraño A, et al. Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum. Exp Parasitol. 2012 Dec;132(4):475-82. PMID: 22995646.

Li XH, Li CY, Xiang ZG, et al. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65. PMID: 22990325.

Zhang L, Zhang H, Miao Y, et al. Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo. Food Chem Toxicol. 2012 Sep;50(9):3306-12. PMID: 22705327.

" Not dangerous goods.

LKT A4441 Allicin, aqueous solution 5 mg 960.8 Organosulfur found in garlic; Kir K+ channel activator, L-type Ca2+ channel blocker. Thio-2-propene-1-sulfinic acid S-allyl ester Allylthiosulphinic acid allyl ester; Diallyl thiosulfinate 539-86-6 ≥98% 162.27 C6H10OS2 C=CCSS(=O)CC=C Extremely heat sensitive Dry Ice -80°C Soluble in water. Miscible with alcohol "Chu YL, Ho CT, Chung JG, et al. Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy. J Agric Food Chem. 2013 Oct 16;61(41):9839-9848. PMID: 24059278.

Tyagi G, Pradhan S, Srivastava T, et al. Nucleic acid binding properties of allicin: Spectroscopic analysis and estimation of anti-tumor potential. Biochim Biophys Acta. 2013 Sep 13;1840(1):350-356. PMID: 24041991.

Liu DS, Gao W, Liang ES, et al. Effects of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction. Eur J Pharmacol. 2013 Aug 15;714(1-3):163-9. PMID: 23792140.

Ashry NA, Gameil NM, Suddek GM. Modulation of cyclophosphamide-induced early lung injury by allicin. Pharm Biol. 2013 Jun;51(6):806-11. PMID: 23675840.

Elkayam A, Peleg E, Grossman E, et al. Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J. 2013 Mar;15(3):170-3. PMID: 23662381.

Huang W, Wang Y, Cao YG, et al. Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin. Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):697-704. PMID: 23604291.

Osman M, Adnan A, Salmah Bakar N, et al. Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats. Pol J Pathol. 2012 Dec;63(4):248-54. PMID: 23359194.

Jesús Corral-Caridad M, Moreno I, Toraño A, et al. Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum. Exp Parasitol. 2012 Dec;132(4):475-82. PMID: 22995646.

Li XH, Li CY, Xiang ZG, et al. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65. PMID: 22990325.

Zhang L, Zhang H, Miao Y, et al. Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo. Food Chem Toxicol. 2012 Sep;50(9):3306-12. PMID: 22705327.

" Not dangerous goods.

LKT T1675 Teriparatide Acetate 0.5 mg 133.5 Synthetic peptide hormone, PTH analog; PTH1R agonist 52232-67-4 ≥95% 4117.72 C181H291N55O51S2 CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC5=CNC=N5)C(=O)NC(CC(=O)N)C(=O)NC(CC6=CC=CC=C6)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)N Ambient -20°C "Tseng YY, Su CH, Lui TN, et al. Prospective comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the treatment of new-onset adjacent vertebral compression fracture after percutaneous vertebroplasty. Osteoporos Int. 2012 May;23(5):1613-22. PMID: 21769661.

File E, Deal C. Clinical update on teriparatide. Curr Rheumatol Rep. 2009 Jul;11(3):169-76. PMID: 19604460.

Kaback LA, Soung do Y, Naik A, et al. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 2008 Sep 1;105(1):219-26. PMID: 18494002.

" Not dangerous goods.

LKT T1675 Teriparatide Acetate 1 mg 200.2 Synthetic peptide hormone, PTH analog; PTH1R agonist 52232-67-4 ≥95% 4117.72 C181H291N55O51S2 CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC2=CNC=N2)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC5=CNC=N5)C(=O)NC(CC(=O)N)C(=O)NC(CC6=CC=CC=C6)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)N Ambient -20°C "Tseng YY, Su CH, Lui TN, et al. Prospective comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the treatment of new-onset adjacent vertebral compression fracture after percutaneous vertebroplasty. Osteoporos Int. 2012 May;23(5):1613-22. PMID: 21769661.

File E, Deal C. Clinical update on teriparatide. Curr Rheumatol Rep. 2009 Jul;11(3):169-76. PMID: 19604460.

Kaback LA, Soung do Y, Naik A, et al. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 2008 Sep 1;105(1):219-26. PMID: 18494002.

" Not dangerous goods.

LKT N3208 Nicardipine 5 g 167.4 Dihydropyridine; L-type Ca2+ channel blocker. 55985-32-5 ≥98% 479.52 C26H29N3O6 CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC Ambient Ambient "Yue W, Wang L, Zhang F, et al. Inhibition of nicardipine on amygdala kindling in rats. Acta Pharmacol Sin. 2001 Apr;22(4):365-8. PMID: 11742591.

Eraković V, Zupan G, Mrsić J, et al. The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):633-47. PMID: 9194145.

Mashimo T, Pak M, Choe H, et al. Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1 on primary afferent nociceptors in humans. J Clin Pharmacol. 1997 Apr;37(4):330-5. PMID: 9115059.

Kanneganti M, Halpern NA. Acute hypertension and calcium-channel blockers. New Horiz. 1996 Feb;4(1):19-25. PMID: 8689271.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Nicardipine)"

LKT N3208 Nicardipine 25 g 418.6 Dihydropyridine; L-type Ca2+ channel blocker. 55985-32-5 ≥98% 479.52 C26H29N3O6 CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC Ambient Ambient "Yue W, Wang L, Zhang F, et al. Inhibition of nicardipine on amygdala kindling in rats. Acta Pharmacol Sin. 2001 Apr;22(4):365-8. PMID: 11742591.

Eraković V, Zupan G, Mrsić J, et al. The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):633-47. PMID: 9194145.

Mashimo T, Pak M, Choe H, et al. Effects of vasodilators guanethidine, nicardipine, nitroglycerin, and prostaglandin E1 on primary afferent nociceptors in humans. J Clin Pharmacol. 1997 Apr;37(4):330-5. PMID: 9115059.

Kanneganti M, Halpern NA. Acute hypertension and calcium-channel blockers. New Horiz. 1996 Feb;4(1):19-25. PMID: 8689271.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Nicardipine)"

LKT D5994 Doxepin Hydrochloride 1 g 40.7 FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, histamine H1/2 antagonist, SERT, NET, H+/K+ ATPase inhibitor. 1229-29-4 ≥98% 315.84 C19H21NO HCl CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl Ambient Ambient "Hassanzadeh P, Hassanzadeh A. The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin. Iran J Basic Med Sci. 2011 Sep;14(5):414-21. PMID: 23493814.

Cheng BC, Chan BR, Chen YW, et al. Doxepin has a potent and long-acting spinal anesthetic effect in rats. Kaohsiung J Med Sci. 2006 Feb;22(2):68-74. PMID: 16568723.

Hajak G, Rodenbeck A, Voderholzer U et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry. 2001 Jun;62(6):453–63. PMID: 11465523.

Figueiredo A, Ribeiro CA, Gonçalo M, et al. Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. PMID: 2141000.

Beil W, Staar U, Schünemann P, et al. Omeprazole, SCH 28080 and doxepin differ in their characteristics to inhibit H+/K+-ATPase driven proton accumulation by parietal cell membrane vesicles. Biochem Pharmacol. 1988 Dec 1;37(23):4487-93. PMID: 2849447.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Doxepin hydrochloride)"

LKT D5994 Doxepin Hydrochloride 5 g 149.5 FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, histamine H1/2 antagonist, SERT, NET, H+/K+ ATPase inhibitor. 1229-29-4 ≥98% 315.84 C19H21NO HCl CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl Ambient Ambient "Hassanzadeh P, Hassanzadeh A. The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin. Iran J Basic Med Sci. 2011 Sep;14(5):414-21. PMID: 23493814.

Cheng BC, Chan BR, Chen YW, et al. Doxepin has a potent and long-acting spinal anesthetic effect in rats. Kaohsiung J Med Sci. 2006 Feb;22(2):68-74. PMID: 16568723.

Hajak G, Rodenbeck A, Voderholzer U et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry. 2001 Jun;62(6):453–63. PMID: 11465523.

Figueiredo A, Ribeiro CA, Gonçalo M, et al. Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. PMID: 2141000.

Beil W, Staar U, Schünemann P, et al. Omeprazole, SCH 28080 and doxepin differ in their characteristics to inhibit H+/K+-ATPase driven proton accumulation by parietal cell membrane vesicles. Biochem Pharmacol. 1988 Dec 1;37(23):4487-93. PMID: 2849447.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Doxepin hydrochloride)"

LKT D5994 Doxepin Hydrochloride 25 g 407.7 FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, histamine H1/2 antagonist, SERT, NET, H+/K+ ATPase inhibitor. 1229-29-4 ≥98% 315.84 C19H21NO HCl CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl Ambient Ambient "Hassanzadeh P, Hassanzadeh A. The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin. Iran J Basic Med Sci. 2011 Sep;14(5):414-21. PMID: 23493814.

Cheng BC, Chan BR, Chen YW, et al. Doxepin has a potent and long-acting spinal anesthetic effect in rats. Kaohsiung J Med Sci. 2006 Feb;22(2):68-74. PMID: 16568723.

Hajak G, Rodenbeck A, Voderholzer U et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry. 2001 Jun;62(6):453–63. PMID: 11465523.

Figueiredo A, Ribeiro CA, Gonçalo M, et al. Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58. PMID: 2141000.

Beil W, Staar U, Schünemann P, et al. Omeprazole, SCH 28080 and doxepin differ in their characteristics to inhibit H+/K+-ATPase driven proton accumulation by parietal cell membrane vesicles. Biochem Pharmacol. 1988 Dec 1;37(23):4487-93. PMID: 2849447.

" "UN number: 2811     Class: 6.1     Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Doxepin hydrochloride)"

LKT O4549 Olmesartan Medoxomil 25 mg 47.6 AT1 inhibitor. (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(methyl)-1H-imidazole-5-carboxylate 144689-63-4 ≥98% 558.59 C29H30N6O6 CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O Ambient Ambient "You J, Wu J, Jiang G, et al. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. PMID: 23188126.

Verdecchia P, Angeli F, Repaci S, et al. Comparative assessment of angiotensin receptor blockers in different clinical settings. Vasc Health Risk Manag. 2009;5:939-48. PMID: 19997575.

Matsumoto S, Shimodozono M, Miyata R, et al. Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke. Hypertens Res. 2009 Nov;32(11):1015-21. PMID: 19745828.

Yamamoto E, Dong YF, Kataoka K, et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition. Hypertension. 2008 Sep;52(3):573-80. PMID: 18678790.

Brousil JA, Burke JM. Olmesartan medoxomil: an angiotensin II-receptor blocker. Clin Ther. 2003 Apr;25(4):1041-55. PMID: 12809956.

" N/A Not dangerous goods.

LKT O4549 Olmesartan Medoxomil 100 mg 136 AT1 inhibitor. (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(methyl)-1H-imidazole-5-carboxylate 144689-63-4 ≥98% 558.59 C29H30N6O6 CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O Ambient Ambient "You J, Wu J, Jiang G, et al. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. PMID: 23188126.

Verdecchia P, Angeli F, Repaci S, et al. Comparative assessment of angiotensin receptor blockers in different clinical settings. Vasc Health Risk Manag. 2009;5:939-48. PMID: 19997575.

Matsumoto S, Shimodozono M, Miyata R, et al. Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke. Hypertens Res. 2009 Nov;32(11):1015-21. PMID: 19745828.

Yamamoto E, Dong YF, Kataoka K, et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition. Hypertension. 2008 Sep;52(3):573-80. PMID: 18678790.

Brousil JA, Burke JM. Olmesartan medoxomil: an angiotensin II-receptor blocker. Clin Ther. 2003 Apr;25(4):1041-55. PMID: 12809956.

" N/A Not dangerous goods.

LKT O4549 Olmesartan Medoxomil 250 mg 237.8 AT1 inhibitor. (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(methyl)-1H-imidazole-5-carboxylate 144689-63-4 ≥98% 558.59 C29H30N6O6 CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O Ambient Ambient "You J, Wu J, Jiang G, et al. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. PMID: 23188126.

Verdecchia P, Angeli F, Repaci S, et al. Comparative assessment of angiotensin receptor blockers in different clinical settings. Vasc Health Risk Manag. 2009;5:939-48. PMID: 19997575.

Matsumoto S, Shimodozono M, Miyata R, et al. Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke. Hypertens Res. 2009 Nov;32(11):1015-21. PMID: 19745828.

Yamamoto E, Dong YF, Kataoka K, et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition. Hypertension. 2008 Sep;52(3):573-80. PMID: 18678790.

Brousil JA, Burke JM. Olmesartan medoxomil: an angiotensin II-receptor blocker. Clin Ther. 2003 Apr;25(4):1041-55. PMID: 12809956.

" N/A Not dangerous goods.

LKT Z5745 Zolmitriptan 25 mg 61.1 5-HT1B/1D agonist. (S)-4-(methyl)-1,3-oxazolidin-2-one 139264-17-8 ≥98% 287.36 C16H21N3O2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3 Ambient Ambient "Lindhe O, Almqvist P, Kågedal M, et al. Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan. Int J Mol Imaging. 2011;2011:694179. PMID: 22013519.

Kayser V, Latrémolière A, Hamon M, et al. N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain. Eur J Pain. 2011 May;15(5):451-8. PMID: 20965753.

Stepień A, Chalimoniuk M, Strosznajder J. Serotonin 5HT1B/1D receptor agonists abolish NMDA receptor-evoked enhancement of nitric oxide synthase activity and cGMP concentration in brain cortex slices. Cephalalgia. 1999 Dec;19(10):859-65. PMID: 10668104.

Cumberbatch MJ, Hill RG, Hargreaves RJ. The effects of 5-HT1A, 5-HT1B and 5-HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats. Eur J Pharmacol. 1998 Nov 27;362(1):43-6. PMID: 9865528.

Pascual J. Mechanism of action of zolmitriptan. Neurologia. 1998 Oct;13 Suppl 2:9-15. PMID: 9859690." Not dangerous goods.

LKT Z5745 Zolmitriptan 100 mg 169.9 5-HT1B/1D agonist. (S)-4-(methyl)-1,3-oxazolidin-2-one 139264-17-8 ≥98% 287.36 C16H21N3O2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3 Ambient Ambient "Lindhe O, Almqvist P, Kågedal M, et al. Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan. Int J Mol Imaging. 2011;2011:694179. PMID: 22013519.

Kayser V, Latrémolière A, Hamon M, et al. N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain. Eur J Pain. 2011 May;15(5):451-8. PMID: 20965753.

Stepień A, Chalimoniuk M, Strosznajder J. Serotonin 5HT1B/1D receptor agonists abolish NMDA receptor-evoked enhancement of nitric oxide synthase activity and cGMP concentration in brain cortex slices. Cephalalgia. 1999 Dec;19(10):859-65. PMID: 10668104.

Cumberbatch MJ, Hill RG, Hargreaves RJ. The effects of 5-HT1A, 5-HT1B and 5-HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats. Eur J Pharmacol. 1998 Nov 27;362(1):43-6. PMID: 9865528.

Pascual J. Mechanism of action of zolmitriptan. Neurologia. 1998 Oct;13 Suppl 2:9-15. PMID: 9859690." Not dangerous goods.

LKT Z5745 Zolmitriptan 250 mg 305.9 5-HT1B/1D agonist. (S)-4-(methyl)-1,3-oxazolidin-2-one 139264-17-8 ≥98% 287.36 C16H21N3O2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3 Ambient Ambient "Lindhe O, Almqvist P, Kågedal M, et al. Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan. Int J Mol Imaging. 2011;2011:694179. PMID: 22013519.

Kayser V, Latrémolière A, Hamon M, et al. N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain. Eur J Pain. 2011 May;15(5):451-8. PMID: 20965753.

Stepień A, Chalimoniuk M, Strosznajder J. Serotonin 5HT1B/1D receptor agonists abolish NMDA receptor-evoked enhancement of nitric oxide synthase activity and cGMP concentration in brain cortex slices. Cephalalgia. 1999 Dec;19(10):859-65. PMID: 10668104.

Cumberbatch MJ, Hill RG, Hargreaves RJ. The effects of 5-HT1A, 5-HT1B and 5-HT1D receptor agonists on trigeminal nociceptive neurotransmission in anaesthetized rats. Eur J Pharmacol. 1998 Nov 27;362(1):43-6. PMID: 9865528.

Pascual J. Mechanism of action of zolmitriptan. Neurologia. 1998 Oct;13 Suppl 2:9-15. PMID: 9859690." Not dangerous goods.

LKT D8145 Duloxetine Hydrochloride 100 mg 61.1 SERT and NET inhibitor, Nav1.7 Na+ channel blocker. (+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride LY-248686 hydrochloride, Cymbalta, Ariclaim 136434-34-9 ≥98% 333.88 C18H19NOS HCl CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl Ambient Ambient "Wang SY, Calderon J, Kuo Wang G. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65. PMID: 20693878.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. PMID: 19480470.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

Müller N, Schennach R, Riedel M, et al. Duloxetine in the treatment of major psychiatric and neuropathic disorders. Expert Rev Neurother. 2008 Apr;8(4):527-36. PMID: 18416656.

Sweeney DD, Chancellor MB. Treatment of stress urinary incontinence with duloxetine hydrochloride. Rev Urol. 2005 Spring;7(2):81-6. PMID: 16985814.

" Not dangerous goods.

LKT D8145 Duloxetine Hydrochloride 250 mg 115.5 SERT and NET inhibitor, Nav1.7 Na+ channel blocker. (+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride LY-248686 hydrochloride, Cymbalta, Ariclaim 136434-34-9 ≥98% 333.88 C18H19NOS HCl CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl Ambient Ambient "Wang SY, Calderon J, Kuo Wang G. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65. PMID: 20693878.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. PMID: 19480470.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

Müller N, Schennach R, Riedel M, et al. Duloxetine in the treatment of major psychiatric and neuropathic disorders. Expert Rev Neurother. 2008 Apr;8(4):527-36. PMID: 18416656.

Sweeney DD, Chancellor MB. Treatment of stress urinary incontinence with duloxetine hydrochloride. Rev Urol. 2005 Spring;7(2):81-6. PMID: 16985814.

" Not dangerous goods.

LKT D8145 Duloxetine Hydrochloride 1 g 271.7 SERT and NET inhibitor, Nav1.7 Na+ channel blocker. (+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride LY-248686 hydrochloride, Cymbalta, Ariclaim 136434-34-9 ≥98% 333.88 C18H19NOS HCl CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl Ambient Ambient "Wang SY, Calderon J, Kuo Wang G. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65. PMID: 20693878.

Carter NJ, McCormack PL. Duloxetine: a review of its use in the treatment of generalized anxiety disorder. CNS Drugs. 2009;23(6):523-41. PMID: 19480470.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

Müller N, Schennach R, Riedel M, et al. Duloxetine in the treatment of major psychiatric and neuropathic disorders. Expert Rev Neurother. 2008 Apr;8(4):527-36. PMID: 18416656.

Sweeney DD, Chancellor MB. Treatment of stress urinary incontinence with duloxetine hydrochloride. Rev Urol. 2005 Spring;7(2):81-6. PMID: 16985814.

" Not dangerous goods.

LKT T5968 Torsemide 100 mg 67.9 Loop diuretic; NKCC symporter and HSP90 inhibitor. N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide Torasemide 56211-40-6 ≥98% 348.42 C16H20N4O3S CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C Ambient Ambient "Sheikha GA, Al-Sha'er MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.

Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.

Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.

Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.

Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.

" Not dangerous goods.

LKT T5968 Torsemide 250 mg 136 Loop diuretic; NKCC symporter and HSP90 inhibitor. N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide Torasemide 56211-40-6 ≥98% 348.42 C16H20N4O3S CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C Ambient Ambient "Sheikha GA, Al-Sha'er MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.

Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.

Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.

Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.

Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.

" Not dangerous goods.

LKT T5968 Torsemide 1 g 407.7 Loop diuretic; NKCC symporter and HSP90 inhibitor. N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide Torasemide 56211-40-6 ≥98% 348.42 C16H20N4O3S CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C Ambient Ambient "Sheikha GA, Al-Sha'er MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.

Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.

Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.

Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.

Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.

" Not dangerous goods.

LKT O4400 Olanzapine 100 mg 67.9 AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mAChR, α1/2-adrenergic antagonist. 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine 132539-06-1 ≥98% 312.43 C17H20N4S CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C Ambient Ambient Practically insoluble in water "Ikegami M, Ikeda H, Ishikawa Y, et al. Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus. Eur J Pharmacol. 2013 Aug 22. [Epub ahead of print]. PMID: 23973646.

Cheon Y, Park JY, Modi HR, et al. Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain. J Neurochem. 2011 Oct;119(2):364-76. PMID: 21812779.

Lee JG, Cho HY, Park SW, et al. Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1001-6. PMID: 20546816.

Sepede G, De Berardis D, Gambi F, et al. Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. J Clin Psychopharmacol. 2006 Feb;26(1):45-9. PMID: 16475705.

Bymaster FP, Calligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. PMID: 8822531.

" Not Dangerous Goods

LKT O4400 Olanzapine 250 mg 136 AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mAChR, α1/2-adrenergic antagonist. 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine 132539-06-1 ≥98% 312.43 C17H20N4S CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C Ambient Ambient Practically insoluble in water "Ikegami M, Ikeda H, Ishikawa Y, et al. Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus. Eur J Pharmacol. 2013 Aug 22. [Epub ahead of print]. PMID: 23973646.

Cheon Y, Park JY, Modi HR, et al. Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain. J Neurochem. 2011 Oct;119(2):364-76. PMID: 21812779.

Lee JG, Cho HY, Park SW, et al. Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1001-6. PMID: 20546816.

Sepede G, De Berardis D, Gambi F, et al. Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. J Clin Psychopharmacol. 2006 Feb;26(1):45-9. PMID: 16475705.

Bymaster FP, Calligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. PMID: 8822531.

" Not Dangerous Goods

LKT O4400 Olanzapine 1 g 407.7 AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mAChR, α1/2-adrenergic antagonist. 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine 132539-06-1 ≥98% 312.43 C17H20N4S CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C Ambient Ambient Practically insoluble in water "Ikegami M, Ikeda H, Ishikawa Y, et al. Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus. Eur J Pharmacol. 2013 Aug 22. [Epub ahead of print]. PMID: 23973646.

Cheon Y, Park JY, Modi HR, et al. Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain. J Neurochem. 2011 Oct;119(2):364-76. PMID: 21812779.

Lee JG, Cho HY, Park SW, et al. Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1001-6. PMID: 20546816.

Sepede G, De Berardis D, Gambi F, et al. Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. J Clin Psychopharmacol. 2006 Feb;26(1):45-9. PMID: 16475705.

Bymaster FP, Calligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. PMID: 8822531.

" Not Dangerous Goods

LKT C0366 Carvedilol Phosphate Hemihydrate 1 g 101.9 FIASMA; α1- and β1/2-adrenergic antagonist. (2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate 610309-89-2 ≥98% 513.47 C24H26N2O4 H3O4P 1/2H2O COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O.OP(=O)(O)O Ambient 4°C "Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

" Not dangerous goods.